Clinical trials: Congestive Heart Failure Treated
Congestive Heart Failure
Echocardiography and Peak Endocardial Acceleration (PEA) Measurements in Cardiac Resynchronization Therapy (CRT)
This study used an external endocardial acceleration sensor (sonR sensor), placed on the patient's chest, to time the closure of aortic and mitral valves, and compared its performance with echocardiography.
- Trial name
- NCT01066078
- Testing
- Echocardiography and SonR recording
- Where
- 4 sites in France
- Volunteers
- 216 people
- Sponsor
- LivaNova
Heart Failure
Evaluation of Sildenafil for the Treatment of Moderate Congestive Heart Failure
The purpose of the study is to evaluate whether sildenafil helps treat heart failure. Some patients with heart failure have high blood pressure in the lungs (referred to as "pulmonary hypertension").
- Trial name
- NCT00793338
- Testing
- Sildenafil
- Where
- United States
- Sponsor
- University of New Mexico
Heart Failure With Reduced Ejection Fraction (HF-rEF)
Multiple Patient Program to Ensure Access to LCZ696 Treatment to Patients Diagnosed With Heart Failure With Reduced Ejection Fraction (HF-rEF)
Novartis has set up this global Multiple Patient Program (MPP) treatment plan to provide access to life-saving treatment with LCZ696 for patients that were not previously exposed to LCZ696 but have no other option to receive…
- Trial name
- NCT02389933
- Testing
- LCZ696
- Where
- 286 sites in United States, Australia and 16 more
- Sponsor
- Novartis Pharmaceuticals
Heart Failure
A Phase Ⅲ Study of Extended-Release Carvedilol Sulfate for the Treatment of Heart Failure
The aim of present study is to evaluate the efficacy and safety of Extended-Release Carvedilol Sulfate versus Sustained-release Metoprolol Succinate in Patients With Mild or Moderate Chronic Heart Failure.
- Trial name
- NCT02012075
- Testing
- Extended-Release Carvedilol Sulfate, Sustained-release Metoprolol Succinate
- Where
- 12 sites in China
- Volunteers
- 316 people
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Heart Failure, Systolic
Narrow QRS Ischemic Patients Treated With Cardiac Resynchronization Therapy (NARROW CRT)
Current recommendations require a QRS duration of ≥120ms as a condition for prescribing cardiac resynchronization therapy (CRT).
- Trial name
- NARROW-CRT (NCT01577446)
- Testing
- cardiac resynchronization therapy
- Where
- Italy
- Volunteers
- 120 people
- Sponsor
- Ospedale Santa Maria di Loreto Mare
Heart Failure
Handheld Ultrasound Evaluation of the Inferior Vena Cava to Guide Heart Failure Treatment
The purpose of this study is to see if using a portable handheld ultrasound to guide diuretic therapy for heart failure patients will prevent hospital readmissions.
- Trial name
- NCT01962688
- Testing
- Handheld ultrasound
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Acute Respiratory Distress Syndrome, Septic Shock
Organ-substituting Technologies in the Treatment of Heart and Pulmonary Failure
The implementation of this project will improve the effectiveness of surgical treatment and reduce the level of complications and mortality among patients with heart failure and heart failure in the terminal stage.
- Conditions
- Acute Respiratory Distress Syndrome, Septic Shock, Sepsis
- Trial name
- OST (NCT05042622)
- Testing
- Cytokine adsorber filter, Extracorporeal hemoperfusion cartridge
- Where
- Kazakhstan
- Volunteers
- 90 people
- Sponsor
- National Research Center for Cardiac Surgery, Kazakhstan
Heart Failure
Lung Ultrasoung Guided Treatment in Chronic Heart Failure Patients: a Randomized Controlled Trial
Introduction: Despite the great advances in treatment, heart failure (HF) continues to be an important health problem because of its high prevalence, morbidity, mortality and associated costs.
- Trial name
- LUS-HF (NCT02959372)
- Testing
- lung ultrasound
- Where
- Spain
- Volunteers
- 124 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Kidney Failure, Chronic
Lung Water by Ultrasound Guided Treatment in Hemodialysis Patients (The Lust Study).
Volume overload is a leading risk factor for death and cardiovascular events in end stage renal disease patients maintained on chronic dialysis, particularly in those with myocardial ischemia and heart failure which represent a…
- Trial name
- LUST (NCT02310061)
- Testing
- Extra-vascular lung water measurements by ultrasound (LW-US), Standard protocol of fluid management in hemodialysis
- Where
- 19 sites in France, Germany and 7 more
- Volunteers
- 383 people
- Sponsor
- Fondazione C.N.R./Regione Toscana "G. Monasterio", Pisa, Italy
Sympathetic Innervation, Chronic Heart Failure
Sympathetic Innervation of the Heart and Cardiac Resynchronization Therapy(CRT)
The purpose of this study is to assess whether baseline sympathetic innervation in patients with chronic heart failure (CHF) is predictive for response to cardiac resynchronization therapy (CRT).
- Trial name
- PET-CRT (NCT00567645)
- Where
- Netherlands
- Sponsor
- University Medical Center Groningen
Shortness of Breath, Acute Respiratory Failure
Enhanced FoCUS in Patients With Shortness of Breath
Retrospective observational study performed in a internal medicine ward of a French university hospital. Included patients were hospitalized for acute shortness of breath who have benefited from a eFOCUS which was defined as a…
- Trial name
- eFOCUS (NCT05403619)
- Testing
- Diagnostic test
- Where
- France
- Volunteers
- 119 people
- Sponsor
- Nantes University Hospital
Heart Failure
Effects of Losartan on Insulin Resistance in Patients With Heart Failure
The purpose of this study is to evaluate the effects of losartan, an ARB, on glucose metabolism and inflammatory cytokines in CHF patients treated with ACE inhibitors.
- Trial name
- NCT00663377
- Testing
- losartan
- Volunteers
- 16 people
- Sponsor
- Tottori University Hospital
Heart Failure
Study to Evaluate the Safety and Efficacy of IV Infusion Treatment With Omecamtiv Mecarbil in Subjects With Left Ventricular Systolic Dysfunction Hospitalized for Acute Heart Failure (ATOMIC-AHF)
The primary objective of the study is to evaluate the effect of 48 hours of intravenous (IV) omecamtiv mecarbil compared with placebo on dyspnea in subjects with left ventricular systolic dysfunction hospitalized for acute heart…
- Trial name
- NCT01300013
- Testing
- Omecamtiv mecarbil
- Where
- 150 sites in United States, Australia and 17 more
- Volunteers
- 614 people
- Sponsor
- Cytokinetics
Myocardial Injury, LV Dysfunction
Study to Assess Safety and Efficacy of Treating Symptomatic, Ischemic, Chronic Congestive Heart Failure Patients with an LVEF of ≤40% with Fresh, Uncultured, Autologous, Adipose-derived Regenerative Cells Isolated from Lipoaspirate.
To investigate patients suffering from iHF and a LVEF of equal or less than 40% despite best medical treatment safety and efficacy of a single retrograde intra-cardiac venous (i.cv.) injection of UA-ADRCs isolated from…
- Conditions
- Myocardial Injury, LV Dysfunction, Coronary Artery Disease, Heart Failure
- Trial name
- NCT06705023
- Testing
- Uncultured, autologous, adipose-derived regenerative cells (UA-ADRCs), Continuation of patient's best guideline based medical treatment
- Where
- Kazakhstan
- Volunteers
- 36 people
- Sponsor
- Ralf Rothoerl
Non Communicable Diseases, Heart Failure
Nurse-assisted Intervention "eHealth@ Hospital -2-home"
A randomized controlled trial with non-communicable disease patients from two medical hospitals in Norway will be recruited prior to hospital discharge.
- Conditions
- Non Communicable Diseases, Heart Failure, Colon Rectal Cancer
- Trial name
- Ehealth@H2H (NCT05750953)
- Testing
- eHealth@Hospital-2-Home
- Where
- Norway
- Volunteers
- 204 people
- Sponsor
- University of Stavanger
Heart Failure
Registrational Study With Omecamtiv Mecarbil (AMG 423) to Treat Chronic Heart Failure With Reduced Ejection Fraction
The purpose of this study is to determine if treatment with omecamtiv mecarbil when added to standard of care is well tolerated and superior to placebo in reducing the risk of cardiovascular death or heart failure events in…
- Trial name
- GALACTIC-HF (NCT02929329)
- Testing
- Omecamtiv Mecarbil, Standard of Care
- Where
- 1,033 sites in United States, Argentina and 34 more
- Volunteers
- 8,256 people
- Sponsor
- Cytokinetics
Heart Failure With Normal Ejection Fraction
High-intensity Interval Training in Heart Failure Patients With Preserved Ejection Fraction
This study investigates the effects of a 12-week high-intensity interval training (HIT) on exercise tolerance, functional status and quality of life in patients with chronic heart failure with preserved ejection fraction (HFpEF)…
- Trial name
- HIT-HF (NCT03184311)
- Testing
- High-intensity interval training (HIT), Moderate-intensity contiuous training (MCT)
- Where
- Switzerland
- Volunteers
- 86 people
- Sponsor
- University of Basel
Heart Failure With Preserved Ejection Fraction (HFpEF)
An Open-label Extension Study Evaluating Safety and Tolerability of LCZ696 in Subjects Who Completed PARAGON-HF in Japan.
This study evaluated the safety and tolerability of LCZ696 treatment in Japanese heart failure patients (NYHA Class II-IV) with preserved ejection fraction after CLCZ696D2301 (PARAGON-HF).
- Trial name
- NCT03909295
- Testing
- LCZ696
- Where
- 17 sites in Japan
- Volunteers
- 52 people
- Sponsor
- Novartis Pharmaceuticals
Multiple Myeloma
A Safety and Efficacy of Pomalyst® Capsules Under the Actual Use in All Patients Who Are Treated With Pomalyst at a Dose of 1 mg, 2 mg, 3 mg, or 4 mg
1. Planned enrollment period One year (The planned number of patients to be enrolled is set to 400 patients.) Since all patients who are prescribed with Pomalyst are registered in RevMate®, enrollment using the Registration Form…
- Trial name
- NCT02921828
- Where
- 2 sites in United States, Japan
- Volunteers
- 1,149 people
- Sponsor
- Celgene
A Feasibility Study on Hypertensive Heart Failure Treatment
Hypertensive Heart Failure Treatment in SSA
Even though, the African-American Heart Failure Trial (A- HeFT) demonstrated that a combination ISDN and HYD (BiDil) improved survival among African-American patients with HF, when compared to placebo, there is no trial on…
- Trial name
- NCT06400784
- Testing
- Isosorbide Dinitrate
- Where
- Nigeria
- Volunteers
- 50 people
- Sponsor
- University of Abuja