Clinical trials: Contraceptive, Oral, Hormonal
Osteoporosis Risk
Prune Consumption and Bone Health in Young Women Using Hormonal Contraceptives
The primary objective of this study is to determine if 12 months of consuming 50 grams of dried plum daily will prevent bone loss or augment bone accrual of young adult oral contraceptive (OC) users.
- Trial name
- NCT04785131
- Testing
- Prune
- Where
- 2 sites in United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- San Diego State University
Polycystic Ovary Syndrome
Effects of Metformin and Oral Hormonal Contraceptive in Adolescents With Polycystic Ovary Syndrome
The polycystic ovary syndrome is the most common endocrinopathy in reproductive age women. The pathophysiology of this syndrome remains unclear, but there are evidences that a decreased in insulin sensitivity may be related in…
- Trial name
- NCT00988078
- Testing
- Metformin
- Where
- Brazil
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Federal University of São Paulo
Contraception, Female Contraception
A Study of Efficacy and Safety With the Transdermal Contraceptive System Versus Triphasil.
The purpose of the study was to compare the contraceptive efficacy and safety of the transdermal patch to Triphasil.
- Trial name
- NCT00236795
- Testing
- norelgestromin + ethinyl estradiol; triphasil.
- Volunteers
- 1,494 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Healthy Volunteers
A Study to Investigate the Effects of BMS-986278 on Drospirenone and Ethinyl Estradiol Drug Levels in Healthy Female Participants
The purpose of the study is to assess the effects of BMS-986278 on Drospirenone (DRSP) and Ethinyl Estradiol (EE) when administered as a combined oral contraceptive in healthy female participants.
- Trial name
- NCT05985590
- Testing
- BMS-986278, Drospirenone/Ethinyl Estradiol
- Where
- Canada
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Bristol-Myers Squibb
Obesity, Bariatric Surgery Candidate
Evaluation of Hormonal Contraceptive Treatments in Obese Women
The aim of our study is to assess the concentrations of different oral contraceptive agents in morbid obese women before and after two types of bariatric surgeries (RYGB and sleeve gastrectomy) in order to study the role of the…
- Conditions
- Obesity, Bariatric Surgery Candidate, Oral Contraceptive
- Trial name
- OBECO (NCT02398903)
- Testing
- Blood samples for measurement of drug Css, DXA and impedancemetry
- Where
- 2 sites in France
- Volunteers
- 174 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Adverse Effect of Oral Contraceptives, Initial Encounter
The Effect of Hormonal Contraception on Female
The aim- To evaluate the impact of combined oral contraceptives on women's psychosexual, metabolic, blood coagulation, hormonal and genetic measures.
- Trial name
- HORMCONTRA (NCT01852786)
- Testing
- Contraceptives, Oral, Combined, Controls
- Where
- Lithuania
- Volunteers
- 340 people, healthy volunteers welcome
- Sponsor
- Lithuanian University of Health Sciences
Menstrual Problem
New Treatments for Troublesome Bleeding in Implanon Users
Most Implanon users experience a reduction in the frequency and volume of menstrual bleeding, but a substantial minority experience unpredictable and frequent and/or prolonged episodes of bleeding.
- Trial name
- NCT01384331
- Testing
- Marvelon
- Where
- Australia
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Family Planning Association New South Wales
Female Contraception
Efficacy, Safety, and Acceptability of Mifepristone 50 mg Once-weekly as a Contraceptive
Participants in the study will use mifepristone 50 mg once-a-week for one year as a contraceptive. With this, we want to confirm that the chances of getting pregnant while using this contraceptive are very small.
- Trial name
- WOMEN&More (NCT06394999)
- Testing
- Mifepristone 50 mg
- Where
- 14 sites in Netherlands
- Volunteers
- 615 people, healthy volunteers welcome
- Sponsor
- Leiden University Medical Center
Menstrual Cycle, Hormonal Contraception
Oxytocin and Reward Processing in Women
Oxytocin is a hypothalamic neuropeptide that is best known for its peripheral physiological effects in the female organism i.e., uterine contractions during birth.
- Trial name
- NCT06222749
- Testing
- Intranasal oxytocin administration
- Where
- Germany
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- International Research Training Group 2804
Contraception
A Comparison of Continuation Rates for Three Hormonal Contraceptive Methods
This study will assess the continuation rates among women using oral contraceptive pills, Depo-Provera and Ortho Evra following a first trimester abortion.
- Trial name
- NCT00253019
- Where
- United States
- Volunteers
- 321 people, healthy volunteers welcome
- Sponsor
- Emory University
Drug Drug Interaction
A Drug-drug Interaction Trial in Healthy Female Participants to Investigate the Effect of Aprocitentan on Combined Hormonal Contraceptives
The goal of this clinical trial is to learn if drug aprocitentan has an effect on hormonal contraceptives in healthy female volunteers.
- Trial name
- NCT06799884
- Testing
- Ethinyl Estradiol / Levonorgestrel Oral Tablet, Aprocitentan
- Where
- Czechia
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Idorsia Pharmaceuticals Ltd.
Initiation of Oral Contraception (OC), Initiation of Depo-Provera (DMPA)
Modulation of Mucosal and Systemic Immunity by Hormonal Contraceptives
The investigators are conducting a research study to understand how cells responsible for fighting infection (immune cells) are affected by hormonal contraceptive use.
- Conditions
- Initiation of Oral Contraception (OC), Initiation of Depo-Provera (DMPA), Initiation of Mirena (LNG-IUD)
- Trial name
- NCT01750476
- Testing
- Mirena, Oral contraception, Depo-Provera
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Thomas Cherpes, DVM, MD
Contraception
A Multicenter, Non-Comparative Trial on the Contraceptive Efficacy, Safety, and Tolerability of LPRI-424, 13 Cycles
The main objective of this trial is to demonstrate the contraceptive efficacy of LPRI424, Additional goals of the trial are to demonstrate the safety and tolerability of LPRI424.
- Trial name
- NCT03945513
- Testing
- LPRI424 (dienogest/ethinylestradiol)
- Where
- United States
- Volunteers
- 1,034 people, healthy volunteers welcome
- Sponsor
- Insud Pharma
Contraception
A Study of Efficacy and Safety With the Transdermal Contraceptive System Versus Mercilon.
The purpose of the study was to compare the contraceptive efficacy and safety of the transdermal patch to Mercilon.
- Trial name
- NCT00236782
- Testing
- norelgestromin + ethinyl estradiol; mercilon
- Volunteers
- 1,517 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Contraceptive Affecting the Autonomic Nervous System, Contraceptive Affecting Blood Pressure
Assessment of Autonomic Tone in Normotensive Women Using Combined Hormonal Oral Contraceptive Containing Drospirenone
The use of combined oral contraceptives has been associated with increased risk of adverse cardiovascular events. The exact mechanism by which these drugs exert this influence is uncertain.
- Trial name
- NCT01590849
- Testing
- Contraceptives, Oral, Combined (Yaz®)
- Where
- Brazil
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Instituto do Coracao
Venous Thrombosis
Birth Control Pill vs Birth Control Patch Study
This study was a randomized, investigator-blinded, cross-over, clinic trial using twenty-four healthy women aged 18-35. All women received two months of the birth control patch or birth control pill, two months without any drug…
- Trial name
- PvP (NCT00554632)
- Testing
- Ethinyl estradiol and norgestimate, Ethinyl estradiol and norelgestromin
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Vermont
Contraception
Effects of St. John's Wort on the Effectiveness of Oral Contraceptives
The purpose of this study is to evaluate the effects of a common herbal remedy, St. John's Wort, on the effectiveness of birth control pills. St. John's Wort has recently been shown to increase metabolism of some drugs.
- Trial name
- NCT00026013
- Testing
- hypericum perforatum
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- National Center for Complementary and Integrative Health (NCCIH)
Contraception, Female Contraception
Postmarketing Study of ORTHO EVRA (Norelgestromin and Ethinyl Estradiol Contraceptive Patch) in Relation to Venous Thromboembolism (Blood Clots), Stroke and Heart Attacks
The purpose of the study is to assess the occurrence of venous thromboembolism (blood clots), stroke, and heart attack in current users of ORTHO EVRA compared to current users of norgestimate-containing oral contraceptives with…
- Trial name
- NCT00331071
- Testing
- Monophasic or triphasic Oral contraceptive tablet, Ortho Evra transdermal patch containing 6 mg NGMN/0.75 mg EE
- Volunteers
- 334 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Contraception
Improving Adolescent Adherence to Hormonal Contraception
The purpose of this study is to determine whether contraceptive compliance by young women can be improved through expanded counseling by a health educator at the initial clinic visit as compared with standard care.
- Trial name
- NCT00584038
- Testing
- educational instruction and phone follow-up, educational instruction in clinic
- Where
- United States
- Volunteers
- 1,155 people, healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
Oral Hormonal Contraceptive Use, Neural Activity
Contraceptive Hormone and Reward Measurement (CHARM Study)
Purpose of this study: The purpose of this study is to learn more about how hormonal oral contraceptives affect brain processes and emotional wellbeing.
- Conditions
- Oral Hormonal Contraceptive Use, Neural Activity, Mood, Hedonic Function
- Trial name
- CHARM (NCT05058872)
- Testing
- Levonorgestrel/ethinyl estradiol
- Where
- United States
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver