Clinical trials: Contraceptive Devices
Menorrhagia
A New Treatment Option for Heavy Menstrual Bleeding
Women with measured menstrual bleeding >80ml per cycle and no contraindications to combined oral contraceptive use will be assigned to an oestradiol/nomegestrol acetate oral contraceptive for 3 cycles during which they will…
- Trial name
- NCT01715025
- Testing
- E2Nomac
- Where
- Australia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Sydney Centre for Reproductive Health Research
Healthy Volunteer Study
Drug-drug Interaction Study of Bemnifosbuvir/Ruzasvir (BEM/RZR) and Ethinyl Estradiol/Levonorgestrel (EE/LNG)
Drug-drug interaction study between Ethinyl Estradioll/Levonorgestrel and Bemnifosbuvir/Ruzasvir
- Trial name
- NCT07272889
- Testing
- Ethinyl Estradioll/Levonorgestrel (EE/LNG), Bemnifosbuvir/Ruzasvir (BEM/RZR), Bemnifosbuvir/Ruzasvir (BEM/RZR) + Ethinyl Estradioll/Levonorgestrel (EE/LNG)
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Atea Pharmaceuticals, Inc.
Contraceptive Usage
Assess Performance Attributes and Acceptability of Non-medicated Intravaginal Rings Among Sexually Active Women in Atlanta, GA
A randomized open label crossover trial to assess performance attributes and acceptability of non-medicated intravaginal rings among sexually active women in Atlanta, GA
- Trial name
- NCT07039591
- Testing
- Pro-type IVR
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Population Council
Contraception
An Open-label Study to Evaluate Contraceptive Efficacy and Safety of the Transdermal Contraceptive System of Norelgestromine and Ethinyl Estradiol
The purpose of this study is to evaluate the contraceptive efficacy, safety, cycle control, compliance, and subject satisfaction of the transdermal contraceptive system, norelgestromine and ethinyl estradiol (NLGM / EE).
- Trial name
- NCT00307632
- Testing
- Norelgestromine (NLGM)/ethinyl estradiol (EE)
- Where
- 12 sites in Brazil, Mexico
- Volunteers
- 580 people, healthy volunteers welcome
- Sponsor
- Janssen-Cilag Farmaceutica Ltda.
Contraception
Qlaira Post-authorization Safety Study Related to Most Common Adverse Events in Mexican Women Who Wish to Avoid Pregnancy
Qlaira is a combined oral contraceptive (COC) containing dienogest/estradiol valerate being the first oral contraceptive delivering estradiol. It has been recently approved in Mexico.
- Trial name
- NCT01602770
- Testing
- EV/DNG (Qlaira, BAY86-5027)
- Where
- Mexico
- Volunteers
- 1 people
- Sponsor
- Bayer
Contraception
Evaluating Household Visits and Small Groups to Increase Contraception Use Among Married Adolescent Girls in Rural Niger
This study entails a quasi-experimental, mixed-methods (i.e., complementary quantitative and qualitative) outcome evaluation to assess the efficacy of the Reaching Married Adolescents (RMA) Interventions developed and implemented…
- Trial name
- IMPACT-RMA (NCT03226730)
- Testing
- Household Visits, Small Groups
- Where
- 2 sites in United States, Niger
- Volunteers
- 2,898 people
- Sponsor
- University of California, San Diego
Healthy
A Study of New Transdermal Contraceptive Patch at End of Shelf Life and Currently Marketed EVRA at the Beginning of Shelf Life in Healthy Women
The main objectives of this study are to determine the bioequivalence of the hormones (example, norelgestromin [NGMN] and ethinyl estradiol [EE]) from the transdermal contraceptive patch using the newly sourced adhesive component…
- Trial name
- NCT04017195
- Testing
- EVRA patch (NGMN+EE) (Treatment A) (Reference), High molecular weight polyisobutylene (HMW PIB) patch (NGMN+EE) (Treatment B) (Test)
- Where
- 3 sites in Belgium, Germany and 1 more
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Janssen Research & Development, LLC
Contraception
EU/LA Pearl Index Study - Transdermal Contraceptive Patch
The aim of the present study is to prove efficacy and safety of a new contraceptive patch.
- Trial name
- NCT00914693
- Testing
- Ethinylestradiol/Gestodene (BAY86-5016)
- Where
- 66 sites in Argentina, Australia and 6 more
- Volunteers
- 1,694 people
- Sponsor
- Bayer
Pharmacokinetics
Comparison of Serum Contraceptive Hormone Levels Between Normal Weight and Obese Users of the NuvaRing®
There are over 60 million women of reproductive age in the U.S. and a majority of these women qualify as overweight or obese. Evidence suggests that there is an association between increased body weight and decreased…
- Trial name
- NCT00710606
- Testing
- NuvaRing
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Columbia University
HIV, Contraception
The Evidence for Contraceptive Options and HIV Outcomes Trial
The ECHO Study is an open-label randomized clinical trial that will compare three highly effective, reversible methods of contraception (including a non-hormonal method) to evaluate whether there is a link between use of any of…
- Trial name
- ECHO (NCT02550067)
- Testing
- DMPA, LNG, Copper IUD
- Where
- 12 sites in Eswatini, Kenya and 2 more
- Volunteers
- 7,830 people, healthy volunteers welcome
- Sponsor
- FHI 360
Contraception
Postpartum Family Planning Service Through Enhanced Family Planning in Immunization Services
The purpose of this study is to determine the effectiveness of an intervention, which is designed to increase contraceptive prevalence among postpartum women attending vaccination services who desire to either space or limit…
- Trial name
- PPFP-IZ (NCT01115361)
- Testing
- Family planning for postpartum women
- Where
- Rwanda
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- FHI 360
Contraception, Liver Metabolism
"E4/DRSP Endocrine Function, Metabolic Control and Hemostasis Study"
The proposed study will provide an assessment of the effect of this combination on endocrine function, metabolic control and hemostasis during 6 treatment cycles. This will be compared to the effects of two reference COCs.
- Conditions
- Contraception, Liver Metabolism, Hemostasis Parameter
- Trial name
- NCT02957630
- Testing
- 15 mg E4/3 mg DRSP, 30 mcg EE/150 mcg LNG, 20 mcg EE/3 mg DRSP
- Where
- Netherlands
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- Estetra
Contraceptive Behavior
Meaningful Use of Technology to Improve Health Care Delivery
While there have been major declines in teenage pregnancy around the country, Baltimore, Maryland has continued to experience increases over the last several years.
- Trial name
- DepoText (NCT01641380)
- Testing
- Text Messaging Intervention
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Contraception
International Active Surveillance Study: Safety of Estrogen Estetrol (E4) Contraceptive Study (INAS-SEECS)
The combined oral contraceptive (COC) containing estetrol (E4) and drospirenone (DRSP) (E4/DRSP) is a novel oral contraceptive containing a fixed dose of E4 (14.2 mg) and DRSP (3 mg).
- Trial name
- INAS-SEECS (NCT06186271)
- Where
- Germany
- Volunteers
- 68,100 people
- Sponsor
- Center for Epidemiology and Health Research, Germany
Contraception
Shoulder Contraceptive Implant Study
This study will be the first to establish pharmacokinetic curves for the etonogestrel contraceptive implant with scapular subdermal insertion.
- Trial name
- NCT04463693
- Testing
- Etonogestrel implant
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Menstrual Cycle, Hormonal Contraception
Oxytocin and Reward Processing in Women
Oxytocin is a hypothalamic neuropeptide that is best known for its peripheral physiological effects in the female organism i.e., uterine contractions during birth.
- Trial name
- NCT06222749
- Testing
- Intranasal oxytocin administration
- Where
- Germany
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- International Research Training Group 2804
Healthy Participants
A Study to Investigate the Effect of AZD6234, AZD9550, and a Combination of AZD9550 and AZD6234 on Pharmacokinetics of Combined Oral Contraceptive Ethinyl Estradiol/Levonorgestrel in Healthy Female Participants Living With Overweight or Obesity
This study will measure the effects of multiple doses of AZD6234, AZD9550 and a combination of AZD9550 and AZD6234 given as injection(s) on pharmacokinetics (PK) of combined oral contraceptive (CoC) ethinyl estradiol…
- Trial name
- NCT07013643
- Testing
- AZD6234, Ethinyl estradiol/Levonorgestrel (EE/LEVO), Acetaminophen (APAP)
- Where
- 2 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
HIV, Contraception
Impact of Different Contraceptives on the Immune System of HIV Infected Women in Zambia
In this study, 66 HIV-infected women who desire contraception will be randomly assigned to use either an IUD or Depo Provera, and will be followed for six months.
- Conditions
- HIV, Contraception, HIV Infections
- Trial name
- MSRC (NCT00807625)
- Testing
- Depo Provera, Copper T Intrauterine contraception device
- Where
- Zambia
- Volunteers
- 66 people
- Sponsor
- University of Alabama at Birmingham
Contraception, Contraception Behavior
Contraception for Solid Organ Transplant Patients: Utilizing Social Media
The purpose of this study is to use an electronic survey to explore Solid Organ Transplant patients' contraceptive knowledge and counseling.
- Conditions
- Contraception, Contraception Behavior, Contraceptive Usage, Reproductive Health
- Trial name
- NCT03979950
- Testing
- Survey
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Asthma
Contraceptive Use and Respiratory Conditions Among Scottish Women
Studies examining the sex differences in the epidemiology and morbidity patterns of asthma show that the rates of disease severity, healthcare utilisation, and poor quality of life are considerably higher in women than in men…
- Trial name
- NCT02039102
- Where
- United Kingdom
- Volunteers
- 3,257 people
- Sponsor
- University of Edinburgh