Clinical trials: Controlled Hypertension
Pulmonary Hypertension
PHIRST-1: Tadalafil in the Treatment of Pulmonary Arterial Hypertension
The purpose of this study is to evaluate the safety and effectiveness of tadalafil for the treatment of pulmonary arterial hypertension.
- Trial name
- NCT00125918
- Testing
- tadalafil
- Where
- 6 sites in United States, France and 1 more
- Volunteers
- 406 people
- Sponsor
- Eli Lilly and Company
Hypertension, Diabetes Mellitus, Type 2
ENCOMPASS: Expansion Study B, RCT
Some patients living with multiple long-term health conditions have difficulty accessing the services they need, despite available primary care and community resources.
- Conditions
- Hypertension, Diabetes Mellitus, Type 2, Chronic Kidney Diseases, Ischemic Heart Disease
- Trial name
- ENCOMPASS (NCT04790617)
- Testing
- Community Health Navigator Program
- Where
- Canada
- Volunteers
- 183 people
- Sponsor
- University of Calgary
Covid19, Diabetes
Camostat and Artemisia Annua vs Placebo in COVID-19 Outpatients
This is a randomized, double-blind, placebo-controlled, multi-arm, multicenter, phase II trial design to allow a rapid efficacy and toxicity assessment of potential therapies (camostat mesilate and artemisia annua) immediately…
- Conditions
- Covid19, Diabetes, Hypertension, Obesity
- Trial name
- NCT04530617
- Testing
- Camostat Mesilate, Artemisia Annua Leaf
- Where
- Mexico
- Volunteers
- 246 people
- Sponsor
- Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
Hypertension
The Standardized Management of Hypertension in Rural Shaanxi
The purpose of the study is to build a prevention and management system of hypertension in rural Shaanxi, China, which tries to use the standardized and economical methods to improve the outcome of chronic cardiovascular diseases.
- Trial name
- NCT04371874
- Testing
- Hydrochlorothiazide, Captopril, Nitrendipine, Aspirin
- Where
- China
- Volunteers
- 1,210 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Hypertension
Efficacy and Safety of LCZ696 Compared to Olmesartan in Essential Hypertensive Patients Not Responsive to Olmesartan
This study will assess the efficacy and safety of LCZ696 in comparison to olmesartan in essential hypertensive patients not adequately responsive to olmesartan
- Trial name
- NCT01876368
- Testing
- LCZ696, Olmesartan
- Where
- 51 sites in United States, Argentina and 5 more
- Volunteers
- 376 people
- Sponsor
- Novartis Pharmaceuticals
Obesity
BLOSSOM: Behavioral Modification and Lorcaserin Second Study for Obesity Management
The purpose of this study is to assess the weight loss effect of lorcaserin during and at the end of 1 year of treatment in overweight and obese patients.
- Trial name
- NCT00603902
- Testing
- Lorcaserin 10 mg once daily (QD), Lorcaserin 10 mg twice a day (BID)
- Where
- United States
- Volunteers
- 4,008 people
- Sponsor
- Eisai Inc.
Hypertension
Study to Compare the Effect of Valsartan vs Atenolol on Pro-thrombotic State in Hypertensive Patients.
A study to compare the effects of Diovan or Atenolol taken for 12 weeks on platelet function of patients who have mild to moderately severe hypertension
- Trial name
- NCT00171756
- Testing
- valsartan/atenolol
- Where
- Switzerland
- Volunteers
- 92 people
- Sponsor
- Novartis
Primary Open Angle Glaucoma, Pseudoexfoliative Glaucoma
Phacotrabeculotomy Versus CCI+Phaco in Patients With Borderline Control of Intraocular Pressure
The purpose of the study is to determine whether combined cataract and glaucoma surgery (phacotrabeculotomy)is more effective in lowering intraocular pressure than cataract surgery alone in patients with borderline control of…
- Trial name
- NCT00346931
- Testing
- Phacoemulsification, implantation of intraocular lens, Phacoemulsification, Implantation of IOL, trabeculotomy
- Volunteers
- 9 people
- Sponsor
- Medical University of Vienna
Hypertension; Community Health Workers
Effectiveness of a Community Health Worker Delivered Care Intervention for Hypertension Control in Uganda
Over 80% of the morbidity and mortality related to non-communicable diseases (NCDs) occurs in low-income and middle-income countries (LMICs).
- Trial name
- CHW-HTC (NCT05068505)
- Testing
- Community health worker delivered multicomponent intervention
- Where
- Uganda
- Volunteers
- 869 people
- Sponsor
- Charite University, Berlin, Germany
Hypertensive Disease
Activating Media for Salt Reduction
Mass media plays more and more important role in health education, especially in some chronic diseases which related closely with the behavior and habits.
- Trial name
- NCT03074851
- Testing
- low sodium salt, informational intervention
- Where
- China
- Volunteers
- 516 people, healthy volunteers welcome
- Sponsor
- The George Institute for Global Health, China
Hypertension
Blood Pressure-Improving Control Among Alaska Native People" (BP-ICAN)
"Blood Pressure: Improving Control among Alaska Native People" (BP-ICAN) that targets blood pressure control among Alaska Native and American Indian (AN/AI) people diagnosed with hypertension.
- Trial name
- CHAR2 (NCT03872856)
- Testing
- BP-ICAN
- Where
- 2 sites in United States
- Volunteers
- 164 people
- Sponsor
- Southcentral Foundation
HYPERTENSION
A Year Long Study to Evaluate the Safety of the Combination of Valsartan (320 mg) and Amlodipine (5 mg) in Patients With Hypertension
A ONE YEAR SAFETY STUDY FOR PATIENTS WHO COMPLETE STUDY VAA489A2307.
- Trial name
- NCT00170976
- Testing
- valsartan + amlodipine
- Where
- 2 sites in Germany, Switzerland
- Volunteers
- 403 people
- Sponsor
- Novartis
Elevated Intraocular Pressure
Prospective, Double-masked, Randomized, Multi-center, Active-controlled, Parallel-group, 3-month Study Assessing the Safety & Ocular Hypotensive Efficacy of TC-002 Ophthalmic Solution Compared to Latanoprost Ophthalmic Solution 0.005% in Subjects With Elevated Intraocular Pressure
Prospective, double-masked, randomized, multi-center, active-controlled, parallel-group, 3-month study assessing the safety and ocular hypotensive efficacy of TearClear latanoprost Ophthalmic Solution, 0.005% (TC-002) compared to…
- Trial name
- TC-002-301 (NCT05165290)
- Testing
- Latanoprost ophthalmic solution, 0.005%, TC-002 latanoprost ophthalmic solution, 0.005%
- Where
- 20 sites in United States
- Volunteers
- 300 people
- Sponsor
- TearClear Corp
Glaucoma, Glaucoma Suspect
Eyedrop Instillation Technique
Eye drop instillation is a problem from glaucoma patients. Studies reveal that 30-50% of glaucoma patients have problems instilling their eyedrops.
- Trial name
- NCT01417689
- Testing
- Encouragement to attempt eye drop instillation with a specific technique
- Where
- Chile
- Volunteers
- 230 people
- Sponsor
- Oftalmologia Hospital Sotero del Rio
Pulmonary Arterial Hypertension (PAH)
Study of REGN13335 in Adult Participants With Pulmonary Arterial Hypertension (PAH)
This study is researching an experimental drug called REGN13335. The study is focused on participants with Pulmonary Arterial Hypertension (PAH).
- Trial name
- ILLUMINATE (NCT07318597)
- Testing
- REGN13335
- Where
- 33 sites in United States, Australia and 8 more
- Volunteers
- 99 people
- Sponsor
- Regeneron Pharmaceuticals
Venous Thromboembolism, Postpartum Period
Pilot PARTUM Trial: Postpartum Aspirin to Reduce Thromboembolism Undue Morbidity
The pilot PARTUM trial is a randomized, multicenter, placebo-controlled trial. Women who are at modest risk of VTE (as defined by the inclusion criteria) will be identified during pregnancy, labor and delivery and up to 48 hours…
- Conditions
- Venous Thromboembolism, Postpartum Period, Aspirin
- Trial name
- PARTUM (NCT04153760)
- Testing
- Aspirin 81 mg
- Where
- 7 sites in Canada, France and 2 more
- Volunteers
- 257 people
- Sponsor
- University of Calgary
Coronary Artery Disease, Hypertension
The Use of Magnesium to Improve Blood Pressure, Cholesterol, and Glucose Control
The purpose of this study is to determine if magnesium can improve blood pressure, cholesterol, and blood sugar control in patients with implantable cardioverter defibrillators (ICDs).
- Conditions
- Coronary Artery Disease, Hypertension, Dyslipidemia, Diabetes
- Trial name
- NCT00282659
- Testing
- magnesium L-lactate
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- Hartford Hospital
Hypertension
Tai Chi for Patients With Essential Hypertension
Several studies investigating Tai Chi for hypertension have been carried out. However, investigators found the results were in high heterogeneity and poor methodological quality.
- Trial name
- NCT04267471
- Testing
- Tai Chi, Walking
- Where
- China
- Volunteers
- 234 people
- Sponsor
- Chengdu University of Traditional Chinese Medicine
Hepatocellular Carcinoma (HCC), Esophageal Varices
Endoscopic Variceal Ligation vs Carvedilol for the Prevention of First Esophageal Variceal Bleeding in Patients With HCC
The goal of this clinical trial is to evaluate whether endoscopic variceal ligation (EVL) or carvedilol is more effective at preventing the first esophageal variceal bleeding (EVB) in patients with hepatocellular carcinoma (HCC).
- Trial name
- P-HCC-CVL (NCT06594744)
- Testing
- Endoscopic variceal ligation, Carvedilol
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Hypertension, Primary Care
Fixed-Dose Combinations Pragmatic Randomized Implementation Trial for Blood Pressure Control
The proposed study is an effectiveness-implementation hybrid type II trial designed to evaluate the impact of provider- and patient-directed interventions on FDC use.
- Trial name
- NCT07228065
- Testing
- Provider nudge, Patient nudge, Pharmacist Virtual Visit
- Where
- United States
- Volunteers
- 720 people
- Sponsor
- Brigham and Women's Hospital
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