Clinical trials: Control Condition
Severe Acute Respiratory Syndrome, Coronavirus
A Study to Evaluate the Safety, Reactogenicity and Immunogenicity of Vaccine CVnCoV in Healthy Adults for COVID-19
This study aims to evaluate the safety and reactogenicity profile after 1 and 2 dose administrations of CVnCoV at different dose levels.
- Conditions
- Severe Acute Respiratory Syndrome, Coronavirus, SARS-CoV-2, COVID-19
- Trial name
- NCT04449276
- Testing
- CVnCoV Vaccine
- Where
- 4 sites in Belgium, Germany
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- CureVac
Hypercholesterolemia
A Single Dose Escalation Study of PCSK9 Inhibitor (JS002) in Health Subjects
JS002 is a recombinant humanized Anti- PCSK9 monoclonal antibody; This is a phase Ia, randomized, double-blind, placebo-controlled study to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of a single…
- Trial name
- NCT04197817
- Testing
- JS002
- Where
- China
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Shanghai Junshi Bioscience Co., Ltd.
HIV
The Effect of Hyperbilirubinemia on CV Disease, Neurocog Function and Renal Function
Use of some protease inhibitors is associated with elevations of a blood pigment called bilirubin. This may occasionally lead to yellowing of the eyes (scleral icterus) or jaundice, but in the general population bilirubin…
- Trial name
- SSAT044 (NCT01475240)
- Where
- United Kingdom
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- St Stephens Aids Trust
Gastroesophageal Reflux Disease, Reflux Esophagitis
The Efficacy of i-Scan for Detecting Reflux Esophagitis
Endoscopy is a widely used modality for the diagnosis and classification of Gastroesophageal reflux disease (GERD), and the extent of esophageal mucosal breaks on endoscopy can be assessed.
- Trial name
- NCT01381991
- Testing
- i-scan
- Where
- South Korea
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Konkuk University Hospital
Penile/Perineal /Perianal Intraepithelial Neoplasia, Anal Intraepithelial Neoplasia
A Phase III Trial to Evaluate the Efficacy, Immunogenicity and Safety of a Recombinant Human Papillomavirus 9-Valent (Types 6, 11, 16, 18, 31, 33, 45, 52, 58) Vaccine (E.Coli) in Chinese Males
This phase III clinical trial was designed to evaluate the efficacy, immunogenicity and safety of a Recombinant Human Papillomavirus 9-Valent (Types 6, 11, 16, 18, 31, 33, 45, 52, 58) Vaccine (E.Coli) manufactured by Xiamen…
- Conditions
- Penile/Perineal /Perianal Intraepithelial Neoplasia, Anal Intraepithelial Neoplasia, Penile/Perianal/Perineal Cancer, Anal Cancer
- Trial name
- NCT06866574
- Testing
- Recombinant Human Papillomavirus 9-Valent (Types 6, 11, 16, 18, 31, 33, 45, 52, 58) Vaccine (E.coli), Aluminum Adjuvant
- Where
- 4 sites in China
- Volunteers
- 9,300 people, healthy volunteers welcome
- Sponsor
- Xiamen University
Hypertension
A Blood Pressure-Lowering Diet for Preventing and Managing Hypertension
This cluster-randomized controlled trial will evaluate whether a 3-month culturally adapted blood pressure-lowering dietary, called the Eastern Blood Pressure-Lowering Diet, can improve blood pressure and related health outcomes…
- Trial name
- NCT07735091
- Testing
- Standard Hypertension Management, Eastern Blood Pressure-Lowering Diet
- Where
- China
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Peking University
Delayed Onset Muscle Soreness (DOMS), Inflammation
Effects of Immediate and Delayed Repeated Cold Exposure After Physical Exertion
The goal of this clinical trial is to learn if applying cold therapy can reduce swelling, inflammation, and pain after physical activity in adults who experience muscle soreness (Delayed Onset Muscle Soreness, or DOMS).
- Conditions
- Delayed Onset Muscle Soreness (DOMS), Inflammation, Muscle Pain, Muscle Damage
- Trial name
- NCT06813690
- Testing
- Cold Therapy with Axanova Cold Hot Pearls Maxi Pack
- Where
- Switzerland
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Applied Sciences and Arts of Southern Switzerland
Loneliness, Sleep Quality
Mindfulness for Lonely Older Adults With Emigrant Children
This study is to examine the feasibility of a proposed mindfulness-based intervention (MBI) and study methodology for future main study.
- Conditions
- Loneliness, Sleep Quality, Quality of Life, Stress
- Trial name
- NCT07711860
- Testing
- Intervention, Active Control
- Where
- Hong Kong
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Hong Kong Metropolitan University
Nausea Gravidarum, Anxiety
Emotional Freedom Technique in Early Pregnancy
One of the most common discomforts in early pregnancy is nausea and vomiting. Although its etiology is not known exactly, it affects an average of 50-90% of pregnant women.
- Conditions
- Nausea Gravidarum, Anxiety, Emotion Regulation, Vomiting of Pregnancy
- Trial name
- NCT05337852
- Testing
- Emotional Freedom Technique
- Where
- Turkey (Türkiye)
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Inonu University
Medication Adherence
The Impact of GlowCaps Connect™ and Its Services on Hypertension Medication Adherence
The investigators hypothesize that providing subjects on a once-a-day hypertension medication with GlowCaps ConnectTM will lead to an improvement in their medication adherence.
- Trial name
- NCT00985452
- Testing
- GlowCaps Connect system, Glow cap system - deactivated
- Volunteers
- 139 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Virtual Reality, Epilepsy
Effect of VR-ESMEPP on Parents' Seizure Management
Objective: This study aims to evaluate the knowledge, skills, and motivation of parents regarding management of epileptic seizures, by developing a "Virtual Reality Based Seizure Management Education Program for Parents…
- Conditions
- Virtual Reality, Epilepsy, Seizure, Child
- Trial name
- VR-ESMEPP (NCT05500638)
- Testing
- Virtual Reality
- Where
- Turkey (Türkiye)
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- Akdeniz University
Influenza Immunization
Study to Evaluate Safety and Immunogenicity of a Pandemic Flu H5 mRNA Vaccine in Healthy Adults Aged 18 Years and Older
The purpose of this study is to evaluate a pandemic flu H5 strain messenger ribonucleic acid (mRNA) vaccine at 3 dose levels (low, medium, and high) in comparison with placebo in 276 healthy adult participants to select the…
- Trial name
- NCT06727058
- Testing
- Pandemic flu H5 mRNA vaccine
- Where
- 14 sites in United States
- Volunteers
- 276 people, healthy volunteers welcome
- Sponsor
- Sanofi Pasteur, a Sanofi Company
Acute Renal Colic
Diclofenac IM Versus Tramadol IV in Acute Renal Colic, RCT
Patients presented with acute pain from renal colic, the standard of care are prescribed NSAIDs, most common drug used is intramuscular (IM) Diclofenac injected at the gluteal muscle.
- Trial name
- NCT06231043
- Testing
- Diclofenac/Tramadol
- Where
- Thailand
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Lampang Hospital
Primary Dysmenorrhea, Menstrual Pain
Effect of Virtual Reality on Pain and Anxiety in Women With Dysmenorrhea
Dysmenorrhea, or painful menstrual periods, is a common condition that can affect daily activities and quality of life. This study aims to evaluate whether using virtual reality (VR) can reduce pain and anxiety in women with…
- Conditions
- Primary Dysmenorrhea, Menstrual Pain, Anxiety
- Trial name
- VR (NCT07853508)
- Testing
- Virtual Reality
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Tokat Gaziosmanpasa University
Pain
Postoperative Pain After Activation of Irrigant
The purpose of this research is to analyze the levels of pain after cleaning and shaping in individuals who are receiving root canal therapy using the IVAC irrigation approach, and those who are treated with ultrasonic irrigation…
- Trial name
- NCT06528574
- Testing
- Conventional root canal treatment, Ultrasonic, Apical negative pressure
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Cleveland Dental Institute
Obesity, Weight Loss
Behavioral Mechanism of Energy Compensation With Exercise
Over 70% of Americans are either overweight or obese, putting them at risk for many chronic diseases including diabetes. Exercise is commonly used as a weight loss and weight loss maintenance strategy.
- Conditions
- Obesity, Weight Loss, Eating Behavior
- Trial name
- NCT04651218
- Testing
- exericse
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Kyle Flack
Colon Polyp, Colon Adenoma
Impacts of Inspection During Instrument Insertion on Colonoscopy Quality
Small colon polyps which are found during colonoscopy insertion are sometimes difficult to find during withdrawal and thus missed.
- Trial name
- NCT03444090
- Testing
- Colon polypectomy
- Where
- Taiwan
- Volunteers
- 428 people, healthy volunteers welcome
- Sponsor
- Evergreen General Hospital, Taiwan
Diabetes, Physical Activity
Feasibility of REHIT in NDH Patients
The aim of this feasibility study was to describe and report data relevant to the acceptability of an exercise intervention (reduced-exertion, high-intensity interval training) in non-diabetic hyperglycaemia patients delivered in…
- Trial name
- NCT04011397
- Testing
- Exercise intervention, Usual care
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University of Huddersfield
Phenylketonuria
GenSci144 Tablets Phase I Clinical Trial
This study is a Phase I single ascending dose clinical trial in which healthy adult volunteers were administered single oral doses of GenSci144 tablets at different levels.
- Trial name
- NCT07685210
- Testing
- GenSci144 tablets
- Where
- China
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Changchun GeneScience Pharmaceutical Co., Ltd.
Gout, Acute Gout Flare
A Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Oral ABP-745 Administration in Healthy Volunteers
A randomized, double-blind, placebo-controlled, dose-escalation study will be conducted in healthy volunteers. This study will evaluate the safety, tolerability, and pharmacokinetics (PK) of ABP-745 following single (Part 1) and…
- Conditions
- Gout, Acute Gout Flare, Gout Flares
- Trial name
- ABP-745 (NCT06258213)
- Testing
- ABP-745
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Atom Therapeutics Co., Ltd