Clinical trials: Controlled Diabetes
Type 2 Diabetes Mellitus, Cognitive Function Abnormal
Efficacy Comparison of Polyethylene Glycol Loxenatide and Gliclazide on the Brain Function in T2DM Patients
This is a prospective, randomized, open label, parallel,4-month study to explore and evaluate the therapeutic effects of polyethylene glycol loxenatide on the cognitive function, olfactory function, and odor-induced brain…
- Trial name
- NCT06217887
- Testing
- loxenatide Group, Gliclazide Group
- Where
- China
- Volunteers
- 58 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Type 2 Diabetes Mellitus
Value-based Emotion-focused Educational Programme to Reduce Diabetes-related Distress
The purpose of the clinical trial is to evaluate the effectiveness of a relatively simple and short value-based emotion-focused educational programme in adults with type 2 diabetes (VEMOFIT) on diabetes-related distress…
- Trial name
- VEMOFIT (NCT02730078)
- Testing
- VEMOFIT, Attention-meetings (AG)
- Volunteers
- 124 people
- Sponsor
- Universiti Putra Malaysia
Osteoarthritis of Knee
Clinical Trial to Evaluate Safety and Efficacy of MesoCellA-Ortho Tissue-Engineered Advanced Therapy Product in Patients With Osteoarthrosis and Civilisation Diseases
The aim of the study is to evaluate safety, tolerability and clinical efficacy of a newly developed MesoCellA-Ortho tissue-engineered advanced therapy medicinal product in adult patients suffering with osteoarthritis and…
- Trial name
- BioMiStem-CT (NCT05081921)
- Testing
- MesoCellA-Ortho administration, HA administration
- Where
- Poland
- Volunteers
- 192 people
- Sponsor
- Jagiellonian University
Diabetes Mellitus
AI-CARE: A Novel AI-Driven Mobile Insulin Calculator Integrating Image- Based Carbohydrate Estimation and CGM
AI-CARE is an artificial intelligence-enabled clinical decision support mobile application designed to support prandial insulin dosing in individuals receiving MDI, incorporating a "human-in-the-loop" approach to ensure user…
- Trial name
- AI-CARE (NCT07884526)
- Testing
- AI-CARE, Usual Care Group
- Where
- Singapore
- Volunteers
- 48 people
- Sponsor
- Tan Tock Seng Hospital
Type 2 Diabetes Mellitus
Efficacy and Safety Study of Saxagliptin + Metformin Immediate Release (IR) Versus Metformin IR Alone in Type 2 Diabetes Mellitus
The purpose of this study is to compare the reduction in hemoglobin A1C (A1C) for participants taking saxagliptin in combination with metformin immediate release (IR) versus metformin IR alone.
- Trial name
- NCT00885378
- Testing
- Saxagliptin plus metformin IR
- Where
- 41 sites in United States, Germany and 2 more
- Volunteers
- 166 people
- Sponsor
- AstraZeneca
Schizophrenia, Diabetes
Antipsychotics and Gene Expression in Soft Tissues
Schizophrenia is a severe chronic and disabling mental disorder and is associated with a significant reduction in life expectancy.
- Trial name
- NCT01185743
- Testing
- olanzapine, ziprasidone
- Where
- Austria
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Diabetes Mellitus, Type II
A Safety and Efficacy Study of T0903131 (INT131) Besylate to Treat Type 2 Diabetes Mellitus
The purpose of the study is to determine if repeated daily doses of T0903131 (INT131) Besylate over 4 weeks can lower fasting blood glucose in patients with Type 2 Diabetes Mellitus.
- Trial name
- NCT00952445
- Testing
- T0903131 Besylate
- Where
- 21 sites in United States
- Volunteers
- 70 people
- Sponsor
- InteKrin Therapeutics, Inc.
Diabetic Nephropathy
Effect of Pyridorin in Patients With Diabetic Nephropathy
The primary objective of the study is to evaluate the safety, tolerability and efficacy of Pyridorin (pyridoxamine dihydrochloride) up to 250 mg given orally twice daily in patients with diabetic kidney disease.
- Trial name
- NCT00320021
- Testing
- Pyridorin (pyridoxamine dihydrochloride)
- Volunteers
- 80 people
- Sponsor
- BioStratum
Type II Diabetes
Effectiveness of an mHealth Mobile App
Type II diabetes is a serious challenge for Pakistan. Not using medications properly increases healthcare costs and diabetes-related deaths.
- Trial name
- mHealth (NCT06387433)
- Testing
- mobile app use
- Where
- Pakistan
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Dow University of Health Sciences
Diabetes Mellitus, Type 2
Comparison of Two Approaches to Insulin Therapy in Patients With Type 2 Diabetes (IOOX)
A study of patients with type 2 diabetes and inadequate glycemic control on two or more oral antihyperglycemic agents comparing adding insulin lispro mid mixture to the oral antihyperglycemic agents to adding insulin glargine to…
- Trial name
- IOOX (NCT00377858)
- Testing
- Insulin lispro mid mixture (MM), Insulin glargine
- Where
- 25 sites in Australia, Canada and 5 more
- Volunteers
- 484 people
- Sponsor
- Eli Lilly and Company
Periodontitis, Diabetes Mellitus
Subgingival Lactobacillus Reuteri as an Adjunct to Non-Surgical Periodontal Therapy in Diabetic Patients
This randomized controlled clinical trial evaluates the adjunctive effect of subgingival administration of Lactobacillus reuteri probiotics in diabetic patients with Stage III Grade B or higher periodontitis receiving…
- Trial name
- LREUTERI-DM (NCT07652255)
- Testing
- Lactobacillus Reuteri Oral Solution [BioGaia], saline control
- Where
- Vietnam
- Volunteers
- 5 people
- Sponsor
- University of Medicine and Pharmacy at Ho Chi Minh City
Gestational Diabetes, Oxidative Stress
Prevention of Maternal and Fetal Metabolic Complications With Diet and Nutraceutical Supplementation in Pregnant Women Affected by Gestational Diabetes: a Randomized, Double-blind Placebo Controlled Trial.
Our trial aims to assess the effect of nutraceutical supplements (omega-3 fatty acids, anthocyanins and alpha-cyclodextrins) in patients affected by gestational diabetes.
- Trial name
- PREDIP2 (NCT05393843)
- Testing
- omega-3 fatty acids, anthocyanins and alpha-cyclodextrins, diet
- Where
- Italy
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Hypertension, Diabetes Mellitus
Comparison of Amlodipine and Aliskiren in Diabetic Hypertensive Patient With Blood Pressure Not Controlled by Losartan
Assess if aliskiren is capable of enhancing vascular stiffness and endothelial function and compare theses effects and renin activity and concentration to those obtained with a calcium channel blocker, amlodipine, in patients…
- Trial name
- NCT01409408
- Testing
- Aliskiren, Amlodipine
- Where
- Brazil
- Sponsor
- Hospital Universitario Pedro Ernesto
Osteomyelitis - Foot
Comparison Between Two Durations of Antibiotherapy for Non-surgically-treated Diabetic Foot Osteomyelitis (CHRONOS-2)
The aim of this clinical study is to compare the efficacy and tolerance of 3 versus 6 weeks of antibiotherapy in patients with diabetic foot osteomyelitis treated medically.
- Trial name
- CHRONOS-2 (NCT05074147)
- Testing
- Reduction in the duration of antibiotic therapy 3 weeks or 6 weeks
- Where
- 18 sites in France
- Sponsor
- Tourcoing Hospital
Obesity or Overweight, Type 2 Diabetes
A Phase III Study to Evaluate the Efficacy and Safety of Petrelintide in Participants With Overweight or Obesity and Type 2 Diabetes
This study will evaluate the efficacy and safety of petrelintide compared with placebo, in conjunction with a reduced-calorie diet and increased physical activity, for weight management in participants living with overweight or…
- Trial name
- ZUPREME-4 (NCT07843485)
- Testing
- Petrelintide
- Where
- 2 sites in United States
- Volunteers
- 600 people
- Sponsor
- Hoffmann-La Roche
Type II Diabetes Mellitus
Efficacy and Safety of GL0034 in Overweight or Obese Adults With Type II Diabetes Mellitus
This is a phase II, randomized, double-blind, placebo-controlled study to evaluate the efficacy and tolerability of GL0034 among type II diabetes mellitus subjects who are obese or overweight with weight-related comorbidities.
- Trial name
- NCT07282743
- Testing
- GL0034 Dose Level 1, GL0034 Dose Level 2, GL0034 Dose Level 3
- Where
- 21 sites in United States, India
- Volunteers
- 285 people
- Sponsor
- Sun Pharmaceutical Industries Limited
Type 2 Diabetes
GALLANT 7 Tesaglitazar Add-on to Sulphonylurea
This is a 24-week randomized double-blind, parallel-group, multi-center, placebo-controlled study of tesaglitazar (0.5 mg and 1 mg) given as add-on therapy to sulphonylurea in patients with type 2 diabetes, not adequately…
- Trial name
- NCT00251940
- Testing
- Tesaglitazar 0.5 or 1 mg, Glibenclamide 2.5, 5, 10 or 15 mg
- Where
- 84 sites in Australia, France and 8 more
- Volunteers
- 555 people
- Sponsor
- AstraZeneca
Diabetes Mellitus, Type 2
Efficacy and Safety of BI 1356 in Combination With Metformin in Patients With Type 2 Diabetes
The objective of the current study is to investigate the efficacy, safety and tolerability of BI 1356 (5.0 mg daily) compared to glimepiride given for 104 weeks as add-on therapy to preferably > 1500 mg metformin in patients with…
- Trial name
- NCT00622284
- Testing
- BI 1356, Glimepiride
- Where
- 221 sites in United States, Bulgaria and 14 more
- Volunteers
- 1,560 people
- Sponsor
- Boehringer Ingelheim
Diabetes Mellitus Type 1
Comparison of Basal (Fasting) Glycemic Control in Type 1 Diabetic Patients With CSII Achieved by the Circadian Slide Ruler Scale or Flat Basal Rate
This is a pilot trial to establish study procedures that allow comparison of various starting basal rate profiles used in Continuous Subcutaneous Insulin Infusion (CSII).
- Trial name
- NCT00569452
- Testing
- Accu-Chek Spirit Insulin Pump
- Where
- Germany
- Volunteers
- 12 people
- Sponsor
- Hoffmann-La Roche
Type 2 Diabetes, Hypertension
10 Prescriptions an Hour. Group Treatment and Physical Activity Referral in a Primary Health Care Setting
The purpose of this study is to determine the effects of group treatment including physical activity referral (PAR) on level of physical activity and quality of life in patients diagnosed with type 2 diabetes and/or hypertension…
- Trial name
- 10PAR (NCT01357304)
- Testing
- Group treatment and PAR
- Where
- Sweden
- Volunteers
- 105 people
- Sponsor
- Region Skane
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