Clinical trials: Contraceptive Implant
Contraception
Antepartum Etonogestrel Contraceptive Implant Insertion at Term
Short-interval pregnancy (SIP) or rapid, repeat pregnancy is defined as a pregnancy within one year of prior delivery. These pregnancies are often unintended and are associated with adverse risks.
- Trial name
- NCT03656289
- Testing
- Etonogestrel 68Mg Implant
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Implant Complication, Contraceptive Device; Complications
Improvement of Symptoms After Removal of the Essure® Contraceptive Implant
ESSURE® is an implantable medical device for definitive and irreversible sterilization indicated for adult women of childbearing age. These implants are inserted into the fallopian tubes by hysteroscopy.
- Trial name
- ABLES (NCT06355713)
- Testing
- Magnetic resonance imaging- Positron Emission Tomography (MRI-PET) examination, blood sample, urine collection
- Where
- 10 sites in France
- Volunteers
- 444 people
- Sponsor
- Hospices Civils de Lyon
Human Immunodeficiency Virus, Contraception
Investigating the Interaction Between Two Long-acting Reversible Methods of Contraception and Dolutegravir, a Treatment for HIV
It is important to make sure that women have access to effective methods of contraception to prevent pregnancy so that they can make choices about when and if they will have their first or next child.
- Conditions
- Human Immunodeficiency Virus, Contraception, ART
- Trial name
- CODA (NCT04910711)
- Testing
- Dolutegravir, Levonorgestrel implant, Depo medroxyprogesterone acetate injection
- Where
- Botswana
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Botswana Harvard AIDS Institute Partnership
Ecchymosis, Adverse Anesthesia Outcome
Comparison of Lidocaine With and Without Adrenaline for Reducing Ecchymosis
This randomized, double-blinded controlled trial evaluates whether lidocaine with adrenaline reduces bruising (ecchymosis) more effectively than lidocaine without adrenaline among women undergoing contraceptive implant insertion…
- Conditions
- Ecchymosis, Adverse Anesthesia Outcome, Complications Associated With Device, Bleeding
- Trial name
- CLEAR (NCT07897201)
- Testing
- 1% Lidocaine with adrenaline, 1% Lidocaine
- Where
- Thailand
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Chulalongkorn University
Contraceptive Usage, HIV Infections
Effect of Dolutegravir on Etonogestrel Levels in HIV-infected Women in Botswana
The primary aim is to assess if etonogestrel (ENG) implant users taking dolutegravir (DTG) have a 20% or greater change in their ENG plasma levels, compared to women taking no antiretroviral therapy (ART).
- Conditions
- Contraceptive Usage, HIV Infections, Drug Interaction
- Trial name
- NCT03336346
- Testing
- dolutegravir, ENG implant, Efavirenz
- Where
- Botswana
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- Columbia University
Contraceptive Usage
Ablation of Subcutaneous Contraceptive Implants in the Operating Room
The ablation of subcutaneous contraceptive implants is usually performed in consultation under local anesthesia. However, it happens that the implant was placed too deeply or that it migrated too deeply making it impossible to…
- Trial name
- TAICS (NCT05932537)
- Testing
- Preoperative visualization techniques
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Hospices Civils de Lyon
Contraception
Vaginal Misoprostol Before Intrauterine Contraceptive Device Insertion
the current study was conducted to assess efficacy of vaginal misoprostol before IUD insertion following previous insertion failure
- Trial name
- NCT03790371
- Testing
- Misoprostol
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Ain Shams University
Cervical Stenosis
Use of Misoprostol in Case of Insertion Failure of Intrauterine Contraceptives
To assess the usefulnes sof misoprostol versus placebo (in a double-blind placebo controlled randomized clinical trial)to facilitate the insertion of copper-IUD and the levonorgestrel-releasing intrauterine system (LNG-IUS) in…
- Trial name
- NCT01754649
- Testing
- Misoprostol
- Where
- 2 sites in Brazil
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Luis Bahamondes
Contraception, Breastfeeding
Immediate Postpartum Contraceptive Implant Placement and Breastfeeding Success in Women at Risk for Low Milk Supply: A Non-inferiority Trial
The investigators goal is to measure the impact of timing of postpartum contraceptive implant insertion on breastfeeding success and duration and to explore women's experiences with and attitudes towards contraceptive and…
- Conditions
- Contraception, Breastfeeding, Postpartum Contraception
- Trial name
- NCT02866279
- Testing
- Etonogestrel Contraceptive Implant
- Where
- United States
- Volunteers
- 155 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Breakthrough Bleeding
Treatment of Prolonged Uterine Bleeding of Etonogestrel (ENG)-Releasing Implant
Long-acting reversible contraceptives [LARC; copper-intrauterine devices (IUDs), the levonorgestrel-releasing intrauterine system (LNG-IUS) and subdermal implants] are the most effective reversible contraceptives available.
- Trial name
- NCT04047875
- Testing
- Norethisterone 10mg/day
- Where
- 2 sites in Brazil
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Contraception
Casea S Contraceptive Implants (Casea S) Trial
This is a single-center, two-part, Phase 1 study to evaluate the pharmacokinetics (PK) of ENG, removability, safety, and tolerability of Casea S pellets inserted subdermally in healthy women of reproductive age.
- Trial name
- NCT05174884
- Testing
- 22.2 mg Etonogestrel (ENG), 44.4 mg Etonogestrel (ENG)
- Where
- Dominican Republic
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- FHI 360
Infections, Bacterial
A Pharmacokinetics, Pharmacodynamics, and Safety Study of an Oral Contraceptive Containing Norethindrone and Ethinyl Estradiol When Co-administered With GSK1322322 in Healthy Adult Women
This study is being conducted to confirm that GSK1322322 has no negative impact on hormone levels and contraceptive efficacy when co-administered with a frequently prescribed oral contraceptive thereby to facilitate the use of…
- Trial name
- NCT01953809
- Testing
- GSK1322322, EE/NE
- Volunteers
- healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Contraception
Nexplanon and Combined Oral Contraceptive (COC) Combined Use Study
Women currently using or starting a combined oral contraceptive will be offered study enrollment. Study subjects will have a Nexplanon placed and followed for 6 months to evaluate if they continue the COC, continue the implant…
- Trial name
- NexTOC (NCT02852265)
- Testing
- Etonogestrel contraceptive implant
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Inflammatory Disease
Pro-inflammatory Cytokines in Case of Essure®
It is estimated that 750,000 women (including 200,000 French) have benefited from permanent sterilization by ESSURE® contraceptive implant.
- Trial name
- ESCYTO (NCT05944822)
- Testing
- pro-inflammatory cytokines
- Where
- France
- Volunteers
- 150 people
- Sponsor
- Hospices Civils de Lyon
Contraception
Assessing Adolescent Use of Nexplanon Over Time
The purpose of this study is to compare Nexplanon decision-making, uptake, satisfaction and contraceptive outcomes (continuation, switching, discontinuation) over a 12-month period among adolescents ages 15-18 to adolescents ages…
- Trial name
- NCT04889079
- Testing
- Contraceptive use (continuation/switching/discontinuation)
- Where
- United States
- Volunteers
- 255 people, healthy volunteers welcome
- Sponsor
- University of Utah
Male Sterilization
Implantable Device for Male Reproductive Sterilization
The study is to evaluate a device for male reproductive sterilization and determine if this device is successful at blocking the sperm. Ninety subjects from two centers in the United Stated will be followed closely for 24 months.
- Trial name
- NCT00335361
- Testing
- Intra Vas Device (IVD)
- Where
- 3 sites in United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Shepherd Medical Company
Contraception, HIV
HIV-Target Cell Response in Women Initiating Various Contraceptive Methods in High HIV-Incidence Areas: Zim CHIC
This study is being done to understand if using birth control causes changes in the immune cells within the reproductive tract of healthy women.
- Conditions
- Contraception, HIV, Immune Cells (Mucosal and Systemic), Microbiota
- Trial name
- Zim CHIC (NCT02038335)
- Testing
- DMPA, NET-EN, MPA/E2
- Where
- Zimbabwe
- Volunteers
- 451 people
- Sponsor
- University of Pittsburgh
Contraception, Unintended Pregnancy
Innovative Model of Patient-Centered ConTraception
This study is testing models of contraceptive care that were developed as part of the Contraceptive CHOICE Project. CHOICE is a prospective cohort study of 9,256 women designed to: 1) promote the use of long-acting reversible…
- Trial name
- IMPACCT (NCT02364037)
- Testing
- CHOICE Project Structured Contraceptive Counseling, Contraceptive Education Session, Cost Support for IUDs and implants
- Where
- 3 sites in United States
- Volunteers
- 1,008 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Contraception
Long Term Evaluation of Scapular-inserted Contraceptive Implants
This study aims to evaluate long-term outcomes when the etonogestrel contraceptive implant is inserted at an alternative site located over the scapular.
- Trial name
- NCT07201402
- Testing
- Scapular-site insertion of etonogestrel contraceptive implant
- Where
- 2 sites in United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Yale University
Mechanical Complication of Intrauterine Device
Immediate Post-placental Insertion of IUCD During Cesarean Delivery Versus 6 Week Post-Cesarean Insertion
The aim of current study is to compare the rates of IUCD expulsion and complications in immediate post-placental insertion versus delayed IUCD insertion (6-weeks after cesarean delivery)
- Trial name
- NCT03404622
- Testing
- IUCD
- Where
- Egypt
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- ALshaimaa Aboalhassan Ali