Clinical trials: Controlled Hypertension
Hypertension,Essential
Phase III Study to Evaluate the Efficacy and Safety of AD-209
The purpose of this study is to evaluate the efficacy and safety of AD-209
- Trial name
- NCT06348576
- Testing
- AD-209, AD-2091
- Where
- South Korea
- Volunteers
- 280 people
- Sponsor
- Addpharma Inc.
Hypertension
Impact of Reducing Antihypertensive Treatment on Mortality in Frail Subjects With Low Systolic Blood Pressure (SBP).
The investigators hypothesize that a gradual reduction in antihypertensive treatment in medical-social institutions patients with low systolic blood pressure (SBP) can improve survival through a controlled increase in SBP and a…
- Trial name
- RETREAT-FRAIL (NCT03453268)
- Testing
- STEP DOWN strategy, Control
- Where
- 124 sites in France
- Volunteers
- 1,048 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Glaucoma, Open-Angle
Nicotinamide in Glaucoma (NAMinG): A Randomised, Placebo-controlled, Multi-centre, Phase III Trial
Glaucoma is the leading cause of sight impairment and blindness worldwide. It is a long-term eye disease which can cause permanent loss of sight and sometimes blindness and affects 1 in 50 people over 50 years of age.
- Trial name
- NAMinG (NCT05405868)
- Testing
- Nicotinomide
- Where
- 10 sites in United Kingdom
- Volunteers
- 496 people
- Sponsor
- University College, London
Glaucoma
Study on Incentives for Glaucoma Medications Adherence
Glaucoma topical eye medications, when adhered to, are effective at controlling disease progression. Yet evidence shows that many glaucoma patients have incomplete adherence to medications, with disease progression resulting in…
- Trial name
- SIGMA (NCT02271269)
- Testing
- Value Pricing Subsidies
- Where
- Singapore
- Volunteers
- 100 people
- Sponsor
- Duke-NUS Graduate Medical School
Hypertension
The Digital Version of Holistic Healthy Life Education(e2HLE)
The digital version of Holistic Healthy Life Education" (e2HLE) is a holistic, person-centric, multi-component and lifestyle modification intervention that we developed, alongside the WHO integrated care for older people (ICOPE)…
- Trial name
- NCT06499961
- Testing
- Digital version of Holistic Healthy Life Education, Waitlist control
- Where
- Hong Kong
- Volunteers
- 150 people
- Sponsor
- The Hong Kong Polytechnic University
Essential Hypertension
Efficacy and Safety of Valsartan and Amlodipine in Patients With Essential Hypertension
The purpose of this study is to evaluate the safety and efficacy of fixed combination of valsartan (40 mg and 80 mg) and amlodipine (2.5 mg and 5 mg), valsartan and amlodipine alone, and placebo in reducing blood pressure.
- Trial name
- NCT00425373
- Testing
- Valsartan + amlodipine 40/2.5 mg, Valsartan + amlodipine 40/5 mg, Valsartan + amlodipine 80/2.5 mg
- Where
- Japan
- Volunteers
- 1,474 people
- Sponsor
- Novartis Pharmaceuticals
Glaucoma
OculusGen-Glaucoma Historical Control Study in Taiwan
The purpose of this study is to determine whether the OculusGen Collagen Matrix are effective and safe to implant as an aid of glaucoma surgery.
- Trial name
- NCT00406822
- Testing
- OculusGen Biodegradable Collagen Matrix Implant
- Where
- Taiwan
- Volunteers
- 48 people
- Sponsor
- Pro Top & Mediking Company Limited
Hypertension, Pulmonary
Hemodynamic Effects of Normobaric Hypoxia During Exercise in Patients With Pulmonary Hypertension
To study hemodynamic effects of acute normobaric hypoxia during exercise in patients with pulmonary hypertension in a single-center randomized controlled trial.
- Trial name
- HEXA (NCT04697875)
- Testing
- Normobaric hypoxia (FiO2 15%)
- Where
- Switzerland
- Volunteers
- 24 people
- Sponsor
- University of Zurich
Hypertension, Home Blood Pressure Measurement
Nurse-led Program Efficacy on Blood Pressure Control
The diagnosis and control of hypertension depend on accurate measurements of blood pressure (BP); alternative approaches to measuring BP, such as ambulatory blood pressure monitoring or home blood-pressure self-measurement…
- Trial name
- NCT04681703
- Testing
- Nurse-led program on accuracy of blood pressure self-measurement
- Volunteers
- 170 people
- Sponsor
- Azienda Sanitaria Locale n. 2 - Lanciano Vasto Chieti
Hypertension
FSU Hypertension Self-Care Training Study
The purpose of this study is to compare the effectiveness of two forms of self-care training on the overall health of adults with hypertension.
- Trial name
- NCT01770756
- Testing
- Self-Care Training
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- Florida State University
BCAA, Cirrhosis
TIPS With or Without BCAA
Cirrhosis is a major global cause of morbidity and mortality in chronic liver disease patients, accounting for 2.4% of global deaths in 2019.
- Conditions
- BCAA, Cirrhosis, Portal Hypertension Related to Cirrhosis, Sarcopenia
- Trial name
- NCT07281846
- Testing
- The BCAA Group (experimental group) takes oral branched-chain amino acid (BCAA) supplements for 3 months starting after TIPS.
- Where
- China
- Volunteers
- 164 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Primary Open Angle Glaucoma of Both Eyes
Comparative Study of Dorzol Eye Drops, 20 mg/ml Versus Trusopt® Eye Drops, 20 mg/ml
The goal of this study is to compare efficacy and safety of Dorzol 20 mg/mL Eye Drops manufactured by JADRAN-GALENSKI LABORATORIJ d.d.
- Trial name
- NCT05973305
- Testing
- Dorzol 20 mg/ml, Trusopt 20 mg/ml
- Where
- Russia
- Volunteers
- 118 people
- Sponsor
- Jadran Galenski laboratorij d.d.
Essential Hypertension
Clinical Trial on Remote Ischemic Conditioning and Hypertension（HOPE）
Nowadays, the incidence of stroke in China has reached 1.6‰, and this disease has became a primary cause of death in China. One of its major risk factors is hypertension.
- Trial name
- NCT03566654
- Testing
- remote ischemic conditioning, ambulatory blood pressure monitoring
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Ji Xunming,MD,PhD
Pulmonary Arterial Hypertension, Pulmonary Hypertension
Sitaxsentan Efficacy And Safety Trial With A Randomized Prospective Assessment Of Adding Sildenafil (SR-PAAS)
This protocol is for subjects with pulmonary arterial hypertension and is the first of 3 studies forming the Sitaxsentan efficacy and safety trial with Randomized Prospective Assessment of Adding Sildenafil (SR-PAAS) program.
- Trial name
- NCT00795639
- Testing
- Sitaxsentan
- Where
- 85 sites in United States, Argentina and 22 more
- Volunteers
- 183 people
- Sponsor
- Pfizer
Open Angle Glaucoma
CoQun Study - (COQUN): a Study to Evaluate the Effects of CoQun in Patients Affected by Open-angle Glaucoma
This is a randomized, parallel arm, multicenter, double-blind trial. Patients with POAG will be randomized 1:1 ratio to receive: Prostaglandin analogue (PGA) monotherapy + CoQun® (Arm A) Prostaglandin analogue (PGA) monotherapy +…
- Trial name
- CoQun (NCT03611530)
- Testing
- Coqun® ophthalmic solution
- Where
- Italy
- Volunteers
- 111 people
- Sponsor
- Mario Negri Institute for Pharmacological Research
Blood Pressure, Hypertension
Effect of Oligopin® on Blood Pressure.
The objective of the study is to evaluate the effect of consumption of a food supplement rich in procyanidins extracted from the bark of French pine, Oligopin®, on blood pressure of people with mild / moderate degree of…
- Trial name
- NCT02063477
- Testing
- Oligopin®
- Where
- Spain
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Technological Centre of Nutrition and Health, Spain
Essential Hypertension, Diabetes Mellitus, Type 2
Evaluation of Efficacy and Safety of ATB-1011+ATB-1012 Co-administration for Essential Hypertension and Type II Diabetes
The purpose of this study is to evaluate safety and efficacy of ATB-1011 and ATB-1012 co-administration in patients with essential hypertension and type II diabetes mellitus
- Trial name
- NCT05573477
- Testing
- ATB-1011, ATB-1012, ATB-1013
- Where
- South Korea
- Volunteers
- 255 people
- Sponsor
- Autotelicbio
Hypertension, Chronic Kidney Disease
Renal Sympathetic Denervation as a New Treatment for Therapy Resistant Hypertension
The aim of this study is to assess whether renal denervation (RD) added to usual care compared to usual care alone reduces blood pressure (BP) as determined with ambulatory BP monitoring (ABPM) after 6 months in subjects with an…
- Trial name
- SYMPATHY (NCT01850901)
- Testing
- Renal sympathetic denervation
- Where
- Netherlands
- Volunteers
- 139 people
- Sponsor
- UMC Utrecht
Hypertension
The Effect of Sodium Nitrite on Renal Function and Blood Pressure in Hypertensive Versus Healthy Subjects
The purpose of this study is to investigate how the effect of infused sodium nitrite differs in hypertensives compared to healthy age and sex matched controls.
- Trial name
- HYCA (NCT02527837)
- Testing
- Sodium nitrite, Sodium chloride
- Where
- Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Erling Bjerregaard Pedersen
Heart Failure With Preserved Ejection Fraction (HFpEF), Hypertension
Study for the Treatment of Heart Failure With Preserved Ejection Fraction Associated With High Blood Pressure Using Right Atrial Pacing Controlled by the PressurePaceTM System
This study is a prospective, double blind, self-controlled, randomized, cross-over study to evaluate the feasibility, efficacy, and safety of treating patients with Heart Failure with preserved Ejection Fraction (HFpEF)…
- Trial name
- RelieveHFpEFII (NCT06036186)
- Testing
- BaroPacing treatment, Standard treatment
- Where
- 3 sites in India
- Volunteers
- 16 people
- Sponsor
- BaroPace Inc.
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