Clinical trials: Controlled Hypertension
Glaucoma, Ocular Hypertension
Multiple Dose-escalation Study of AMA0076 in Patients With Ocular Hypertension or Primary Open-angle Glaucoma
The objective of this dose-escalation study is to evaluate the safety, tolerability and efficacy of AMA0076 in reduction of intraocular pressure in subjects with ocular hypertension or primary open-angle glaucoma.
- Conditions
- Glaucoma, Ocular Hypertension, Eye Disease
- Trial name
- NCT01693315
- Testing
- AMA0076
- Where
- 6 sites in United States
- Volunteers
- 82 people
- Sponsor
- Amakem, NV
Glaucoma
Metformin as a Neuroprotective Therapy for Glaucoma
Glaucoma, a chronic degenerative disease of the optic nerve, is the leading cause of irreversible blindness worldwide. Although lowering the intraocular pressure (IOP) has been shown to be effective to slow optic nerve…
- Trial name
- NCT05426044
- Testing
- Metformin
- Where
- Hong Kong
- Volunteers
- 125 people
- Sponsor
- Christopher Kai Shun Leung
Eye Movement Desensitization and Reprocessing Intervention, Blood Pressure
The Effect of Eye Movement Desensitization and Reprocessing Intervention in Hypertension Patient.
Eye Movement Desensitization and Reprocessing intervention may improve anxiety, depression, systolic blood pressure and heart rate variability in patients with hypertension.
- Conditions
- Eye Movement Desensitization and Reprocessing Intervention, Blood Pressure, Heart Rate Variability, Anxiety
- Trial name
- EMDR (NCT05836181)
- Testing
- Eye Movement Desensitization and Reprocessing
- Where
- Taiwan
- Volunteers
- 110 people
- Sponsor
- Miao-Yi Chen
Neovascular, Glaucoma
Intravitreal Bevacizumab for Neovascular Glaucoma
Several studies have confirmed high levels of vascular endothelial growth factor (VEGF) in eyes with neovascular glaucoma (NVG).
- Trial name
- IVB NVG (NCT00384631)
- Testing
- subconjunctival normal saline, Avastin
- Where
- Iran
- Volunteers
- 26 people
- Sponsor
- Shahid Beheshti University of Medical Sciences
Cardiovascular Diseases, Heart Diseases
Polyunsaturates and KCL to Control Mild Hypertension
To test the efficacy of omega-3 fatty acids in untreated mild hypertensives and magnesium, calcium, and potassium supplementation supplementation in non-hypertensives.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Hypertension, Vascular Diseases
- Trial name
- NCT00000511
- Testing
- mineral supplements, Trial 1: fatty acids, omega-3; Trial 2: Mineral supplements, dietary supplements
- Sponsor
- Brigham and Women's Hospital
Hypertension, Pulmonary
Safety and Efficacy of Terbogrel in Patients With Primary Pulmonary Hypertension
This study sought to determine whether terbogrel was an effective treatment for primary pulmonary hypertension (PPH) by comparing its efficacy and safety to that of placebo.
- Trial name
- NCT02223481
- Testing
- Terbogrel low dose, Terbogrel high dose
- Volunteers
- 71 people
- Sponsor
- Boehringer Ingelheim
Systemic Sclerosis
Effect of Rosuvastatin on Systemic Sclerosis-related Pulmonary Hypertension
Although the aetiology of SSc-PAH remains elusive, vascular dysfunction seems to be the initial event and statins through their vasculoprotective effect might be of value in the treatment armamentarium of PAH related to SSc.
- Trial name
- NCT00984932
- Testing
- Rosuvastatin
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Alexandria
Pulmonary Arterial Hypertension
FK506 (Tacrolimus) in Pulmonary Arterial Hypertension
Mutations in bone morphogenetic protein receptor 2 (BMPR2) are present in >80% of familial and ~20% of sporadic pulmonary arterial hypertension (PAH) patients.
- Trial name
- TransformPAH (NCT01647945)
- Testing
- FK506 level < 2 ng/ml, FK506 level 2-3 ng/ml, FK506 level 3-5 ng/ml
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Edda Spiekerkoetter
Hypertension
STITCH (Simplified Therapeutic Intervention To Control Hypertension)
The objective of this study is to assess whether the implementation of a primary treatment algorithm using a fixed dose combination therapy will improve the management of hypertension when compared to usual management.
- Trial name
- NCT00129909
- Testing
- fixed dose combination therapy
- Where
- Canada
- Volunteers
- 2,081 people
- Sponsor
- University of Western Ontario, Canada
Hypertension
The Effect of Amiloride and Spironolactone in Patients With Hypertension
The investigators wish to investigate the potential effects of potassium. In this study we will examine patients with hypertension and increase their potassium-levels using Amiloride and Spironolactone.
- Trial name
- hass (NCT01388088)
- Testing
- Spironolactone, Amiloride
- Where
- Denmark
- Volunteers
- 23 people
- Sponsor
- Erling Bjerregaard Pedersen
Preeclampsia
Aspirin Versus Metformin in Pregnancies at High Risk of Preterm Preeclampsia: a 3-arm Randomized Controlled Trial
This is a prospective, multicenter, randomized controlled, double-blind trial of three treatment arms: (1) aspirin 75 mg/day vs. (2) aspirin 150 mg/day vs.
- Trial name
- NCT05580523
- Testing
- 75 mg acetylsalicylic acid, 1.5g Metformin, 150 mg acetylsalicylic acid
- Where
- 6 sites in China
- Volunteers
- 3,000 people
- Sponsor
- Chinese University of Hong Kong
Medication Adherence, Medication Compliance
Connected Healthcare for Individuals Living at Home With Chronic Conditions
Managing and taking medications as prescribed can be a difficult task. This is especially true for older adults living at home with chronic conditions while managing multiple prescribed medications.
- Conditions
- Medication Adherence, Medication Compliance, Medication Nonadherence, Hypertension
- Trial name
- NCT04339296
- Testing
- Spencer
- Where
- Canada
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- Alberta Health Services, Calgary
Arterial Hypertension
Aliskiren on Retinal Vasculature Treatment Study
Hypertension affects approximately one fourth of the world population and therefore contributes substantially to the worldwide burden of cardiovascular (CV) disease and end-organ damage.
- Trial name
- ARTS (NCT01318395)
- Testing
- Aliskiren
- Where
- 2 sites in Germany
- Volunteers
- 56 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Essential Hypertension, Type 2 Diabetes
Sacubitril/Valsartan Treats Patients With Essential Hypertension and Type 2 Diabetic Nephropathy
This study aims to compare the efficacy and safety of Sacubitril/Valsartan versus Valsartan in patients with essential hypertension and type 2 diabetic nephropathy over a 12-week treatment period, including two treatment groups…
- Conditions
- Essential Hypertension, Type 2 Diabetes, Nephropathy
- Trial name
- Hyper-Save (NCT06501651)
- Testing
- Sacubitril/Valsartan, Valsartan
- Where
- China
- Volunteers
- 297 people
- Sponsor
- Sichuan Academy of Medical Sciences
Hypertension, Anxiety
Comparison of Tandospirone, Amlodipine and Their Combination in Adults With Hypertension and Anxiety
This study compares the antihypertensive effects between different treatment groups including antihypertensive drug, anxiolytic, and both, which provide a new clinical evidence for controlling blood pressure in patients with…
- Trial name
- NCT03667677
- Testing
- Tandospirone + Amlodipine
- Where
- 7 sites in China
- Volunteers
- 256 people
- Sponsor
- Chongqing Medical University
Healthy Adult Participants, Controlled Hypertension
Ginkgo Active App-Based Exercise Training
The purpose of this study is to investigate the effectiveness and usability of a Gingko app based exercise training in middle and older aged adults.
- Conditions
- Healthy Adult Participants, Controlled Hypertension, Controlled Diabetes
- Trial name
- NCT07411339
- Testing
- Ginkgo App-based Exercise Training, NIA Booklet Exercise
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Sarcopenia, High Blood Pressure
The Impact of a Resistance Training Intervention on Blood Pressure Control in Older Adults With Sarcopenia
Current prevention and treatment of high blood pressure (BP) in sarcopenia, by non-pharmacological approaches remain limited and are far from optimal.
- Conditions
- Sarcopenia, High Blood Pressure, Hypertension
- Trial name
- INERTIA (NCT04255745)
- Testing
- progressive resistance training
- Where
- United States
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Primary Hypertension
The Effectiveness of "MaRiTensi" in Increasing Self-Care and Blood Pressure Control: Randomized Controlled Trial
This study aims to know the effectiveness of "MaRiTensi" in improving knowledge, motivation, efficacy, self-care and blood pressure control for hypertension patients.
- Trial name
- "MaRiTensi" (NCT06049862)
- Testing
- MaRiTensi App
- Where
- 3 sites in Indonesia
- Volunteers
- 99 people
- Sponsor
- Chatarina Setya Widyastuti
Hypertension
A Study on the Efficacy and Safety of Nebivolol Monotherapy in Hispanic Hypertensive Patients
This study will evaluate the efficacy and safety of nebivolol monotherapy in Hispanic patients with stage 1 or stage 2 hypertension
- Trial name
- NCT00770861
- Testing
- Nebivolol
- Where
- 32 sites in United States, Puerto Rico
- Volunteers
- 277 people
- Sponsor
- Forest Laboratories
AKI, CKD
Genetics in the Progression of Nephropathies
This study evaluates the role of genetic in the development and progression of different nephropaties with particular attention to: AKI CKD Hypertension ADPKD CKD-MBD Patients with decompensated heart failure undergoing either…
- Conditions
- AKI, CKD, Ckd-Mbd, CKD (Chronic Kidney Disease) Stage 5D
- Trial name
- NCT06416761
- Testing
- genetic polymorphisms
- Where
- Italy
- Volunteers
- 10,000 people
- Sponsor
- Ospedale San Raffaele
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