Clinical trials: Cornea
Keratoconus, Irregular; Contour of Cornea
Scleral Lens Fitting Using Wide-Field OCT
The purpose of this study is to see if OCT technology can optimize scleral contact lens fittings. Subjects with keratoconus, post-penetrating keratoplasty (PK), post-LASIK ectasia, post-radial keratotomy (RK), or a variety of…
- Trial name
- NCT04570020
- Where
- United States
- Volunteers
- 258 people
- Sponsor
- Oregon Health and Science University
Cornea
Intranasal Neurostimulation in Ameliorating Symptoms of Neuropathic Corneal Pain
This study is a prospective, interventional, open-label, single arm, non-randomized trial treating 30 patients with peripheral or mixed neuropathic corneal pain at their baseline exam and following 45 days and 90 days of daily…
- Trial name
- INSTANT (NCT03674892)
- Testing
- TrueTear™ intranasal neurostimulator (ITN)
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Tufts Medical Center
Donor Corneas Preservation
In Vitro Study on Donor Corneas Preservation in IRESTORE Storage Medium. A Post Marketing Interventional Study on Device
Donor corneas are harvested and then stored in the Eye Bank to maintain their viability until analysis and subsequent release for transplantation.
- Trial name
- IRESTORE (NCT07134946)
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Cornea
INTACS for Non Ectatic With High Cylinder
Intra-corneal rings implantation for correcting high cylinder errors in non ectatic corneas
- Trial name
- NCT06963099
- Testing
- INTACS implantation
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Elshimaa A.Mateen
Cornea
Assessment of Corneal Topography and Densitometry in Rheumatoid Patients
Corneal transparency is a result of its unique ultrastructure with collagen fibrils regularity, integrity of connective tissue, and balanced keratocyte components.
- Trial name
- NCT06759207
- Where
- 2 sites in Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Sohag University
Pterygium, Pterygium of the Conjunctiva and Cornea
CsA vs MMC for Preventing Pterygium Recurrence
aimed to compare the efficacy and safety of topical cyclosporin A (CsA) versus mitomycin C (MMC) as adjunctive therapies in preventing pterygium recurrence after surgical excision.
- Trial name
- MMC (NCT06944132)
- Testing
- Excision of the pterygium, Post-operative application of CsA, Intra-operative application of MMC
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Benha University
Map Dot Fingerprint Dystrophy, Post-penetrating Keratoplasty
Brillouin Microscopy Used to Evaluate Corneal Mechanical Properties
This study aims to explore the mechanical properties of the cornea using a non-invasive imaging technique called Brillouin microscopy.
- Conditions
- Map Dot Fingerprint Dystrophy, Post-penetrating Keratoplasty, Post-Descemet Membrane Endothelial Keratoplasty, Healthy Corneas
- Trial name
- NCT06914817
- Testing
- Brillouin optical scanning system (Intelon Optics) (BOSS)
- Where
- Austria
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Vienna Institute for Research in Ocular Surgery
Silicon Oil Effect on Cornea, Corneal Biomechanics
Silicone Effect on Corneal Endothelium and Corneal Biomechanics Using Corvis ST
Brief Summary The goal of this observational study is to investigate the effects of silicone oil tamponade on corneal endothelial cell density (ECD), morphology, and biomechanics in patients undergoing vitrectomy for retinal…
- Trial name
- NCT06861946
- Testing
- Corvis ST, Conrneal endothelial cell density
- Where
- 2 sites in Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Beni-Suef University
Cornea Transplant
Study of the Anatomical and Functional Recovery and Quality of Life of Patients Undergoing Corneal Transplantation
Evaluate the well-being of patients and clinicl outcomes of the cornea after transplantation
- Trial name
- NCT06830538
- Where
- Italy
- Volunteers
- 2,000 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Normal Cornea, Corneal Abnormality
The Heidelberg Engineering ANTERION Corneal Epithelium Thickness Precision and Agreement Study
This is a prospective clinical study that will be conducted at one clinical site located in the United States to assess corneal epithelial thickness parameters with the ANTERION
- Trial name
- NCT05051813
- Testing
- ANTERION
- Where
- United States
- Volunteers
- 151 people, healthy volunteers welcome
- Sponsor
- Heidelberg Engineering GmbH
Keratoconus, Cornea Disease
Effects of Topical Insulin on Corneal Epithelium Healing After Corneal Crosslinking in Patients With Keratoconus
The cornea plays a fundamental role in vision, being a complex tissue essential for ocular health. In ophthalmological practice, there are situations such as corneal crosslinking, where damage to the corneal epithelium occurs.
- Conditions
- Keratoconus, Cornea Disease, Eye Diseases, Wound Heal
- Trial name
- NCT06601101
- Testing
- Insulin
- Where
- Brazil
- Volunteers
- 36 people
- Sponsor
- University of Campinas, Brazil
Mesenchymal Stromal Cells, Cornea
Safety of Locally Delivered Allogeneic Mesenchymal Stromal Cells
This study is a longitudinal assessment using a classic dose-escalation study design to assess the safety and maximal tolerated dose (MTD) of locally delivered allogeneic mesenchymal stromal cells (MSC) for promoting corneal…
- Conditions
- Mesenchymal Stromal Cells, Cornea, Safety, Corneal Defect
- Trial name
- NCT04626583
- Testing
- Allogeneic MSC
- Where
- 4 sites in United States
- Volunteers
- 8 people
- Sponsor
- University of Illinois at Chicago
Pterygium of Conjunctiva and Cornea, Pterygium of Both Eyes
Clinical Outcomes of Sutured Versus Sutureless Conjunctival Autograft in Primary Pterygium Excision
The goal of this study is to find out if a certain technique in pterygium excision surgery ,using no sutures, is better than the technique mostly used ,which uses sutures.
- Conditions
- Pterygium of Conjunctiva and Cornea, Pterygium of Both Eyes, Pterygium
- Trial name
- NCT06734663
- Testing
- Clinical outcomes of sutured versus sutureless conjunctival autograft in primary pterygium excision, pterygium excision and conjuctival graft suturing, pterygium excision and conjuctival graft placement by autologous blood
- Where
- 2 sites in Egypt
- Volunteers
- 70 people
- Sponsor
- Assiut University
Keratoconus, Cornea Ectasia
Safety and Efficacy of Corneal Crosslinking Using the PXL-Platinum 330 for Eyes With Corneal Ectatic Conditions
To evaluate the safety and effectiveness of the PXL Platinum 330 device for performing Corneal Crosslinking in patients with corneal thinning conditions.
- Trial name
- NCT04240457
- Testing
- Epithelial-on Corneal Crosslinking with the PXL 330 Platinum system.
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Arbor Center for Eye Care
Keratoconus, Unstable, Bacterial Keratitis
Safety and Effectiveness of the PXL-Platinum 330 System for Corneal Cross-Linking
To determine whether the Peschke PXL-330 system is safe and effective in the treatment of corneal thinning conditions.
- Conditions
- Keratoconus, Unstable, Bacterial Keratitis, Ectasia of Cornea
- Trial name
- NCT03918408
- Testing
- PXL-330 Platinum device for crosslinking with Peschke ribofflavin solution
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Pacific Clear Vision Institute
Cornea Ectasia
Clinical Outcomes of Two Symmetrical Kera-rings Implantation in Grade Three Keratoconus
Clinical Outcomes of Two Symmetrical Kera-rings Implantation in Grade Three Keratoconus
- Trial name
- NCT06498570
- Testing
- Intracorneal rings
- Where
- Egypt
- Volunteers
- 23 people
- Sponsor
- Sohag University
Normal Subject, Glaucoma
Assessment of an Automated Optical Coherence Tomography and Camera : Effectiveness of Vision-700
The objective of study is to assess the repeatability and agreement of the retina and cornea measurement by Vision-700 in comparison with those by 3D OCT-1.
- Conditions
- Normal Subject, Glaucoma, Retinal Disease, Cornea
- Trial name
- NCT06496763
- Testing
- Vision-700
- Where
- Taiwan
- Volunteers
- 159 people, healthy volunteers welcome
- Sponsor
- Crystalvue Medical Coporation
Cornea
Comparison of Oral Isotretinoin vs Ancomparison of Oral Isotretinoin vs Antibiotics on Corneal Thickness With AV
Comparison of Oral Isotretinoin versus comparison of Oral Isotretinoin versus Antibiotics on Corneal Thickness in Patients with Acne Vulgaris
- Trial name
- NCT06483971
- Testing
- Oral Isotretinoin, Antibiotics
- Where
- Pakistan
- Volunteers
- 36 people
- Sponsor
- Superior University
Cataract, Healthy Eye
The Heidelberg Engineering ANTERION Anterior Segment Cornea and IOL Precision and Agreement Study
This is a prospective clinical study that will be conducted at one clinical site located in the United States to assess anterior segment parameters with the ANTERION
- Conditions
- Cataract, Healthy Eye, Cornea Abnormality, Post-Keratorefractive Surgery
- Trial name
- NCT04130490
- Testing
- ANTERION
- Where
- United States
- Volunteers
- 176 people, healthy volunteers welcome
- Sponsor
- Heidelberg Engineering GmbH
Myopia, Cornea
Euclid Phoenix Lens Design Trial 2
Lens wettability and subjective comfort of Euclid orthokeratology lenses with and without an enhanced coating will be compared in 50 children. Axial elongation will be monitored in pediatric patients who qualify and consent.
- Trial name
- NCT06392607
- Testing
- Euclid orthokeratology (standard coating), Euclid orthokeratology (enhanced coating)
- Where
- 5 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Euclid Systems Corporation