Clinical trials: Conns Syndrome
Primary Aldosteronism, Finerenone
The Clinical Efficacy and Safety of Finerenone in the Treatment of Primary Aldosteronism
The purpose of our research is to clarify the therapeutic efficacy and safety of Finerenone in patients with Primary Aldosteronism and explore the effective clinical predictive indicators of Finerenone in the treatment of Primary…
- Conditions
- Primary Aldosteronism, Finerenone, Mineralocorticoid Receptor Antagonist
- Trial name
- NCT06381323
- Testing
- Finerenone
- Where
- China
- Volunteers
- 55 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Hypertension, Hypertension Resistant to Conventional Therapy
High Prevalence of Secondary Arterial Hypertension (HIPRESH) with Prospective Systematic Screening in a Cohort of Consecutive Hypertensive Patients Referring to Regional Specialized Center
Hypertensive Patients referring to our center will undergo a systematic diagnostic workup aimed at finding the cause(s) of their high blood pressure.
- Conditions
- Hypertension, Hypertension Resistant to Conventional Therapy, Secondary Hypertension to Endocrine Disorders, Secondary Hypertension
- Trial name
- HIPRESH (NCT06664255)
- Volunteers
- 1,400 people
- Sponsor
- University Hospital Padova
Atrial Fibrillation, Sleep Apnea
Left-atrial Fibrosis in Persistent Atrial Fibrillation and Its Comorbidities
Pulmonary vein isolation is an established intervention for atrial fibrillation. Patients with a paroxysmal atrial fibrillation have no or only few comorbidities and a good prognosis in respect to their atrial fibrillation.
- Conditions
- Atrial Fibrillation, Sleep Apnea, Primary Aldosteronism
- Trial name
- PAfOSAS (NCT07857044)
- Testing
- Screening on comorbidites
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- Christina Berr. MD
Hyperaldosteronism, Conn Syndrome
Laparoscopic Adrenalectomy Versus Radiofrequency Ablation
This is a prospective randomized controlled study comparing laparoscopic adrenalectomy (LA) versus image-guided percutaneous radiofrequency ablation (RFA) in treating aldosterone-producing adenoma.
- Conditions
- Hyperaldosteronism, Conn Syndrome, Adrenocortical Adenoma
- Trial name
- LARFA (NCT02030587)
- Testing
- Radiofrequency Ablation, Laparoscopic Adrenalectomy
- Where
- Hong Kong
- Volunteers
- 36 people
- Sponsor
- Chinese University of Hong Kong
Primary Aldosteronism Due to Adrenal Hyperplasia
Effects of Glucocorticoid Therapy on Renal Function in Patients With PA Complicated by CKD After Adrenalectomy: A Multicenter RCT
This multicenter randomized controlled trial plans to enroll primary aldosteronism (PA) patients who meet the following criteria: confirmed unilateral dominant secretion by adrenal vein sampling (AVS), willingness to undergo…
- Trial name
- GRAFT_PA (NCT07558811)
- Testing
- Intervention_1
- Volunteers
- 90 people
- Sponsor
- Ruijin Hospital
Primary Aldosteronism, High Blood Pressure
Diagnosing Variable Primary Aldosteronism.
The goal of this observational study is to see if there is a cyclical or exaggerated diurnal variation in aldosterone production in people with Primary Aldosteronism.
- Trial name
- NCT05765786
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- Queen Mary University of London
Primary Aldosteronism
Multi-omics Studies of Primary Aldosteronism
Primary aldosteronism is a prevalent yet underdiagnosed cause of secondary hypertension, contributing to significant cardiovascular morbidity and renal dysfunction.
- Trial name
- NCT07111351
- Testing
- Without intervention
- Where
- China
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Peking University First Hospital
Primary Aldosteronism, Autonomous Cortisol Secretion
68Ga-Pentixafor PET/CT Versus Adrenal Vein Sampling in Diagnosing Unilateral Subtype of Primary Aldosteronism Concurrent With Autonomous Cortisol Secretion (PREDICT)
To validate the accuracy of 68Ga-Pentixafor PET/CT and adrenal venous sampling (AVS) in subtype diagnosis of PA/ACS patients with adrenal nodules, based on biochemical and clinical remission outcomes, and to determine whether the…
- Trial name
- NCT06833437
- Testing
- 68Ga-Pentixafor PET/CT, AVS
- Where
- China
- Volunteers
- 178 people
- Sponsor
- Qifu Li
Hypertension, Primary Aldosteronism
Screening for Primary Aldosteronism in Hypertension With 24-hour URinary aLdosterone
This is an observational study compares the positivity rates of two tests for screening for primary aldosteronism: plasma aldosterone renin ratio and 24-hour urine aldosterone in patients with young-onset hypertension with or…
- Conditions
- Hypertension, Primary Aldosteronism, Urine Aldosterone
- Trial name
- PURL (NCT06047912)
- Where
- United Kingdom
- Volunteers
- 120 people
- Sponsor
- Dr Ian B Wilkinson
Primary Hyperaldosteronism, Hypertensive Disorder of Pregnancy
HyperAldosteronism in Pregnancy Predicted Impacts (H.A.P.P.I. Trial)
Primary hyperaldosteronism confers a higher risk of cardiovascular complications compared to essential hypertension. Preliminary data is controversial in regards of excessive maternal fetal and neonatal excessive risks in…
- Trial name
- NCT05636995
- Testing
- Aldosterone/Renin Ratio
- Where
- 2 sites in Canada
- Volunteers
- 200 people
- Sponsor
- Université de Sherbrooke
Adrenal Disease
Comparison Between Posterior Retroperitoneoscopic Adrenalectomy and Laparoscopic Adrenalectomy
The purpose of this study is to compare two surgical methods of adrenalectomy. One is called PRA(posterior retroperitoneal adrenalectomy), which is performed through 3 or 4 holes at patient's back.
- Trial name
- PRA (NCT01676025)
- Testing
- PRA, LA
- Where
- South Korea
- Volunteers
- 83 people
- Sponsor
- Seoul National University Hospital
Primary Aldosteronism
Study on Postoperative Adrenal Function Assessment in Patients With Primary Aldosteronism
This study employs a prospective, single-center, open, observational research design to evaluate postoperative adrenal cortical function in patients with primary aldosteronism (PA) and to explore indicators predicting…
- Trial name
- NCT06534268
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Ruijin Hospital
Primary Aldosteronism, Endocrine Hypertension
Effect of a Proposed Cav1.3 Inhibitor in Primary Aldosteronism
The goal of this pilot, open-label prospective study is to evaluate if the effect of calcium channel blockade on plasma aldosterone levels in people with primary aldosteronism (PA) is due primarily to Cav1.3 blockade.
- Trial name
- NCT05686993
- Testing
- Cinnarizine, NIFEdipine ER
- Where
- United Kingdom
- Volunteers
- 15 people
- Sponsor
- Queen Mary University of London
Primary Aldosteronism
Evaluation of [68Ga]Ga-PentixaFor PET Imaging for the Identification of Unilateral Adrenal Secretion of ALdosterON in Patients With Primary Aldosteronism
PentixaFor radiolabeled with 68Gallium (68Ga) is a radiopharmaceutical targeting the CXC chemokine receptor 4 (CXCR4) receptor. The CXCR4 receptor is expressed in zona glomerulosa of the adrenal cortex and in aldosterone…
- Trial name
- PENTALON (NCT06478875)
- Testing
- [68Ga]Ga-PentixaFor PET imaging
- Where
- 2 sites in France
- Volunteers
- 20 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Primary Aldosteronism, Resistant Hypertension
Electronic Alert to Improve Testing For Primary Aldosteronism in Patients With Hypertension
Primary aldosteronism (PA) is common but rarely recognized cause of hypertension that carries excess cardiovascular and renal risk and has approved targeted treatments.
- Conditions
- Primary Aldosteronism, Resistant Hypertension, Secondary Hypertension, Hyperaldosteronism
- Trial name
- ALERT-PA (NCT05925569)
- Testing
- Best Practice Advisory Computerized Alert
- Where
- United States
- Volunteers
- 12,501 people
- Sponsor
- Brigham and Women's Hospital
Aldosterone Disorder, Adrenal Gland Disease
Prospective Phenotyping of Autonomous Aldosterone Secretion
This prospective cohort study will investigate the physiology and progression of autonomous aldosterone secretion.
- Conditions
- Aldosterone Disorder, Adrenal Gland Disease, Blood Pressure
- Trial name
- NCT03484130
- Testing
- Sodium loaded diet, Restricted sodium diet
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Primary Aldosteronism
Aldosterone Renin Ratio (ARR) Test to Increase Case-detection of Primary Aldosteronism (PA)
The mission of this project is to increase the detection of Primary Aldosteronism (PA), the most common cause of secondary hypertension, which can either be cured surgically or treated with targeted medications.
- Trial name
- ARR (NCT05757076)
- Testing
- Blood test for ARR
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- The Cleveland Clinic
Post Operative Pain, Acute
Comparison of Needlescopic vs. Conventional Laparoscopic Adrenalectomy for Tumor Less Than 4 cm
The investigator conduct a randomized clinical trial for the needlescopic and conventional laparoscopic adrenalectomy to assess whether mini laparoscopic adrenalectomy is better than conventional laparoscopic adrenalectomy in…
- Trial name
- NCT05675124
- Testing
- Needlescopic laparoscopic adrenalectomy, conventional laparoscopic adrenalectomy
- Where
- Taiwan
- Volunteers
- 130 people
- Sponsor
- National Taiwan University Hospital
Hypertension, Primary Aldosteronism
Genetic Predisposition to High Blood Pressure
Primary aldosteronism (PA) is a known but underdiagnosed cause of high blood pressure. It is estimated that more than 10% of all people with high blood pressure (HT) suffer from PA, which is often caused by aldosterone-producing…
- Conditions
- Hypertension, Primary Aldosteronism, Genetic Predisposition to Disease
- Trial name
- NCT07181213
- Testing
- Adrenalectomy
- Where
- Sweden
- Volunteers
- 76 people
- Sponsor
- Linkoeping University
Primary Aldosteronism
The Effect of SAAE on Ventricular Remodeling in PA Patients
The study aims to assess the effect of superselective adrenal arterial embolization on ventricular remodeling in primary aldosteronism without lateralized aldosterone secretion by comparing it with spironolactone therapy.
- Trial name
- NCT05501080
- Testing
- Super selective adrenal artery embolization, Spironolactone
- Where
- China
- Volunteers
- 112 people
- Sponsor
- Second Affiliated Hospital of Nanchang University