Clinical trials: Congo, The Democratic Republic of the
Ebola Vaccines
A Clinical Trial on the Candidate Vaccine cAd3-EBOZ in Healthy Adults in Switzerland
The objective of this trial is to assess in healthy adults the safety and reactogenicity of a new candidate vaccine, cAd3-EBOZ, made of a chimpanzee Adenovirus vector encoding the glycoprotein of Zaire Ebola virus.
- Trial name
- NCT02289027
- Testing
- cAd3-EBOZ vaccine
- Where
- Switzerland
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Mpox
Mpox Biology, Outcome, Transmission and Epidemiology - Tracking the Immune Response After mpoX vaCcination (MBOTE-TRAXX): Clinical Study to Monitor the Immunological Response Following Mpox Vaccination in the City of Kinshasa, Democratic Republic of the Congo
The study Mbote-TRAXX evaluates humoral and cellular immune responses in individuals vaccinated against mpox with the MVA-BN or LC16m8 vaccine administered as part of a routine mpox vaccination campaign in Kinshasa, Democratic…
- Trial name
- MBOTE-TRAXX (NCT07499739)
- Testing
- blood sample collection
- Where
- 3 sites in Democratic Republic of the Congo
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Institute of Tropical Medicine, Belgium
Malaria
Safety and Efficacy of Recommended Antimalarial in the Democratic Republic of the Congo
Despite all efforts, malaria remains a public health concern, in particular in the Democratic Republic of the Congo (DRC). The National Malaria Control program recommends artemisinin-based combination treatments (ACTs), in…
- Trial name
- TET2020 (NCT04618523)
- Testing
- Artesunate-amodiaquine, Artemether-lumefantrine
- Where
- 6 sites in Democratic Republic of the Congo
- Volunteers
- 1,117 people
- Sponsor
- Ministry of Public Health, Democratic Republic of the Congo
Immune Response, Vaccination
Immune Durability After VSV-EBOV Vaccination
This prospective observational cohort study will follow the roughly 100 adults who received the VSV-ZEBOV vaccine in the Geneva phase 1 randomized controlled trial in 2014-2015 in order to determine their long-term (5-year)…
- Conditions
- Immune Response, Vaccination, Durability
- Trial name
- NCT02933931
- Volunteers
- 95 people
- Sponsor
- University Hospital, Geneva
Ebolavirus Disease
VSV-ZEBOV Geneva Vaccine Trial
The hemorrhagic fever resulting from Ebola infection is frequently fatal; the current Ebola outbreak, still in its ascendant phase, has a mortality rate over 50%. There is no proven therapy or prevention available at this time.
- Trial name
- VSV-ZEBOV (NCT02287480)
- Testing
- VSV-ZEBOV
- Where
- Switzerland
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- University Hospital, Geneva
Ebola
A Study in Tanzania of a New Vaccine Against Two Types of Ebola
An open label, first in human, non-randomised, dose escalation, single centre, phase Ib clinical trial
- Trial name
- NCT05301504
- Testing
- ChAdOx1 biEBOV
- Where
- Tanzania
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Ebola Hemorrhagic Fever, Bundibugyo Virus Disease
Study of Vaccines Against Bundibugyo Virus Disease in Contacts of Cases in the Democratic Republic of the Congo
Bundibugyo virus (BDBV) causes severe and often fatal outbreaks of Bundibugyo virus disease (BVD). No vaccine against BDBV is licensed.
- Trial name
- TUMAINI (NCT07842107)
- Testing
- Candidate BDBV vaccine, Active comparator
- Where
- Democratic Republic of the Congo
- Volunteers
- 3,620 people, healthy volunteers welcome
- Sponsor
- Jean-Pierre Van geertruyden
Neurological Disorders, Cerebral Malaria
Rapid Diagnostic Tests and Clinical/Laboratory Predictors of Tropical Diseases in Neurological Disorders in DRC
The impact of neurological disorders is enormous worldwide, and it is increased in poor settings, due to lack of diagnosis and treatment facilities as well as delayed management.
- Conditions
- Neurological Disorders, Cerebral Malaria, Bacterial Meningitis, Central Nervous System Tuberculosis
- Trial name
- Nidiag-Neuro (NCT01589289)
- Testing
- Immunochromatographic HAT tests (DSD), Card Agglutination Trypanosoma Test, TB POC Nucleic Acid Amplification Test (Molbio Diagnostics)
- Where
- Democratic Republic of the Congo
- Volunteers
- 352 people
- Sponsor
- Institute of Tropical Medicine, Belgium
Plague, Bubonic; Plague, Skin
Testing of a New Rapid Antigen Test for Plague in Ituri, Democratic Republic of the Congo.
This study is being done to learn more about the disease in Ituri and to evaluate a new rapid test that may help doctors find the disease more quickly.
- Conditions
- Plague, Bubonic; Plague, Skin, Plague, Pneumonic
- Trial name
- RAPID-IT (NCT07174648)
- Where
- Democratic Republic of the Congo
- Volunteers
- 300 people
- Sponsor
- Institute of Tropical Medicine, Belgium
Malaria
Comparison of Two Regimens of Artemether-lumefantrine for the Treatment of Malaria in Pregnancy
Malaria in pregnancy is a major cause of maternal and newborn morbidity and mortality in sub-Saharan Africa]. Effective antimalarial preventive and treatment regimens can significantly reduce malaria-related morbidity and…
- Trial name
- ALN5P (NCT01916954)
- Testing
- 3-day artemether-lumefantrine, 5-day artemether-lumefantrine
- Where
- Republic of the Congo
- Volunteers
- 96 people
- Sponsor
- University of Oxford
Severe Malnutrition
Effects of Cash Transfers on Severe Acute Malnutrition
Cash transfer, aims to strengthen food security for vulnerable households by giving families enough purchasing power to consume an adequate and balanced diet, maintain a good standard of hygiene, access health services, and…
- Trial name
- NCT02460848
- Testing
- Outpatient therapeutic program, counseling and cash transfer, Outpatient therapeutic program and counseling
- Where
- Democratic Republic of the Congo
- Volunteers
- 1,600 people
- Sponsor
- UNICEF
HIV/AIDS, Antiretroviral Therapy
Long Term Outcomes of Therapy in Women Initiated on Lifelong ART Because of Pregnancy in DR Congo
Despite the rapid adoption of the World Health Organization's 2013 guidelines, many children continue to be infected with HIV perinatally because of sub-optimal adherence to the continuum of HIV care in maternal and child health…
- Conditions
- HIV/AIDS, Antiretroviral Therapy, Pregnancy Outcomes, HIV-exposed Infants
- Trial name
- CQI-PMTCT (NCT03048669)
- Testing
- Continuous quality improvement
- Where
- Democratic Republic of the Congo
- Volunteers
- 5,053 people
- Sponsor
- Albert Einstein College of Medicine
Ebola Virus Disease
Study to Evaluate the Immunogenicity and Safety of a Heterologous Vaccine Regimen Against Ebola
This Phase 2 study aims to improve preparedness for future Ebola outbreaks by vaccination of a well-known population at risk, ie, a cohort of health care providers (HCP) (such as primary, emergency, and community health care…
- Trial name
- EBOVAC3DRC (NCT04186000)
- Testing
- Ad26.ZEBOV vaccine
- Where
- Democratic Republic of the Congo
- Volunteers
- 699 people, healthy volunteers welcome
- Sponsor
- Universiteit Antwerpen
Invasive Non-Typhoidal Salmonella Disease, Malaria
Effectiveness of Malaria Vaccines in Reducing the Risk of Invasive Non-typhoidal Salmonella Disease
The goal of this observational study is to learn about the impact of malaria vaccination on the risk of invasive non-typhoidal Salmonella disease in children below the age of 5.
- Conditions
- Invasive Non-Typhoidal Salmonella Disease, Malaria, Malaria Vaccine
- Trial name
- VINS (NCT07416461)
- Testing
- R21/Matrix-M malaria vaccine
- Where
- Democratic Republic of the Congo
- Volunteers
- 10,000 people
- Sponsor
- International Vaccine Institute
Skin and Connective Tissue Diseases, Neglected Tropical Diseases
Early Detection and AI-Based Management of Skin-Related Neglected Tropical Diseases in Sub-Saharan Africa by Frontline Health Workers
Skin-related Neglected Tropical Diseases (Skin NTDs) affect about 1.8 billion people worldwide, particularly in poor and rural communities where healthcare access is limited.
- Conditions
- Skin and Connective Tissue Diseases, Neglected Tropical Diseases, Leprosy, Buruli Ulcer
- Trial name
- SkincAIr (NCT07506967)
- Testing
- A mobile app with AI functionality for diagnosing skin-related NTDs
- Where
- 5 sites in Democratic Republic of the Congo, Ethiopia and 3 more
- Volunteers
- 2,420 people
- Sponsor
- Kenya Medical Research Institute
Bloodstream Infection, Salmonella Bacteremia
Clinical Decision Support in Non-typhoidal Salmonella Bloodstream Infections in Children
In sub-Saharan Africa, non-typhoidal Salmonella (NTS) are a frequent cause of bloodstream infection, display high levels of antibiotic resistance and have a high case fatality rate (15%).
- Conditions
- Bloodstream Infection, Salmonella Bacteremia, Malaria,Falciparum, Severe Malaria
- Trial name
- DeNTS (NCT04473768)
- Where
- Belgium
- Volunteers
- 1,880 people
- Sponsor
- Institute of Tropical Medicine, Belgium
Covid19
Transmission Dynamics of COVID-19 in a Rural Setting of the Democratic Republic of the Congo
A fixed cohort of adults in rural Kimpese will be followed up every two months since they are assumed to be at above average risk of contracting COVID-19.
- Trial name
- DynaCovid (NCT04701996)
- Testing
- serological surveillance
- Where
- Democratic Republic of the Congo
- Volunteers
- 1,709 people, healthy volunteers welcome
- Sponsor
- Institute of Tropical Medicine, Belgium
Fever
Non-inferiority Trial of Conditional vs Universal Follow up for Children With Fever in Democratic Republic of Congo
Providers in integrated Community Case Management (iCCM) programs in low resource settings often see children without any danger signs, presenting with fever but not having pneumonia, malaria, or diarrhea.
- Trial name
- NCT02595827
- Testing
- Conditional Advice
- Where
- Democratic Republic of the Congo
- Volunteers
- 4,451 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Mpox (Monkeypox), Vaccination
Phase 3 Infant Safety & Immunogenicity Trial of MVA-BN® in DRC
This Phase 3 double-blinded, randomized study aims to evaluate the safety and immunogenicity of the two-dose MVA-BN mpox vaccine regimen, administered subcutaneously, in infants and children aged 4 to 24 months in the Democratic…
- Conditions
- Mpox (Monkeypox), Vaccination, Immunogenicity, Safety
- Trial name
- PregInPoxVac (NCT06844487)
- Testing
- MVA-BN standard regimen, MVA-BN half-dose regimen
- Where
- Democratic Republic of the Congo
- Volunteers
- 344 people, healthy volunteers welcome
- Sponsor
- Jean-Pierre Van geertruyden
Mpox (Monkeypox), Monkeypox Virus Infection
DiagRaMIE Mpox Virus-RDC for the Diagnostic of Monkeypox
Monkeypox, caused by a virus in the Orthopoxvirus genus, is a zoonotic disease first identified in 1970 in the Democratic Republic of Congo (DRC).
- Trial name
- DiagRaMIE Mpox (NCT06840197)
- Testing
- NG-TestⓇ Monkeypox virus kit
- Where
- 3 sites in Republic of the Congo
- Volunteers
- 197 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris