Clinical trials: Contraceptive Devices
Migraine
Impact of Combined Oral Contraceptive Pills on Migraine
The investigators will assess the effect of combined oral contraceptive pills (COCs) on migraine features and treatment response to allow better interpretation of the exact consequence of hormonal contraceptive use on migraineurs.
- Trial name
- NCT06509503
- Testing
- Combined oral contraceptive, Vaginal Ring
- Where
- Egypt
- Volunteers
- 400 people
- Sponsor
- Kafrelsheikh University
Abortion; Induced
Same-day Long-acting Reversible Contraception for Medication Abortion
Contraception after abortion is an important public health issue, as women who have an abortion are at high risk for additional unintended pregnancy.
- Trial name
- SaLMA (NCT01356927)
- Testing
- DMPA, Etonogestrel implant
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Boston University
Healthy
Effect of PF-06651600 on the Pharmacokinetics of Oral Contraceptive Steroids
This is a Phase 1, randomized, 2 way crossover, open-label study of the effect of multiple-dose PF 06651600 on single-dose oral contraceptive (OC) pharmacokinetics (PK) in healthy female subjects.
- Trial name
- NCT04018274
- Testing
- PF-06651600, Ethinyl estradiol (EE) and levonorgestrel(LN)
- Where
- 2 sites in United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Pfizer
Healthy Participants
Evaluate the Effect of Vimseltinib on Pharmacokinetics of Combined Oral Contraceptive (Ethinyl Estradiol/Levonorgestrel)
The main purpose of this study is to determine the effect of vimseltinib on pharmacokinetics of combined oral contraceptive (COC) (ethinyl estradiol/levonorgestrel) in healthy female participants.
- Trial name
- NCT07539090
- Testing
- Vimseltinib, Combined Oral Contraceptive (COC) (ethinyl estradiol [EE]/levonorgestrel [LNG])
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Deciphera Pharmaceuticals, LLC
Contraception, Immigrant
Implementing Best Practice Postpartum Contraceptive Services Through a Quality Improvement Initiative
Immigrant women in Europe has reported lower use of effective contraception, higher risks of multiple births, and unintended pregnancies compared to native-born women.
- Conditions
- Contraception, Immigrant, Post Partum
- Trial name
- IMPROVE-it (NCT05521646)
- Testing
- Quality Improvement Collaborative
- Where
- Sweden
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Healthy Volunteers, Pharmacokinetics of Mirabegron
A Study to Evaluate the Possible Effects of Taking Mirabegron While Taking a Contraceptive Pill
The objective of this study is to determine the effect of multiple doses of mirabegron on the pharmacokinetics of an oral contraceptive.
- Trial name
- NCT01297179
- Testing
- Mirabegron, Minidril
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Astellas Pharma Inc
Pregnancy Prevention
Comparative Study of the Contraceptive Efficacy of the Cupid, Cupid 2 and FC2 Female Condom
This research study aims to assess the effectiveness of three female condoms [Cupid, Cupid 2 and Female Condom 2(FC2)] for the prevention of pregnancy among women choosing the female condom (FC) as their method of fertility…
- Trial name
- NCT04233632
- Testing
- FC2 Condom, Cupid Condom, Cupid 2 Condom
- Where
- South Africa
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Prof Mags Beksinska
Intrauterine Device Complications, Contraceptive Device Failure
Patient Factors Associated With Fragmentation of Copper Intrauterine Device (IUD) Requiring Hysteroscopic Removal
The purpose of this retrospective chart review was to identify risks factors for patients associated to Cooper IUD fragmentation upon removal resulting in the requirement of a hysteroscopy evaluation.
- Conditions
- Intrauterine Device Complications, Contraceptive Device Failure, IUD Fragmentation, Retained Intrauterine Device
- Trial name
- NCT07351084
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- University of Kansas Medical Center
Solid Tumors
A Drug-Drug Interaction Study to Assess the Effect of Trametinib on the Pharmacokinetics of an Oral Contraceptive in Female Patients With Solid Tumors
The purpose of this study is to evaluate the effect of trametinib once daily on the pharmacokinetics (PK) of a daily dosing oral contraceptives (OCs) containing norethindrone (NE) and ethinyl estradiol (EE) in female patients…
- Trial name
- NCT02705963
- Testing
- Trametinib, Oral Contraceptive (1mg norethindrone, 0.035mg ethinyl estradiol)
- Where
- 7 sites in United States, Belgium and 3 more
- Volunteers
- 19 people
- Sponsor
- Novartis Pharmaceuticals
Contraception
Contraceptive Efficacy Study of Ovaprene
This will be a multi-center, single arm, open-label study of Ovaprene, a non-hormonal intravaginal ring, to investigate the contraceptive effectiveness, safety and acceptability of Ovaprene.
- Trial name
- NCT06127199
- Testing
- Ovaprene
- Where
- 27 sites in United States
- Volunteers
- 656 people, healthy volunteers welcome
- Sponsor
- Daré Bioscience, Inc.
Contraception
Safety, Tolerability, and Efficacy of ellaOne® (Ulipristal Acetate) for Emergency Contraception in Postmenarcheal Adolescent Girls and Women
The purpose of this observational study is to assess the safety and tolerability of ellaOne® in routine conditions of use for emergency contraception in postmenarcheal adolescents and adult women who want to prevent pregnancy up…
- Trial name
- NCT01107106
- Testing
- ellaOne® (ulipristal acetate)
- Where
- 6 sites in United States, Sweden and 1 more
- Volunteers
- 579 people, healthy volunteers welcome
- Sponsor
- HRA Pharma
Contraception
Study of the Contraceptive Efficacy and Safety of a NOMAC-E2 Combined Oral Contraceptive (COC)(P06448)
The purpose of this study was to assess the contraceptive efficacy of a nomegestrol acetate + 17ß-estradiol (NOMAC-E2) combined oral contraceptive (COC) in healthy, sexually-active American women at risk for pregnancy.
- Trial name
- NCT01656434
- Testing
- NOMAC-E2, NETA-EE, ethinylestradiol (EE)
- Volunteers
- 3,173 people, healthy volunteers welcome
- Sponsor
- Organon and Co
Contraception
Validation of Effectiveness on NaturalCycles Users
The goal of this observational study is to measure the effectiveness of the Natural Cycles digital birth control application at preventing pregnancy in sexually active women aged 18 to 35 with no known history of infertility.
- Trial name
- VENUS (NCT07566793)
- Testing
- Log daily intercourse information, Natural Cycles application
- Where
- United States
- Volunteers
- 2,000 people
- Sponsor
- Natural Cycles
HIV/AIDS, HIV Infections
Interactions Between Antiretrovirals (ARVs) and Combined Oral Contraceptives (COCs)
Non-randomized, comparative study (1:1 allocation) to study interactions between nevirapine-containing antiretroviral therapies and combined oral contraceptive pills.
- Trial name
- NCT00829114
- Testing
- ETHINYL ESTRADIOL AND LEVOGESTREL
- Where
- 2 sites in South Africa, Uganda
- Volunteers
- 370 people
- Sponsor
- FHI 360
Weight Gain, Disorder of Bone Density and Structure, Unspecified
Drug Exposure and Depot Medroxyprogesterone Acetate (DMPA) in Adolescent Subjects
The investigators are doing this study to look at how different doses of the Depot medroxyprogesterone acetate (DMPA) shot effect weight gain and bone mineral density in teens.
- Conditions
- Weight Gain, Disorder of Bone Density and Structure, Unspecified, Uterine Bleeding
- Trial name
- NCT01461824
- Testing
- Depot medroxyprogesterone acetate (DMPA)
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Nationwide Children's Hospital
Adenomyosis
LNG-IUS for Treatment of Dysmenorrhea
Adenomyosis is a disease entity diagnosed when endometrial glands and stroma deep in the myometrium are associated with surrounding myometrial hypertrophy.
- Trial name
- LNGIUSAD (NCT01601366)
- Testing
- LNG-IUS, Combined oral contraceptives
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Omar Mamdouh Shaaban
Contraception
A Multicenter, Non-Comparative Trial on the Contraceptive Efficacy, Safety, and Tolerability of LPRI-424, 13 Cycles
The main objective of this trial is to demonstrate the contraceptive efficacy of LPRI424, Additional goals of the trial are to demonstrate the safety and tolerability of LPRI424.
- Trial name
- NCT03945513
- Testing
- LPRI424 (dienogest/ethinylestradiol)
- Where
- United States
- Volunteers
- 1,034 people, healthy volunteers welcome
- Sponsor
- Insud Pharma
Contraception
Effects on Hemostasis, Lipids, Carbohydrate Metabolism, Adrenal & Thyroid Function of the Combined Oral Contraceptive NOMAC-E2 Compared to a COC Containing LNG-EE (292004)(COMPLETED)(P05764)
The primary purpose of this study is to evaluate the effects of the combined oral contraceptive (COC) NOMAC-E2 on hemostasis, lipids, carbohydrate metabolism, adrenal function, and thyroid function.
- Trial name
- NCT00511355
- Testing
- NOMAC-E2, Levonorgestrel and Ethinyl Estradiol
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- Organon and Co
Contraception
UCSF College Health Study on Contraceptive Training and Education at Community Colleges
The purpose of this study is to measure whether a training and education intervention for clinic staff and young women aged 18-25 on contraceptive methods, including intrauterine devices (IUDs) and the implant, will result in…
- Trial name
- NCT03519685
- Testing
- Contraceptive Training and Education
- Where
- United States
- Volunteers
- 2,086 people
- Sponsor
- University of California, San Francisco
Polycystic Ovarian Syndrome, Insulin Sensitivity
PED/PEA-15 Protein, PCOS, Obesity, Insulin Sensitivity Indexes, Metformin, Oral Contraceptives
Insulin-resistance plays an important role in polycystic ovary syndrome (PCOS) physiopathology. The phosphoprotein enriched in the diabetes (PED/PEA-15), a 15 kDa protein related to insulin sensitivity, is over-expressed in type…
- Trial name
- NCT00948402
- Testing
- Metformin, oral contraceptive
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Federico II University