Clinical trials: Controlled Hypertension
Pulmonary Arterial Hypertension
Study of Macitentan (ACT-064992) on Morbidity and Mortality in Patients With Symptomatic Pulmonary Arterial Hypertension
The AC-055-302/SERAPHIN study will be an event-driven Phase III study, comparing two different doses of macitentan (ACT-064992) (3 and 10 mg) vs placebo in patients with symptomatic PAH.
- Trial name
- SERAPHIN (NCT00660179)
- Testing
- macitentan (ACT-064992)
- Where
- 153 sites in United States, Argentina and 36 more
- Volunteers
- 742 people
- Sponsor
- Actelion
HIV, Hypertension
Leveraging the HIV Platform for Hypertension Control in Uganda (INTEGRATED HIV/HTN) STUDY
The INTEGRATED HIV/HTN is a hybrid type-1 effectiveness/implementation cluster randomised trial evaluating the introduction of a multi-component integrated HIV/HTN care model intervention, randomised to 13 districts in the…
- Trial name
- NCT04624061
- Testing
- Integrated HIV/HTN care model
- Where
- Uganda
- Volunteers
- 2,600 people, healthy volunteers welcome
- Sponsor
- Infectious Diseases Research Collaboration, Uganda
Gestational Diabetes, Gestational Hypertension
The Effect of High Dose Folic Acid Versus Placebo on the Rate of Gestational Diabetes or Gestational Hypertension in Pregnant Women
The purpose of this study is to determine if higher-than usual doses of daily folic acid has an effect on the rate of gestational diabetes mellitus (GDM) or gestational hypertension in pregnant women while determining status of…
- Trial name
- NCT01302756
- Testing
- Folic Acid
- Sponsor
- Mike O'Callaghan Military Hospital
Hypertension
Telmisartan (Micardis) and Amlodipine (Norvasc) - Factorial Design Study for the Treatment of Hypertension
To demonstrate that Micardis and Norvasc when used together are more effective at lowering blood pre ssure.
- Trial name
- NCT00281580
- Testing
- Amlodipine 5 mg, Telmisartan 20 mg, Telmisartan 40 mg
- Where
- 136 sites in United States, Argentina and 3 more
- Volunteers
- 1,461 people
- Sponsor
- Boehringer Ingelheim
Hypertension
Effectiveness of MICARDIS® (Telmisartan) on Blood Pressure Control and Quality of Live in Patients With Essential Hypertension
Study to assess the effect of Telmisartan on diastolic and systolic blood pressure and to establish the effect on patient's quality of life scores.
- Trial name
- MicCAT (NCT02242370)
- Testing
- Low dose of telmisartan, High dose of telmisartan
- Volunteers
- 3,045 people
- Sponsor
- Boehringer Ingelheim
Safety Issues, Tolerance
First-in-human Trial to Evaluate the Safety, Tolerability and Pharmacokinetics of C106 in Healthy Subjects
This is a FIH, double-blind, placebo-controlled, within-group randomised, trial designed to evaluate the safety, tolerability, and pharmacokinetics (PK) of single and multiple ascending oral doses of compound 106 (C106) in…
- Conditions
- Safety Issues, Tolerance, Idiopathic Pulmonary Fibrosis, Pulmonary Hypertension
- Trial name
- NCT05427253
- Testing
- C106 solution
- Where
- Sweden
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Vicore Pharma AB
Open-angle Glaucoma
24-hour Study of Dorzolamide/Timolol and Latanoprost/Timolol Fixed Combinations
The primary objective of this crossover trial is to compare the 3-month mean 24-hour intraocular pressure (IOP) control and safety of dorzolamide/timolol fixed combination (DTFC) given twice daily, versus latanoprost/timolol…
- Trial name
- NCT00397241
- Testing
- Drug: dorzolamide/timolol, Drug: latanoprost/timolol, dorzolamide/timolol and latanoprost
- Where
- Greece
- Volunteers
- 33 people
- Sponsor
- Aristotle University Of Thessaloniki
Resistant Hypertension
The RESPLASH Study
To assess the safety and effectiveness of renal artery denervation with subsequent splanchnic nerves denervation via catheter-based radiofrequency ablation in improving blood pressure and glycemic control in patients with…
- Trial name
- NCT06880562
- Testing
- Splanchnic Nerve Denervation, Renal Denervation Only
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Tulane University
Gastric Varices, Cirrhosis
Efficiency and Safety of Prophylactic Use of Antibiotics in Endoscopic Injection of Tissue Adhesive in Gastric Varices
The purpose of the study is to assess the efficiency and safety of prophylactic use of antibiotics in endoscopic injection of tissue adhesive in gastric varices.
- Trial name
- NCT02693951
- Testing
- Cefotiam
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Shanghai Zhongshan Hospital
Pulmonary Hypertension
ARIES - Ambrisentan in Patients With Moderate to Severe Pulmonary Arterial Hypertension (PAH)
The primary objective is to determine the effect of ambrisentan on exercise capacity in subjects with PAH.
- Trial name
- NCT00091598
- Testing
- Ambrisentan
- Where
- 46 sites in United States, Australia and 1 more
- Volunteers
- 372 people
- Sponsor
- Gilead Sciences
Open-Angle Glaucoma, Ocular Hypertension
A Study to Evaluate Efficacy and Safety of a Fixed Combination Ocular Insert in Participants With Open-angle Glaucoma or Ocular Hypertension
The purpose of this study is to determine if a combination of two drugs (bimatoprost and timolol) delivered to the surface of the eye over 10 weeks is better at lowering intraocular pressure (IOP) than either of the drugs…
- Trial name
- NCT02742649
- Testing
- Fixed Combination, Bimatoprost, Timolol
- Where
- Panama
- Volunteers
- 55 people
- Sponsor
- ForSight Vision5, Inc.
Glaucoma, Ocular Hypertension
Preservative-Free Tafluprost (MK-2452) for the Treatment of Open-Angle Glaucoma or Ocular Hypertension (MK-2452-002)
This study will test the hypothesis that preservative-free tafluprost (MK-2452) is non-inferior to preservative-free timolol maleate with respect to the diurnal intraocular pressure (IOP) change from baseline after 4 weeks of…
- Trial name
- NCT01254604
- Testing
- Preservative-Free Tafluprost or vehicle, Preservative-Free Timolol maleate
- Volunteers
- 190 people
- Sponsor
- Merck Sharp & Dohme LLC
Ocular Hypertension, Glaucoma
Study of Netarsudil (AR-13324) Ophthalmic Solution in Patients With Glaucoma or Ocular Hypertension
The purpose of this study is to evaluate the ocular and systemic safety of Netarsudil (AR-13324) Ophthalmic Solution, 0.02% q.d. and b.i.d. for 12 months compared to the active comparator Timolol Maleate Ophthalmic Solution, 0.5%.
- Trial name
- NCT02246764
- Testing
- AR-13324 Ophthalmic Solution 0.02%, AR-13324 Ophthalmic Solution 0.02% BID, Timolol maleate Ophthalmic Solution 0.5% BID
- Where
- United States
- Volunteers
- 93 people
- Sponsor
- Aerie Pharmaceuticals
Glaucoma
Value of an Intervention to Enhance Adherence in Glaucoma Patients
A one-year, randomized, attention placebo-controlled trial investigating the value of comprehensive adherence specific interventions, over the course of one year, to enhance adherence in both (a) newly diagnosed open-angle…
- Trial name
- NCT00756184
- Testing
- TDA adherence monitor for travoprost therapy, TDA and travoprost monotherapy
- Volunteers
- 107 people
- Sponsor
- Aristotle University Of Thessaloniki
Hypertension,Essential
Hypertension Treatment Adherence Improving Trial
Persistent adherence to lifestyle modifications and blood pressure lowering medications were the best way to control blood pressure.
- Trial name
- NCT04565548
- Testing
- Educational program for hypertensive patients, Usual care
- Where
- 2 sites in China, Hong Kong
- Volunteers
- 148 people
- Sponsor
- The Hong Kong Polytechnic University
Hypertension
A Blood Pressure-Lowering Diet for Preventing and Managing Hypertension
This cluster-randomized controlled trial will evaluate whether a 3-month culturally adapted blood pressure-lowering dietary, called the Eastern Blood Pressure-Lowering Diet, can improve blood pressure and related health outcomes…
- Trial name
- NCT07735091
- Testing
- Standard Hypertension Management, Eastern Blood Pressure-Lowering Diet
- Where
- China
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Peking University
Hypertension
COmmuNity-engaged SimULation Training for Blood Pressure Control
The goal of CONSULT-BP is to train early-stage healthcare providers, including residents and nurse practitioner (NP) students, to mitigate providers' bias, improve communication skills, and enhance providers' ability to develop…
- Trial name
- CONSULT-BP (NCT03375918)
- Testing
- CONSULT-BP Educational Intervention
- Where
- 4 sites in United States
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- University of Massachusetts, Worcester
Hypertension, Pulmonary
Hemodynamic Effects During Exercise in Patients With Pulmonary Hypertension Receiving Sildenafil
To study hemodynamic effects of Sildenafil during exercise in patients with pulmonary hypertension.
- Trial name
- HEXASN (NCT04706546)
- Testing
- Hemodynamic effect of exercise under Sildenafil, Hemodynamic effect of exercise
- Where
- 2 sites in Switzerland
- Volunteers
- 24 people
- Sponsor
- University of Zurich
Hypertension
An Comparative Pharmacokinetic Study of Amlodipine Besylate Controlled-release Tablets,China in Normal, Healthy, Adult, Human Subjects Under Fasting Conditions
Amlodipine Besylate Controlled-release Tablets in Healthy Volunteers in a Randomized, Open, Two-cycle, Double-cross, Fasting State Comparative Pharmacokinetic Study.
- Trial name
- NCT05667818
- Testing
- Amlodipine besylate tablets (trade name: Norfloxacin ®）, Amlodipine besylate controlled-release tablets
- Where
- China
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Overseas Pharmaceuticals, Ltd.
Cardiovascular Risk Factors, Hypertension
Clinical Management of Cardiovascular Risk Factors in Adult Patients: A Before-and-After Interventional Study
This study aims to evaluate cardiovascular risk factors, clinical characteristics, and outcomes in adult patients attending an outpatient cardiology clinic.
- Conditions
- Cardiovascular Risk Factors, Hypertension, Dyslipidemia, Type 2 Diabetes Mellitus
- Trial name
- CV-RISK (NCT07447362)
- Testing
- Structured Cardiovascular Risk Management
- Where
- Chile
- Volunteers
- 220 people
- Sponsor
- Universidad Católica San Antonio de Murcia
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