Clinical trials: Controls
AVP Deficiency, Diabetes Insipidus
Plasma Oxytocin Response to Oral Estrogens in Healthy Controls and AVP-Deficiency
The PHOENIX study aims to investigate whether oral estradiol valerate (EV) and ethinylestradiol (EE) can stimulate oxytocin (OXT) and neurophysin-1 (NP-1) release in humans.
- Trial name
- PHOENIX (NCT07361263)
- Testing
- estradiol valerate, esthinylestradiol
- Where
- Switzerland
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Vasomotor Rhinitis
Nasal Physiologic Reactivity of Nonallergic Rhinitics to Cold Air Provocation
This study seeks to compare patients with vasomotor rhinitis ("perennial nonallergic rhinitis," "idiopathic rhinitis") with normal controls with respect to their nasal physiologic reactivity to cold air challenge.
- Trial name
- NCT00415493
- Testing
- Cold-dry air provocation, Warm-moist air provocation
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Associated Scientists to Help Minimize Allergies
Parkinson's Disease, Multiple System Atrophy
PET Imaging Evaluation of [11C]SY08
The overall goal of the proposed research is to evaluate the use of [11C]SY08 as a PET radiotracer for aggregated alpha synuclein (αS) in individuals with Parkinson's disease (PD), Multiple system atrophy (MSA), Dementia with…
- Conditions
- Parkinson's Disease, Multiple System Atrophy, Dementia With Lewy Bodies, Healthy Controls
- Trial name
- NCT06098612
- Testing
- C11-SY08
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Depression, Involutional
Function of Catecholamines in the Brain During Depression
This study will explore brain function related to depressive symptoms and will examine DNA for genes that may be involved in depressive disorders, particularly genes that regulate synthesis and metabolism of the brain…
- Trial name
- NCT00082030
- Where
- United States
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Alteration of Mitochondrial Membrane, Type2 Diabetes
Mitochondrial Effects of C18:0 Supplementation in Humans
The purpose of this crossover study is to determine whether nutritional supplementation of C18:0 in humans has mitochondrial effects as shown in Drosophila and human cell culture.
- Conditions
- Alteration of Mitochondrial Membrane, Type2 Diabetes, Fatty Acid Deficiency
- Trial name
- NCT02957838
- Testing
- C18:0, mock
- Where
- Germany
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University Hospital Heidelberg
Tobacco Use Disorder, Schizophrenia
Smoking Abstinence and Lapse Effects in Smokers With Schizophrenia and Controls
This project tests two hypotheses concerning the low smoking cessation rates in smokers with schizophrenia. The first hypothesis is that smokers with schizophrenia experience stronger and more sustained effects of smoking…
- Trial name
- WREN (NCT01214005)
- Testing
- smoking abstinence
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Brown University
Anemia, Iron-deficiency Anemia
Neurovascular Complications and White Matter Damage in Acquired Anemias
This is an observational trial, in patients with moderate to severe anemia and control subjects. The main purpose of this study is to understand whether normal brain blood flow, oxygen extraction reserve, white matter volumes…
- Conditions
- Anemia, Iron-deficiency Anemia, Healthy Controls
- Trial name
- NCT04320966
- Where
- 4 sites in United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Children's Hospital Los Angeles
Psoriasis (PsO), Periodontal Disease
Evaluation of TNF-α, IL-17A, and YKL-40 in GCF and Serum of Psoriasis Patients and Healthy Controls
Background: Psoriasis is a chronic inflammatory skin disease that affects 2-3% of the global population and is linked to immune dysregulation and systemic inflammation.
- Trial name
- NCT06897722
- Testing
- TNF-α analysis in GCF, IL-17A analysis in GCF, YKL-40 analysis in GCF
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Zhala Vatankha Sain
Plantar Fasciopathy, Achilles Tendinopathy
QUANTIFY: Quantitative Understanding of Advanced Novel Techniques for Imaging Fasciitis and Yielding Biomarkers
This study is to create a test that can accurately find and measure the problem areas in muscle and fascia tissue, also known as myofascial pain.
- Conditions
- Plantar Fasciopathy, Achilles Tendinopathy, Controls
- Trial name
- QUANTIFY (NCT06803056)
- Testing
- Clinical exam, Ultrasound imaging, Magnetic Resonance Imaging
- Where
- United States
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Ruth Chimenti
Traumatic Brain Injury, Cortical Excitability
Cortical Excitability in Post-traumatic Epilepsy
To test whether measures of cortical excitability derived from motor cortex transcranial magnetic stimulation (TMS) in patients with traumatic brain injury reflect heightened excitability relative to healthy controls and whether…
- Conditions
- Traumatic Brain Injury, Cortical Excitability, Epilepsy
- Trial name
- NCT05517954
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Mid-Atlantic Epilepsy and Sleep Center, LLC
Healthy
Does Serotonin System Stimulation Increase Pro-social Behavior? - A Comparative Pharmacological Neuroscientific Study in Healthy Humans
The study looks into whether administering psychedelic substances that stimulate the serotonin system influences pro-social behavior when compared to administering substances that stimulate the dopamine system in healthy…
- Trial name
- NCT06081179
- Testing
- Psilocybin, 3,4 Methylenedioxymethamphetamine, Methylphenidate
- Where
- Switzerland
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Type 2 Diabetes
Marathon Runners Compared to Sedentary Matched Control Subjects
The investigators wish to compare very active runners in healthy untrained control subjects on a number of parameters. The project aims to understand the underlying mechanisms by which physical inactivity causes diseases.
- Trial name
- NCT02001805
- Where
- Denmark
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Inge Holm
Healthy, Healthy Adult
Assessment of Lung Function (Lufu) at Sea Level LA vs. High Altitude HA in Healthy Individuals
To study the effect of a re-ascent to high altitude (Quito Ecuador: 2850m) after a one-week stay at sea level (after prior descent from 2850m) on lung function and pulmonary resistance/reactance in healthy individuals, who live…
- Conditions
- Healthy, Healthy Adult, High Altitude Effects, High Altitude
- Trial name
- NCT07804537
- Testing
- Re-ascent from sea level to 2850m
- Where
- Switzerland
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Silvia Ulrich Somaini
Keratoconus
Astigmatism in Keratoconus Patients
Keratoconus is a bilateral (but usually asymmetrical) non-inflammatory progressive thinning process of the cornea. It manifests as characteristic cone-like ectasia of the cornea associated with irregular stromal thinning…
- Trial name
- NCT03450213
- Testing
- Pentacam
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Assiut University
Cephalic Phase, Oncology Patients
Cephalic Phase of Oncology Patients Before and After Chemotherapy as Compared to Healthy Controls
The objective of this trial is to examine the cephalic phase insulin response (CPIR) and pancreatic polypeptide (PP) release as indicators of the cephalic phase occurrence and magnitude to palatable food stimulus (chocolate cake)…
- Trial name
- Cephalic chemo (NCT00493740)
- Testing
- chocolate cake
- Where
- Israel
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Atrial Fibrillation
Biomarkers and Epigenetic Markers Associated With Pain in Patients With Symptomatic Atrial Fibrillation
Atrial fibrillation (AF) is the most common sustained arrhythmia and the number of patients with AF is expected to increase substantially in the coming decades.
- Trial name
- PAIN (NCT05201989)
- Where
- Sweden
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Region Örebro County
Spine Fusion, Postoperative Pain
Suzetrigine (Journavx) for Pain Management After Spine Surgery
This prospective, single-center interventional study will evaluate the effect of suzetrigine (Journavx), a selective NaV1.8 inhibitor, on postoperative opioid requirements in patients undergoing spine surgery.
- Trial name
- NCT07829718
- Testing
- Suzetrigine (Journavx)
- Volunteers
- 110 people
- Sponsor
- Ohio State University
Depression
Exploratory Study of the Effects of Vortioxetine (Lu AA21004) on Cognition and Blood Oxygen Level Dependent (BOLD) Functional Magnetic Resonance Imaging (fMRI) Signals in Subjects Remitted From Depression and in Controls
The purpose of this study is to determine if Vortioxetine 20 mg/day will lead to changes in neural activity (BOLD signal), as measured using fMRI, in brain areas associated with executive functioning and memory during cognitive…
- Trial name
- NCT01607125
- Testing
- Vortioxetine (Lu AA21004)
- Where
- United Kingdom
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- H. Lundbeck A/S
Menopause, Depression
Brain Imaging Study in Menopausal Women With and Without Major Depressive Disorder
The purpose this study is to measure cortical gama-aminobutyric acid levels (GABA) levels in menopausal women with major depressive disorder and healthy subjects using nuclear magnetic resonance spectroscopy (MRS).
- Trial name
- NCT00626340
- Testing
- MDD diagnosis and Estrogen treatment, MDD diagnosis and Fluoxetine treatment, MDD diagnosis with both Estrogen and Fluoxetine treatment
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Moral Development, Moral Dilemma
Moral Reasoning Intervention on Moral Justification Abilities
The primary aim of this study is to evaluate the short (immediate) and mid-term (one month) impact of moral (vs non-moral) reasoning interventions on the moral justification abilities in non-expert subjects.
- Conditions
- Moral Development, Moral Dilemma, Healthy Controls, Moral Justification
- Trial name
- NCT06735989
- Testing
- Lecture on moral reasoning, Lecture on logical reasoning
- Where
- Italy
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele