Clinical trials: Controlled Hypertension
Portal Hypertension, Chronic Liver Disease
EUS vs TJ for Liver Biopsy and Portal Pressure Gradient Measurement
This study will directly compare the endoscopic ultrasound guided approach to obtain adequate liver biopsies and portal pressure gradient measurements to the current standard of care which uses the transjugular approach.
- Conditions
- Portal Hypertension, Chronic Liver Disease, Cirrhosis
- Trial name
- NCT05118308
- Testing
- Transjugular hepatic venous pressure gradient measurement with liver biopsy, Endoscopic ultrasound portal pressure gradient measurement with liver biopsy
- Where
- Canada
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Diabetes Mellitus, Type 1, Celiac Disease in Children
Carbohydrate Counting and DASH Intervention Among Children With Diabetes and Celiac Disease.
Study is an interventional clinical trial. children (aged 6-18 years) diagnosed with type 1 diabetes and celiac disease will be recruited conveniently from Endocrinology pediatric clinic at Prince Hamzah Hospital. Amman, Jordan.
- Trial name
- NCT05132725
- Testing
- diet therapy
- Where
- Jordan
- Volunteers
- 45 people
- Sponsor
- University of Jordan
Pulmonary Arterial Hypertension (PAH), Pulmonary Arterial Hypertension (PAH) (WHO Group 1 PH)
A Phase 2 Study of IkT-001Pro in Pulmonary Arterial Hypertension (PAH)
This is a randomized, double-blind, multi-center, placebo-controlled dose-ranging clinical trial of two IkT-001Pro doses in patients with PAH designed to assess safety, tolerability and efficacy.
- Trial name
- NCT06643143
- Testing
- IkT-001Pro
- Sponsor
- Inhibikase Therapeutics
Hypertension
Isometric Handgrip Home Training to Lower Blood Pressure in Hypertensive Older adulTs
This Study evaluates the effect of 20 weeks of isometric handgrip (IHG) home training in adults aged 50 years or more. Half of the participants will serve as a control group and will only receive hypertension-guidelines on…
- Trial name
- POTENT (NCT03069443)
- Testing
- IHG home training
- Where
- Denmark
- Volunteers
- 48 people
- Sponsor
- Aalborg University Hospital
Hypertension, Hyperhomocysteinemia
CSPPT- Chronic Kidney Diseases Study
The purpose of this trial is to confirm that enalapril maleate and folic acid tablets is more effective in preventing renal function decline among the patients with primary hypertension when compared to enalapril maleate.
- Trial name
- CSPPT-CKD (NCT01871740)
- Testing
- Enalapril maleate and folic acid tablets, Enalapril maleate
- Where
- 2 sites in China
- Sponsor
- Shenzhen Ausa Pharmed Co.,Ltd
Mortality, Acute Pancreatitis
Laparotomy Versus Percutaneous Puncture in Patients With Abdominal Compartment Syndrome During Acute Pancreatitis
Decompressive laparotomy with temporary abdominal closure, will decrease of overall mortality and major morbidity in patients with abdominal compartment syndrome during acute pancreatitis in comparison with percutaneous puncture…
- Trial name
- DECOMPRESS (NCT00793715)
- Testing
- Decompressive laparotomy with temporary abdominal closure, Percutaneous puncture with placement of abdominal catheter
- Where
- 5 sites in Serbia
- Volunteers
- 100 people
- Sponsor
- University of Belgrade
Pulmonary Arterial Hypertension
Study to Evaluate Efficacy and Safety of JTT-251 in Participants With Pulmonary Arterial Hypertension
Study to evaluate the efficacy, safety, tolerability and pharmacokinetics of JTT-251 administered for 24 weeks in participants with pulmonary arterial hypertension (PAH)
- Trial name
- RELIEF-PAH (NCT03789643)
- Testing
- JTT-251
- Sponsor
- Shionogi Inc.
Hypertension
Community Hypertension Control Using the Health Belief Model and PRECEDE-PROCEED
This protocol describes a community-based cluster randomized controlled trial in Kamalgonj Upazila, Moulvibazar district, Bangladesh, evaluating a theory-driven intervention to improve blood pressure (BP) control among adults…
- Trial name
- HBM-HTN-CRT (NCT07426978)
- Testing
- HBM-based Health Education
- Volunteers
- 480 people, healthy volunteers welcome
- Sponsor
- Bangladesh Medical University
Arterial Hypertension
Identifying Most Effective Treatment Strategies to Control Arterial Hypertension in Sub-Saharan Africa
This study is to compare the effectiveness of three different antihypertensive treatment strategies for reaching a target blood pressure (clinic BP) of </= 130/80 mmHg among patients <65years of age and </= 140/90 mmHg among…
- Trial name
- coArtHA (NCT04129840)
- Testing
- dual combination, triple combination, Standard of care
- Where
- 3 sites in Lesotho, Switzerland and 1 more
- Volunteers
- 1,268 people
- Sponsor
- University Hospital, Basel, Switzerland
Preeclampsia With Severe Features, Chronic Hypertension in Obstetric Context
Acute Control of Chronic Hypertension
The purpose of this study is to understand if administration of a personalized dose of the anti-hypertensive medication, labetalol, based on patient's history of preexisting hypertension, will be more effective at controlling…
- Trial name
- ACCTIVE (NCT03877692)
- Testing
- Experimental dosing of labetalol, Standard dosing of labetalol
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Albany Medical College
Esophageal Varices
Transparent Cap-assisted Endoscopic Sclerotherapy
The aim of this study is to evaluate efficacy and safety of transparent cap-assisted endoscopic sclerotherapyI(lauromacrogol injection) in management of esophageal varices.
- Trial name
- NCT02361593
- Testing
- assistance of a transparent cap, without a transparent cap
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Shanghai Zhongshan Hospital
Portopulmonary Hypertension
PORtopulmonary Hypertension Treatment wIth maCitentan - a randOmized Clinical Trial
24-week study to evaluate the efficacy and safety of macitentan for the treatment of portopulmonary hypertension.
- Trial name
- PORTICO (NCT02382016)
- Testing
- Macitentan
- Where
- 52 sites in United States, Brazil and 5 more
- Volunteers
- 85 people
- Sponsor
- Actelion
Arterial Hypertension, Dyslipidemias
Fixed Combination for Lipid and Blood Pressure Control
The aim of this study is to compare the effect of fixed and free combination of atorvastatin/perindopril/amlodipine on blood pressure and lipid levels.
- Conditions
- Arterial Hypertension, Dyslipidemias, Blood Pressure, Lipid Metabolism Disorders
- Trial name
- FILIP (NCT03047538)
- Testing
- Atorvastatin, Amlodipine, Perindopril
- Where
- Czechia
- Sponsor
- Charles University, Czech Republic
Hypertension
Olive Leaf Extracts in the Control of Hypertension
This study will be carried out in 2 emergency departments (at the exit of the emergency room) and 2 external consultations (endocrinology of the CHU FB Monastir and diabetology consultation, Jemmal hospital).
- Trial name
- Atherolive (NCT05636826)
- Testing
- atherolive-drug
- Where
- Tunisia
- Volunteers
- 500 people
- Sponsor
- University of Monastir
Glaucoma, Open-Angle, Ocular Hypertension
Evaluate Efficacy and Safety of PA5108 Ocular Implants in Primary Open Angle Glaucoma or Ocular Hypertension
The goal of this clinical trial is to determine the dose of PA5108 Ocular Implant that is effective and safe for the reduction of intraocular pressure in adult patients with open-angle glaucoma or ocular hypertension, compared to…
- Trial name
- NCT06964191
- Testing
- PA5108 Ocular Implant low dose, PA5108 Ocular Implant, high dose, Latanoprost 0.005% Ophthalmic Solution
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- PolyActiva Pty Ltd
Hypertension, Dyslipidemia
Caduet in an Untreated Subject Population
The purpose of this study is to determine if Caduet will lower blood pressure to <140/90 mmHg and lower LDL Cholesterol to <100 mg/dL in subjects with hypertension and dyslipidemia who are not currently being treated for these…
- Trial name
- CUSP (NCT00332761)
- Testing
- Caduet
- Where
- 34 sites in United States
- Volunteers
- 220 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Essential Hypertension
The Effects of Amiloride and Spironolactone on Renophysiological and Cardiovascular Variables
The investigators wish to study the effect of retaining potassium. The participants have essential hypertension. The test substances are Amiloride, Spironolactone and placebo.
- Trial name
- hass (NCT01195805)
- Testing
- Spironolactone, Amiloride
- Where
- Denmark
- Volunteers
- 25 people
- Sponsor
- Regional Hospital Holstebro
Hypertension (HTN), Blood Pressure
Team-Based Shared Decision-Making Program in Hypertension Control (Healthy Heart - BP Program)
The main goal of the study is to conduct a pilot trial to test the feasibility of the Team-Based Shared Decision-Making (SDM) Program, supported by Healthy Heart, involving 90 adults with uncontrolled hypertension (HTN) at…
- Trial name
- SDM in BP (NCT07909161)
- Testing
- Pharmacist-led Team-Based SDM on health behavior change and medication management for HTN control, Nurse-led Team-Based SDM on health behavior change and medication management for HTN control, Telehealth SDM visits focus on medication management and health behavior change
- Volunteers
- 90 people
- Sponsor
- Johns Hopkins University
Intra-abdominal Hypertension
Efficacy and Safety Profile of Cisatracurium Besylate for IAH
This study is a randomized, double-blinded, controlled design. In this study, Cisatracurium Besylate was selected for treatment in Intra-abdominal hypertension or abdominal compartment syndrome,accompanied with evaluating the…
- Trial name
- NCT05172531
- Testing
- Cisatracurium Besylate, saline 0.12ml/kg/hr
- Volunteers
- 80 people
- Sponsor
- Tianjin Nankai Hospital
Aortic Stenosis, Aortic Regurgitation
Study to Evaluate the Effect on Improvement of LVH by the Control of BP in Hypertension Patients With AV Disease
To compare changes in Left Ventricular Mass (LVM) depending on each blood pressure regulation between the intensive care group and the usual care group for patients with hypertension accompanied by aortic valve disease and…
- Conditions
- Aortic Stenosis, Aortic Regurgitation, Hypertension, LVM
- Trial name
- NCT03666351
- Testing
- Amlodipine 5mg, Losartan, Losartan and Amlodipine
- Where
- South Korea
- Volunteers
- 128 people
- Sponsor
- Hanmi Pharmaceutical Company Limited
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