Clinical trials: Constipation, completed
Cystic Fibrosis
Multicenter Study of Patient-reported Gastrointestinal Symptoms in People With Cystic Fibrosis
This is a prospective, multicenter, observational study designed to collect gastrointestinal related data in patients with Cystic Fibrosis (CF).
- Trial name
- GALAXY (NCT03801993)
- Where
- 26 sites in United States
- Volunteers
- 402 people
- Sponsor
- Chris Goss
Palliative Care, Constipation
The Effect of Constipation Insoles on the Management of Constipation
Constipation is a common symptom among patients receiving palliative care and significantly affects their quality of life. Effective management of constipation requires both pharmacological and non-pharmacological approaches.
- Trial name
- NCT07339293
- Testing
- constipation insole, Walk
- Where
- Turkey (Türkiye)
- Volunteers
- 139 people, healthy volunteers welcome
- Sponsor
- Istanbul Aydın University
Irritable Bowel Syndrome (IBS)
Abdominal Symptom Phenotype Study in Children
Children and adults commonly suffer from recurrent abdominal (stomach) pain. One type is called irritable bowel syndrome (IBS). IBS in adults and children is one of the most common and costly health care problems in the US.
- Trial name
- ASPPNB (NCT01204515)
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Care, Constipation
Care Package for Postoperative Constipation
Background: Postoperative constipation is a common complication. The effectiveness of a care package constituting warm water intake, abdominal massage, and a high-fiber diet has not been investigated in patients undergoing…
- Trial name
- Car_Package (NCT06399133)
- Testing
- Warm water intake, High-fiber diet, Abdominal massage
- Where
- Turkey (Türkiye)
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Kubra KAYA
Constipation
Magnetic Resonance Imaging in Paediatric Constipation
Constipation in children is a common problem. Managing these children is difficult, partly because they do not respond to laxatives and partly because their bowel problem cannot be defined.
- Trial name
- MAGIC (NCT03564249)
- Testing
- MiniCap
- Where
- United Kingdom
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Nottingham University Hospitals NHS Trust
Microbiota, Constipation
A Probiotic Blend Reduces Gastrointestinal Symptoms and Positively Impacts Microbiota Modulation in a Randomized Study
This randomized, placebo-controlled, double-blind study will determine the effect of daily supplementation with a probiotic blend in 60 apparently healthy men and women recruited at a single investigational center in Northeast…
- Conditions
- Microbiota, Constipation, Candida
- Trial name
- NCT05614726
- Testing
- 575mg [30 billion colony forming units] probiotic blend of Bifidobacterium breve, Lactobacillus acidophilus, Lacticaseibacillus rhamnosus, Saccharomyces boulardii, and alpha amylase
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- The Center for Applied Health Sciences, LLC
Chronic Idiopathic Constipation
A Safety and Efficacy Evaluation of BLI400 Laxative in Constipated Adults
The purpose of this study is to evaluate a daily dose of BLI400 Laxative for safety and efficacy versus lubiprostone in constipated adults.
- Trial name
- NCT02481947
- Testing
- BLI400 Laxative, Lubiprostone
- Where
- 50 sites in United States
- Volunteers
- 459 people
- Sponsor
- Braintree Laboratories
Constipation
Effect of Inulin-type Fructans on Constipated Children.
The main objective of this Pilot study was to assess the beneficial effects of a daily supplementation with Orafti inulin-type fructans in 2-5 year old constipated children The study is primary aimed to develop a feasibility…
- Trial name
- CONSTICHILD (NCT02863848)
- Testing
- OraftiR inulin-type fructans
- Where
- Spain
- Volunteers
- 22 people
- Sponsor
- Institut Investigacio Sanitaria Pere Virgili
Constipation
Investigation of Supra Fiber in the Treatment of Adults With Constipation
Background: Whether Supra-Fiber, a plum-derived fiber supplement is useful in the treatment of constipation is not known. Supra Fiber is the first fiber supplement that has a blend of whole food fruit as its main ingredient.
- Trial name
- NCT01288508
- Testing
- Supra Fiber, Psyllium
- Where
- United States
- Volunteers
- 89 people
- Sponsor
- Augusta University
Constipation
Drink Milk Consumption Benefits With Culture Probiotic in the Treatment of Constipation
Constipation is defined as a disorder characterized by persistent difficulty to evacuate or a feeling of incomplete evacuation and / or infrequent bowel movements.
- Trial name
- NCT02446080
- Testing
- Milk drink with probiotic culture, Milk drink
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Centro Universitário Univates
Gut Microbiota, Constipation
Fecal Microbiota Transplantation for Constipation
Difficult defecation is a common symptom involving with patients'life quality. The stool pattern of these patients might be related to the contribution of gut microbiota.
- Trial name
- NCT03308461
- Testing
- Fecal Microbiota suspension
- Where
- China
- Volunteers
- 22 people
- Sponsor
- The Second Hospital of Nanjing Medical University
Opioid-induced Constipation
Compassionate Use Study of Methylnaltrexone
This is an open label compassionate use study of subcutaneously administered methylnaltrexone (MNTX) in participants with advance medical illness and opioid-induced constipation.
- Trial name
- NCT01368562
- Testing
- Methylnaltrexone
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Bausch Health Americas, Inc.
Functional Constipation
A Proof of Concept Study of Pradigastat in Patients With Functional Constipation
The purpose of this study is to evaluate the efficacy, safety, and tolerability of pradigastat 20 and 40 mg as compared to placebo in patients with Functional Constipation.
- Trial name
- NCT04620161
- Testing
- Pradigastat Tablets 20mg, Pradigastat Tablets 40mg
- Where
- 25 sites in United States, China
- Volunteers
- 181 people
- Sponsor
- Anji Pharma
Constipation
The Efficacy of Mutaflor(E. Coli Nissle 1917, Mutaflor®) for Chronic Constipation:Multicenter Study
Chronic constipation is a prevalent, burdensome gastrointestinal disorder whose treatment remains challenging. There exist effective pharmacological therapies for chronic constipation, however, many patients do not well respond…
- Trial name
- NCT02726295
- Testing
- E. coli Nissle 1917(Mutaflor®)
- Where
- South Korea
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Keimyung University Dongsan Medical Center
Constipation, Hirschsprung Disease
Endoscopic Mucosal Resection for the Diagnosis of a-Ganglionosis, a Controlled Prospective Trial (EDGE Trial)
Patients undergoing routine rectal suction biopsy will undergo as part of the study an additional Endoscopic mucosal resection. The biopsy results will also be correlated with patient's clinical data including clinical history…
- Trial name
- EDGE (NCT01515501)
- Testing
- Endoscopic mucosal resection (EMR)
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Massachusetts General Hospital
Drug Induced Constipation
Study in Healthy Volunteers to Investigate the Effects of Diltiazem on the Pharmacokinetics of Naloxegol
Study in healthy volunteers to investigate the effects of Diltiazem on the Pharmacokinetics of naloxegol.
- Trial name
- NCT01594619
- Testing
- Naloxegol, Diltiazem XR
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Functional Constipation
Visceral Osteopathy in Functional Constipation
It is a functional bowel disease characterized by excessive straining during defecation, infrequent defecation, and the feeling of incomplete evacuation.
- Trial name
- NCT06196073
- Testing
- Osteopathic manual therapy, conservative treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 27 people
- Sponsor
- Pamukkale University
Constipation
Fiber Regimens for Constipation Symptoms
The objective of the current study is to compare the effects of bowel recipe with psyllium on symptoms associated with constipation.
- Trial name
- constipation (NCT03845673)
- Testing
- Psyllium, Bowel recipe
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Parkinson's Disease
Amitiza in Constipation Associated With PD (Parkinson's Disease)
The purpose of this study is to determine if Amitiza (lubiprostone), a drug proven to be safe and effective for chronic constipation, will also improve constipation symptoms in Parkinson's Disease patients.
- Trial name
- AMITIZA (NCT00908076)
- Testing
- LUBIPROSTONE
- Where
- 2 sites in United States
- Volunteers
- 78 people
- Sponsor
- Baylor College of Medicine
Constipation
Efficacy of Different Nerve Stimulation Methods in Individuals With Chronic Constipation
Constipation is the most common digestive complaint in the general population. Normal stool frequency ranges from at least three times a week to a maximum of two times a day.
- Trial name
- NCT05833191
- Testing
- Auricular vagus stimulation, Tibial Nerve Stimulation
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 16 people
- Sponsor
- Istanbul Medipol University Hospital