Clinical trials: Conversion Therapy
Anemia
A Study of Subcutaneous (sc) Mircera in Dialysis Patients With Chronic Renal Anemia.
This study will determine the appropriate dose and frequency of administration of sc Mircera maintenance therapy in dialysis patients with chronic renal anemia who were previously receiving sc epoetin alfa or beta.
- Trial name
- NCT00364832
- Testing
- methoxy polyethylene glycol-epoetin beta [Mircera]
- Where
- 23 sites in United States, Germany and 2 more
- Volunteers
- 137 people
- Sponsor
- Hoffmann-La Roche
Globus Pharyngeus
The Efficacy of Kinesio Taping With Therapy in the Treatment of Globus Pharyngeus
Globus pharyngeus or sensation may be defined as a feeling of something a lump in the throat without dysphagia. Kinesio tex tape is a medical tap developed by Dr.
- Trial name
- NCT04768205
- Testing
- Kinesio tape
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization
Locally Advanced Pancreatic Cancer
NALIRIFOX Combined With PD-1 Sequential Radiotherapy Versus NALIRIFOX as Conversion Therapy of Locally Advanced Pancreatic Cancer
The purpose of the prospective, open, randomized controlled, multicenter, exploratory clinical study is to evaluate efficacy and safety of NALIRIFOX Combined With PD-1 Sequential Radiotherapy Versus NALIRIFOX for Conversion…
- Trial name
- NALIRIFOX (NCT06669078)
- Testing
- Nal-lRl+Oxaliplain+5- FU +PD 1, Nal-lRl+Oxaliplain+5- FU
- Volunteers
- 120 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Chronic Endometritis
RCT(Randomized Clinical Trial ) of Antibiotic Therapy in Chronic Endometritis
120 cases with a diagnosis of chronic endometritis, confirmed by the presence of plasma cells in endometrial biopsy sample identified by immunohistochemical staining using CD138 antibody, have been recruited.
- Trial name
- NCT02648698
- Testing
- Antibiotics
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Fu Xing Hospital, Capital Medical University
Intrahepatic Cholangiocarcinoma
HAIC Plus Targeted Therapy and/or PD-1 Inhibitors for Unresectable Intrahepatic Cholangiocarcinoma
Intrahepatic cholangiocarcinoma (ICC) is associated with poor prognosis. This study aims to explore the efficacy and safety FOLFOX-HAIC in combination with targeted therapy and/or PD-1 inhibitors for patients with initially…
- Trial name
- NCT05489692
- Testing
- hepatic arterial infusion chemotherapy (HAIC) of oxaliplatin, fluorouracil, and leucovorin (FOLFOX)
- Where
- China
- Volunteers
- 43 people
- Sponsor
- Sun Yat-sen University
Colorectal Cancer
A Real-World Study of Neoadjuvant/Conversion Therapy for Colorectal Cancer With Chemotherapy And Anti-Angiogenic Targeted Agents
Fruquintinib is already the standard third-line treatment for metastatic colorectal cancer, but the efficacy of fruquintinib in neoadjuvant and conversion therapy for locally advanced/advanced colorectal cancer has not yet been…
- Trial name
- NCT06470178
- Testing
- corhot1: chemotherapy combined with fruquintinib, corhot2: chemotherapy combined with fruquintinib
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Wuhan University
EGFR-mutant Non-small Cell Lung Cancer, Potentially Resectable
Neoadjuvant Sacituzumab Tirumotecan and Limertinib for Potentially Resectable Stage Ⅲ EGFR-mutant Non-small Cell Lung Cancer
This study is a prospective, single-arm, exploratory clinical research aimed at evaluating the efficacy and safety of lucetamab in combination with leucovorin in the conversion therapy of locally advanced potentially resectable…
- Trial name
- NCT07323056
- Testing
- Sacituzumab Tirumotecan and Limertinib
- Where
- China
- Volunteers
- 36 people
- Sponsor
- Shanghai Pulmonary Hospital, Shanghai, China
Acute Thermal Burns
The Effects of Hyperbaric Oxygen Therapy (HBOT) on Acute Thermal Burns
The blinded RCTstudy aims to: Determine the effects of HBOT on burns conversion for patients who have fresh thermal burns injury using the LDI.
- Trial name
- NCT00824551
- Testing
- Hyperbaric Oxygen Therapy, Standard care
- Where
- Singapore
- Volunteers
- 80 people
- Sponsor
- Singapore General Hospital
Graft Rejection, Kidney Failure
Study Comparing Conversion From Calcineurin Inhibitors to Rapamune Versus Standard Therapy in Established Renal Allograft Recipients
The purpose of the study is to determine the effect of conversion from calcineurin inhibitor based therapy to Rapamune based therapy in patients with mild to moderate renal insufficiency.
- Conditions
- Graft Rejection, Kidney Failure, Kidney Transplantation
- Trial name
- NCT00273871
- Testing
- Cyclosporin or tacrolimus
- Volunteers
- 190 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Convulsion, Non-Epileptic, Conversion Disorder
Treatments for Psychogenic Nonepileptic Seizures (NES)
The investigators propose that treatment of the comorbid disorders (depression, anxiety, and impulsivity) with sertraline in patients with lone psychogenic nonepileptic seizures (NES), will result in a decreased number of NES.
- Conditions
- Convulsion, Non-Epileptic, Conversion Disorder, Depression, Stress Disorders, Post-Traumatic
- Trial name
- NES (NCT00159965)
- Testing
- sertraline
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Rhode Island Hospital
Acute Stroke
Risk Factors of Conversion From Local to General Sedation in Endovascular Stroke Therapy
Thrombectomy is now the standard of care of revascularization in acute ischaemic stroke. Data tend to show that final neurologic outcome is superior if the thrombectomy procedure was performed under conscious sedation.
- Trial name
- AMAS (NCT02895776)
- Where
- France
- Volunteers
- 28 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Renal Anemia
Biosimilar Erythropoietin in Anaemia Treatment (Maintenance Phase Study)
This study is aimed to comprehensively establish the bio-similarity/bioequivalence in EPIAO® and EPREX® in terms of 52-week comparisons in efficacy, safety and immunogenicity.
- Trial name
- BEAT_002 (NCT02947438)
- Testing
- EPREX®, EPIAO®
- Where
- 19 sites in Russia, Thailand
- Volunteers
- 207 people
- Sponsor
- Shenyang Sunshine Pharmaceutical Co., LTD.
Colorectal Cancer
Plasma Multi - Omics Detection for Evaluating Efficacy and Recurrence Risk in Oligometastatic Colorectal Cancer Conversion Therapy
This prospective study (PMEIRR-OCCCT) evaluates the utility of plasma multi-omics-including circulating tumor DNA (ctDNA), cell-free RNA (cfRNA), proteomics, and metabolomics-in assessing response to conversion therapy and…
- Trial name
- PMEIRR - OCCCT (NCT07492238)
- Testing
- Plasma Multi - omics Detection
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Xiujuan Qu
Peritoneal Metastasis, Gastric Cancer
The Role of 18F-FDG&68Ga-FAPI PET/CT in the Assessment of Conversion Therapy Efficacy in Gastric Cancer with Peritoneal Metastasis.
This study aims to investigate the value of 18F-FDG\&68Ga-FAPI PET/CT in evaluating the outcome of conversion therapy and the prognosis of people with peritoneal metastases from gastric cancer.
- Trial name
- NCT06597526
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Ruijin Hospital
Kidney Transplant
Clinical Outcome of Delayed or Standard Prograf Together With Induction Therapy Followed by Conversion to Advagraf in Donation After Cardiac (or Circulatory) Death (DCD) Kidney Transplant Recipients
The purpose of this study is to confirm non-inferiority of delayed Prograf treatment to standard Prograf treatment in the incidence of delayed graft function (DGF) within 1 week between the 2 immunosuppressive (IS) treatment…
- Trial name
- NCT03644485
- Testing
- Tacrolimus immediate-release formulation, Tacrolimus prolonged-release formulation, Induction therapy
- Where
- 14 sites in China
- Volunteers
- 284 people
- Sponsor
- Astellas Pharma China, Inc.
Esophageal Squamous Cell Carcinoma, Tislelizumab
Chemoradiation Plus Tislelizumab for Conversion Therapy of Locally Nonresectable ESCC
This is a single institution and single-arm phase I/II study to assess the feasibility and efficacy of tislelizumab plus chemoradiation for conversion therapy of patients with locally nonresectable ESCC.
- Conditions
- Esophageal Squamous Cell Carcinoma, Tislelizumab, Chemoradiation
- Trial name
- LATE (NCT05394415)
- Testing
- Tislelizumab, Paclitaxel, Carboplatin
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Jiangsu Cancer Institute & Hospital
Pancreatic Cancer
AG Followed by FOLFIRINOX Both Combined With PD-L1 Antibodies as a Conversion Therapy for Borderline Resectable and Locally Advanced Pancreatic Cancer.
The goal of this interventional study is to learn about the clinical efficacy of sequential therapy (albumin paclitaxel, gemcitabine combined with PD-L1 antibodies, followed by liposomal irinotecan, oxaliplatin and 5-FU/LV…
- Trial name
- ZSPAC-14 (NCT07208539)
- Testing
- Treatment: AG & anti-PD-L1 + FOLFIRINOX & anti-PD-L1
- Volunteers
- 77 people
- Sponsor
- Shanghai Zhongshan Hospital
Somatoform Disorders, Globus Hystericus
Treatment of Globus Sensations With Psychotherapy
The purpose of this study is to determine whether psychotherapy (based on exposure techniques) is effective in the treatment of functional somatic symptoms (FSS)/Somatoform Disorders (as exemplified here in subjects with globus…
- Trial name
- NCT01590992
- Testing
- Exposure-based psychotherapy for somatic symptoms, Relaxation therapy
- Where
- Switzerland
- Volunteers
- 175 people
- Sponsor
- University Hospital, Basel, Switzerland
Compare the Response Rate of Atypical GERD After PPI Therapy
Comparison of the Efficiency of Two Different PPI Formula in Atypical GERD
Patients with atypical gastro-esophageal reflux disease (GERD), include cough, globus, and non-cardiac chest pain (NCCP) usually require more aggressive or double dose proton pump inhibitor (PPI) therapy than patients with typical…
- Trial name
- NCT03418337
- Testing
- dexilansoprazole (Dexilant 60 mg), lansoprazole (Takepron OD 30 mg)
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Hepatocellular Carcinoma, Chemotherapy Effect
Concurrently vs Sequentially Combined HAIC With Targeted and Immunotherapy in Potentially Resectable HCC
The goal of this clinical trial is to compare HAIC concurrently with sequentially combined with targeted and immunotherapies in terms of efficacy and safety in patients with potentially resectable intermediate and advanced HCC…
- Conditions
- Hepatocellular Carcinoma, Chemotherapy Effect, Chemotherapeutic Toxicity
- Trial name
- HAIC (NCT06041477)
- Testing
- Oxaliplatin,calcium folinic acid, levofolinic acid, 5-FU, Concurrent Lenvatinib, Concurrent PD-1 antibody
- Where
- China
- Volunteers
- 540 people
- Sponsor
- Sun Yat-sen University