Clinical trials: Contact Lenses
Myopia
Changes in Eye Shape With Myopia Management Interventions
The goal of this clinical trial is to study changes in eye shape of nearsighted young adults using low-dose atropine eye drops or soft multifocal contact lenses.
- Trial name
- NCT06450132
- Testing
- Atropine Ophthalmic, MiSight 1-day disposable contact lenses
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Contact Lens Comfort and Successful Refitting, Presbyopia
Refitting Satisfied INFUSE One-Day Multifocal Wearers to DAILIES TOTAL1 Multifocal Contact Lenses
The purpose of this study is to determine the comfort and vision of DAILIES TOTAL1 Multifocal contact lenses in a population of satisfied INFUSE One-Day Multifocal contact lens wearers
- Trial name
- INFUSETODT1 (NCT07638943)
- Testing
- DAILIES TOTAL1 Multifocal (delefilcon A)
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Gordon Schanzlin New Vision
Contact Lens Disinfecting Solutions
Comparison of Two Multi-Purpose Solution and Lens Material Combinations on Corneal Barrier Function
The purpose of this study is to measure the relative "barrier" function of the top layer of the cornea (called the epithelium), or the degree to which the cornea can prevent the penetration of the colored dye sodium fluorescein…
- Trial name
- NCT00560898
- Testing
- ProClear Lens Material soaked in ReNu Multiplus Multipurpose Solution, Acuvue Advance Lens Material soaked in ReNu Multiplus Multipurpose Solution, Acuvue Advance Lens Material soaked in Optifree RepleniSH Multipurpose Solution
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Southern California College of Optometry at Marshall B. Ketchum University
Contact Lens Complication
The Impact of Soft Contact Lenses on the Corneal Neuromediators and Optical Quality in High Myopia Prior to SMILE
To investigate the influence of Neuromediators expression in corneal stromal lenticules and corneal injury repair after small incision extraction
- Trial name
- NCT06650306
- Testing
- This study does not involve any interventions
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- yuhao shao
Visual Acuity
Comparison of Two Silicone Hydrogel Multifocal Contact Lenses
This is a single-masked, randomized-controlled, dispensing clinical trial. A total of approximately 40 eligible hyperopic and myopic subjects will be targeted to complete the study.
- Trial name
- NCT04093258
- Testing
- Dailies Total 1® Multifocal Contact Lenses, Air Optix® Multifocal Contact Lenses Plus HydraGlyde®
- Where
- 3 sites in United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Vision Care, Inc.
Vision
Wettability of Contact Lenses With a Multi-Purpose Solution
Measure wettability of hydrogel and silicone hydrogel contact lenses presoaked in a Multi-Purpose Solution.
- Trial name
- NCT00713076
- Testing
- Polyquaternium-preserved Multi-purpose Lens Cleaning Solution 109182
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Alcon Research
Hyperopia, Myopia
Clinical Study of Clariti Monthly Contact Lens
A clinical study report follows; this clinical study evaluated the safety and efficacy of SAUFLON CLARITI Soft Silicone Hydrogel Contact Lens with UV Blocker by comparison with Air Optix Aqua silicone hydrogel contact lenses…
- Trial name
- NCT01392950
- Testing
- Air Optix Aqua, Clariti
- Where
- United Kingdom
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Sauflon Pharmaceuticals Ltd
Presbyopia, Refractive Error
Dispensing Study to Assess the Visual Performance of Optimised Prototype Contact Lenses
The aim of this study is to assess the visual performance of multiple optimised prototype soft contact lens designs compared to commercially available contact lenses.
- Trial name
- NCT02484586
- Testing
- Etafilcon A, Nelfilcon A, Nesofilcon A
- Where
- Australia
- Volunteers
- 161 people, healthy volunteers welcome
- Sponsor
- Brien Holden Vision
Corneal Staining
Assessment of Tear Film-Based Proteins Associated With Care Solution Induced Corneal Staining
The purpose of this study was to investigate the association of inflammatory mediators found in the tear film during the development and following the induction of contact lens solution-induced corneal staining.
- Trial name
- NCT01100424
- Testing
- Opti-Free RepleniSH, ReNu MultiPlus, Balafilcon A
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Alcon Research
Presbyopia
Evaluation of Soft Multifocal Lenses in Presbyopic Previous Contact Lens Wearers
To explore the wear experience in Dailies TOTAL1 Multifocal contact lenses in presbyopic adults who have previously dropped out of contact lens wear.
- Trial name
- NCT06053463
- Testing
- Daily disposable multifocal soft contact lens
- Where
- 2 sites in United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Jennifer Fogt
Visual Acuity
Evaluation of Visual Performance of Two Types of Cosmetic Contact Lenses
This is a single visit, brand-masked, non-dispensing, 2×2 bilateral crossover study. Each subject will be bilaterally fitted with one of the two test articles in each of the study periods in a random order with a 5-minute washout…
- Trial name
- NCT04534764
- Testing
- etafilcon A with cosmetic pattern, 1-Day Acuvue DEFINE Vivid Style
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Vision Care, Inc.
Visual Acuity
Evaluation of Astigmatic Contact Lenses
Randomized, double-masked, 5-visit, bilateral dispensing, parallel group study to demonstrate that the investigational contact lens meets the design requirements related to corneal staining, lens fit, visual acuity and rotational…
- Trial name
- NCT03086447
- Testing
- Investigational Contact Lens, Marketed Contact Lens
- Where
- 17 sites in United States
- Volunteers
- 267 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Vision Care, Inc.
Contact Lens Comfort
Contact Lens Adaptation in Neophytes
Eye care professionals prescribe contact lenses to new wearers on a daily basis, and it is common practice for practitioners to educate their patients to gradually increase their contact lens wear time over their first few days…
- Trial name
- CLAN (NCT02148263)
- Testing
- senofilcon A
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Keratitis
Study of the Presence and Extent of Corneal Disturbance Associated With B+L Biotrue MPS Used With B+L PureVision Lenses
Corneal epithelial disruption, commonly termed "corneal staining" has been frequently associated with contact lens wear. Previous research has demonstrated higher levels of observed corneal staining when certain combinations of…
- Trial name
- NCT01268306
- Testing
- B+L Biotrue MPS and B+L PureVision
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Epstein, Arthur B., OD, FAAO
Vision Disorders
Study of A New Contact Lens Cleaning and Disinfecting Solution
The objective of this study is to evaluate the safety and efficacy of a new investigational cleaning and disinfecting solution (Test) compared to Clear Care cleaning and disinfecting solution (Control) when used by contact lens…
- Trial name
- NCT01318577
- Testing
- Investigational Cleaning & Disinfecting Solution, Clear Care Solution
- Where
- United States
- Volunteers
- 444 people, healthy volunteers welcome
- Sponsor
- Bausch & Lomb Incorporated
Dry Eye, Contact Lens Complication
Dailies Total 1 Sphere Contact Lenses
CL discomfort is a complex phenomenon that has been defined by the Tear Film and Ocular Surface Society in their seminal report on contact lens (CL) discomfort as a condition that results in "episodic or persistent adverse ocular…
- Trial name
- NCT05239494
- Testing
- DT1 Sphere Contact Lenses
- Where
- 4 sites in United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Ametropia
Evaluation of Monthly Replacement Lenses in Habitual Soft Contact Lens Wearers Who Report Frequent Digital Devise Use
To evaluate the clinical performance of two monthly silicone hydrogel contact lenses in habitual wearers of frequent replacement (FRP) lenses when worn for 1-month.
- Trial name
- NCT05166902
- Testing
- Lens A (comfilcon A lens), Lens B (lehfilcon A lens)
- Where
- 4 sites in United States, Canada
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- CooperVision, Inc.
Visual Acuity
Evaluation of Approved Contact Lenses
This is a prospective, randomized, controlled, subject-masked, bilateral, dispensing, multi-site, 2 lenses × 3 wearing periods crossover study to evaluate visual acuity.
- Trial name
- NCT07174596
- Testing
- B+L Infuse spherical soft contact lenses, J&J ACUVUE OASYS 1-Day spherical soft contact lenses
- Where
- 4 sites in United States
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Vision Care, Inc.
Corneal Ulcer
Studying the Relationship Between Contact Lens Packaging Solutions and Bacterial Binding to Surface Eye Cells
The goal of this study is to investigate the overall theory that the use of chemically preserved solutions associated with contact lenses promotes an increase in bacterial infection.
- Trial name
- NCT01104961
- Testing
- Contact lens packaging solution, Balanced salt solution (BSS)
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Ametropia
Endothelial Bleb Response With Toric Lenses
Evaluate the short-term corneal response of oxygen deprivation when using toric contact lenses. The response will be noted by endothelial bleb formation in both open eye and closed eye state.
- Trial name
- NCT00630305
- Testing
- alphafilcon A toric, lotrafilcon B toric, senofilcon A toric
- Where
- Australia
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Vision Care, Inc.