Clinical trials: Congestive Heart Failure Acute
Heart Failure, Acute Myocardial Infarction (AMI)
Efficacy and Safety of Early Initiation of Vericiguat in Heart Failure After Acute Myocardial Infarction
Heart failure (HF) is a severe cardiovascular disease with extremely high morbidity and mortality rates worldwide, and ischemic cardiomyopathy is an important cause of heart failure.
- Conditions
- Heart Failure, Acute Myocardial Infarction (AMI), Acute Heart Failure (AHF)
- Trial name
- VIC-MI (NCT06812546)
- Testing
- Vericiguat
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Dongying Zhang
Acute on Chronic Systolic Congestive Heart Failure, Cardiorenal Syndrome
Feasibility of the SCD in Cardiorenal Syndrome Patients Awaiting LVAD
Cardiovascular disease is the leading cause of mortality in the US, accounting for 45% of all deaths. Chronic Heart Failure (CHF) is now understood to be a multi-system disease process involving not only the cardiovascular system…
- Trial name
- NEUTRALIZE-CRS (NCT03836482)
- Testing
- Selective Cytopheretic Device
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- SeaStar Medical
Primary Percutaneous Coronary Intervention
Short Term Outcomes of Primary Percutaneous Coronary Intervention (PCI) Patients Presented With Acute Heart Failure in Assuit University Heart Hospital
Observational study outcome of PCI in patients presented with acute heart failure
- Trial name
- NCT06825780
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Assiut University
Pulmonary Embolism
Comparison of Thrombgolytic and Anticoagulation Therapy in Submassive Pulmonary Embolism
Currently there is no clear guidance for the treatment of moderate risk of pulmonary embolism. The aim of the study is to compare two different therapeutic modalities - standard anticoagulation versus thrombolytic treatment…
- Trial name
- CONTACT-SPE (NCT02132689)
- Testing
- Actilyse (Thrombolytic therapy), Heparine (Standard anticoagulation therapy)
- Where
- 2 sites in Czechia
- Volunteers
- 100 people
- Sponsor
- University Hospital Ostrava
Heart Failure With Preserved Ejection Fraction
Acute Effects of Exogenous Ketone Ester Administration in Heart Failure
The purpose of this study is to test whether a ketone ester drink will improve exercise in people with heart failure (HF) compared to a placebo.
- Trial name
- NCT04633460
- Testing
- Ketone ester
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- University of Pennsylvania
Dyspnea, Hypertension
Clevidipine vs Placebo or Standard of Care for Dyspnea and Blood Pressure Control in AHF
The purpose of this study is to evaluate dyspnea improvement and other parameters of efficacy and safety in acute heart failure (AHF) patients receiving an intravenous (IV) infusion of clevidipine in comparison to standard of…
- Conditions
- Dyspnea, Hypertension, Acute Heart Failure
- Trial name
- PRONTO II (NCT04592380)
- Testing
- Stage 1: Clevidipine (double-blinded), Stage 2: Clevidipine (open-label), Stage 2: Standard of Care (open-label)
- Where
- 9 sites in United States
- Sponsor
- The Medicines Company
Cardiogenic Shock, Acute Myocardial Infarction (AMI)
Routine Microaxial Heart Pump Support and Protocolized Pulmonary Artery Catheter Monitoring Versus Standard Care in Heart Attack-Related Cardiogenic Shock
The goal of this clinical trial is to learn which treatment strategies improve survival in adult patients with acute myocardial infarction complicated by cardiogenic shock (AMI-CS).
- Conditions
- Cardiogenic Shock, Acute Myocardial Infarction (AMI), Heart Failure, Acute
- Trial name
- DOUBLE-SHOCK (NCT07762560)
- Testing
- Microaxial flow pump (left ventricular assist device), Pulmonary artery catheter, Conventional hemodynamic monitoring
- Where
- Germany
- Volunteers
- 780 people
- Sponsor
- Leipzig Heart Science gGmbH
Acute Heart Failure
Parameters of Cardiac Indices on the Ultrasonic Cardiac Output Monitor As Potential Indicators for Predicting the Achievement of Ultrafiltration Endpoint for Acute Heart Failure Treatment
Background: The feasibility of the ultrasonic cardiac output monitor (USCOM)applying for determining ultrafiltration (UF) endpoints during acute heart failure (AHF) treatments was evaluated.
- Trial name
- NCT06533124
- Testing
- The ultrasonic cardiac output monitor 1A system (USCOM Ltd., Sydney, Australia) is a non-invasive Doppler stroke volume (SV) technique derived from echocardiography.
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Shanghai Tong Ren Hospital
Heart Failure, Congestive
An Exploratory Study of Nesiritide in Participants With Acute Heart Failure
The purpose of this exploratory study is to assess the efficacy and safety of nesiritide in participants with acute (a quick and severe form of illness in its early stage) heart failure (when the heart inadequately pumps blood…
- Trial name
- NCT00490724
- Testing
- Nesiritide (1+0.01), Nesiritide (2+0.005), Nesritide (2+0.01)
- Where
- 11 sites in Japan
- Volunteers
- 67 people
- Sponsor
- Janssen Pharmaceutical K.K.
Acute Heart Failure
Digoxin Short Term Treatment Assessment Randomized Trial in AHF
AHFS management is challenging and most of the used drugs has failed to decrease post-discharge mortality and readmission rates which represent the most important goal in AHFS.
- Trial name
- DIG-STA-AHF (NCT02544815)
- Testing
- Digoxin
- Where
- 2 sites in Tunisia
- Volunteers
- 500 people
- Sponsor
- University of Monastir
Heart Failure, Congestive
Efficacy and Safety of Relaxin for the Treatment of Acute Heart Failure
Different doses of relaxin will be compared to placebo to determine efficacy and safety for the treatment of patients hospitalized with acute heart failure
- Trial name
- RELAX-AHF (NCT00520806)
- Testing
- Relaxin
- Where
- 3 sites in United States, Israel
- Volunteers
- 1,161 people
- Sponsor
- Corthera, Inc.(formerly BAS Medical, Inc.), a member of the Novartis group of companies
Acute Heart Failure
0.5M Na Lactate Solution in Acute Heart Failure (AHF)
The objective of this trial to see whether: -Cardiac performance (cardiac index and secondary outcomes)can be improved in patients with acute heart failure (AHF) and symptoms and consequences of fluid overload (pulmonary and…
- Trial name
- SOLACE1 (NCT01981655)
- Testing
- 0.5M Sodium lactate, Hartmann's solution
- Where
- Australia
- Volunteers
- 41 people
- Sponsor
- Nepean Blue Mountains Local Health District
Heart Failure
Study of Percutaneous Renal Artery Intervention for Patient With Heart Failure
This study will address the role of percutaneous renal intervention for a hemodynamically significant renal artery stenosis in patients with heart failure exacerbations.
- Trial name
- STRETCH (NCT01403714)
- Testing
- Renal Artery Stenting
- Where
- United States
- Sponsor
- University of Pennsylvania
Acute Decompensated Heart Failure; Renal Dysfunction
Safety and Efficacy Study to Evaluate the Effect of SLV320 on Renal Function in Patients With Worsening Heart Failure
The purpose of this study is to determine the efficacy and safety of IV SLV320 in acute heart failure patients with renal dysfunction.
- Trial name
- NCT00744341
- Testing
- SLV320
- Where
- 105 sites in United States, Canada and 9 more
- Volunteers
- 46 people
- Sponsor
- Solvay Pharmaceuticals
Acute Coronary Syndrome, Heart Failure
Increasing Exercise and Decreasing Sedentary Behavior Among Patients in a Cardiac Rehabilitation Clinic
Cardiac rehabilitation patients often fail to exercise as prescribed on days they are not attending rehabilitation and there is a steep drop off in exercise following rehabilitation completion.
- Conditions
- Acute Coronary Syndrome, Heart Failure, Other Cardiac Conditions Among Cardiac Rehabilitation Participants
- Trial name
- NCT02679599
- Testing
- B-MOBILE-CARDIAC smartphone application, Cardiac rehabilitation as usual
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- The Miriam Hospital
Acute Heart Failure
Heart Failure Hospital Readmissions and Physical Therapy
This is a dissertation study which is divided into three different studies in order to answer the main research question (Study 3).
- Trial name
- NCT03517514
- Testing
- Physical Therapy service
- Where
- United States
- Volunteers
- 102 people
- Sponsor
- The Methodist Hospital Research Institute
Acute Heart Failure
a PRagmatic Observational Study of Congestion proFILes in patiEnts With Acute Heart Failure
The goal of this observational is to study the prevalence of distinct congestion phenotypes and study their association with response to therapy and outcomes in acute heart failure patients.
- Trial name
- PROFILE-AHF (NCT06587854)
- Where
- Netherlands
- Volunteers
- 270 people
- Sponsor
- University Medical Center Groningen
Acute Heart Failure (AHF), Dyspnoea
Acute Heart Failure in Elderly Patients Admitted to the Emergency Department with Acute Dyspnea: a Multimarker Approach Prognostic Study
Background and Rationale: Acute dyspnea is a frequent presenting symptom in emergency departments (ED), with acute heart failure (AHF) being the most common cause leading to hospitalization in elderly patients.
- Trial name
- READ-MA-PRONO (NCT06692439)
- Volunteers
- 185 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Heart Failure
Study of High-dose Spironolactone vs. Placebo Therapy in Acute Heart Failure
The primary objective of this study is to test the hypothesis that high-dose spironolactone will lead to greater proportional reduction in NT-proBNP levels from randomization to 96 hours over standard of care.
- Trial name
- ATHENA-HF (NCT02235077)
- Testing
- Spironolactone
- Where
- 22 sites in United States
- Volunteers
- 360 people
- Sponsor
- Duke University
Cardio-Renal Syndrome, Coronary Angiography
Risk Factors and Prognosis of Adverse Cardiovascular and Kidney Events After Coronary Intervention
As a single center, retrospective observation study in Guangdong Institute of Cardiovascular Diseases, this study included the main study population of patients who underwent coronary angiography and / or coronary intervention…
- Conditions
- Cardio-Renal Syndrome, Coronary Angiography, Coronary Artery Disease, Kidney Diseases
- Trial name
- NCT04407936
- Where
- China
- Volunteers
- 88,938 people
- Sponsor
- Guangdong Provincial People's Hospital