Clinical trials: Conns Syndrome
Primary Aldosteronism
Subtyping Primary Aldosteronism With Para-chloro-2-[18F]Fluoroethyl-etomidate
The goal of this clinical trial is to investigate the uptake characteristics of [18F]CETO in adrenal tissue in patients with two different subtypes of primary aldosteronism.
- Trial name
- SPACE (NCT06616142)
- Testing
- [18F]CETO tracer, Dexamethasone oral, Adrenal vein sampling
- Where
- Netherlands
- Volunteers
- 12 people
- Sponsor
- University Medical Center Groningen
Primary Aldosteronism, Hypertension
The Diagnostic Performance of 24-hour Urinary Aldosterone for Primary Aldosteronism
This is an observational study to define the cut-off value of 24-hour urinary aldosterone for diagnosing primary aldosteronism in hypertensive patients in our center.
- Trial name
- NCT06236698
- Testing
- 24-hour urinary aldosterone measurement
- Where
- China
- Volunteers
- 999 people
- Sponsor
- Zhiming Zhu
Adrenal Gland Neoplasm, Hypertension
Clinical and Molecular Characteristics of Primary Aldosteronism in Blacks
Background: The adrenal gland makes the hormone aldosterone. This helps regulate blood pressure. An adrenal gland tumor that makes too much aldosterone can cause high blood pressure and low potassium.
- Conditions
- Adrenal Gland Neoplasm, Hypertension, Bone Diseases, Metabolic, Cardiovascular Disease
- Trial name
- NCT03374215
- Where
- United States
- Volunteers
- 1,150 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Primary Aldosteronism
Influence of Synacthen Infusion on the Results of Adrenal Venous Sampling in Patient With Primary Aldosteronism
The project is aimed to determine the value of synacthen infusion on the results of adrenal venous sampling in patients examined for primary aldosteronism
- Trial name
- ISIRA (NCT02127840)
- Testing
- Synacthen infusion during adrenal venous sampling
- Where
- Czechia
- Volunteers
- 40 people
- Sponsor
- Charles University, Czech Republic
Primary Aldosteronism
Renal Cysts and Primary Aldosteronism
During routine subtyping of confirmed primary aldosteronism by adrenal vein sampling extra plasma samples are drawn from both renal veins and from inferior vena cava.
- Trial name
- NCT05435703
- Where
- Finland
- Volunteers
- 115 people
- Sponsor
- Tampere University Hospital
Primary Aldosteronism
Untargeted Metabolomics for Primary Aldosteronism
Primary aldosteronism (PA) is a common and likely under-diagnosed cause of secondary hypertension with associated cardiovascular morbidity and mortality.
- Trial name
- PUMPAP (NCT06076473)
- Testing
- Untargeted metabolomics
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Liverpool University Hospitals NHS Foundation Trust
Primary Aldosteronism
Study on Cutoff Revision Effects and Evaluation of NNT in Primary Aldosteronism
The goal of this observational study is to evaluate the real-world impact of applying the revised aldosterone-to-renin ratio (ARR) cutoff recommended in the 2025 primary aldosteronism guideline in adults with hypertension and…
- Trial name
- SCREEN-PA (NCT07621458)
- Testing
- Saline Infusion Test
- Where
- South Korea
- Volunteers
- 150 people
- Sponsor
- Seoul National University Hospital
Primary Aldosteronism
Primary Aldosteronism in Malaysia: A Nationwide Multicentre Study
This research focuses on the prevalence of Primary Aldosteronism in the Malaysian adult population.
- Trial name
- MyEndo-PA (NCT02257450)
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- International Islamic University Malaysia
Primary Aldosteronism, Primary Aldosteronism Due to Aldosterone Producing Adenoma
Outcome of Patients With Primary Aldosteronism
Majority of patients with hypertension have primary hypertension (without an underlying cause). Primary aldosteronism (PA) is the most common cause of secondary hypertension, and can be found in 5-10% of patients locally.
- Conditions
- Primary Aldosteronism, Primary Aldosteronism Due to Aldosterone Producing Adenoma, Primary Aldosteronism Due to Adrenal Hyperplasia (Bilateral), Adrenalectomy; Status
- Trial name
- PA_Outcome (NCT04428827)
- Testing
- Unilateral adrenalectomy in patients with unilateral disease
- Where
- Singapore
- Volunteers
- 600 people
- Sponsor
- Changi General Hospital
Primary Aldosteronism, Adrenal Adenoma
Radiofrequency Ablation for Aldosterone-producting Adenoma in Patients With Primary Aldosteronism
The aim of the study is to evaluate the novel use of adrenal radiofrequency ablation on a prospective cohort of patients with primary aldosteronism and unilateral adrenal adenoma concerning the efficacy on blood pressure control.
- Trial name
- ADERADHTA (NCT02756754)
- Testing
- Radiofrequency ablation
- Where
- 2 sites in France
- Volunteers
- 31 people
- Sponsor
- University Hospital, Toulouse
Primary Aldosteronism, Hypertension
Adrenal Artery Ablation Treats Primary Aldosteronism
Primary aldosteronism (PA) is one of the most common cause of endocrine and resistant hypertension. Current studies have shown that the activation of the renin-angiotensin-aldosterone system (RAAS) and the increased sympathetic…
- Trial name
- NCT03398785
- Testing
- Endovascular chemical Ablation of Adrenal Gland
- Where
- China
- Volunteers
- 66 people
- Sponsor
- Third Military Medical University
Primary Aldosteronism
CXCR4 Targeted PET Imaging in the Diagnosis and Identification of Primary Aldosteronism
This study aimed to prospectively evaluate the utility of C-X-C chemokine receptor type 4 (CXCR4) positron emission tomography (PET) imaging in patients with clinical suspected primary aldosteronism (PA), with postoperative…
- Trial name
- NCT06183554
- Testing
- CXCR4
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Xiao Chen
Primary Aldosteronism
The Effect of SAAE on Ventricular Remodeling in PA Patients
The study aims to assess the effect of superselective adrenal arterial embolization on ventricular remodeling in primary aldosteronism without lateralized aldosterone secretion by comparing it with spironolactone therapy.
- Trial name
- NCT05501080
- Testing
- Super selective adrenal artery embolization, Spironolactone
- Where
- China
- Volunteers
- 112 people
- Sponsor
- Second Affiliated Hospital of Nanchang University
Resistant Hypertension
Adrenal Artery Ablation for Primary Aldosteronism With Resistant Hypertension
Primary aldosteronism(PA) is the most common endocrine cause of resistant hypertension. Surgery and medicine are the main treatment for PA by the current guidelines.
- Trial name
- NCT04345198
- Testing
- Adrenal Artery Ablation
- Where
- China
- Volunteers
- 36 people
- Sponsor
- Third Military Medical University
Primary Aldosteronism, Hypertension
Regular Sauna Use to Lower Blood Pressure in Primary Aldosteronism
1. Background and Rationale: Primary aldosteronism is a hypertension-related disorder where salt restriction/salt loss is a central part of therapy.
- Trial name
- SAUNA-PA (NCT07796048)
- Testing
- sauna session
- Volunteers
- 10 people
- Sponsor
- University of Calgary
Adrenal Tumor, Primary Aldosteronism
Development of Clinical Evidence for Optimal Management of Adrenal Diseases Based on Real-World Data
This research aims to establish clinical evidence for optimal treatment guidelines for adrenal diseases using real-world data. The approach involves building prospective and retrospective patient registries, which will be…
- Conditions
- Adrenal Tumor, Primary Aldosteronism, Cushing Syndrome, Pheochromocytoma
- Trial name
- NCT06229405
- Where
- South Korea
- Volunteers
- 8,200 people
- Sponsor
- Seoul National University Hospital
Primary Aldosteronism, Autonomous Cortisol Secretion
68Ga-Pentixafor PET/CT Versus Adrenal Vein Sampling in Diagnosing Unilateral Subtype of Primary Aldosteronism Concurrent With Autonomous Cortisol Secretion (PREDICT)
To validate the accuracy of 68Ga-Pentixafor PET/CT and adrenal venous sampling (AVS) in subtype diagnosis of PA/ACS patients with adrenal nodules, based on biochemical and clinical remission outcomes, and to determine whether the…
- Trial name
- NCT06833437
- Testing
- 68Ga-Pentixafor PET/CT, AVS
- Where
- China
- Volunteers
- 178 people
- Sponsor
- Qifu Li
Primary Hyperaldosteronism, Hypertensive Disorder of Pregnancy
HyperAldosteronism in Pregnancy Predicted Impacts (H.A.P.P.I. Trial)
Primary hyperaldosteronism confers a higher risk of cardiovascular complications compared to essential hypertension. Preliminary data is controversial in regards of excessive maternal fetal and neonatal excessive risks in…
- Trial name
- NCT05636995
- Testing
- Aldosterone/Renin Ratio
- Where
- 2 sites in Canada
- Volunteers
- 200 people
- Sponsor
- Université de Sherbrooke
Primary Aldosteronism
REnin-guided TherApy With MinEralocorticoid Receptor Antagonists in Primary Aldosteronism - Feasibility Study
High blood pressure, or hypertension, can be caused by a condition called Primary Aldosteronism (PA), where the body produces too much of a hormone called aldosterone.
- Trial name
- RETAME-PA (NCT06108427)
- Testing
- Renin measurements
- Where
- Canada
- Volunteers
- 58 people
- Sponsor
- Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal
Hyperaldosteronism
SPARTACUS: Subtyping Primary Aldosteronism: a Randomized Trial Comparing Adrenal Vein Sampling and Computed Tomography Scan.
Rationale: Primary hyperaldosteronism (PA) is the most frequent form of secondary hypertension. In PA autonomous hypersecretion of aldosterone by one or both adrenal glands causes hypertension that is often refractory to…
- Trial name
- SPARTACUS (NCT01096654)
- Testing
- Ct-scan or adrenal vein sampling
- Where
- Netherlands
- Volunteers
- 200 people
- Sponsor
- Radboud University Medical Center