Clinical trials: Contraceptive Devices
HIV Infections, Pregnancy
Drug Interactions Between Lopinavir/Ritonavir and Oral or Patch Contraceptives in HIV Infected Women
The purpose of this study is to examine the drug interactions between a protease inhibitor (PI)-based regimen including lopinavir/ritonavir (LPV/r) and two forms of contraceptive medications in HIV infected women.
- Trial name
- NCT00125983
- Testing
- Lopinavir/ritonavir, Ortho Novum 1/35, Ortho Evra
- Where
- 9 sites in United States, Puerto Rico
- Volunteers
- 32 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Healthy Volunteer
Oral AQX-1125 and Combination Oral Contraceptive Drug-Drug Interaction Study
This is an open-label, fixed sequence, 4 cycle, drug-drug interaction (DDI) study of AQX-1125 in healthy female subjects on combination oral contraceptives (COC).
- Trial name
- DDI-COC (NCT03478020)
- Testing
- AQX-1125, Combined Oral Contraceptive
- Where
- Netherlands
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Aquinox Pharmaceuticals (Canada) Inc.
Healthy
A Drug Interaction Study of Danicopan
This was a 3-part study (Part 1, Part 2, Part 3) with each part being an open-label, fixed sequence, 2-period study in healthy adult participants.
- Trial name
- NCT04709094
- Testing
- Danicopan, Warfarin, Bupropion
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Alexion Pharmaceuticals, Inc.
Contraception
Study of the Safety, Efficacy and Cycle Control of a Contraceptive Vaginal Ring
The purpose of this study is to evaluate the one-year data on the contraceptive efficacy and safety of the 150/15 NES/EE CVR as the basis for regulatory approvals of this CVR as a new delivery system for contraception.
- Trial name
- NCT00455156
- Testing
- 150 mg of Nestorone and 15 mg of ethinyl estradiol (150/15 NES/EE CVR)
- Where
- 15 sites in United States
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Premier Research
Anemia
Levonorgestrel Intrauterine System Effects on Hemoglobin and Serum Ferritin Among Anemic Women in Kenya
Women with mild/moderate anemia who are seeking contraception will be randomized to a levonorgestrel (LNG) intrauterine system (IUS) or an LNG/ethinyl estradiol (EE)/ferrous fumarate combined oral contraceptive (COC) regimen and…
- Trial name
- LISA (NCT05233956)
- Testing
- LNG IUS, COCs
- Where
- Kenya
- Volunteers
- 405 people, healthy volunteers welcome
- Sponsor
- FHI 360
Healthy
Oral Contraceptive DDI Study
A Two-way Study to Evaluate the Potential Pharmacokinetic Interactions Between Sotagliflozin (LX4211) and an Oral Contraceptive Containing Norgestimate and Ethinyl Estradiol, in Healthy Premenopausal Women.
- Trial name
- NCT02494609
- Testing
- sotagliflozin, oral contraceptive, oral contraceptive + sotagliflozin
- Where
- 2 sites in United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Lexicon Pharmaceuticals
Contraception
Breastfeeding Etonogestrel Implant Study
The investigators are studying the effect of placing the etonogestrel implant (Nexplanon) in the first 24 hours after birth on breastfeeding.
- Trial name
- LACTO-Rod (NCT03978598)
- Testing
- Etonogestrel, Nexplanon
- Where
- 2 sites in United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of New Mexico
Contraceptive Usage
A Phase I Study to Evaluate the PK and PD of a Single Injection of Levonorgestrel Butanoate for Female Contraception
To evaluate the levonorgestrel (LNG) pharmacokinetic (PK) profile following injection of a single 20 mg dose of levonorgestrel butanoate (LB).
- Trial name
- CCN011 (NCT02173808)
- Testing
- levonorgestrel butanoate
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Premier Research
Contraception
Open-label Study to Evaluate the Efficacy and Safety of an Extended-cycle, Low Dose Combination Oral Contraceptive
This is an open-label, single treatment study. All subjects will receive one year of oral contraceptive therapy with DR-1011. Study participants will receive physical and gynecological exams, including Pap smear.
- Trial name
- NCT00196326
- Testing
- DR-1011
- Where
- 55 sites in United States
- Volunteers
- 2,235 people, healthy volunteers welcome
- Sponsor
- Duramed Research
Preterm Birth, Health Care Utilization
Testing Feasibility of Care Coordination and Motivational Interviewing for Women With a Recent Preterm Birth
This study continues an adaptation of care coordination to address the needs of women after preterm birth. This is a small single arm open trial designed to test intervention implementation and refine the intervention before…
- Conditions
- Preterm Birth, Health Care Utilization, Tobacco Use, Contraceptive Usage
- Trial name
- NCT05120843
- Testing
- Care coordination and motivational interviewing
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Philadelphia
Contraception
Investigation of Three Contraceptive Hormone Patches in Regard to Inhibition of Ovulation Following Application Over 3 Treatment Cycles in Healthy, Young Women.
The primary objective of this trial is to examine whether ovulation is suppressed after use of hormone patches containing different dosages of ethinyl estradiol (EE) and gestodene (GSD) for 3 treatment cycles.
- Trial name
- NCT01204190
- Testing
- Gestodene/EE Patch (BAY86-5016)
- Where
- 2 sites in Germany, Netherlands
- Volunteers
- 173 people, healthy volunteers welcome
- Sponsor
- Bayer
Healthy
Effect of PF-06651600 on the Pharmacokinetics of Oral Contraceptive Steroids
This is a Phase 1, randomized, 2 way crossover, open-label study of the effect of multiple-dose PF 06651600 on single-dose oral contraceptive (OC) pharmacokinetics (PK) in healthy female subjects.
- Trial name
- NCT04018274
- Testing
- PF-06651600, Ethinyl estradiol (EE) and levonorgestrel(LN)
- Where
- 2 sites in United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Pfizer
Contraception
Efficacy and Safety of a Combined Oral Contraceptive of Estradiol Valerate and Dienogest in Healthy Female Subjects
To evaluate the efficacy and safety of a combined oral contraceptive of estradiol valerate and dienogest in healthy female subjects.
- Trial name
- NCT01638910
- Testing
- EV/DNG (Qlaira, BAY86-5027)
- Where
- 39 sites in China, Hong Kong and 3 more
- Volunteers
- 955 people, healthy volunteers welcome
- Sponsor
- Bayer
Contraception
I-CAN Uganda Effectiveness Trial
This is a cluster-randomized controlled trial to determine the effectiveness of the community-based "I-CAN" intervention to improve agency in contraceptive decision-making and use in rural Uganda.
- Trial name
- I-CAN (NCT07711717)
- Testing
- I-CAN
- Where
- Uganda
- Volunteers
- 1,560 people
- Sponsor
- University of California, San Francisco
Continuation Rate of Contraceptive Implant
Immediate vs. Delayed Postpartum Etonogestrel Implant
The investigators are examining if there is a difference in continuation rates of the etonogestrel contraceptive implant between women who have the device placed immediately after delivery, before leaving the hospital, and women…
- Trial name
- NCT01767285
- Testing
- Etonogestrel implant
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Duke University
Asherman Syndrome
Adjuvant Therapy for Intrauterine Adhesions Between Two Groups
This study was taken out to compare two mechanical devices (intrauterine balloon and Intrauterine Contraceptive Device Plus Foley Catheter) in the therapy for intrauterine adhesions after hysteroscopic adhesiolysis.
- Trial name
- NCT02867202
- Testing
- Intrauterine balloon, Intrauterine Contraceptive Device Plus Foley Catheter
- Where
- China
- Volunteers
- 171 people
- Sponsor
- Wenzhou Medical University
Women, Contraception
Annovera™ Drug-Drug Interaction Study
A Drug-Drug Interaction (DDI) study to evaluate the effects of itraconazole and rifampin on the Pharmacokinetics of Segesterone Acetate and Ethinyl Estradiol from the Annovera Contraceptive Vaginal System (CVS)
- Trial name
- NCT04290390
- Testing
- Segesterone Acetate and Ethinyl Estradiol, Rifampin, Itraconazole
- Where
- Canada
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- TherapeuticsMD
Contraception, Knowledge, Attitudes, Practice
Testing the Impact of Two Posters on Contraceptive Knowledge, Contraceptive Preferences, and Perceived Pregnancy Risk
This study tests two posters that teach people about contraception: one designed by the Centers for Disease Control (CDC), and one designed by the researchers.
- Trial name
- NCT03372369
- Testing
- View CDC Poster, View Patient-Centered Poster
- Where
- United States
- Volunteers
- 990 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Contraception
Contraceptive Choice at the Time of Uterine Evacuation
The goal of this project is to investigate whether a pre-visit telephone intervention could increase awareness of long-acting reversible contraception (LARC) availability at the time of uterine evacuation.
- Trial name
- NCT02836561
- Testing
- Telephone message
- Where
- United States
- Volunteers
- 234 people, healthy volunteers welcome
- Sponsor
- Planned Parenthood League of Massachusetts
Contraception
Efficacy and Safety of Etonogestrel + 17β-Estradiol Vaginal Ring in Women at Risk for Pregnancy (MK-8342B-061)
The purpose of this study is to assess the contraceptive efficacy of the Etonogestrel (ENG) + 17β-Estradiol (E2) vaginal ring in women between 18 and 35 years of age based on the number of in-treatment pregnancies as expressed by…
- Trial name
- NCT02524288
- Testing
- ENG-E2 125 μg/300 μg vaginal ring
- Volunteers
- 1,941 people, healthy volunteers welcome
- Sponsor
- Organon and Co