Clinical trials: Contraceptive Devices, open to volunteers
Endometriotic Cyst of Ovary
Letrozole in Preventing Recurrence of Endometrioma Following Laparoscopic Ovarian Cystectomy
Endometriosis is a chronic inflammatory disease that affects approximately 10-15% of women of reproductive age. Symptoms include dysmenorrhoea, chronic pelvic pain, dyspareunia and infertility.
- Trial name
- NCT05487092
- Testing
- Letrozole
- Where
- 5 sites in Hong Kong
- Volunteers
- 194 people
- Sponsor
- The University of Hong Kong
Contraceptive Usage, Telemedicine
Telemedicine Contraceptive Counselling (TECC) Versus Standard Care
Overall purpose of the PILOT and RCT: This research project aims to increase access and uptake of contraception after abortion through the systematic development and testing of a new telemedicine service for contraceptive…
- Trial name
- TECC (NCT06682065)
- Testing
- Telemedicine for contraceptive counseling (TECC), Standard Care
- Where
- 2 sites in South Africa
- Volunteers
- 510 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Substance Use Disorder (SUD), Sexual and Reproductive Health
WORTH Paths Intervention
Women in the criminal legal system are more likely to experience substance use disorders and unintended pregnancy than women in the general public.
- Conditions
- Substance Use Disorder (SUD), Sexual and Reproductive Health, Sexual Risk Behavior
- Trial name
- NCT06889831
- Testing
- WORTH Paths Digital Intervention, WORTH Paths Wellness Group
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Fairleigh Dickinson University
Energy Deficiency Due to Short-term Fasting, Hormonal Contraception
Energy Deficiency on Hormones in Contraceptive Users
The purpose of the present study is to characterize the endocrine and metabolic responses to a modest, short-term energy deficiency (~250 kcal/day) across the menstrual cycle in recreationally active women using different…
- Trial name
- NCT07651800
- Testing
- Energy Deficiency of approximately ~250 kcal/day
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Southern California
Overweight, Obesity
A Research Study Looking Into How UBT251 Works With Birth Control Tablets and Emptying of the Stomach in Women With Excess Body Weight Not Able to Become Pregnant
The purpose of this clinical study is to find out if UBT251 is safe and effective to be taken together with medicines, like birth control tablets, and emptying of the stomach in women not able to become pregnant living with…
- Trial name
- NCT07710729
- Testing
- UBT251, Oral contraceptive, Acetaminophen
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Novo Nordisk A/S
Ectopic Pregnancy
Reproductive Health Education, Birth Control and Sexual Quality of Life in Ectopic Pregnancy
Ectopic pregnancy (EP) is defined as the implantation of a fertilized ovum outside the uterine cavity, most commonly in the fallopian tubes.
- Trial name
- NCT07431411
- Testing
- Reproductive Health Counseling and Educational Brochure
- Volunteers
- 102 people
- Sponsor
- Buket Kömürcü
Menstrual Cycle, Oral Contraceptive Use
Effects of the Menstrual Cycle and Oral Contraceptive Use on Health and Performance in Athletes
A review of the sports medicine literature reveals a clear underrepresentation of female athletes in research. In the current era of precision medicine, increasing attention has been directed toward the regulatory roles of…
- Conditions
- Menstrual Cycle, Oral Contraceptive Use, Athlete
- Trial name
- Flow2Perform (NCT07591818)
- Where
- Portugal
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Faculdade de Motricidade Humana
Advanced Malignancies
A Drug-drug Interaction Study to Evaluate the Effects of Pelabresib on the Pharmacokinetics of Repaglinide, Midazolam, and Combined Oral Contraceptive in Patients With Advanced Malignancies
This drug-drug interaction (DDI) study aims to evaluate the impact of pelabresib at steady-state plasma concentrations on the pharmacokinetic (PK) profile of A) a single dose of repaglinide and a single dose of midazolam, and B)…
- Trial name
- NCT07340190
- Testing
- pelabresib, repaglinide, midazolam
- Where
- 6 sites in France, Italy and 1 more
- Volunteers
- 24 people
- Sponsor
- Novartis Pharmaceuticals
Contraception Use
Flo Digital Contraceptive Study
The goal of this clinical trial is to learn if the Flo Digital Contraceptive (FDC) app can effectively prevent unintended pregnancy in women aged 18 years and older residing in the United States.
- Trial name
- FDC (NCT07630064)
- Testing
- Flo Digital Contraceptive
- Where
- United States
- Volunteers
- 3,800 people
- Sponsor
- Flo Health Inc.
Contraception Use
Sildosin as a Male Contraceptive Non Hormonal
In all, 200 healthy, sexually active, fertile male candidates will be assigned 100 in silodosin group and 100 in placebo group. Males using other contraceptive methods will be excluded.
- Trial name
- NCT07195097
- Testing
- Oral intake of sildosin
- Volunteers
- 200 people
- Sponsor
- Benha University
Pregnancy
Michigan Contraceptive Access, Research, and Evaluation Study Children: Phase 1
This project builds on the Michigan Contraceptive Access Research and Evaluation Study (M-CARES) to evaluate the long-term effects of mothers' access to free contraceptives and reductions in unintended pregnancies on their…
- Trial name
- M-CARES-K (NCT04371900)
- Testing
- Mother receives voucher valued at 100% of cost of name-brand IUD (March 4, 2019-March 31, 2023), Mother receives voucher valued at 50% of cost of name-brand IUD (August 26, 2018-March 3, 2019)
- Where
- 9 sites in United States
- Volunteers
- 4,700 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Early-phase Safety and PK Study of a Vaginal Gel
FIH Lead-in Study of YASO GEL Followed by a Phase 1 Randomized, Double-blind Study to Assess Safety and Pharmacokinetics of YASO GEL
The goal of this clinical trial is to assess the safety and pharmacokinetics of YASO GEL in healthy adult participants. This is a first-in-human study designed to understand how the gel is absorbed and distributed in plasma and…
- Trial name
- PPCM-01 (NCT07281404)
- Testing
- YASO GEL
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Yaso Therapeutics Corporation
Contraception
Long Term Evaluation of Scapular-inserted Contraceptive Implants
This study aims to evaluate long-term outcomes when the etonogestrel contraceptive implant is inserted at an alternative site located over the scapular.
- Trial name
- NCT07201402
- Testing
- Scapular-site insertion of etonogestrel contraceptive implant
- Where
- 2 sites in United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Yale University
Implant Complication, Contraceptive Device; Complications
Improvement of Symptoms After Removal of the Essure® Contraceptive Implant
ESSURE® is an implantable medical device for definitive and irreversible sterilization indicated for adult women of childbearing age. These implants are inserted into the fallopian tubes by hysteroscopy.
- Trial name
- ABLES (NCT06355713)
- Testing
- Magnetic resonance imaging- Positron Emission Tomography (MRI-PET) examination, blood sample, urine collection
- Where
- 10 sites in France
- Volunteers
- 444 people
- Sponsor
- Hospices Civils de Lyon
Contraceptive Usage
Assess Performance Attributes and Acceptability of Non-medicated Intravaginal Rings Among Sexually Active Women in Atlanta, GA
A randomized open label crossover trial to assess performance attributes and acceptability of non-medicated intravaginal rings among sexually active women in Atlanta, GA
- Trial name
- NCT07039591
- Testing
- Pro-type IVR
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Population Council
Contraception
International Active Surveillance Study: Safety of Estrogen Estetrol (E4) Contraceptive Study (INAS-SEECS)
The combined oral contraceptive (COC) containing estetrol (E4) and drospirenone (DRSP) (E4/DRSP) is a novel oral contraceptive containing a fixed dose of E4 (14.2 mg) and DRSP (3 mg).
- Trial name
- INAS-SEECS (NCT06186271)
- Where
- Germany
- Volunteers
- 68,100 people
- Sponsor
- Center for Epidemiology and Health Research, Germany
Menstrual Cycle, Hormonal Contraception
Oxytocin and Reward Processing in Women
Oxytocin is a hypothalamic neuropeptide that is best known for its peripheral physiological effects in the female organism i.e., uterine contractions during birth.
- Trial name
- NCT06222749
- Testing
- Intranasal oxytocin administration
- Where
- Germany
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- International Research Training Group 2804
Contraceptive Usage, Contraceptive Behavior
A Web-Based Tool to Help People With Health Conditions Make Contraceptive Decisions
Among people who do not want to get pregnant, some do not use any birth control. This is also called contraceptive nonuse. Common reasons for contraceptive nonuse include concerns about birth control safety or side effects.
- Conditions
- Contraceptive Usage, Contraceptive Behavior, Chronic Disease, Chronic Condition
- Trial name
- NCT07075536
- Testing
- My Health, My Choice Web-Based Contraceptive Decision Tool, Usual Contraceptive Care
- Where
- 19 sites in United States, Puerto Rico
- Volunteers
- 795 people
- Sponsor
- University of Michigan
Migraine
Impact of Combined Oral Contraceptive Pills on Migraine
The investigators will assess the effect of combined oral contraceptive pills (COCs) on migraine features and treatment response to allow better interpretation of the exact consequence of hormonal contraceptive use on migraineurs.
- Trial name
- NCT06509503
- Testing
- Combined oral contraceptive, Vaginal Ring
- Where
- Egypt
- Volunteers
- 400 people
- Sponsor
- Kafrelsheikh University
Contraception
Contraceptive Efficacy Study of Ovaprene
This will be a multi-center, single arm, open-label study of Ovaprene, a non-hormonal intravaginal ring, to investigate the contraceptive effectiveness, safety and acceptability of Ovaprene.
- Trial name
- NCT06127199
- Testing
- Ovaprene
- Where
- 27 sites in United States
- Volunteers
- 656 people, healthy volunteers welcome
- Sponsor
- Daré Bioscience, Inc.