Clinical trials: Contrast Media
Radiographic Contrast Agent Nephropathy
Contrast Media Reduction and Removal in Patients With Chronic Kidney Disease (CKD) (PRESERV)
The purpose of this clinical trial is to demonstrate the efficacy and safety of the Osprey Medical CINCOR™ Contrast Removal System.
- Trial name
- NCT01168024
- Testing
- CINCOR™ System and contrast conservation unit (CCS-1), Standard of Care plus peri-procedural hydration
- Where
- 21 sites in United States, Germany
- Volunteers
- 16 people
- Sponsor
- Osprey Medical, Inc
Contrast Induced Nephropathy
Contrast Nephropathy and Nitrates
Contrast-induced nephropathy (CIN) is a complication of percutaneous coronary angiography that occurs in about 10 to 20% of patients exposed to contrast media.
- Trial name
- CoNaN (NCT01999517)
- Testing
- Intravenous Nitroglycerin, IV Fluids
- Where
- United States
- Volunteers
- 122 people
- Sponsor
- Mt. Sinai Medical Center, Miami
Healthy
Open Label, Randomized Study of Low Concentration Ioforminol Injections for Use in Abdominal CECT in Healthy Volunteers
To optimize both the Ioforminol concentration and dosage(s) for CECT of the abdomen. To evaluate the safety and tolerability of low concentration Ioforminol Injections. Study recruits healthy volunteers.
- Trial name
- NCT01672996
- Testing
- Ioforminol 160 mgI/mL, Ioforminol 200 mgI/mL, Iopamidol 300 mgI/mL
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- GE Healthcare
Coronary Computed Tomographic Angiography
Comparison of Isovue 370 vs. Standard Protocol in Coronary Computed Tomographic Angiography (CTA)
Computed Tomography Angiogram (CTA) scans are performed routinely to look at the vessels in the body as an alternative to directly injecting contrast into the vessels and taking pictures.
- Trial name
- NCT02171247
- Testing
- Isovue 370, Visipaque 320
- Volunteers
- 35 people
- Sponsor
- Duke University
Breast Cancer
Quantitative Subharmonic Breast Imaging
This is a non-randomized trial of 450 women with a breast abnormality, who are scheduled for a breast biopsy of this abnormality. The study will be conducted at two clinical sites.
- Trial name
- NCT01490892
- Testing
- 3D HI and SHI of UCA
- Where
- 2 sites in United States
- Volunteers
- 219 people
- Sponsor
- Thomas Jefferson University
Renal Failure
Sodium Bicarbonate for Prevention of Contrast-Induced Nephropathy
The purpose of this study is to determine whether hydration with sodium bicarbonate is superior to hydration with saline to prevent contrast-induced nephropathy.
- Trial name
- NCT01172353
- Testing
- sodium bicarbonate, saline
- Where
- Brazil
- Volunteers
- 301 people
- Sponsor
- Hospital Sao Lucas da PUCRS
Chronic Kidney Disease
RenalGuard System and Contrast Media
The purpose of the present study is to assess the role of the RenalGuard System as compared to the optimal strategy (sodium bicarbonate infusion plus N-acetylcysteine (NAC)) in high and very-high risk patients to prevent…
- Trial name
- REMEDIALII (NCT01098032)
- Testing
- RenalGuard system, Systemic alone therapy
- Where
- 4 sites in Italy
- Volunteers
- 294 people
- Sponsor
- Clinica Mediterranea
Abdominal Trauma
BEFAST (Bubble-Enhanced FAST) for the Evaluation of Solid Organ Injury
The Focused Assessment with Sonography for Trauma (FAST) exam is widely used and accepted as part of advanced trauma life support (ATLS) protocol, but its low sensitivity for identifying solid organ injury in the absence of…
- Trial name
- BEFAST (NCT05025449)
- Testing
- Focused Assessment with Sonography for Trauma (FAST), Bubble-Enhanced FAST (BEFAST)
- Where
- United States
- Volunteers
- 267 people
- Sponsor
- Emory University
Pediatric Congenital Heart Disease
Feraheme As An MRI Contrast Agent For Pediatric Congenital Heart Disease
The standard clinical cardiovascular MRI practice for children with CHD frequently involves the use of gadolinium-based contrast agents (GBCA) to enhance tissue contrast.
- Trial name
- NCT02752191
- Testing
- ferumoxytol, gadofosveset
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Paul Finn
Percutaneous Coronary Intervention
Adenosine Contrast CorrELations in Evaluating RevAscularizaTION
The purpose of this study is to compare FFR measurements done with adenosine to FFR measurements done with contrast, where the contrast is injected using the ACIST CVi automated contrast injector.
- Trial name
- ACCELERATION (NCT03557385)
- Testing
- Iopamidol, adenosine, Navvus® Catheter
- Where
- 5 sites in United States
- Volunteers
- 201 people
- Sponsor
- Duke University
Peripheral Artery Disease
Optical Imaging Measurement of Intravascular Solution Efficacy Trial
Iodinated contrast is the current gold standard for infrainguinal angiography imaging in patients without renal insufficiency and has also been used with intravascular Optical Coherence Tomography (iOCT) to improve image quality…
- Trial name
- OPTIMISE (NCT01743872)
- Testing
- Contrast Injection, Dextran Injection, CO2 Injection
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University Hospitals Cleveland Medical Center
Rheumatoid Arthritis
Dynamic Contrast-Enhanced Magnetic Resonance Imaging (DCE-MRI) to Measure Response to Etanercept in Rheumatoid Arthritis
The purpose of this study is to assess whether DCE-MRI can detect changes of active disease in rheumatoid arthritis (RA) patients after 4, 8 and 12 weeks of etanercept.
- Trial name
- NCT00361634
- Testing
- Etanercept
- Where
- 3 sites in United States, United Kingdom
- Volunteers
- 14 people
- Sponsor
- Amgen
Transplantation, Kidney
IRB 14-009240, Does CEUS Positively Influence Selection of Biopsy Sites When Evaluating Transplant Kidneys?
This is a pilot study to investigate whether contrast-enhanced ultrasound (CEUS) may help evaluate segmental differences in renal perfusion better than Doppler Ultrasound and thus help direct the biopsy to the most abnormal part…
- Trial name
- NCT02625428
- Testing
- Optison, Ultrasound (US), Contrast-enhanced ultrasound (CEUS)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Mayo Clinic
Known or Suspected Focal Liver Lesions
Efficacy and Safety of Primovist in Chinese Patients
Participants who had been diagnosed or suspected by doctors to have focal liver lesions that need further evaluation in order to make an accurate diagnosis.
- Trial name
- NCT00526188
- Testing
- Gadoxetic Acid Disodium (Primovist, BAY86-4873)
- Where
- 6 sites in China
- Volunteers
- 234 people
- Sponsor
- Bayer
Peripheral Arterial Disease
Efficacy Evaluation of Dotarem Compared to Gadovist in the Diagnosis of Peripheral Arterial Disease
This study is an efficacy evaluation of Dotarem®-enhanced magnetic resonance angiography (MRA) compared to Gadovist®-enhanced MRA in the diagnosis of clinically significant abdominal or lower limb arterial diseases.
- Trial name
- DALIA (NCT01026389)
- Testing
- Dotarem, Gadovist
- Where
- Austria
- Volunteers
- 189 people
- Sponsor
- Guerbet
Vascular Diseases
Efficacy and Safety Study to Evaluate Gadavist (Gadobutrol) as Contrast Agent in Magnetic Resonance Imaging (MRI) of Vascular Diseases in Chinese Patients
The purpose of this study is to determine if the contrast agent is effective and safe in the Magnetic Resonance Imaging (MRI) of vascular diseases in patients of Chinese origin.
- Trial name
- NCT00395733
- Testing
- Gadobutrol (Gadavist, Gadovist, BAY86-4875), Gadopentate dimeglumine (Magnevist, BAY86-4882)
- Where
- 3 sites in China
- Volunteers
- 83 people
- Sponsor
- Bayer
Vesico-Ureteral Reflux
CeVUS With Intravesical Administration of OPTISON TM (Trademark) in Children
In this clinical trial the investigators aim to evaluate the diagnostic feasibility and safety of ceVUS with the intravesical use of OPTISON for vesicoureteral reflux detection and urethral imaging in children.
- Trial name
- ceVUS (NCT02204917)
- Testing
- OPTISON
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Kassa Darge
Healthy Volunteers
Cardiac Safety Evaluation of P03277
The study is a Phase I, Single center, Randomized, Cross-over Double-blind Placebo-controlled and Open-label Positive-controlled (moxifloxacin) in healthy volunteers.
- Trial name
- NCT03657264
- Testing
- P03277 0.1 mmol/kg, Moxifloxacin 400mg, NaCl 0.9%
- Where
- Belgium
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Guerbet
CT of the Abdomen and Pelvis With Contrast Material
Customized Contrast Media Dose Clinical Trial
1. To determine if a formula derived from PCA using specific patient parameters can be used to determine the individual contrast material dose and provide a more consistent level of vascular and parenchymal enhancement during…
- Trial name
- NCT02433665
- Testing
- Iopamidol, Mydose
- Where
- United States
- Volunteers
- 166 people
- Sponsor
- Duke University
Acute Coronary Syndrome, Pulmonary Embolism
Assessment of Acute Disease to Reduce Imaging Costs
Overtesting for Acute Coronary Syndrome(ACS) and Pulmonary Embolism (PE) in low risk Emergency Department(ED) patients can increase exposure of nondiseased patients to radiation, intravenous contrast and anticoagulation.
- Trial name
- QUAADRICs (NCT01059500)
- Testing
- Webtool
- Where
- 4 sites in United States
- Volunteers
- 550 people
- Sponsor
- Wake Forest University Health Sciences