Clinical trials: Controlled Hypertension
Hypertension, Abdominal Obesity
Treatment of Adiposity Related hypErTension (TARGET)
High blood pressure (hypertension) is an important cause of myocardial infarction and stroke. High blood pressure often occurs in people who are overweight. These people frequently also have abnormal fat and sugar metabolism.
- Conditions
- Hypertension, Abdominal Obesity, Metabolic Syndrome
- Trial name
- TARGET (NCT01138423)
- Testing
- Aliskiren, Moxonidine, Hydrochlorothiazide
- Where
- Netherlands
- Volunteers
- 32 people
- Sponsor
- UMC Utrecht
Chronic Thromboembolic Pulmonary Hypertension, Acute Lung Injury
Lung Protective Ventilation in Pulmonary Thromboendarterectomy (PTE) Patients
Chronic thromboembolic pulmonary hypertension (CTEPH) is caused by unresolved thromboemboli in the pulmonary arteries, which lead to pulmonary hypertension and, left untreated, right heart failure.
- Trial name
- NCT00747045
- Testing
- Ventilation Strategy
- Where
- United States
- Volunteers
- 128 people
- Sponsor
- University of California, San Diego
Glaucoma, Open-Angle, Ocular Hypertension
To Compare the Safety and Efficacy of Perrigo's Product to an FDA Approved Product for the Treatment of Glaucoma or Ocular Hypertension in Both Eyes
To compare the safety and efficacy of Perrigo's product to an FDA approved product in the treatment of Primary Open Angle Glaucoma or Ocular Hypertension in Both Eyes.
- Trial name
- NCT04024072
- Testing
- Brinzolamide 1% ophthalmic suspension, Azopt 1% Ophthalmic Suspension
- Where
- United States
- Volunteers
- 495 people
- Sponsor
- Padagis LLC
Hypertension, Inflammation
Dietary Nitrate, Vascular Function and Inflammation
The risk for cardiovascular diseases (CVD) increases with advancing age. Developing effective lifestyle-based strategies to promote, preserve or restore cardiovascular health with aging is a high priority.
- Trial name
- NCT04584372
- Testing
- High-nitrate intervention, Low-nitrate intervention
- Where
- 2 sites in Austria
- Volunteers
- 20 people
- Sponsor
- University of Vienna
Hypertension
Home Blood Pressure Monitoring and Blood Pressure Control
Hypertension is a common problem in Canada with a prevalence of about 15%. The goal of hypertension therapy should be to maximize blood pressure control.
- Trial name
- NCT00202137
- Testing
- Home blood pressure monitoring, Physician monitoring of blood pressure
- Where
- Canada
- Volunteers
- 597 people
- Sponsor
- Queen's University
Portal Hypertension
Treatment of Low-grade Cirrhotic Portal Hypertension Due to Hepatitis B Virus With Fuzheng Huayu and Entecavir
Portal hypertension is a common pathology in chronic liver disease, particularly in liver cirrhosis. Hepatitis B Virus (HBV) is one of most etiologies of liver cirrhosis in China.
- Trial name
- NCT02945956
- Testing
- Entecavir, Entecavir + Fuzheng Huayu
- Where
- 3 sites in China
- Volunteers
- 192 people
- Sponsor
- ShuGuang Hospital
High Cardiovascular Risk, Hypertension
Zilebesiran as Add-on Therapy in Patients With High Cardiovascular Risk and Hypertension Not Adequately Controlled by Standard of Care Antihypertensive Medications (KARDIA-3)
The purpose of this study is to evaluate the effect of zilebesiran as add-on therapy in patients with high cardiovascular risk and hypertension not adequately controlled by standard of care antihypertensive medications.
- Trial name
- KARDIA-3 (NCT06272487)
- Testing
- Zilebesiran
- Where
- 195 sites in United States, Australia and 4 more
- Volunteers
- 375 people
- Sponsor
- Alnylam Pharmaceuticals
Hypertension, Primary Hypertension
Effectiveness of SMS Reminders of Blood Pressure-lowering Drugs Intake
By conducting the SPPA trial we try to find out, whether personalized Short Message Service (SMS) reminders of blood pressure-lowering medication can effectively increase patients' adherence to blood pressure-lowering medication.
- Conditions
- Hypertension, Primary Hypertension, Non-Adherence, Medication, Non-Adherence, Patient
- Trial name
- SPPA (NCT03105687)
- Testing
- SMS reminders of medicines intake
- Where
- 24 sites in Slovakia
- Volunteers
- 300 people
- Sponsor
- Comenius University
Hypertension in Pregnancy, Postpartum Preeclampsia
Oral Combined Hydrochlorothiazide/Lisinopril Versus Oral Nifedipine for Postpartum Hypertension
The purpose of this study is to see if a combined pill of Angiotensin-converting enzyme (ACE) inhibitors (a medication that helps relax your veins and arteries to lower your blood pressure) with diuretics (sometimes called water…
- Trial name
- ACE (NCT05049616)
- Testing
- ACE Inhibitors and Diuretics, NIFEdipine ER
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- The University of Texas Health Science Center, Houston
Severe Preeclampsia
Protocols for Magnesium Sulfate Maintenance Dose in Overweight and Obese Women Diagnosed With Preeclampsia
There is still no evidence of the appropriate dose to be used. Serum magnesium sulfate concentration is not measured regularly, thus we may be using sub-therapeutic level or reaching a toxic level.Overweight and obese women have…
- Trial name
- NCT06486025
- Testing
- maintenance magnesium sulphate1g/h, maintenance magnesium sulphate2g/h
- Volunteers
- 100 people
- Sponsor
- Ain Shams University
Preeclampsia/Eclampsia
Low Dose Magnesium Sulphate Versus Standard Pritchard Regimen In Management Of Severe Preeclampsia/Eclampsia
Background - Preeclampsia/eclampsia, a pregnancy specific multi-systemic disease, is associated with considerable maternal and perinatal morbidity and mortality.
- Trial name
- NCT04501289
- Testing
- Low dose magnesium sulphate, Pritchard regimen
- Where
- Nigeria
- Volunteers
- 114 people
- Sponsor
- Adebayo Joshua Adeniyi
Hypertension, Metabolic Syndrome
Comprehensive Lifestyle Modification for Patients With Hypertension and Metabolic Syndrome: a Multicenter Randomized Controlled Trial
Different forms of diet, e.g. Mediterranean diet, DASH diet, or fasting, have demonstrated efficacy in reducing elevated blood pressure.
- Trial name
- NCT02099968
- Testing
- Comprehensive Lifestyle Modification, Standard Lifestyle Modification / modified DASH
- Where
- 2 sites in Germany
- Volunteers
- 145 people
- Sponsor
- Universität Duisburg-Essen
Preeclampsia
Pharmacokinetics, Safety and Efficacy Study of Recombinant Antithrombin Versus Placebo in Preterm Preeclampsia
The purpose of the study is to assess the efficacy, safety and pharmacokinetics (PK) of recombinant human antithrombin (ATryn) in addition to expectant management for the treatment of preterm preeclampsia (PPE).
- Trial name
- PRESERVE-1 (NCT02059135)
- Testing
- Recombinant human antithrombin (ATryn), Normal Saline 0.9%
- Where
- 23 sites in United States
- Volunteers
- 120 people
- Sponsor
- rEVO Biologics
Hypercortisolism
A Study of the Efficacy and Safety of Relacorilant in Patients With Cortisol-Secreting Adrenal Adenomas
This is a Phase 3, randomized, double-blind, placebo-controlled study to assess the efficacy, and safety of relacorilant to treat hypercortisolism in patients with cortisol-secreting adrenal adenoma or hyperplasia associated with…
- Trial name
- GRADIENT (NCT04308590)
- Testing
- Relacorilant
- Where
- 45 sites in United States, Austria and 7 more
- Volunteers
- 137 people
- Sponsor
- Corcept Therapeutics
Hypertension
Telemonitoring of Hypertensive Patients
The proportion of hypertensive patients achieving adequate blood pressure control meeting guideline targets remains low. Of hypertensive patients, only 50% are on antihypertensive medications.
- Trial name
- LAPTOHP (NCT01743170)
- Testing
- Telemonitoring of self-measured blood pressure
- Where
- 7 sites in Belgium
- Volunteers
- 240 people
- Sponsor
- KU Leuven
Ocular Hypertension, Open-angle Glaucoma
Evaluation of Netarsudil (AR-13324) Ophthalmic Solution in Patients With Glaucoma and Ocular Hypertension
Evaluation of the ocular hypotensive efficacy and safety of Netarsudil (AR-13324) Ophthalmic Solution compared to Timolol Maleate Ophthalmic Solution
- Trial name
- NCT02207621
- Testing
- AR-13324 Ophthalmic Solution 0.02%, Timolol maleate Ophthalmic Solution 0.5% BID, AR-13324 Ophthalmic Solution 0.02% BID
- Where
- United States
- Volunteers
- 756 people
- Sponsor
- Aerie Pharmaceuticals
Macular Edema, Diabetic Retinopathy
Effectiveness of Oral Acetazolamide, Brimonidine Tartarate, and Anterior Chamber Paracentesis in Intraocular Pressure (IOP) After Bevacizumab
Purpose: To evaluate the effects of anterior chamber paracentesis, brimonidine and oral acetazolamide to reduce intra-ocular pressure (IOP) variations after intravitreal bevacizumab injection (IVBV).
- Conditions
- Macular Edema, Diabetic Retinopathy, Macular Degeneration
- Trial name
- NCT00804921
- Testing
- bevacizumab, anterior chamber paracentesis, acetazolamide
- Where
- Brazil
- Sponsor
- University of Sao Paulo
Preeclampsia, Labor, Premature
Use of Nitrous Oxide Donor for Labor Induction in Women With PreEclampsia
A randomized controlled trial (RCT) of nitric-oxide donor (NOD) isosorbide mononitrate (IMN) versus placebo as an adjuvant to misoprostol/ intra-cervical Foley bulb for induction of labor to decrease rate of cesarean deliveries…
- Trial name
- NOPE (NCT03171480)
- Testing
- Monoket Pill
- Where
- United States
- Volunteers
- 176 people
- Sponsor
- Ohio State University
Glaucoma, Primary Open Angle Glaucoma (POAG)
Evaluation of BRUDYGLAUCO (DHA + Citicoline) in Patients With Glaucoma
This study aims to evaluate the effects of BrudyGlauco, a nutritional supplement containing DHA (docosahexaenoic acid) and citicoline, on visual function in people with glaucoma.
- Conditions
- Glaucoma, Primary Open Angle Glaucoma (POAG), Neuroprotection
- Trial name
- BRUDYGLAUCO (NCT07322965)
- Testing
- BrudyGlauco
- Where
- 2 sites in Spain
- Volunteers
- 108 people
- Sponsor
- Institut Catala de Retina
Hypertension
Sevicontrol-1: Efficacy and Safety of a Fixed Combination of Olmesartan/ Amlodipine
The investigators want to find out whether a recently introduced combination of two blood pressure lowering agents (olmesartan and amlodipine) has a different blood pressure lowering effect than a single active substance.
- Trial name
- Sevicontrol1 (NCT01613209)
- Testing
- Candesartan cilexetil, Olmesartan/Amlodipin
- Where
- 12 sites in Germany
- Volunteers
- 83 people
- Sponsor
- Institut für Pharmakologie und Präventive Medizin
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