Clinical trials: Control, open to volunteers
Diabetes Type 2 on Insulin, Hypoglycemia (Diabetic)
Comparing Glycemic Outcomes of Carbohydrate Counting vs. Fixed Mealtime Insulin Dosing in Hospitalized Patients With Hyperglycemia
The study compares two current practices for calculating insulin dose for admitted patients: flexible fixed mealtime dosing based on percent of meal eaten and carbohydrate counting based on amount of carbohydrates eaten.
- Conditions
- Diabetes Type 2 on Insulin, Hypoglycemia (Diabetic), Hyperglycemia Due to Type 2 Diabetes Mellitus
- Trial name
- MEND (NCT07808398)
- Testing
- Carbohydrate-counting-based prandial rapid-acting insulin dosing, Flexible fixed mealtime rapid-acting insulin dosing based on percentage of meal consumed
- Volunteers
- 500 people
- Sponsor
- Mayo Clinic
Artificial Intelligence in Education, Nursing Education
The Effect of an Artificial Intelligence-Based Branching Path Simulation for First Aid Education on Nursing Students' Knowledge, Satisfaction, and Motivation
Background: Rapid advancements in educational technology are necessitating a renewal of teaching approaches in nursing education.
- Trial name
- NCT07761221
- Testing
- Artificial Intelligence-Based Branching Path Simulation for First Aid Education
- Where
- Turkey (Türkiye)
- Volunteers
- 164 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
Denture Retention, Patient Satisfaction
Comparing Impression Techniques for Maxillary Complete Denture Retention
The primary objective of this protocol is to compare retention in maxillary complete dentures using single-versus two-step Poly-vinyl Siloxane (PVS) impressions in edentulous patients at denture delivery.
- Trial name
- NCT06497621
- Testing
- Single step PVS impression, Conventional two-step PVS impression
- Volunteers
- 35 people
- Sponsor
- Aga Khan University
Gonorrhea Female, Chlamydia Females
The Integrated Female Sexually Transmitted Infection Testing for HIV Epidemic Control Through PrEP (IN-STEP) Study
Globally, new HIV infections are concentrated in eastern and southern Africa where the infections are largely acquired by women outside of known key populations.
- Conditions
- Gonorrhea Female, Chlamydia Females, Syphilis Female, Trichomonas Vaginalis
- Trial name
- IN-STEP (NCT06743204)
- Testing
- Self-Reported Risk Screening for PrEP and Diagnostic STI testing, Self-reported risk screening for PrEP and syndromic management for STIs
- Where
- Uganda
- Volunteers
- 5,560 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Sport Retirement, Psychoeducation
Preparation for Sports Retirement: Study Protocol
Background: This article presents the protocol for a randomised controlled trial designed to develop and evaluate a psychoeducational intervention aimed at preparing high-performance athletes for the challenges and opportunities…
- Conditions
- Sport Retirement, Psychoeducation, Retirement, Adaptation
- Trial name
- NCT07303504
- Testing
- Psychoeducational Programme, Education Programme
- Where
- Spain
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Salamanca
Obsessive-Compulsive Disorder
Accelerated Rotational Field Deep TMS for Treating OCD
A Prospective Double Blind Randomized Controlled Trial to Evaluate the Efficacy and Durability of the BrainsWay Rotational Field Deep Transcranial Magnetic Stimulation (Deep TMS) in Obsessive-Compulsive Subjects
- Trial name
- NCT07116785
- Testing
- BrainsWay Deep TMS HAC/H7-Coil
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Ben-Gurion University of the Negev
Accidental Falls/Prevention and Control, Osteoporosis
Prevention of Injury in Skilled Nursing Facilities Through Optimizing Medications
The goal of this clinical trial is to compare three care models for optimizing medications and preventing falls with broken bones in patients receiving rehabilitation after a hospitalization for a broken bone.
- Trial name
- PRISM (NCT06304428)
- Testing
- Deprescribing Care Model, Bone Health Service Model, Injury Prevention Service Model
- Where
- 2 sites in United States
- Volunteers
- 3,780 people
- Sponsor
- Duke University
Shoulder Instability
Effectiveness of a Standardised Stabilisation Exercise Protocol in Volleyball Players With Non-traumatic Shoulder Instability
This randomized controlled clinical trial aims to evaluate the effectiveness of a standardized shoulder stabilization exercise program in amateur volleyball players diagnosed with atraumatic shoulder instability.
- Trial name
- NCT07400900
- Testing
- Exercise
- Volunteers
- 22 people
- Sponsor
- Universidad Francisco de Vitoria
Rectal Cancer, Advanced Stage Colorectal Cancer
SCRT VS LCRT Followed by PD-L1 Inhibitor Plus CAPEOX as TNT in Patients With LARC
This is a multicenter, cohort, prospective study to evaluate the efficacy and safety of Adebrelimab combined with radiotherapy and chemotherapy as preoperative neoadjuvant therapy for patients with locally advanced rectal cancer.
- Conditions
- Rectal Cancer, Advanced Stage Colorectal Cancer, Radiotherapy
- Trial name
- NCT07284992
- Testing
- short-term radiotherapy combined with Adebrelimab and capox, long-term radiotherapy combined with Adebrelimab and capox
- Where
- China
- Volunteers
- 208 people
- Sponsor
- Shandong Provincial Hospital
Inguinal Hernia, Postoperative Pain
Ultrasound-Guided Ilioinguinal-Iliohypogastric Nerve Block Following Spinal Anesthesia Comparing Dexmedetomidine Versus Nalbuphine as Adjuvants to Bupivacaine in Unilateral Inguinal Hernia Repair
This study evaluates and compares the pain-relieving efficacy and safety of adding either dexmedetomidine or nalbuphine to bupivacaine in an ultrasound-guided ilioinguinal-iliohypogastric nerve block for patients undergoing…
- Trial name
- NCT07837492
- Testing
- Bupivacaine, Nalbuphine, Dexmedetomidine
- Volunteers
- 102 people
- Sponsor
- Assiut University
Cesarean Delivery, Postpartum Hemorrhage (PPH)
Topical Tranexamic Acid to Reduce Blood Loss During Cesarean Delivery
The goal of this clinical trial is to learn whether applying topical tranexamic acid (TXA) directly to the uterine incision during cesarean delivery can reduce surgical bleeding compared to placebo.
- Conditions
- Cesarean Delivery, Postpartum Hemorrhage (PPH), Intraoperative Blood Loss, Hemostasis
- Trial name
- NCT07362992
- Testing
- Tranexamic Acid (Topical)
- Where
- 4 sites in Israel
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Wolfson Medical Center
Ventilator-Associated Pneumonia (VAP)
Colistin Methanesulfonate Sodium Inhalation for Prophylaxis of Ventilator-Associated Pneumonia (CIVAP): A Prospective, Multicentre, Double-Blind, Randomized, Placebo-Controlled Trial
Previous studies have identified Acinetobacter baumannii (AB), Pseudomonas aeruginosa (PA), and Klebsiella pneumoniae (KP) as the predominant pathogens responsible for ventilator-associated pneumonia (VAP).
- Trial name
- CIVAP (NCT06834971)
- Testing
- Colistimethate sodium (CMS)
- Where
- China
- Volunteers
- 508 people
- Sponsor
- Qilu Hospital of Shandong University
Vulvar Diseases, HPV Infection
Phase II Study of Artesunate Ointment for the Treatment of Vulvar High Grade Squamous Intraepithelial Lesions (Vulvar HSIL, VIN2/3)
This is a phase II double-blind, placebo-controlled study of artesunate ointment for the treatment of HPV-associated vulvar HSIL (usual type vulvar intraepithelial neoplasia 2/3).
- Conditions
- Vulvar Diseases, HPV Infection, Vulvar HSIL, Pre-Cancerous Dysplasia
- Trial name
- ART-VIN IIB (NCT06075264)
- Testing
- Artesunate ointment
- Where
- 5 sites in United States
- Volunteers
- 27 people
- Sponsor
- Frantz Viral Therapeutics, LLC
Caffeine, Placebo - Control
Effects of Caffeine Ingestion on Morning Cognitive and Muscle Repeated Sprint Performance in Males
Athletes often compete in the morning when they are biologically weaker; normally in competition heats or quarterfinals to qualify for the finals scheduled in the evening.
- Conditions
- Caffeine, Placebo - Control, No Pill
- Trial name
- NCT07466732
- Testing
- Caffeine, Placabo, No Pill
- Where
- United Kingdom
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Liverpool John Moores University
Type I Diabetes
Pharmacokinetic and Early Efficacy of OPT101 in Patients With Type 1 Diabetes Mellitus
This study will examine the safety of three times weekly SC injections of OPT101 at each of three dose levels over two weeks as well as one year of treatment with SC OPT101 or placebo to match at a single dose level.
- Trial name
- NCT06964087
- Testing
- OPT101
- Where
- 5 sites in United States
- Volunteers
- 72 people
- Sponsor
- Op-T LLC
Depressive Episode
Chronotherapy for Depressive Episodes
Evidence-based treatments for depression, such as antidepressive medication, usually have a latency of 4 to 6 weeks before they achieve a therapeutic effect.
- Trial name
- NCT05691647
- Testing
- Chronotherapy, Treatment as usual
- Where
- Norway
- Volunteers
- 76 people
- Sponsor
- St. Olavs Hospital
Atrial Fibrillation
Preventing Stroke, Premature Death and Cognitive Decline in a Broader Community of Patients With Atrial Fibrillation
The DaRe2 approach (healthcare Data for pragmatic clinical Research in the NHS - primary 2 secondary) is designed to operationalise efficient, nationwide, primary care approaches for randomised trials embedded within the UK…
- Trial name
- DaRe2THINK (NCT04700826)
- Testing
- Direct Oral Anticoagulants
- Where
- United Kingdom
- Volunteers
- 3,000 people
- Sponsor
- University of Birmingham
Small Cell Lung Cancer Extensive Stage
Tislelizumab in Combination with Chemotherapy ± Radiotherapy for Extensive-Stage Oligometastatic Small Cell Lung Cancer.
The goal of this clinical trial is to learn the efficacy and safety of tislelizumab in combination with chemotherapy(etoposide/cisplatin ) ± concurrent radiotherapy for extensive-stage oligometastatic small cell lung cancer.
- Trial name
- TERE (NCT06851819)
- Testing
- radiotherapy, immunechemotherapy
- Where
- China
- Volunteers
- 64 people
- Sponsor
- Hebei Medical University Fourth Hospital
Cancer
Oncology Acute Care Follow-up Intervention Study
This pragmatic randomized controlled study evaluates an education intervention designed to increase patient engagement with Oncology Acute Care (OAC) services among patients being treated for cancer at Parkland Health.
- Trial name
- NCT07550192
- Testing
- Follow-up messaging
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of Texas Southwestern Medical Center
Adolescent - Emotional Problem, Parent Child Relationship
Randomized Controlled Trial of a Family-focused Intervention for Caregivers and Young Adolescents (Phase 3 of FLOURISH)
The aim of this study is to conduct a multi-country randomized waitlist controlled trial to evaluate the effectiveness, cost-effectiveness, and scalability of the optimized Parenting for Lifelong Health (PLH) for Parents and…
- Conditions
- Adolescent - Emotional Problem, Parent Child Relationship, Family Functioning, Well-Being, Psychological
- Trial name
- FLOURISH (NCT07240571)
- Testing
- Optimized Parenting for Lifelong Health (PLH) for Parents and Teens
- Where
- 2 sites in Moldova, North Macedonia
- Volunteers
- 1,280 people, healthy volunteers welcome
- Sponsor
- University of Klagenfurt