Clinical trials: Controlled Hypertension
Hypertension
A Randomized, Double-Blind, Placebo-Controlled, 3x3 Factorial Design, Phase II Study to Evaluate the Antihypertensive Efficacy and Safety of Combination of Fimasartan and Amlodipine in Patients With Essential Hypertension
The purpose of this study is to evaluate the antihypertensive efficacy and safety of Fimasartan
- Trial name
- NCT01518998
- Where
- South Korea
- Volunteers
- 420 people
- Sponsor
- Boryung Pharmaceutical Co., Ltd
Resistant Hypertension, Difficult to Control Hypertension
Safety And Tolerability Of Subcutaneous MANP In Difficult To Control/Resistant Hypertensive Subjects
A randomized, double-blind, placebo-controlled multiple ascending dose study in hypertensive subjects on stable doses of at least three hypertensive drugs for at least 6 weeks prior to Screening.
- Trial name
- DTC/RHS (NCT05247528)
- Testing
- MANP
- Where
- 5 sites in United States
- Volunteers
- 37 people
- Sponsor
- E-Star BioTech, LLC
Glaucoma
A Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of RO5093151 in Patients With Primary Open Angle Glaucoma (POAG) or Ocular Hypertension (OHT).
The purpose of the study is to assess the safety, tolerability, and IOP effects of RO5093151 following 7 days of topical ocular treatment in patients with primary open angle glaucoma or ocular hypertension.
- Trial name
- NCT02622334
- Testing
- Latanoprost, RO5093151
- Where
- 7 sites in United States, Singapore
- Volunteers
- 45 people
- Sponsor
- Hoffmann-La Roche
Hypertension, Renal Transplant
Allopurinol for Renal Transplant Associated Hypertension in Children
To test the hypothesis that lowering serum uric acid will ameliorate hypertension in children after renal transplantation.
- Trial name
- NCT00288171
- Testing
- Allopurinol
- Where
- United States
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Hemodynamic Instability
Prophylactic Norepinephrine and Phenylephrine Infusion for Hemodynamic Effects in Patients With Preeclampsia
The purpose of this study is to investigate the maternal cardiac output response to prophylactic norepinephrine and phenylephrine infusion for postspinal anesthesia hypotension in parturients with preeclampsia undergoing cesarean…
- Trial name
- NCT05035498
- Testing
- Phenylephrine, Norepinephrine
- Where
- China
- Volunteers
- 72 people
- Sponsor
- General Hospital of Ningxia Medical University
Hypertension, Obstructive Sleep Apnea
Impact of Sleep-Disordered Breathing Management in Systemic Hypertension Control: METASLEEP Project
Hypertension is a frequent condition affecting 11M Spanish citizens and is the leading modifiable contributor to cardiovascular disease and death.
- Trial name
- NCT05986487
- Testing
- CPAP or usual practice, Monitoring and intervention in follow-up
- Where
- Spain
- Volunteers
- 1,523 people
- Sponsor
- Sociedad Española de Neumología y Cirugía Torácica
Hypertension, Diabetes Mellitus, Type 2
Implementation of a Comprehensive Intervention on Hypertension（HTN） and Type 2 Diabetes Mellitus（DM） at PHC Level
Background: The disease burden of hypertension(HTN) and type 2 diabetes mellitus(DM) is rising rapidly in China.Comprehensive interventions(Implementation strategies for providers and interventions for patients) are critical to…
- Trial name
- NCT05353699
- Testing
- Implementation strategies
- Where
- China
- Volunteers
- 12,648 people
- Sponsor
- National Center for Chronic and Noncommunicable Disease Control and Prevention, China CDC
Open Angle Glaucoma, Ocular Hypertension
A Comparative Study of SPARC's SDP-133 Once Daily and Lumigan in Subjects With Open Angle Glaucoma or Ocular Hypertension
To evaluate the efficacy of once daily dosing with SPARC's novel ophthalmic formulation of bimatoprost compared with Lumigan 0.01% in subjects with open-angle glaucoma or ocular hypertension.
- Trial name
- NCT03927443
- Testing
- SDP-133, Lumigan
- Sponsor
- Sun Pharmaceutical Industries Limited
Preeclampsia
Anti-Hypertensive Treatment In Stable Pregnant Women With Severe Pre-Eclampsia (Metildopape)
Introduction: Hypertensive emergency in pregnant women with pre-eclampsia should be treated for preventing stroke and placental abruption.
- Trial name
- METILDOPAPE (NCT01361425)
- Testing
- methildopa
- Where
- 2 sites in Brazil
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Professor Fernando Figueira Integral Medicine Institute
Pulmonary Hypertension
Efficacy and Safety of Oral Bosentan in Pulmonary Arterial Hypertension Class II
The present trial investigates a possible use of oral bosentan, which is currently approved for the treatment of symptoms of pulmonary arterial hypertension (PAH) Class III and IV, to patients suffering from PAH Class II.
- Trial name
- NCT00091715
- Testing
- bosentan
- Where
- 34 sites in United States, Australia and 12 more
- Volunteers
- 185 people
- Sponsor
- Actelion
Chronic Kidney Diseases, Hypertension
Phase 2b Study of KBP-5074 in Subjects With Uncontrolled Hypertension and Advanced Chronic Kidney Disease
This is a Phase 2 randomized, double-blind, placebo-controlled, multi-center study to assess the efficacy, safety, and pharmacokinetics of KBP-5074 in patients with moderate-to-severe chronic kidney disease and uncontrolled…
- Trial name
- BLOCKCKD (NCT03574363)
- Testing
- KBP-5074 0.25 mg tablet, KBP-5074 0.5 mg tablet
- Where
- 2 sites in United States
- Volunteers
- 162 people
- Sponsor
- KBP Biosciences
Atrial Fibrillation, Paroxysmal
Clinical Efficacy of Potassium Canrenoate in Sinus Rhythm Restoration Among Patients With Atrial Fibrillation.
The purpose of this randomized, double blind, placebo-controlled, superiority clinical trial was to assess clinical efficacy of potassium canrenoate - canrenone in rapid conversion of atrial fibrillation to sinus rhythm.
- Trial name
- CANREN-AF (NCT03536806)
- Testing
- Saline 0.9%, Canrenone
- Volunteers
- 80 people
- Sponsor
- National Institute of Cardiology, Warsaw, Poland
Hypertension
Effect of a Nitric Oxide Supplementation Product on Endothelial Dysfunction and Prehypertensive Adults
The nitric oxide supplementation product, Neo40 Daily®, provides a dietary source of No2-. The product also allows for robust No2-reduction to NO from the extremely potent nitrite-reducing capacity of the polyphenols found in…
- Trial name
- NCT03895749
- Testing
- NEO40 Daily
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Hypertension Institute, Nashville
Glaucoma, Neovascular
Japanese Phase 3 Study of Aflibercept in Neovascular Glaucoma Patients
To assess the efficacy and safety of the administration of aflibercept by intravitreal injection in comparison to sham to control intraocular pressure in patients with neovascular glaucoma.
- Trial name
- VEGA (NCT02396316)
- Testing
- Aflibercept (Eylea, BAY 86-5321)
- Where
- 19 sites in Japan
- Volunteers
- 54 people
- Sponsor
- Bayer
Hypertension, Cardiovascular Diseases
Home Blood Pressure Monitoring in Kidney Transplant Recipients
Randomized controlled study of home blood pressure monitoring in kidney transplant recipients.
- Conditions
- Hypertension, Cardiovascular Diseases, Kidney Transplant; Complications
- Trial name
- HOBiT (NCT04364126)
- Testing
- Home blood pressure apparatus, Clinic blood pressure
- Where
- Norway
- Volunteers
- 21 people
- Sponsor
- Oslo University Hospital
Type 2 Diabetes Mellitus, Hypertension
LLM-Assisted Diabetes and Hypertension Management by Village Doctors
This is a prospective, assessor-blinded, randomized controlled study designed to evaluate whether large language model (LLM)-assisted decision support can improve village doctors' abilities in the comprehensive management of…
- Trial name
- NCT07678658
- Testing
- LLM
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Jiangsu Taizhou People's Hospital
Hypertension
A Randomized Controlled Trial for Hypertension Control by Integrating Cloud BP System and CPOE
Importance: Less than fifty percent of patients with hypertensive disease manage to maintain their blood pressure (BP) within normal levels.
- Trial name
- NCT02175511
- Testing
- Cloud-based home BP monitoring
- Volunteers
- 382 people
- Sponsor
- Taipei Medical University
Hypertension, Obesity
Preparing a Food is Medicine Intervention to Promote Healthy Eating and Blood Pressure Control
Hypertension and obesity are both major risk factors for cardiovascular disease (CVD), a leading cause of death for Black women in the United States.
- Conditions
- Hypertension, Obesity, Healthy Nutrition, Blood Pressure
- Trial name
- NCT05796648
- Testing
- RN-CHeFRx
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- University of Illinois Chicago
Essential Hypertension
Efficacy and Safety Study of Olmesartan Medoxomil, Amlodipine and Hydrochlorothiazide Combination Therapy in Patients With Hypertension Not Controlled With Olmesartan Medoxomil and Hydrochlorothiazide Combination Therapy
CS-8635 combines three widely prescribed antihypertensive medications, olmesartan medoxomil(OM), amlodipine (AML), and hydrochlorothiazide (HCTZ), to lower blood pressure.
- Trial name
- NCT01838850
- Where
- 39 sites in South Korea
- Volunteers
- 344 people
- Sponsor
- Daiichi Sankyo Korea Co., Ltd., a Daiichi Sankyo Company
Hypertension
Safety and Efficacy of MK0736 & MK0916 in Patients With Hypertension (High Blood Pressure)(0736-003)(COMPLETED)
The objective of this study is to evaluate the safety and efficacy of two investigational drugs (MK-0736 and MK-0916) in lowering blood pressure and body weight in patients with hypertension (high blood pressure).
- Trial name
- NCT00274716
- Testing
- MK0736, MK0916
- Volunteers
- 249 people
- Sponsor
- Merck Sharp & Dohme LLC
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