Clinical trials: Congestive Heart Failure Acute
Heart Failure, Diabetes Mellitus
CGM Use in Heart Failure
Heart failure (HF) is a major cause of hospital admissions in the US, with over 6 million hospital days annually. More than 40% of hospitalized patients with HF have diabetes mellitus (DM), which increases the risk of recurrent…
- Trial name
- NCT07045298
- Testing
- Libre 2 rt-CGM, POC BG + Blinded CGM
- Where
- United States
- Volunteers
- 140 people
- Sponsor
- Emory University
Myocardial Infarction, Death
BAMI. The Effect of Intracoronary Reinfusion of Bone Marrow-derived Mononuclear Cells(BM-MNC) on All Cause Mortality in Acute Myocardial Infarction
This is a multinational, multicentre, randomised open-label, controlled, parallel-group phase III study. Its aim is to demonstrate that a single intracoronary infusion of autologous bone marrow-derived mononuclear cells is safe…
- Trial name
- BAMI (NCT01569178)
- Testing
- Bone Marrow aspiration and intracoronary reinfusion
- Where
- 33 sites in Belgium, Czechia and 8 more
- Volunteers
- 375 people
- Sponsor
- Queen Mary University of London
Heart Failure With Preserved Ejection Fraction
Acute Effects of Exogenous Ketone Ester Administration in Heart Failure
The purpose of this study is to test whether a ketone ester drink will improve exercise in people with heart failure (HF) compared to a placebo.
- Trial name
- NCT04633460
- Testing
- Ketone ester
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- University of Pennsylvania
Kidney Injury, Acute, Cardiac Function Failed
Effect of Vasopressin on Kidney and Cardiac Function in Septic Shock
Septic shock is a syndrome characterized by tissue hypoperfusion and hypotension secondary to an uncontrolled infection. It is a frequent cause of admission to the intensive care unit (ICU) and has an associated mortality around…
- Trial name
- NCT06125184
- Testing
- Vasopressor test
- Where
- Chile
- Volunteers
- 50 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Acute Decompensated Heart Failure
Interest of Levosimendan in Reducing Weaning Failures of ExtraCorporeal Life Support - ECLS
Extracorporeal life support (ECLS) is a circulatory cardio supplementation technique; it therefore makes it possible to compensate for a defective cardiac or cardio-respiratory function.
- Trial name
- Weanilevo (NCT04158674)
- Testing
- Levosimendan, Cernevit
- Where
- France
- Volunteers
- 82 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Right Heart Failure, Mechanical Ventilation
Effect of APRV vs. LTV on Right Heart Function in ARDS Patients: a Single-center Randomized Controlled Study
Acute Respiratory Distress Syndrome (ARDS) is often complicated by Right Ventricular Dysfunction (RVD), and the incidence can be as high as 64%.
- Conditions
- Right Heart Failure, Mechanical Ventilation, Acute Respiratory Distress Syndrome
- Trial name
- NCT05922631
- Testing
- Airway pressure release ventilation, low tidal volume
- Where
- China
- Volunteers
- 60 people
- Sponsor
- XiaoJing Zou,MD
Acute Heart Failure (AHF)
Early Gliflozin for Elderly Patients With Acute Decompensated Heart Failure in the Emergency Department
Background: SGLT2 inhibitors reduce CHF morbidity/mortality but are underutilized in elderly patients with acute decompensated CHF (ADCHF) admitted outside cardiology departments.
- Trial name
- GlifloFastER (NCT07392788)
- Testing
- Early initiation of dapagliflozin 10mg daily within 24h of emergency department admission, Telephone follow-up by cardiac nurse practitioner at 1 month, Standard acute decompensated heart failure care
- Volunteers
- 144 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Myocardial Infarction, Acute
COLchicine to Prevent Sympathetic Denervation After an Acute Myocardial Infarction
This study evaluates the benefit of colchicine on induced denervation after myocardial infarction. Patients who have suffered a documented De Novo myocardial infarction and completed a revascularization procedure will receive…
- Trial name
- COLD-MI (NCT04420624)
- Testing
- Colchicine
- Where
- France
- Volunteers
- 54 people
- Sponsor
- University Hospital, Montpellier
Atrial Fibrillation, Heart Failure
Diltiazem vs. Metoprolol in the Acute Management of AF in Patients With HFrEF
Atrial fibrillation (AF) is the most common arrhythmia, accounting for one third of all hospital admissions and 1% of all emergency department visits (ED). Approximately 65% of those presenting to the ED with AF are admitted.
- Trial name
- NCT02938260
- Testing
- Metoprolol vs Diltiazem
- Volunteers
- 48 people
- Sponsor
- RaeAnn Hirschy
Heart Failure, Acute Myocardial Infarction (AMI)
Efficacy and Safety of Early Initiation of Vericiguat in Heart Failure After Acute Myocardial Infarction
Heart failure (HF) is a severe cardiovascular disease with extremely high morbidity and mortality rates worldwide, and ischemic cardiomyopathy is an important cause of heart failure.
- Conditions
- Heart Failure, Acute Myocardial Infarction (AMI), Acute Heart Failure (AHF)
- Trial name
- VIC-MI (NCT06812546)
- Testing
- Vericiguat
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Dongying Zhang
Cardiovascular Diseases
A Registry Study of Biomarkers in Progression of Acute Heart Failure(BIOMS-POAHF)
The registry study aims to discover the prognostic value of bio-markers in acute heart failure
- Trial name
- NCT04108182
- Where
- China
- Volunteers
- 850 people
- Sponsor
- Beijing Institute of Heart, Lung and Blood Vessel Diseases
Cardiogenic Shock
Study on Early Intra-aortic Balloon Pump Placement in Acute Decompensated Heart Failure Complicated by Cardiogenic Shock
The aim of the study is to demonstrate the superiority of early intra-aortic balloon pump implantation at admission over local clinical practice (pharmacological only) in acute decompensated heart failure patients with…
- Trial name
- Altshock-2 (NCT04369573)
- Testing
- Early intra-aortic balloon pump (IABP) implantation, Standard of care as vasoactive agent
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Niguarda Hospital
Acute Heart Failure
Effect of Short-term Prednisone Therapy on C-reactive Protein in Patients With Acute Heart Failure
This is a multicenter, parallel-group, randomized, open-label, controlled trial. Patients with a diagnosis of acute heart failure (AHF) in the emergency department (ED) or after emergency presentation to hospital will be screened…
- Trial name
- CORTAHF (NCT05916586)
- Testing
- Prednisone
- Where
- 3 sites in Armenia
- Volunteers
- 101 people
- Sponsor
- Heart Initiative
Acute Myocardial Infarction, Cardiovascular Morbidity
Dapagliflozin Effects on Mayor Adverse Cardiovascular Events in Patients With Acute Myocardial Infarction (DAPA-AMI)
The actual evidence is solid about the use of de SGLT2-inhibitors in wide spectrum of cardiorenal targets, which has been shown in a great amount of randomized clinical trials compared with placebo.
- Conditions
- Acute Myocardial Infarction, Cardiovascular Morbidity, Heart Failure, Angina, Unstable
- Trial name
- DAPA-AMI (NCT04717986)
- Testing
- Dapagliflozin 10Mg Tab
- Where
- Mexico
- Volunteers
- 188 people
- Sponsor
- Instituto Mexicano del Seguro Social
Heart Failure, Left Bundle-Branch Block
LV Only MPP With SyncAV
The objective of this clinical investigation is to evaluate the clinical benefits of left ventricle (LV) only pacing combined with automatic adjustment of AV timing (SyncAV) in patients receiving cardiac resynchronization therapy…
- Trial name
- NCT03567096
- Testing
- BiV pacing with MPP and SyncAV, LV only pacing with MPP and SyncAV
- Where
- 6 sites in Canada, France and 2 more
- Volunteers
- 101 people
- Sponsor
- Abbott Medical Devices
Acute Heart Failure
Pharmacokinetics & Safety of Serelaxin on Top of Standard of Care Therapy in Pediatric Patients With Acute Heart Failure
The purpose of the study was to evaluate the safety, tolerability and pharmacokinetics of an intravenous infusion of serelaxin on top of standard of care therapy, in pediatric patients with acute heart failure (AHF)
- Trial name
- RELAX-PEDS-PK (NCT02151383)
- Testing
- Serelaxin
- Where
- 10 sites in United States, Germany and 2 more
- Volunteers
- 12 people
- Sponsor
- Novartis Pharmaceuticals
Heart Failure
Therapeutic Education Strategy for Patients With Acute Heart Failure
The EduStra-HF study will examine the impact of an intensive therapeutic education on patients discharged from hospital after an episode of acute heart failure (HF).
- Trial name
- EduStra-HF (NCT03035123)
- Testing
- Therapeutic education
- Where
- 6 sites in France
- Volunteers
- 318 people
- Sponsor
- Resicard
Acute Heart Failure
Clinical Outcomes of Dapagliflozin in Acute Heart Failure With Reduced Ejection Fraction (CODA-HFrEF)
The goal of this clinical trial is to evaluate the short-term clinical outcomes of starting Dapagliflozin on the same day of hospital admission in patients with acute decompensated heart failure (ADHF) with reduced ejection…
- Trial name
- NCT06012279
- Testing
- Dapagliflozin 10mg Tab
- Where
- 2 sites in Egypt
- Volunteers
- 117 people
- Sponsor
- Cairo University
Acute Heart Failure, Renal Failure
Sequential Cystatin C Levels and Renal Impairment in Acute Heart Failure
Renal Compromise after treatment of decompensated heart failure with diuretics is not uncommon. The purpose of our study is to investigate the relationship between cystatin C and worsening renal function in this setting.
- Trial name
- NCT00561483
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- The Cleveland Clinic
Acute Heart Failure, Acute Renal Failure
Bladder Pressure Predicting Renal Failure in Critically Ill Patients as Compared to Hemodynamic Parameters
Studies have shown that more than 30% of the overall acute decompensated heart failure (ADHF) patients develop renal dysfunction.
- Trial name
- NCT01363505
- Testing
- BARD® Intra-abdominal Pressure monitor
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Northwell Health