Clinical trials: Congestive Heart Failure Acute
Heart Disease, Heart Failure With Preserved Ejection Fraction
Acute Effects of Inorganic Nitrite on Cardiovascular Hemodynamics in Heart Failure With Preserved Ejection Fraction
Heart failure with preserved ejection fraction (HFpEF) is a major public health problem that has no proven effective treatment. This study assessed the effects of acute nitrite administration on resting and exercise hemodynamics…
- Conditions
- Heart Disease, Heart Failure With Preserved Ejection Fraction, Exercise Intolerance, Pulmonary Hypertension
- Trial name
- NCT01932606
- Testing
- Nitrite
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Barry Borlaug
Acute Myocardial Infarction
Effect of Intravenous Immunglobulin (IVIG) After Myocardial Infarction
The instigators hypothesize that IVIG, given in the acute phase following MI in patients at risk for developing HF, will improve cardiac performance, and by attenuating cardiac remodeling in this phase, such therapy will prevent…
- Trial name
- NCT00430885
- Testing
- Octagam (IVIG)
- Where
- Norway
- Volunteers
- 62 people
- Sponsor
- Oslo University Hospital
Myocardial Infarction (MI)
Efficacy and Safety Study of Proposed Biosimilar Product Reveliza vs Actilise in Patients With ST-segment Elevation Myocardial Infarction
Thi is is a multi-center, randomized, single-blind, parallel group clinical trial to evaluate the efficacy and safety of the intravenious thrombolysis with Revelise® (GENERIUM, Russia) in comparosin with the Actilyse® (Boehringer…
- Trial name
- NCT07146360
- Testing
- Revelise (GENERIUM, Russia), Actilyse® (Boehringer Ingelheim Pharma GmbH and Co.KG, Germany)
- Where
- 22 sites in Russia
- Volunteers
- 180 people
- Sponsor
- AO GENERIUM
Acute Decompensated Heart Failure
Compression Therapy of the Lower Limbs in Patients With Decompensated Heart Failure
Randomized 1:1 multicenter double-blind clinical investigation evaluating the efficacy and safety of compression therapy of the lower limbs plus parenteral administration of diuretics vs.
- Trial name
- NCT06418932
- Testing
- UrgoK2 / UrgoK2 Lite, Controll
- Where
- 8 sites in Spain
- Volunteers
- 106 people
- Sponsor
- Fundación para la Investigación del Hospital Clínico de Valencia
Heart Failure, Congestive
A Method Validation Study for Evaluation of Novel Treatments Limiting Pulmonary Oedema in Cardiac Failure
Transient receptor potential vanilloid 4 (TRPV4) channel blockade may be promising in the treatment of pulmonary oedema and dyspnoea in heart failure (HF) and acute decompensated heart failure (ADHF) patients by re-establishing…
- Trial name
- NCT02135861
- Testing
- DCE-MRI scans, Gadobutrol
- Where
- United Kingdom
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Acute Decompensated Heart Failure, Obstructive Sleep Apnea
Motivational Enhancement - Acute Decompensated Heart Failure and OSA
A feasibility randomized controlled trial will be conducted with a 6-month follow up to: Examine the impact of early intensive telemedicine motivational enhancement (TIME) vs standard of care on PAP adherence (n=40/group) and…
- Conditions
- Acute Decompensated Heart Failure, Obstructive Sleep Apnea, Motivational Enhancement, PAP Adherence
- Trial name
- NCT04752462
- Testing
- Telemedicine Intensive Motivational Enhancement
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- The Cleveland Clinic
Heart Failure
NAtional TUnisian REgistry of Heart Failure
NATURE-HF is an observational, multicentric and longitudinal study of heart failure performed with 100 tunisian cardiologists.
- Trial name
- NATURE-HF (NCT03262675)
- Where
- Tunisia
- Volunteers
- 2,040 people
- Sponsor
- Dacima Consulting
Heart Failure, Ischemic Cardiomyopathy
Molecular Pathways of Cardiac Remodellation in Patients With Acute and Chronic Left Ventricular Disfunction
Chronic heart failure represents an extremely complex clinical syndrome, defined as the inability of the heart muscle to generate a volume adequate to the metabolic needs of peripheral tissues, or to do so only in the face of…
- Trial name
- HFrEF (NCT05745571)
- Testing
- Blood sample
- Where
- Italy
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Heart Failure，Congestive
Dapagliflozin on Volume Vascular Outcomes.
The purpose of the DAPA-VOLVO trial is to investigate the effects of Dapagliflozin on top of recommended standard therapy on volume status and vascular function in clinically stable de novo or chronic heart failure patients after…
- Trial name
- DAPA-VOLVO (NCT04869124)
- Testing
- Dapagliflozin
- Where
- Switzerland
- Volunteers
- 80 people
- Sponsor
- Frank Ruschitzka
Respiratory Tract Infections, Pneumonia, Bacterial
Procalcitonin in Early Antibiotic Interruption in Patient With Bacterial Pulmonary infeCtion and Acute Heart Failure
Introduction: Acute Heart Failure is frequently decompensated by pulmonary infection, but the diagnosis of pulmonary infection sometimes is difficult in these patients due to similar signals and clinical symptoms in both…
- Conditions
- Respiratory Tract Infections, Pneumonia, Bacterial, Heart Failure
- Trial name
- EPICAD (NCT02787603)
- Testing
- Interruption of antibiotic treatment due to PCT measurement
- Where
- Brazil
- Volunteers
- 46 people
- Sponsor
- University of Sao Paulo General Hospital
Symptomatic Decompensated Congestive Heart Failure, Congestive Heart Failure in Acute Coronary Syndrome
A Study Comparing Blood Flow and Clinical and Safety Effects of the Addition of Natrecor (Nesiritide), Placebo or Intravenous Nitroglycerin to Standard Care for the Treatment of Worsening Congestive Heart Failure.
The purpose of this study is to compare the hemodynamic (blood flow) and clinical effects of the study drug, Natrecor (nesiritide, a recombinant form of the natural human peptide normally secreted by the heart in response to…
- Trial name
- NCT00270374
- Testing
- nesiritide
- Volunteers
- 498 people
- Sponsor
- Scios, Inc.
Heart Failure, COPD
Ultrasound in Acute Dyspnea in the Field
Acute heart failure is one of the main causes of acute respiratory distres in prehospital emergency setting. The early and correct diagnosis is important because the misdiagnosis can result in deleterious consequeance to…
- Conditions
- Heart Failure, COPD, Asthma
- Trial name
- NCT01235182
- Where
- Slovenia
- Volunteers
- 248 people
- Sponsor
- University Medical Centre Maribor
Myocardial Infarction, Acute
T2 Heart Mapping in AMI Population for the Prediction of Short Term Major Adverse Cardiovascular Events
A novel Cardiac MRI sequence, developed by Dr. Maria Altbach (Double Inversion radial fast Spin Echo T2 mapping), has been tested clinically.
- Trial name
- T2 AMI MRI (NCT01796743)
- Where
- United States
- Sponsor
- University of Arizona
Acute Heart Failure, Emergencies
Risk Stratification Using MEESSI-AHF Scale in ED and Impact on AHF Outcomes
Evaluate the impact the application of the MESSI-AHF scale (a risk stratification scale specifically derived and validated in patients diagnosed with acute heart failure, AHF) in decision making (admission vs.
- Trial name
- MEESSI (NCT05919225)
- Testing
- Risk stratification before decision-making about patient hospitalization or discharge
- Where
- 19 sites in Spain
- Volunteers
- 3,200 people
- Sponsor
- Hospital Clinic of Barcelona
Acute Decompensated Heart Failure, COPD Exacerbation
Use of ΔIVC for Early Diagnosis of AHF in AECOPD
Acute Heart failure (AHF) is a common cause of acute exacerbation of chronic obstructive pulmonary disease (AECOPD). This association is frequently underestimated with regard to the difficulty of clinical diagnosis.
- Trial name
- NCT05327374
- Testing
- calculation of the inferior vena cava collapsibility index
- Where
- 3 sites in Tunisia
- Volunteers
- 401 people
- Sponsor
- University of Monastir
Acute Heart Failure
Functional Impact of GLP-1 for Heart Failure Treatment (FIGHT)
The primary objective is to test the hypothesis that, compared with placebo, therapy with Subcutaneous (SQ) GLP-1 agonist in the post-Acute Heart Failure Syndrome (AHFS) discharge period will be associated with greater clinical…
- Trial name
- FIGHT (NCT01800968)
- Testing
- Liraglutide
- Where
- 25 sites in United States
- Volunteers
- 300 people
- Sponsor
- Duke University
Acute Heart Failure
Pre-Hospital Lung Ultrasound Impact on Diagnosis
Acute heart failure (AHF) is a major reason patients seek emergency care and is a significant public health burden. The ability to differentiate AHF from other etiologies of dyspnea remains a challenge as symptoms and physical…
- Trial name
- NCT05461547
- Testing
- Lung Ultrasound, Usual Care
- Where
- United States
- Volunteers
- 107 people
- Sponsor
- Indiana University
Heart Failure, Acute Coronary Syndrome
Platform Therapeutic Education in Heart Failure and Coronary Disease
A first therapeutic education is given before patient's discharge at the hospital, then a dedicated nurse follows patients through the phone,regularly according to patients' needs, continues to give advise on risk factors…
- Conditions
- Heart Failure, Acute Coronary Syndrome, Coronary Bypass Graft Stenosis of Native Artery Graft
- Trial name
- METISCARDIO (NCT01869452)
- Testing
- therapeutic education
- Where
- 4 sites in France
- Volunteers
- 555 people
- Sponsor
- Resicard
Acute Heart Failure, Acute Renal Failure
Recombinant BNP on Heart and Renal Function in Acute Heart Failure
The purpose of this study is to evaluate the efficacy and safety of recombinant human B-type natriuretic peptide (rhBNP) on heart and renal function in patients with acute decompensated heart failure (ADHF) and acute renal injury…
- Trial name
- NCT01625403
- Testing
- rhBNP, standard of care
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Shanghai Chest Hospital
Acute Myocardial Infarction, Heart Failure
The Benefits of Wearable AI in Post-Discharge Management of AMI Patients
Myocardial infarction (MI) remains a major threat to human health. Although interventional treatment techniques have advanced rapidly, many patients still experience major adverse cardiovascular events (MACE) and require hospital…
- Trial name
- NCT07288229
- Testing
- Optimized Integrated Management Based on AI-Guided Wearable Data
- Volunteers
- 200 people
- Sponsor
- RenJi Hospital