Clinical trials: Controlled Hypertension
End Stage Renal Disease
Conventional Hemodialysis vs. Short Daily Hemodialysis (6 Days / Week) and Mechanisms of Blood Pressure Control
More than 80% of patients with end stage renal disease have hypertension; 70% of whom are poorly controlled using conventional Hemodialysis therapy.
- Trial name
- NCT00759967
- Testing
- Microneurography, Bioimpedance testing
- Where
- Canada
- Volunteers
- 22 people
- Sponsor
- Ottawa Hospital Research Institute
Overweight, Obesity
Efficacy and Safety of IBI362 in Hypertensive Patients With Overweight/Obesity
A multicenter, randomized, double-blind, placebo-controlled clinical study to evaluate the efficacy and safety of IBI362 in participants with mild to moderate hypertension complicated by overweight/obesity who have not received…
- Conditions
- Overweight, Obesity, Hypertensive
- Trial name
- NCT07469800
- Testing
- IBI362
- Where
- China
- Volunteers
- 336 people
- Sponsor
- Innovent Biologics (Suzhou) Co. Ltd.
Stroke
Hispanic Secondary Stroke Prevention Initiative
Stroke is a leading cause of death and functional impairments and stroke risk factors (SRFs) disproportionately affect Latino populations.
- Trial name
- HISSPI (NCT02251834)
- Testing
- Community Health Worker (CHW), usual care and health education brochures every 4 months.
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of Miami
Hypertension
Zilebesiran as Add-on Therapy in Patients With Hypertension Not Adequately Controlled by a Standard of Care Antihypertensive Medication (KARDIA-2)
The purpose of this study is to evaluate the effect of zilebesiran on systolic and diastolic blood pressure and to characterize the pharmacodynamic (PD) effects and safety of zilebesiran as add-on therapy.
- Trial name
- KARDIA-2 (NCT05103332)
- Testing
- Indapamide, Amlodipine, Olmesartan
- Where
- 110 sites in United States, Canada and 6 more
- Volunteers
- 663 people
- Sponsor
- Alnylam Pharmaceuticals
Pulmonary Hypertension, COPD
SPHERIC-1. Sildenafil and Pulmonary HypERtension In COPD
Although pulmonary hypertension (PH) is a quite frequent complication of advanced pulmonary diseases, and it is an independent prognostic factor, until now no evidence-based treatment approach exists for those patients.
- Trial name
- SPHERIC-1 (NCT01441934)
- Testing
- Sildenafil citrate, Sugar pills
- Where
- 10 sites in Italy
- Volunteers
- 32 people
- Sponsor
- Italian Association of Hospital Pneumologists
Pre-hypertension
A Study to Investigate the Effect of a Nitric Oxide Supplementation on Pre- and Mildly Hypertensive Adults
This study will investigate the effect of a nitric oxide supplementation product, Neo40 Daily®, on blood pressure in pre-hypertensive and mildly hypertensive adults.
- Trial name
- 15NBHN (NCT02679248)
- Testing
- Neo40 Daily®
- Where
- 2 sites in Canada
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- KGK Science Inc.
Atrial Fibrillation (Persistent), Catheter Ablation
An Investigator-initiated, Prospective, Open-label, Multicenter Randomized Controlled Trial, Comparing the Efficacy of Sacubitril/Valsartan and Standard Treatment on Atrial Fibrillation Recurrence After Catheter Ablation in Persistent Atrial Fibrillation Patients Without Hypertensive
The goal of this clinical trial is to investigate the efficacy and safety of angiotensin receptor-neprilysin inhibitor (sacubitril/valsartan) in preventing recurrence of atrial fibrillation after catheter ablation in…
- Conditions
- Atrial Fibrillation (Persistent), Catheter Ablation, Non-hypertension, Angiotensin Receptor/Neprilysin Inhibitor
- Trial name
- SUPERIOR 2 (NCT07910058)
- Testing
- Sacubitril/Valsartan, Standard Care
- Volunteers
- 472 people
- Sponsor
- Ruijin Hospital
Hypertension
Firibastat in Treatment-resistant Hypertension
This is a double-blind, placebo-controlled, multicenter, efficacy and safety study of firibastat (QGC001) administered po bid over 12 weeks in male and female subjects ≥18 years of age at Screening, with uncontrolled primary HTN.
- Trial name
- FRESH (NCT04277884)
- Testing
- Firibastat
- Where
- 20 sites in United States, Czechia and 4 more
- Volunteers
- 515 people
- Sponsor
- Quantum Genomics SA
Hypertension, Body Weight
Increasing Calcium Dietary Intake Helps to Control Blood Presure and Body Weight
Mediterranean diet is relatively poor in calcium (about 700 mg/daily) whilst there are several reports indicating beneficial effects of calcium-rich diets.
- Trial name
- NCT02295852
- Testing
- LOW-SODIUM LOW LIPID CALCIUM RICH DIET, LOW-SODIUM LOW LIPID DIET
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- Federico II University
Hypertension
The Effect of Pharmacist-Initiated Home Blood Pressure Monitoring on Blood Pressure Control in Women
To evaluate the impact of home blood pressure monitoring when used in addition to pharmacist care, compared to usual care, in women with elevated blood pressure (BP). Randomized 1:1 two-arm controlled trial.
- Trial name
- NCT05991414
- Testing
- Home blood pressure monitor, Enhanced community pharmacist care, Usual pharmacist care
- Where
- 26 sites in Canada
- Volunteers
- 368 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Hypertension
Efficacy of Education Via Phone-based Text Messaging (SMS) on Patients With Uncontrolled Hypertension
Uncontrolled hypertension (HTN) is a major public health worldwide, which increases the risk of cardiovascular diseases. Low adherence to medication, unhealthy lifestyle and poor knowledge of HTN diagnosis and treatment are among…
- Trial name
- NCT05711004
- Testing
- Education via SMS
- Volunteers
- 200 people
- Sponsor
- Shiraz University of Medical Sciences
Pre-eclampsia
Saccadic Reaction Time and Preterm Pre-eclampsia
This study is recruiting two groups of women over the age of 18; those who are pregnant and who have pre-eclampsia; and those who are pregnant but do not have pre-eclampsia.
- Trial name
- NCT02613793
- Where
- United Kingdom
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Oxford University Hospitals NHS Trust
Pulmonary Hypertension
FREEDOM DR: Oral Treprostinil in Combination With an Endothelin Receptor Antagonist (ERA) and/or a Phosphodiesterase-5 (PDE-5) Inhibitor or as Monotherapy for the Treatment of Pulmonary Arterial Hypertension (PAH)
This study is an international, multi-center, randomized, double-blind, placebo-controlled study in subjects with PAH who are currently receiving approved therapy for their PAH (i.e., endothelin receptor antagonist and/or…
- Trial name
- NCT00760916
- Testing
- UT-15C 1 mg, UT-15C 0.25 mg, UT-15C 5 mg
- Where
- 31 sites in United States, Australia and 1 more
- Sponsor
- United Therapeutics
Hypertension, Stroke
Controlling Hypertension Outcomes by Improved Communication & Engagement
This randomized control study tested the feasibility of two communication enhancement interventions: one with veterans who had a stroke and demonstrated poorly controlled hypertension; the other with VA primary care providers who…
- Trial name
- CHOICE (NCT01134887)
- Testing
- Informational Guide for Patients, Video-Assisted Coaching, Monograph for Physicians
- Where
- 2 sites in United States
- Volunteers
- 26 people
- Sponsor
- VA Office of Research and Development
Non-insulin-dependent Diabetes Mellitus
Rosiglitazone And Plaque Study for Type 2 Diabetes Mellitus
This is a phase IIIb, randomised, double blind, placebo controlled, study in patients with type 2 diabetes mellitus and coexisting vascular disease or hypertension. The total duration of the study will be approximately 60 weeks.
- Trial name
- NCT00231387
- Testing
- rosiglitazone
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- GlaxoSmithKline
Hypertensiona, Menopause
EFFECTS of BEETROOT JUICE INTAKE and PHYSICAL EXERCISE in POSTMENOPAUSAL HYPERTENSIVE WOMEN
The goal of this clinical trial is to verify the hemodynamic and biomarker responses of aerobic physical exercise and beetroot juice intake in postmenopausal women with hypertension.
- Trial name
- EBJPEPHW (NCT06585904)
- Testing
- 1 dose of Beetroot juice intake, Exercise
- Where
- Brazil
- Volunteers
- 48 people
- Sponsor
- Federal University of Uberlandia
Adverse Effect
Phenylephrine Prophylaxis for Postspinal Anesthesia Hypotension in Parturients With Preeclampsia
The purpose of this study is to investigate the suitable infusion dose of phenylephrine for prophylaxis against postspinal anesthesia hypotension in parturients with preeclampsia undergoing cesarean section.
- Trial name
- NCT04576663
- Testing
- Normal saline, Phenylephrine
- Volunteers
- 95 people
- Sponsor
- General Hospital of Ningxia Medical University
Meconium Aspiration Syndrome, Persistent Pulmonary Hypertension of Newborn
Oral Sildenafil in Persistent Pulmonary Hypertension Secondary to Meconium Aspiration Syndrome in Newborns
The purpose of this study is to to study the role of oral Sildenafil in Persistent Pulmonary Hypertension of Newborn (PPHN) secondary to Meconium Aspiration Syndrome (MAS) in newborns and to study risk factors of MAS developing…
- Trial name
- OSiNPH (NCT01757782)
- Testing
- Oral Sildenafil
- Where
- India
- Volunteers
- 96 people
- Sponsor
- Sir Takhtasinhji General Hospital
Hypertension
Use of Podcasts in the Education of Hypertension Patients
Hypertension is an important public health problem all over the world due to its high prevalence and its association with increased risk of cardiovascular disease.
- Trial name
- NCT06401759
- Testing
- Podcast
- Where
- Turkey (Türkiye)
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Firat University
Esophageal Varices
Cross-section Band Ligation Versus Stepladder Band Ligation of Esophageal Varices
The goal of this randomized controlled trial is to evaluate the cross-section band ligation technique versus the stepladder band ligation technique in esophageal varices prophylaxis.
- Trial name
- NCT06881082
- Testing
- endoscopic band ligation with cross-section technique, Endoscopic band ligation using stepladder technique
- Where
- Egypt
- Volunteers
- 320 people
- Sponsor
- Tanta University