Clinical trials: Control, open to volunteers
Traumatic Brain Injury
Baricitinib for Moderate and Severe Traumatic Intracerebral Hemorrhage/Contusions
The purpose of the present study is to study the effect of baricitinib administration on outcome of participants with moderate and severe traumatic intracerebral hemorrhage/contusions.
- Trial name
- NCT06065046
- Testing
- Baricitinib 4 MG, Standard treatment
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Tang-Du Hospital
Irreducible Atlantoaxial Dislocation
Surgical Treatment of Irreducible Atlantoaxial Dislocation
At present, there is a lack of standardized, large-scale, and high-level evidence-based medicine research on the safety and effectiveness of treatment of irreducible atlantoaxial dislocation (IAAD).Based on this, the goal of this…
- Trial name
- NCT05847270
- Testing
- Anterior and posterior treatment strategy, Simple posterior approach treatment strategy
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Peking University Third Hospital
Premenstrual Dysphoric Disorder
Emotion Regulation-based Internet-delivered Cognitive Behavioural Therapy for Premenstrual Dysphoric Disorder
Premenstrual dysphoric disorder (PMDD) is a debilitating cyclic mental disorder affecting about 2-5% of women of reproductive age.
- Trial name
- Premensis-s (NCT06496139)
- Testing
- Therapist-guided internet-delivered cognitive behavioural therapy
- Where
- Sweden
- Volunteers
- 164 people
- Sponsor
- Uppsala University
Gynecologic Cancers
Communication About Sexual Health in Gynecologic Cancer
The goal of this clinical trial is to learn if an educational video and workbook can help gynecologic cancer patients talk to their cancer providers about sexual health concerns. The main questions it aims to answer are: 1.
- Trial name
- NCT06904339
- Testing
- Starting the Conversation, Sexual Health Resources
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Fox Chase Cancer Center
Advanced Age, Recurrent Pregnancy Loss(RPL)
Noninvasive Implantation Potential vs Morphology-Based Selection in IVF Single Blastocyst Transfer
Background: Morphology-based embryo selection cannot detect aneuploidy, which is common in advanced maternal age and recurrent pregnancy loss.
- Conditions
- Advanced Age, Recurrent Pregnancy Loss(RPL), Infertility (IVF Patients), Sequence Analysis
- Trial name
- NICSAI-SBT-RCT (NCT07461077)
- Testing
- NICS-AI, Morphology group
- Where
- China
- Volunteers
- 520 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Vitreomacular Traction (VMT)
A Study Evaluating the Efficacy and Safety of Recombinant Human Truncated Plasmin Injection (JZB32) in Patients With Vitreomacular Traction
This study aims to evaluate the efficacy of JZB32 in patients with vitreomacular traction (VMT). Based on a randomized, double-blind, multicenter, sham injection-controlled, parallel-group design, the proportion of study eyes…
- Trial name
- NCT07910630
- Testing
- Recombinant Human Truncated Plasmin Injection (JZB32)
- Where
- 15 sites in China
- Volunteers
- 48 people
- Sponsor
- Jiangsu Jingze Biopharmaceutical Co., Ltd.
Asthma
Clinical Study on the Efficacy and Safety of SHR-4597 Inhalant in Adult Patients With Asthma
To evaluate the efficacy and safety of SHR-4597 inhalants in adults with asthma: a multicenter, randomized, open-label, positive-controlled Phase II clinical study
- Trial name
- NCT06940700
- Testing
- SHR4597, Budesonide inhalant
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Guangdong Hengrui Pharmaceutical Co., Ltd
Brain Cysticercosis
Oxfendazole in Mild Parenchymal Brain Cysticercosis
The goal of this clinical trial is to compare a single and multiple dose regimens of oxfendazole with the standard treatment in patients with mild (one or two lesions) parenchymal brain cysticercosis.
- Trial name
- NCT06565507
- Testing
- Oxfendazole single dose, Oxfendazole three doses, albendazole plus praziquantel regime
- Volunteers
- 544 people
- Sponsor
- Universidad Peruana Cayetano Heredia
Cardiac Pacing, Permanent Pacemaker Implantation
Ultrasound-Guided PECS II Block for Permanent Pacemaker Implantation
This single-center, prospective, randomized, controlled clinical trial aims to evaluate whether ultrasound-guided PECS II block, when added to standard local infiltration anesthesia, improves perioperative analgesia in patients…
- Conditions
- Cardiac Pacing, Permanent Pacemaker Implantation, Postoperative Pain
- Trial name
- PACE-PECS (NCT07739407)
- Testing
- Ultrasound-Guided PECS II Block, Standard Local Infiltration Anesthesia
- Volunteers
- 72 people
- Sponsor
- ferdi gülaştı
Idiopathic Pulmonary Fibrosis (IPF)
A Trial of AGMB-447 in Participants With Idiopathic Pulmonary Fibrosis
The main goal of this clinical trial is to find out if an experimental inhaled drug, AGMB-447, can help improve lung function in people living with a lung disease called idiopathic pulmonary fibrosis (IPF).
- Trial name
- NCT07862634
- Testing
- AGMB-447
- Volunteers
- 120 people
- Sponsor
- Agomab Spain S.L.U.
Dementia, Caregiver Burden of People With Dementia
VR-based Mindfulness for Dementia Caregivers in the Home Environment (Mind-body Interventions)
To explore the feasibility, acceptability, and potential effectiveness among dementia caregivers of the mindfulness-based interventions delivered by VR technology (VR-based MBI) in improving psychological well-being and…
- Trial name
- vrmdc (NCT07103434)
- Testing
- VR Mindfulness intervention, Audio-based MBI, Waitlist control
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Acute Coronary Syndrome, Interventional Cardiology
Ticagrelor With Low-dose Versus Regular Aspirin in Patients With Acute Coronary Syndrome (ACS) at High-Risk for Ischemia After Percutaneous Coronary Intervention
The present study is aimed to compare the safety and efficacy of Ticagrelor with low-dose Aspirin versus standard dual anti-platelet therapy (DAPT) in patients with acute coronary syndrome (ACS) at high risk for ischemic events…
- Trial name
- LD-ASPIRIN (NCT04240834)
- Testing
- Aspirin, Ticagrelor
- Where
- China
- Volunteers
- 1,220 people
- Sponsor
- Fu Wai Hospital, Beijing, China
Molar-Incisor Hypomineralization (MIH)
Nano Silver Fluoride and Photobiomodulation Therapy for Hypersensitivity and Pain in MIH-Affected Molars
Molar-incisor hypomineralization (MIH) is a developmental condition affecting primarily the first permanent molars and may be associated with post-eruptive enamel breakdown, hypersensitivity, and difficulties in achieving…
- Trial name
- NCT07826130
- Testing
- Nano Silver Fluoride, Photobiomodulation Therapy, Pre-appointment analgesics
- Volunteers
- 45 people
- Sponsor
- Ain Shams University
Acute Ischemic Stroke
A Phase 1b Study to Assess the Safety and Tolerability of AB126 Neural Exosomes in Patients With Moderate to Severe Acute Ischemic Stroke
The goal of this clinical trial is to learn if AB126, an investigational treatment made from neural exosomes, is safe and well tolerated when given to adults with moderate to severe acute ischemic stroke (AIS) who have undergone…
- Trial name
- NEXIS (NCT07813130)
- Testing
- AB126 Neural Exosomes Intravenous Injection
- Where
- 3 sites in United States
- Volunteers
- 20 people
- Sponsor
- Aruna Bio, Inc.
Progressive Supranuclear Palsy, Corticobasal Degeneration
A Study to Evaluate the Safety, Tolerability and Pharmacodynamics of NIO752 in Primary Tauopathies
This is a phase II study intended to evaluate the safety, tolerability and pharmacodynamics of NIO752 in participants with primary tauopathies.
- Conditions
- Progressive Supranuclear Palsy, Corticobasal Degeneration, Frontotemporal Lobar Degeneration, Tauopathies
- Trial name
- NCT07868328
- Testing
- NIO752
- Volunteers
- 48 people
- Sponsor
- Novartis Pharmaceuticals
Acetabular Fracture
Weight-bearing of Surgically Treated Acetabular Fractures.
The purpose of this study is to determine whether patients with operatively treated acetabular fractures benefit from early weight-bearing as tolerated.
- Trial name
- NCT04724811
- Testing
- Open reduction and internal fixation (ORIF)
- Where
- Finland
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Hospital District of Helsinki and Uusimaa
Tumor Hyperinsulinism (Tumor HI)
A Phase 3 Study of Ersodetug in Patients With Tumor Hyperinsulinism
The objectives of this study are to evaluate the glycemic efficacy, safety, and tolerability of ersodetug as add-on to standard of care (SOC) therapy for treatment of hypoglycemia in patients with Tumor Hyperinsulinism (Tumor HI).
- Trial name
- Tumor HI (NCT06881992)
- Testing
- Ersodetug
- Where
- 13 sites in United States, France and 3 more
- Volunteers
- 16 people
- Sponsor
- Rezolute
Trauma, Psychological, Stress, Psychological
EMDR Therapy in Young Children, a Double-blinded Randomized Controlled Trial
This project aims to answer to the question of EMDR effectiveness in young children and to determine whether or not the therapy effectiveness is related to the level of cognitive functioning in young children.
- Conditions
- Trauma, Psychological, Stress, Psychological, Anxiety Disorders
- Trial name
- EMDRJEER (NCT05419934)
- Testing
- EMDR therapy, CBT Control therapy
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Fondation Lenval
Anxiety
STOP-4P for Reducing Anxiety Before Amniocentesis
The goal of this clinical trial is to learn if STOP-4P can lower anxiety in pregnant women having amniocentesis. Amniocentesis is a prenatal test. A doctor uses a needle to collect a small amount of fluid around the baby.
- Trial name
- NCT07835464
- Testing
- STOP4P, Informational Video and Supportive Activities
- Where
- Vietnam
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Hung Vuong Hospital
Healthy
Safety and Immunogenicity of V540B in Healthy Adults (V540B-002).
Researchers are looking for new ways to prevent cancers related to human papillomavirus (HPV). HPV is a common virus that can cause an infection. There are many different types of HPV.
- Trial name
- NCT06623409
- Testing
- GARDASIL®9 (G9), V540B
- Where
- 4 sites in United States
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
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