Clinical trials: Constipation Chronic Idiopathic
Constipation - Functional, Constipation-predominant Irritable Bowel Syndrome
MOWOOT Device Treatment for Adults With Chronic Constipation
The primary objective is to compare the effectiveness of the experimental Intermittent Colonic Exoperistalsis (ICE) treatment with MOWOOT, with the active control of trans-anal irrigation (TAI) as standard-of-care.
- Conditions
- Constipation - Functional, Constipation-predominant Irritable Bowel Syndrome, Constipation Chronic Idiopathic, Constipation; Neurogenic
- Trial name
- MOTACC (NCT04666155)
- Testing
- Intermittent Colonic Exoperistalsis with MOWOOT device, Standard of care with Trans-Anal Irrigation
- Where
- 3 sites in United Kingdom
- Volunteers
- 86 people
- Sponsor
- usMIMA S.L.
Constipation Chronic Idiopathic
MowOot and Trans-anal Irrigation fOr coNstipation
This prospective, open-labelled, longitudinal, controlled study aims to evaluate the suitability of Intermittent Colonic Exoperistalsis (ICE) treatment for adults with refractory chronic constipation who are awaiting trans-anal…
- Trial name
- MOTION (NCT06833684)
- Testing
- ICE Treatment, TAI Standard-of-Care Treatment
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- usMIMA S.L.
Constipation Chronic Idiopathic, Cystic Fibrosis
Maralixibat in Patients With Cystic Fibrosis and Constipation
Chronic constipation is common in children with cystic fibrosis (CF), likely due to impaired chloride channel function that reduces intestinal secretions.
- Trial name
- NCT06413368
- Testing
- Maralixibat 9.5 MG/ML [Livmarli]
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Children's Hospital Los Angeles
Chronic Idiopathic Constipation, Functional Constipation
Botulinum Toxin Injection Versus Anal Myectomy in Management of Idiopathic Constipation
Chronic idiopathic constipation is most common cause of Constipation in childhood with numerous cases in Egypt. Numerous conservative measures were tried but many fail.
- Trial name
- NCT02361749
- Testing
- Botulinum Toxin, Anal Myectomy
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University
Chronic Pancreatitis, Inflammatory Bowel Diseases
Genomic Resources for Enhancing Available Therapies (GREAT1.0) Study
This is a prospective, descriptive, observational research study designed to observe and document the clinical practice by domain experts, and how the knowledge of new findings that are published in the medical literature affect…
- Conditions
- Chronic Pancreatitis, Inflammatory Bowel Diseases, Hepatitis, NASH - Nonalcoholic Steatohepatitis
- Trial name
- GREAT1 (NCT04306939)
- Testing
- venipuncture, Questionnaires, Additional Sample Collections
- Where
- United States
- Volunteers
- 120,000 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Functional Constipation (FC), Chronic Idiopathic Constipation (CIC)
A Study to Assess Adverse Events and Change in Symptoms With Linaclotide Versus Placebo in Pediatric Subjects, Ages 2 to 5 Years, With Functional Constipation
Functional constipation (FC) is a common healthcare problem in children of all ages, potentially due to genetic predisposition, inadequate fiber and fluid intake, and immobility.
- Trial name
- NCT05652205
- Testing
- Linaclotide
- Where
- 48 sites in United States, Bulgaria and 2 more
- Volunteers
- 123 people
- Sponsor
- AbbVie
Chronic Idiopathic Constipation
Efficacy and Safety of Vibrant Capsule vs. Placebo for the Treatment of Chronic Idiopathic Constipation
The study is a prospective, randomized, multicenter, adaptive design, double blinded, placebo-controlled study, to evaluate the efficacy and safety of Vibrant Capsule vs.
- Trial name
- Vibrant (NCT03879239)
- Testing
- Vibrating capsule
- Where
- 8 sites in United States
- Volunteers
- 349 people
- Sponsor
- Vibrant Ltd.
Chronic Idiopathic Constipation
26 Week Efficacy and Safety Trial for Patients With Chronic Idiopathic Constipation
Efficacy and Safety Trial of elobixibat in Patients with Chronic Idiopathic Constipation treated for 26 Weeks.
- Trial name
- NCT01827592
- Testing
- Elobixibat 10 mg, Elobixibat 5 mg
- Where
- 94 sites in United States, Belgium and 8 more
- Volunteers
- 376 people
- Sponsor
- Ferring Pharmaceuticals
Chronic Idiopathic Constipation
Lubiprostone Effect on Gastrointestinal Tract Transit Times Measured by Smartpill in Patients With Chronic Constipation
The purpose of this study is to determine if lubiprostone may change the rate of movement of food and activities in the stomach and intestines in subjects whose gastrointestinal (GI) tract is slower due to constipation.
- Trial name
- NCT01469819
- Testing
- Lubiprostone
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- Texas Tech University Health Sciences Center, El Paso
Chronic Idiopathic Constipation
Efficacy of Linaclotide to Senna for CIC
In this prospective, randomized, double blind study, the aim is to determine the efficacy of Linaclotide in relation to Senna in relieving the symptoms of chronic idiopathic constipation (CIC).
- Trial name
- NCT02239510
- Testing
- Senna, Linzess
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- TriHealth Inc.
Constipation
Efficacy and Safety Study of Prucalopride for the Treatment of Chronic Constipation
The purpose of this study is to determine which dose of prucalopride is safe and effective in patients with chronic idiopathic constipation.
- Trial name
- NCT00617513
- Testing
- Prucalopride
- Volunteers
- 174 people
- Sponsor
- Movetis
Constipation Chronic Idiopathic
Tolerability Study of Panosyl Isomaltooligosaccharides (PIMO), in Subjects With Chronic Idiopathic Constipation (CIC)
This is a randomized, double blind, placebo controlled trial to evaluate the tolerability of MHS 1031. Tolerability will be assessed using the change in complete spontaneous bowel movements (CSBM), PRO questionnaires, concomitant…
- Trial name
- NCT05129618
- Testing
- MHS 1031
- Where
- United States
- Volunteers
- 172 people
- Sponsor
- Microbiome Health Sciences
Constipation, Irritable Bowel Syndrome
Cognitive and Psychiatric Effects of Linaclotide on Patients With Constipation
Irritable Bowel syndrome - constipation predominant (IBS-C) is a chronic and disabling,disorder of the gut that is characterized by abdominal pain or discomfort.
- Trial name
- NCT03342287
- Testing
- questionnaires, cognitive evaluation, Blood
- Where
- Canada
- Sponsor
- McMaster University
Chronic Idiopathic Constipation
Trial of Linaclotide in Patients With Chronic Idiopathic Constipation
The objective of this trial was to determine the efficacy and safety of linaclotide 72 ug administered once daily to patients with chronic idiopathic constipation (CIC).
- Trial name
- NCT02291679
- Testing
- Linaclotide
- Where
- 95 sites in United States
- Volunteers
- 1,223 people
- Sponsor
- Ironwood Pharmaceuticals, Inc.
Constipation, Constipation - Functional
Soluble and Osmotic Fibre (SOLOS) Diet for Constipation
This research aims to study the dual effectiveness of incorporating soluble fibre and osmotic carbohydrates (SOLOS), with or without restricting fructans and GOS, and present novel findings in managing GI symptoms in patients…
- Conditions
- Constipation, Constipation - Functional, Constipation Chronic Idiopathic, Constipation Predominant Irritable Bowel Syndrome
- Trial name
- SOLOS (NCT07388589)
- Testing
- Diet
- Where
- Singapore
- Volunteers
- 180 people
- Sponsor
- Singapore Institute of Technology
Chronic Idiopathic Constipation
12-Week Study of Plecanatide for CIC (The National CIC3 Study)
The purpose of this study is to confirm that the investigational medication, plecanatide, is safe and effective in treating chronic idiopathic constipation.
- Trial name
- CIC (NCT02122471)
- Testing
- Plecanatide
- Where
- 167 sites in United States
- Volunteers
- 1,410 people
- Sponsor
- Bausch Health Americas, Inc.
Constipation
Prucalopride in Patients With Chronic Idiopathic Constipation
The purpose of this study is to determine whether prucalopride is safe and effective in the treatment of chronic idiopathic constipation. Hypothesis: Prucalopride given at a dose of 1 mg o.d.
- Trial name
- NCT00575614
- Testing
- prucalopride
- Volunteers
- 87 people
- Sponsor
- Movetis
Chronic Idiopathic Constipation
A Safety and Efficacy Evaluation of BLI400 Laxative in Constipated Adults
The purpose of this study is to evaluate a daily dose of BLI400 Laxative for safety and efficacy versus lubiprostone in constipated adults.
- Trial name
- NCT02481947
- Testing
- BLI400 Laxative, Lubiprostone
- Where
- 50 sites in United States
- Volunteers
- 459 people
- Sponsor
- Braintree Laboratories
Constipation Chronic Idiopathic
Vibrant Capsule vs. Placebo for Patient Suffering From Constipation
The objectives are to assess the efficacy and safety of Vibrant capsule administered twice a week
- Trial name
- Capsule (NCT05036369)
- Testing
- Vibrant capsule
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- Vibrant Ltd.
Chronic Idiopathic Constipation
Lubiprostone for Treatment of Chronic Idiopathic Constipation
The purpose of this study was to evaluate the efficacy and safety of oral administration of lubiprostone 24 μg twice daily (BID) for 4 weeks in participants with chronic idiopathic constipation (CIC) compared with placebo.
- Trial name
- NCT02695719
- Testing
- Lubiprostone
- Where
- 5 sites in South Korea
- Volunteers
- 156 people
- Sponsor
- Takeda