Clinical trials: Controlled Hypertension
Preeclampsia
Hypertensive Disorders of Pregnancy in Adolescence and Primipaternity
Hypertensive disorders of pregnancy are one of the most frequent complications of pregnancy, being a serious health problem around the world.
- Trial name
- NCT01374477
- Where
- Panama
- Volunteers
- 110 people
- Sponsor
- Saint Thomas Hospital, Panama
Hypertension, Diabetes
Arts & Health Education to Improve Health, Resilience, and Well-Being
This is an 8-week randomized controlled trial to help address health, resilience, and well-being. Participants are randomized into either a health education group or an arts-based health education group.
- Conditions
- Hypertension, Diabetes, Obesity, COPD
- Trial name
- NCT04154579
- Testing
- HeRe We Arts, HeRe We Ed
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Lisa Gallagher
Hypertension
Effect of Probiotics on Primary Hypertension
Gut microbiota was found to play a causal role in the pathogenesis of hypertension. Probiotics were shown to have a potential anti-hypertensive effect in human/rodent studies.
- Trial name
- NCT05095350
- Testing
- Probiotic powder
- Where
- 6 sites in China
- Volunteers
- 115 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Cataract, Glaucoma
The Effects of a Large Language Model on Clinical Questioning Skills
The researchers have used the ophthalmology textbook, clinical guideline consensus, the Internet conversation data and knowledge base of Zhongshan Ophthalmology Center in the early stage, combined with artificial feedback…
- Conditions
- Cataract, Glaucoma, Diabetic Retinopathy, Keratitis
- Trial name
- NCT06229379
- Testing
- "Digital twin patient", Interaction with real patients
- Where
- China
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Hypertension
Acute Hemodynamic Effects of Cocoa Polyphenols in Subjects With Hypertension and Optimal Blood Pressure
Intake of cocoa-containing foods has been found to lower blood pressure (BP) in several clinical trials. It is supposed that the cocoa polyphenols represent the active principle, lowering BP by increasing the formation of…
- Trial name
- NCT00654862
- Testing
- cocoa polyphenols
- Where
- Germany
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Cologne
Heart Failure, Heart Failure With Preserved Ejection Fraction
Randomized Controlled Pilot Trial of DASH Feeding in Older Low Socioeconomic Adults Without Heart Failure
This is a study of the DASH diet (Dietary Approaches to Stop Hypertension) in the exploration of effective strategies for Heart failure (HF) with preserved ejection fraction (HFPEF) prevention.
- Trial name
- DASHF (NCT04113291)
- Testing
- DASH Diet, Usual diet
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Narrow-Angle Glaucoma
Combined VCST With Phacoemulsification Versus Phacoemulsification in Primary Angle Closure Glaucoma
As ab externo metal probe trabeculotomy cannot achieve 360-degree circumferential angle surgery, prolene suture can be used to achieve this without the need for an illuminated microcatheter.
- Trial name
- NCT06120621
- Testing
- Arm 1 : VCST-phaco group , Arm 2 : phaco group.
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Mansoura University
Unruptured Intracranial Aneurysm, Hypertension
China Antihypertensive Trial for Intracranial Aneurysm
The goal of this randomized controlled trial is to evaluate the benefits and safety of controlled hypotension in Chinese patients with unruptured intracranial aneurysms(UIA).
- Trial name
- ChATIA-1 (NCT05941377)
- Testing
- blood pressure lowering
- Where
- China
- Volunteers
- 577 people
- Sponsor
- Beijing Tiantan Hospital
Preeclampsia
Progesterone in Expectantly Managed Early-onset Preeclampsia
Preeclampsia is a disorder of widespread vascular endothelial malfunction and vasospasm that occurs after 20 weeks' gestation and can present as late as 4-6 weeks postpartum
- Trial name
- NCT04077853
- Testing
- 17 Hydroxyprogesterone Capronate
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Assiut University
Type 2 Diabetes Mellitus, Hypertension
Technology-augmented Self-monitoring Model Among Patients With Type 2 Diabetes and Hypertension
Objective: To develop and evaluate a technology-augmented self-monitoring model using a randomized controlled trial to demonstrate whether patients with co-morbid type 2 diabetes mellitus and hypertension can improve their…
- Trial name
- NCT02799953
- Testing
- Technology-based self-management model
- Where
- China
- Volunteers
- 299 people
- Sponsor
- The University of Hong Kong
Hypertension
Comparison of Effects Between Amlodipine and Hydrochlorothiazide in Combination With Losartan on 24-hr Central Blood Pressure in Hypertensive Patients
The purpose of this study is to investigate which combination therapy is more effective for improving the blood pressure (BP) and AM central SBP in hypertensive patients:Angiotensin II receptor blocker (ARB) plus calcium channel…
- Trial name
- NCT02294539
- Testing
- Losartan 50mg/amlodipine 5mg, Losartan 100mg/amlodipine 5mg, Losartan 50mg/Hydrochlorothiazide 12.5mg
- Where
- South Korea
- Volunteers
- 231 people
- Sponsor
- Chong-Jin Kim
Ischemic Heart Disease, Myocardial Infarction
Polyamine Treatment in Elderly Patients With Coronary Artery Disease
The present study is testing spermidine treatment in elderly patients with coronary artery disease. The study is a randomized, double-blind, placebo-controlled, two-armed, parallel-group, single centre, clinical study.
- Conditions
- Ischemic Heart Disease, Myocardial Infarction, Cardiovascular Diseases, Hypertensive Heart Disease
- Trial name
- PolyCAD (NCT06186102)
- Testing
- Spermidine
- Where
- Denmark
- Volunteers
- 187 people
- Sponsor
- University of Aarhus
Hypertension, Abdominal Obesity
Treatment of Adiposity Related hypErTension (TARGET)
High blood pressure (hypertension) is an important cause of myocardial infarction and stroke. High blood pressure often occurs in people who are overweight. These people frequently also have abnormal fat and sugar metabolism.
- Conditions
- Hypertension, Abdominal Obesity, Metabolic Syndrome
- Trial name
- TARGET (NCT01138423)
- Testing
- Aliskiren, Moxonidine, Hydrochlorothiazide
- Where
- Netherlands
- Volunteers
- 32 people
- Sponsor
- UMC Utrecht
Elevated Intracranial Pressure (ICP)
Optic Nerve Sheath Diameter (ONSD) With the Raised PCO2 and Internal Jugular Venous Occlusion
Monitoring the ICP is the most important aspect of the management of these patients. Recently, transorbital ultrasonography has gained popularity as a noninvasive bedside exam that has been shown to be useful in the diagnosis of…
- Trial name
- NCT02361658
- Testing
- Ultrasonographic of the optic nerve sheath diameter, RespirAct™, Neck collar
- Where
- Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Lashmi Venkatraghavan
Hypertension
A Feasibility Study of the Impact on Blood Pressure Control of Supplementing Community Pharmacist Services With Structured Information on Blood Pressure and Its Treatment
Hypertension is a major health problem, however its control is unsatisfactory. One of the reasons for such a high prevalence of this disease includes poor patient compliance to treatment.
- Trial name
- NCT01939860
- Testing
- Written and verbal patient education on hypertension and its treatment
- Where
- United Kingdom
- Volunteers
- 56 people
- Sponsor
- University of Warwick
Idiopathic Intracranial Hypertension
A Trial to Determine the Efficacy and Safety of Presendin in IIH
Idiopathic intracranial hypertension (IIH) has significant associated morbidity and reduced quality of life. There is a significant risk of visual loss and patients also typically suffer with chronic disabling headaches.
- Trial name
- IIH EVOLVE (NCT05347147)
- Testing
- Presendin
- Where
- 24 sites in United States, Australia and 4 more
- Volunteers
- 14 people
- Sponsor
- Invex Therapeutics Ltd.
Meconium Aspiration Syndrome, Persistent Pulmonary Hypertension of Newborn
Oral Sildenafil in Persistent Pulmonary Hypertension Secondary to Meconium Aspiration Syndrome in Newborns
The purpose of this study is to to study the role of oral Sildenafil in Persistent Pulmonary Hypertension of Newborn (PPHN) secondary to Meconium Aspiration Syndrome (MAS) in newborns and to study risk factors of MAS developing…
- Trial name
- OSiNPH (NCT01757782)
- Testing
- Oral Sildenafil
- Where
- India
- Volunteers
- 96 people
- Sponsor
- Sir Takhtasinhji General Hospital
Open Angle Glaucoma and Cataract
RCT to Investigate if Prostaglandin Analogue Drops Increase the Risk of Cystoid Macular Oedema After Cataract Surgery.
Post-operative cystoid macular oedema (CMO) is a common complication causing visual loss following routine cataract surgery. This complication is more prevalent in eyes with excessive inflammation as they heal from surgery.
- Trial name
- CMO (NCT03292796)
- Testing
- Prostaglandins
- Where
- United Kingdom
- Volunteers
- 56 people
- Sponsor
- Julie Dawson
Esophageal Varices, Bleeding
EVL (Endoscopic Variceal Ligation) Plus Vasoconstrictor vs.Ligation Plus PPI( Proton Pump Inhibitor) in the Control of Acute Esophageal Variceal Bleeding
Previous studies showed that combination of endoscopic therapy with vasoconstrictor is better than either vasoconstrictor or endoscopic therapy alone in achieving the successful hemostatsis of acute variceal bleeding.
- Trial name
- EVL (NCT01112852)
- Testing
- pantoloc 40 mg, somatostatin or terlipressin
- Volunteers
- 118 people
- Sponsor
- National Science and Technology Council, Taiwan
Hypertension
Efficacy/Safety of Valsartan Plus Amlodipine and Valsartan Alone in Patients With Hypertension
This study evaluated the safety and efficacy of the fixed combination of valsartan/amlodipine in adult patients with mild to moderate hypertension.
- Trial name
- NCT00413413
- Testing
- Valsartan/amlodipine 80/5 mg, Valsartan 80 mg, Valsartan 160 mg
- Where
- 19 sites in China
- Volunteers
- 1,134 people
- Sponsor
- Novartis Pharmaceuticals
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