Clinical trials: Contrast Agent
Dysphagia, Swallowing Disorder
Feasibility of a Water-soluble Contrast Application Into Dysphagia Evaluation
In traditional video-fluoroscopic-swallowing study, a lipid-soluble contrast (barium sulfate) has been used more than 30 years. However, it can cause chemical pneumonitis and subsequently impair reliability of…
- Trial name
- NCT03598491
- Where
- South Korea
- Volunteers
- 755 people
- Sponsor
- Ulsan University Hospital
Stroke, Complex Regional Pain Syndrome
Contrast Compression Therapy for Post-Stroke Complex Regional Pain Syndrome
This study aims to evaluate the effectiveness of contrast compression therapy as an adjunct to conventional rehabilitation in patients diagnosed with complex regional pain syndrome (CRPS) following stroke.
- Conditions
- Stroke, Complex Regional Pain Syndrome, Hemiplegia
- Trial name
- NCT07062913
- Testing
- Conventional Rehabilitation, Contrast Compression Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people
- Sponsor
- Meltem Gunes Akinci
Vascular Diseases
Quantitative Perfusion Imaging Using Contrast Enhanced Perfusion Ultrasound, MRI and Perfusion Angiography
Peripheral Arterial Disease is the narrowing and blocking of the blood vessels that supply the legs and feet. It is a common and progressive condition that affects patients of all backgrounds and genders and is more common in…
- Trial name
- QPiPAD (NCT06103708)
- Where
- United Kingdom
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University College, London
Acute Kidney Injury
Remote Ischemic Preconditioning and Risk of Contrast-Induced Acute Kidney Injury in Patients Undergoing Coronary Stent Implantation
This single-center, randomized controlled trial is to investigate the impact of remote ischemic preconditioning (RIPC) on the risk contrast-induced acute kidney injury and its long-term impact on renal function for patients with…
- Trial name
- REPAIR (NCT01827891)
- Testing
- remote ischemic preconditioning (RIPC)
- Where
- China
- Volunteers
- 310 people
- Sponsor
- Beijing Anzhen Hospital
Coronary Artery Disease
Coronary CT Angiography Using a Novel 3rd Generation Dual-Source CT System
Coronary CT angiography is used to examine the coronary arteries in a non-invasive way when a patient is suspected of having coronary artery disease.
- Trial name
- NCT02218060
- Testing
- Coronary CT angiography on SOMATOM Force, Previous coronary CT angiography on 2nd generation CT scanner
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Medical University of South Carolina
Acute Kidney Failure
Clinical Trial of Sodium Bicarbonate to Prevent Contrast-Induced Nephropathy
The purpose of this study is to determine whether sodium bicarbonate is effective in the prevention of sodium-induced nephropathy
- Trial name
- NCT00424320
- Testing
- Sodium bicarbonate
- Where
- 2 sites in Mexico
- Volunteers
- 100 people
- Sponsor
- Instituto Nacional de Cardiologia Ignacio Chavez
Acute Ischemic Stroke, Tenecteplase
Unknown Time of Onset Stroke RePerfusIon Without Advanced Imaging
The benefit of intravenous tenecteplase for acute ischemic stroke with unknown time of onset, e.g. wake-up stroke, remains uncertain.
- Trial name
- UTOPIA (NCT07475949)
- Testing
- Tenecteplase (TNK) (0.25 mg/kg, to maximum of 25mg), Standard medical treatment
- Where
- 15 sites in China
- Volunteers
- 352 people
- Sponsor
- First Affiliated Hospital of Guangxi Medical University
Nasopharyngeal Carcinoma
Combining MRI and CEUS to Diagnose Small Cervical Lymph Node Metastases in NPC Patients
This is a single-center diagnostic accuracy study, with the purpose to define the criteria to diagnose small cervical lymph node metastases in patients with nasopharyngeal carcinoma by combining MRI scanning and contrast-enhanced…
- Trial name
- NPC-LN (NCT05389306)
- Testing
- MRI Scanning, Contrast-Enhanced Ultrasonography, Ultrasound-guided Lymph Node Aspiration
- Where
- China
- Volunteers
- 348 people
- Sponsor
- Sun Yat-sen University
Breast Cancer
Contrast-Enhanced Digital Mammography (CEDM) for Identifying a Change in Management of Women With Newly Diagnosed Breast Cancer
Enrolled women will undergo a bilateral Contrast-Enhanced Breast Magnetic Resonance Imaging (CE-BMRI) as per usual clinical practice within 30 days of breast cancer diagnosis.
- Trial name
- NCT01303419
- Testing
- CE-BMRI, DE-CEDM
- Where
- 5 sites in United States, Belgium and 3 more
- Volunteers
- 224 people
- Sponsor
- GE Healthcare
Breast Abnormalities
Use of Contrast Enhanced Spectral Mammography (CESM) for Women With Palpable Breast Abnormalities
Contrast Enhanced Spectral Mammography (CESM) is an advanced form of mammography which is performed after injection of contrast or dye into a vein in the arm. This dye is the same dye that is used for CT scans.
- Trial name
- NCT02406274
- Testing
- Contrast Enhanced Spectral Mammography (CESM)
- Where
- United States
- Volunteers
- 249 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Transesophageal Echocardiography Contrast Agents
Agitated Saline, Albumin, or Propofol-albumin Mixture for Enhanced Contrast in TEE Examinations
This is a prospective, randomized, controlled study to determine if albumin and propofol or albumin only will provide superior qualitative contrast enhancement during TEE bubble studies compared to agitated saline.
- Trial name
- NCT02613052
- Testing
- normal saline, human albumin, human albumin and propofol
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- University of California, San Diego
Coronary Artery Disease
CONTRAST (Can cONTrast Injection Better Approximate FFR compAred to Pure reSTing Physiology?)
The purpose of this study is to determine the diagnostic performances of iodine contrast medium and resting conditions to predict fractional flow reserve (FFR). Reference FFR will be measured using standard adenosine.
- Trial name
- CONTRAST (NCT02184117)
- Testing
- Adenosine, Contrast Media, Resting conditions
- Where
- 11 sites in United States, Belgium and 7 more
- Volunteers
- 763 people
- Sponsor
- The University of Texas Health Science Center, Houston
Contrast Enhancement in Magnetic Resonance Imaging
A Study Called GUS to Understand How Much of the Contrast Agent Gadavist is Used and How Much is Wasted in Two Different Containers (Single-dose Vials and Imaging Bulk Packages ) in a Real-world Setting
This is an observational study, in which data associated with the wastage with the use of Gadavist single-dose vials, as compared to the wastage associated with the use of the Gadavist imaging bulk packages (IBP) used for…
- Trial name
- NCT05350189
- Testing
- Gadobutrol (Gadavist/Gadovist, BAY86-4875)
- Where
- 2 sites in United States
- Volunteers
- 1,602 people
- Sponsor
- Bayer
Prostate Cancer
Multiparametric Ultrasound-Study for the Detection of Prostate Cancer
The primary objective of the study is the matching of sensitivity, specificity, the negative predicate value and the positive predictive value of Contrast-Enhanced Ultrasound (CEUS), Shear Wave Elastography (SWE) and the…
- Trial name
- NCT03091231
- Testing
- mpUS multiparametric Ultrasound
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- Martini-Klinik am UKE GmbH
Squamous Cell Carcinoma of the Head and Neck
Performance of PET 18 F-FDG Coupled to CT With Contrast Injection Iodized in the Diagnosis of Early Recurrences of Head and Neck Carcinoma Treated With Concurrent Chemoradiation. Comparison With 18F-FDG PET Coupled With CT Not Injected With Filling CT Standard Injection
Early detection of viable residual tumor or early neoplastic recurrence represents a real challenge in monitoring patients treated with concomitant chemoradiotherapy squamous cell carcinoma of the upper aerodigestive tract.
- Trial name
- TEPVAD (NCT02510872)
- Testing
- 18F-FDG PET combined with CT with iodinated contrast injection, 18F-FDG PET combined with CT without injection
- Where
- France
- Volunteers
- 19 people
- Sponsor
- University Hospital, Caen
Coronary Artery Disease, Diabetes Mellitus Type 2
Effects of Hyperglycemia on Myocardial Perfusion in Humans With and Without Type 2 Diabetes
The overall goal of this proposal is to determine the effects of acute hyperglycemia and its modulation by Glucagon-like Peptide-1 (GLP-1) on myocardial perfusion in type 2 diabetes (DM).
- Trial name
- GLP-1 (NCT01021865)
- Testing
- Glucagon-Like-Peptide-1/Regadenoson/Perflutren Lipid Microsphere
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Magnetic Resonance Imaging
Evaluation of 4D Magnetic Resonance Flow Sequence at Hepatic Level
The objective of the project is to establish the 3D velocity mapping of the hepatic vasculature and its consistency
- Trial name
- HEPAFLUX (NCT02821078)
- Testing
- 4D flow imaging sequence
- Where
- France
- Volunteers
- 44 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
- Study Focus: Renal Retention of Lipid Microbubbles
Renal Retention of Microbubbles
Flank pain has been reported with ultrasound (US) contrast agents. The purpose of this study is to determine whether there is retention of ultrasound contrast agents in the renal microcirculation, which has been described in mice.
- Trial name
- NCT01647464
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Oregon Health and Science University
Optic Neuritis, Multiple Sclerosis
Post-COntrast 3D SE T1 Versus Coronal SE T1-WI MRI in Detecting Optic Neuritis (COCON)
3D FLAIR, 3D T1 FAT SAT, coronal T2 and coronal T1 dixon sequences were usually used to assess visual deficits in MRI. Optic nerve examination is preferably performed using a coronal T2 sequence in order to detect a hypersignal…
- Trial name
- COCON (NCT04793087)
- Testing
- Magnetic Resonance Imaging
- Where
- France
- Volunteers
- 1,200 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Liver Cancer, Adult
The Diagnostic Efficacy and Lesion Detection Advantages of 18F-FDG PET/Contrast-enhanced MRI in Malignant Liver Lesions
Liver disease, a major global health burden, ranges from mild dysfunction to severe conditions like cirrhosis and hepatocellular carcinoma (HCC), the fifth most common cancer.
- Trial name
- NCT07055048
- Volunteers
- 60 people
- Sponsor
- Shanghai East Hospital
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