Clinical trials: Continuous Renal Replacement Therapy
Metabolic Acidosis, Acute Kidney Injury
High Versus Low Bicarbonate Bath in Critically-ill Patients Receiving Continuous Renal Replacement Therapy
Researchers are trying to determine which dialysis solution, low bicarbonate fluid (22 mmol/L) or high bicarbonate fluid (32 mmol/L), is better in subjects with acute kidney injury (acute kidney failure) and metabolic acidosis…
- Conditions
- Metabolic Acidosis, Acute Kidney Injury, Acute Kidney Failure
- Trial name
- NCT03846258
- Testing
- Low bicarbonate solution (22 mmol/L), High Bicarbonate solution (32 mmol/L)
- Where
- United States
- Sponsor
- Mayo Clinic
Venoarterial Extracorporeal Membrane Oxygenation, Renal Replacement Therapy
Evaluation of Integrated Versus Parallel Connection for Renal Replacement Therapy in ECMO Patients
Extracorporeal membrane oxygenation (ECMO) is an extra-corporeal assistance used in case of respiratory or circulatory failure. In case of circulatory failure, ECMO is in the veno-arterial configuration (VA-ECMO).
- Conditions
- Venoarterial Extracorporeal Membrane Oxygenation, Renal Replacement Therapy, Acute Kidney Injury
- Trial name
- EPIC-ECMO (NCT06038162)
- Testing
- Parallel connection, Integrated connection
- Where
- 12 sites in France
- Volunteers
- 158 people
- Sponsor
- Hospices Civils de Lyon
ARDS, Human, Acute Kidney Injury
Regional Citrate Anticoagulation for RRT During V-V ECMO
Anticoagulation is an essential component of all extracorporeal therapies. Currently locoregional citrate anticoagulation is the recommended technique for continuous renal replacement therapy (CRRT).
- Trial name
- CRRT ECMO (NCT05148026)
- Testing
- Unfractionated heparin + RCA first, Unfractionated heparin first
- Where
- Italy
- Volunteers
- 18 people
- Sponsor
- University of Milano Bicocca
Continuous Renal Replacement Therapy, CO2 Removal
Plasma CO2 Removal Due to CRRT and Its Influence on Indirect Calorimetry
The aim of the present study is to assess the metabolic impact of Continuous Renal Replacement Therapy and overview the obstacles and important factors compromising the use of Indirect Calorimetry in CRRT and suggest a model to…
- Conditions
- Continuous Renal Replacement Therapy, CO2 Removal, Nutrition Poor, Acute Renal Failure
- Trial name
- MECCIAS (NCT03314363)
- Testing
- blood gas analysis under citrate predilution, filter replacement, IC
- Where
- Belgium
- Volunteers
- 10 people
- Sponsor
- Universitair Ziekenhuis Brussel
Vitamin D3 Deficiency
Vitamin D3 Supplementation in Critically Ill Patients Undergoing CRRT
Patients hospitalized in intensive care units (ICU) are particularly susceptible to vitamin D3 deficiencies. This can be due to the severity of their underlying disease, the type of treatment they are on, malnutrition before and…
- Trial name
- NephroD (NCT05657678)
- Testing
- Vitamin D3 - 750 000 IU, Vitamin D3 - 500 000 IU
- Where
- 4 sites in Poland
- Volunteers
- 138 people
- Sponsor
- Uniwersytecki Szpital Kliniczny w Opolu
Kidney Replacement Disorder
Anticoagulation and Activation - Comparison in Continuous Renal Replacement Therapy
Actual clinical practice predominantly makes use of heparin (systemically) or citrate regionally as anticoagulation in the extracorporeal circulation for renal replacement therapy.
- Trial name
- NCT01276392
- Where
- Germany
- Sponsor
- Klinik für Anästhesiologie
Acute Kidney Injury, Dialysis; Complications
LoW Dose-Intensity vs. Standard Dose-Intensity COntinuous Renal ReplaceMent Therapy in Critically Ill Patients (WISDOM)
An estimated 10-15% of critically ill patients with acute kidney failure in the intensive care unit receive acute dialysis therapy.
- Trial name
- WISDOM (NCT06446739)
- Testing
- Continuous Renal Replacement Therapy (CRRT)
- Where
- 10 sites in United States, Canada and 1 more
- Volunteers
- 100 people
- Sponsor
- University of Alberta
Fluid Overload
Bio Electrical Impedance Analysis to Monitor Fluid Status During Deresuscitation Strategy in Continuous Renal Replacement Therapy
Fluid overload is a poor prognostic factor in patients undergoing continuous renal replacement therapy in critical care. A strategy of active fluid removal by net ultrafiltration (UFnet) is one of the means to correct it.
- Trial name
- UF BIA (NCT05160467)
- Testing
- Segmental multi-frequency bio electrical impedance analysis
- Where
- France
- Volunteers
- 23 people
- Sponsor
- Hospices Civils de Lyon
Acute Kidney Injury, Continuous Renal Replacement Therapy
Continuous Renal Replacement Therapy for Acute Kidney Injury by Cooling Blood
Acute kidney injury (AKI) is common in intensive care unit (ICU) patients and is associated with longer hospital stays and worse survival.
- Trial name
- NCT04103307
- Testing
- Dialysis cooling
- Where
- Canada
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Septic Shock, Acute Kidney Injury
MCO Membrane Efficiency in Septic Shock Patients
This is a monocentre randomized pilot study. All patients received two consecutive RRT: CVVHD with MCO filter (Ultraflux® EMiC®2) and post-Continuous Veno-Venous Hemodiafiltration (CVVHDF) with HFF(AV1000S®) in a controlled…
- Trial name
- NCT04834921
- Testing
- Ultraflux® EMiC®2
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Fiorenza Ferrari
COVID-19
Registry of CytoSorb Therapy in COVID-19 ICU Patients
The CTC Registry collects patient-level clinical data on CytoSorb hemoadsorption provided to COVID-19 ICU patients via integration of the CytoSorb device into ECMO, CRRT, or hemoperfusion extracorporeal circuits.
- Trial name
- CTC REGISTRY (NCT04391920)
- Testing
- CytoSorb 300 mL device
- Where
- 7 sites in United States
- Volunteers
- 138 people
- Sponsor
- CytoSorbents, Inc
Infection During Renal Replacement Therapy, Critically Ill
Ceftaroline Pharmacokinetics in Continuous Renal Replacement Therapy
Dosing of ceftaroline in patients with chronic kidney disease is defined, but there is no data on pharmacokinetics and pharmacodynamics of the drug in patients receiving continuous renal replacement therapy (CRRT).
- Trial name
- NCT04152694
- Testing
- Ceftaroline levels in CRRT
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of Maryland, Baltimore
Critically Ill, Hemodialysis
Pharmacokinetics of Daptomycin in Critically Ill Patients Receiving Continuous Venovenous Hemodialysis (CVVHD)
Daptomycin is an antibiotic that is affective against many strains of antibiotic resistant microorganisms. This antibiotic would be appropriate for use in the intensive care unit (ICU) considering the severity of illness and high…
- Trial name
- NCT00663403
- Testing
- Daptomycin
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Michigan
Acute-On-Chronic Liver Failure, Hepatic Encephalopathy
Early Postoperative CRRT After Liver Transplantation in ACLF Patients With Overt HE
Pretransplant hepatoencephalopathy (HE) markedly impacts recipient outcomes after liver transplantation. Intraoperative CRRT showed benefits but feasibility was much concerned.
- Trial name
- LTeCRRT (NCT04317222)
- Testing
- eCRRT
- Volunteers
- 250 people
- Sponsor
- Third Affiliated Hospital, Sun Yat-Sen University
Acute Kidney Injury
Investigating Different Anticoagulants for Renal Replacement Therapy
The aim of this study is to evaluate the effect of regional citrate anticoagulation within the scope of continuous renal replacement (CRRT) in critically ill patients with acute kidney injury (AKI) on filter life span and 90-day…
- Trial name
- RICH (NCT02669589)
- Testing
- Heparin, Citrate
- Where
- 31 sites in Germany
- Volunteers
- 638 people
- Sponsor
- University Hospital Muenster
Acute Kidney Failure Stage 3, Continuous Renal Replacement Therapy (CRRT)
Effect of High Versus Standard Protein Intake in Critically Ill Patients With Acute Kidney Injury Requiring Continuous Renal Replacement Therapy
During critical illness, patients experience a hypercatabolic state. This hypercatabolic state causes muscle wasting in patients, resulting in intensive care unit acquired weakness (ICU-AW).
- Trial name
- PROTEIN-CRRT (NCT07596043)
- Testing
- High protein group, Standard protein group
- Where
- Thailand
- Volunteers
- 56 people
- Sponsor
- Chulalongkorn University
Renal Replacement Therapy
Impact of Dialysis Modality on Coagulation and Platelet Function
The investigators will evaluate the impact of dialysis modality (intermittent hemodialysis or continuous renal replacement therapy) in coagulation and platelet function in critically ill patients
- Trial name
- NCT04512131
- Testing
- dialysis mode
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Seoul National University Hospital
AKI - Acute Kidney Injury, Critical Illness
Continuous Renal Replacement Therapy, Impact on Intensive Care Unit Length of Stay
This large national cohort study, including over 500,000 patients, where around 5% are treated with continuous renal replacement therapy (CRRT) , aims to evaluate the association between time to initiation of CRRT and intensive…
- Trial name
- CIILOS (NCT07586059)
- Testing
- continuous renal replacement therapy
- Volunteers
- 500,000 people
- Sponsor
- Karolinska Institutet
Cardiogenic Shock, Acute Kidney Injury
Accelerated vs. Standard Continuous Renal Replacement Therapy for Patients With Cardiogenic Shock Undergoing Veno-arterial ExtraCorporeal Membrane Oxygenator
This study was designed to compare the safety and efficacy of early continuous renal replacement therapy with standard continuous renal replacement therapy in the presence of acute kidney injury (stage 2 or greater acute kidney…
- Trial name
- REDUCE-ECMO (NCT06696235)
- Testing
- Early initiation of continuous renal replacement therapy, Standard initiation of continuous renal replacement therapy
- Where
- 2 sites in South Korea
- Volunteers
- 408 people
- Sponsor
- Samsung Medical Center
Acute Kidney Injury
Citrate Versus Heparin Anticoagulation in Continuous Venovenous Hemofiltration
The purpose of this study is to compare citrate regional anticoagulation with systemic heparinization in continuous venovenous hemofiltration.
- Trial name
- CASH-CVVH (NCT00209378)
- Testing
- regional anticoagulation with citrate, HfCitPre
- Where
- 9 sites in Netherlands
- Volunteers
- 139 people
- Sponsor
- Universitair Ziekenhuis Brussel