Clinical trials: Controlled Hypertension
Hypercholesterolemia, Hypertension
Evaluation of ETC-1002 in Participants With Hypercholesterolemia and Hypertension
This Phase 2 study will assess the efficacy and safety of ETC-1002 monotherapy versus placebo in participants with hypercholesterolemia and hypertension.
- Trial name
- NCT02178098
- Testing
- ETC-1002
- Where
- 43 sites in United States
- Volunteers
- 143 people
- Sponsor
- Esperion Therapeutics, Inc.
Pulmonary Hypertension
Efficacy and Safety of Oral UT-15C Tablets to Treat Pulmonary Arterial Hypertension
This study is an international, multi-center, randomized, double-blind, placebo-controlled study in subjects with PAH who are currently receiving approved therapy for their PAH (i.e., endothelin receptor antagonist and/or…
- Trial name
- FREEDOM-C2 (NCT00887978)
- Testing
- UT-15C SR
- Where
- 62 sites in United States, Belgium and 10 more
- Volunteers
- 310 people
- Sponsor
- United Therapeutics
Essential Hypertension, Vascular Diseases
Sympathetic Mapping/ Ablation of Renal Nerves Trial (SMART) HTN-OFF MED Study
To evaluate the efficacy and safety of selected renal sympathetic denervation using SyMapCath I™ Catheter and SYMPIONEER S1™ Stimulator/Generator in patients with hypertension in the absence of antihypertensive medications, or…
- Conditions
- Essential Hypertension, Vascular Diseases, Cardiovascular Diseases
- Trial name
- SMART OFF-MED (NCT03885843)
- Testing
- Renal nerve stimulation, mapping and denervation
- Where
- China
- Volunteers
- 80 people
- Sponsor
- The Second Affiliated Hospital of Chongqing Medical University
Type 2 Diabetes Mellitus, Hypertension
Dose-ranging Study to Evaluate the Effectiveness and Tolerability of MK0736 in Patients With Type 2 Diabetes Mellitus (T2DM) and Hypertension (0736-007)
The study will assess the efficacy and tolerability of MK0736 in patients with Type 2 Diabetes Mellitus and Hypertension who are on ongoing therapy with Angiotensin-Converting Enzyme or Angiotensin Receptor Blocker.
- Trial name
- NCT00806585
- Testing
- MK-0736, Comparator: HCTZ
- Volunteers
- 620 people
- Sponsor
- Merck Sharp & Dohme LLC
Hypertension
Natriuretic Effect of Telmisartan Versus Placebo in Patients With Mild-to-Moderate Hypertension
Study to compare the natriuretic effect of telmisartan to placebo in mild-to-moderate hypertensive patients on a controlled sodium diet as well as to explore the effects of telmisartan on norepinephrine, plasma renin activity…
- Trial name
- NCT02176499
- Testing
- Telmisartan, low dose, Telmisartan, high dose
- Volunteers
- 26 people
- Sponsor
- Boehringer Ingelheim
Chronic Kidney Diseases, Chronic Disease
Controlling Hypertension Through Education and Coaching in Kidney Disease
Chronic kidney disease (CKD) is a serious and growing public health problem. The purpose of this study is to find out if an educational worksheet, called the Encounter Decision Intervention (EDI), combined with health coaching…
- Conditions
- Chronic Kidney Diseases, Chronic Disease, Chronic Kidney Disease, Stage 3 (Moderate), Chronic Kidney Disease, Stage 4 (Severe)
- Trial name
- CHECK-D (NCT04087798)
- Testing
- Control-EDI, Intervention-EDI, Health coaching
- Where
- 11 sites in United States
- Volunteers
- 320 people
- Sponsor
- University of Michigan
Hypertension, Sleep Apnea
Effect of Antihypertensive Agents on Diastolic Function in Patients With Sleep Apnea
The investigators investigated diastolic function among patients with obstructive sleep apnea (OSA) and hypertension stage I. In this randomized controlled trial, participants were randomly allocated to one of two groups…
- Trial name
- DOSA-2 (NCT02896621)
- Testing
- Chlorthalidone plus amiloride, Amlodipine
- Where
- Brazil
- Volunteers
- 69 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Glaucoma
OculusGen™ Collagen Matrix Implant for Phaco-Trabeculectomy in Primary Glaucoma: a Case-Control Study
Frequently glaucoma is not controlled with clinical treatment ("eyedrops") or laser surgery to control your eye pressure. If this raised pressure is sustained over a long period of time it can lead to permanent damage to the…
- Trial name
- NCT01027247
- Testing
- Ologen TM
- Sponsor
- Singapore National Eye Centre
Arterial Hypertension, Vitamin D Deficiency
Styrian Vitamin D Hypertension Trial
In this randomized, double-blind, placebo-controlled trial we plan to enrol 200 vitamin D deficient hypertensive patients. Our main objective is to evaluate whether vitamin D3 supplementation with 2,800 IU daily for 8 weeks has…
- Trial name
- NCT02136771
- Testing
- Vitamin D3
- Where
- Austria
- Volunteers
- 200 people
- Sponsor
- Medical University of Graz
Pulmonary Hypertension
Visa-versa! Breaking Instead of Pushing the Pedals-A
Eccentric muscle work is defined as lengthening of a muscle while applying force. It was shown that with eccentric work, muscles are able to perform four times as much power compared to usual concentric work, which results in…
- Trial name
- NCT05186987
- Testing
- 15 minutes eccentric cycling, 15 minutes concentric (normal) cycling
- Where
- Switzerland
- Volunteers
- 33 people
- Sponsor
- University of Zurich
Pre-eclampsia
Saccadic Reaction Time and Preterm Pre-eclampsia
This study is recruiting two groups of women over the age of 18; those who are pregnant and who have pre-eclampsia; and those who are pregnant but do not have pre-eclampsia.
- Trial name
- NCT02613793
- Where
- United Kingdom
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Oxford University Hospitals NHS Trust
Pulmonary Arterial Hypertension
Efficacy and Safety Study of Udenafil in Patient With Pulmonary Arterial Hypertension(PAH)
This is a placebo-controlled, double-blind, phase II clinical study to evaluate the efficacy and safety of Udenafil in patient with Pulmonary Arterial Hypertension(PAH).
- Trial name
- NCT01553721
- Testing
- udenafil
- Where
- 9 sites in South Korea
- Volunteers
- 63 people
- Sponsor
- Dong-A ST Co., Ltd.
Essential Hypertension
A Multicenter, Randomized, Double-Blind Phase 3 Trial of KDF1901 in Patients With Essential Hypertension
This randomized, double-blind, multicenter phase 3 clinical trial evaluated the efficacy and safety of KDF1901, a single-pill triple combination of valsartan, amlodipine, and chlorthalidone, in patients with essential…
- Trial name
- NCT07116863
- Testing
- KDF1901-R0, KDF1901-L, KDF1901
- Where
- 2 sites in South Korea
- Volunteers
- 286 people
- Sponsor
- Kyungdong Pharmaceutical Co., Ltd.
Essential Hypertension
Efficacy and Safety of Azilsartan in Participants With Mild to Moderate Uncomplicated Essential Hypertension
The purpose of this study was to evaluate the dose-response relationships of azilsartan, once daily (QD) in participants with mild to moderate uncomplicated essential hypertension.
- Trial name
- NCT01289132
- Testing
- Azilsartan, Candesartan cilexetil
- Volunteers
- 926 people
- Sponsor
- Takeda
Glaucoma, Open-angle, Primary Open Angle Glaucoma (POAG)
Nicotinamide for Retinal Protection in Primary Open-Angle Glaucoma (NADIR Trial)
The goal of this clinical trial is to learn whether a high-dose vitamin B3 supplement called nicotinamide can protect retinal nerve cells in adults with primary open-angle glaucoma (POAG) who are already receiving standard…
- Trial name
- NADIR (NCT07808333)
- Testing
- Nicotinamide, Standard Glaucoma Therapy
- Where
- United States
- Volunteers
- 96 people
- Sponsor
- University of Chicago
Hypertension
OptiZ: Real World Evidence Study
Hypertension, or high blood pressure, is a major cause of preventable illness and premature death, affecting millions in the UK. Despite effective treatments, many patients struggle to achieve adequate blood pressure control.
- Trial name
- NCT06745726
- Testing
- Zestril
- Where
- United Kingdom
- Sponsor
- Closed Loop Medicine
Pulmonary Arterial Hypertension
Study to Compare Triple Therapy (Oral Treprostinil, Ambrisentan, and Tadalafil) With Dual Therapy (Ambrisentan, Tadalafil, and Placebo) in Subjects With Pulmonary Arterial Hypertension
This is a multicenter, randomized (2:1 oral treprostinil: placebo), double-blind, placebo-controlled study in subjects with Pulmonary Arterial Hypertension (PAH) who are currently receiving background dual therapy (ambrisentan…
- Trial name
- NCT02999906
- Testing
- Oral Treprostinil
- Sponsor
- United Therapeutics
Dyslipidemias, Hypertension
Efficacy and Safety of Atorvastatin + Perindopril Fixed-Dose Combination S05167 in Adult Patients With Arterial Hypertension and Dyslipidemia
The purpose of this study is to demonstrate the superiority of atorvastatin/perindopril fixed dose combination (FDC) S05167 as compared to atorvastatin reference drug alone or perindopril drug alone on systolic blood pressure…
- Trial name
- NCT04591808
- Testing
- Atorvastatin/Perindopril, Atorvastatin, Perindopril
- Where
- 43 sites in Georgia, Russia and 1 more
- Volunteers
- 146 people
- Sponsor
- Institut de Recherches Internationales Servier
Hypertension
A MOST Framework Trial Evaluating the MOst effectiVe Exercise Types for Blood Pressure Control
Exercise is known to prevent nearly one in three cases of hypertension and slow its progression in young adults, but we do not know which specific exercise types are most effective.
- Trial name
- MOVE-BP (NCT07915752)
- Testing
- Core intervention (Fitbit tracking and BP health education), Aerobic training (AT), Dynamic resistance training (DRT)
- Where
- United States
- Volunteers
- 264 people
- Sponsor
- Northwestern University
Blood Pressure, Coronary Artery Disease
Ambulatory Blood Pressure Monitoring in Patients With Coronary Artery Disease
Background: Office blood pressure (OBP) is used for diagnosing and treating hypertension but ambulatory blood pressure measurement (ABPM) associates more accurately with patient outcome.
- Conditions
- Blood Pressure, Coronary Artery Disease, Hypertension
- Trial name
- PCI-BP (NCT04649463)
- Testing
- Open ABPM results
- Volunteers
- 200 people
- Sponsor
- Karolinska Institutet
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