Clinical trials: Cornea Disease
Corneal Perforation, Exposure Keratitis
The Role of OmniLenz® in the Treatment of Small Corneal Perforations Secondary to Exposure Keratitis in ICU Patients
Case series of 5 ICU patients in Farwaniya Hospital who developed exposure keratitis and a subsequent small corneal perforation between April 2022 and April 2024.
- Conditions
- Corneal Perforation, Exposure Keratitis, Infectious Keratitis
- Trial name
- NCT06539663
- Testing
- OmniLenz®
- Where
- Kuwait
- Volunteers
- 5 people
- Sponsor
- Farwaniya Hospital
Keratoconus
Effects of Corneal Anatomical Match Between Donor and Recipient During DALK Surgery on Final Visual and Refractive Outcomes in Patients With KCN
Patients with KCN who undergo cornea transplantation divided to 2 groups: Group1: After mechanical trephination, horizontal meridian of donor's cornea sutured to horizontal meridian of recipient cornea Group 2: After mechanical…
- Trial name
- NCT04130334
- Testing
- After mechanical trephination, horizontal meridian of donor's cornea sutured to horizontal meridian of recipient cornea, : After mechanical trephination, horizontal meridian of donor's cornea sutured to vertical meridian of recipient cornea
- Where
- Iran
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Shahid Beheshti University of Medical Sciences
Keratoconus, Pellucid Marginal Degeneration
Corneal Cross Linking and Topography Guided Excimer Laser Treatment
Topography guided laser treatment enables the surgeon to correct higher order aberrations in corneas with irregular astigmatism.
- Trial name
- NCT01682993
- Testing
- Topography guided Excimer Laser treatment and Corneal Cross Linking, Corneal Cross Linking
- Where
- Austria
- Volunteers
- 30 people
- Sponsor
- Medical University of Vienna
Limbal Stem Cell Deficiency
Multicenter Study of CAOMECS Transplantation to Patients With Total Limbal Stem Cell Deficiency
This clinical study is a scientific study on patients who do not have any limbal stem cells. In this clinical study tissue is taken from the inside of the mouth, and cells from that tissue (epithelial cells) will be grown to form…
- Trial name
- NCT01489501
- Testing
- Surgical transplantation of CAOMECS to the ocular surface
- Where
- Germany
- Sponsor
- CellSeed France S.A.R.L.
Keratoconus
Corneal De-epithelization Associated With a Therapeutic Photokeratectomy in Patients With Evolutive Keratoconus
Keratoconus is a symmetrical, bilateral, non-inflammatory, idiopathic corneal pathology, characterized by a progressive corneal thinning.
- Trial name
- KERADES (NCT02857881)
- Testing
- De-epithelization and therapeutic photokeratectomy
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Corneal Neovascularization, Corneal Graft Failure
A Multi-Center Study of the Safety and Efficacy of Bevacizumab in High-Risk Corneal Transplant Survival
The goal of this study is to investigate whether using bevacizumab (Avastin®) is both safe and effective at decreasing the likelihood of a high-risk corneal graft rejection.
- Trial name
- NCT01996826
- Testing
- Avastin® (bevacizumab), 0.9% NaCl & Refresh Liquigel
- Where
- 3 sites in United States
- Volunteers
- 75 people
- Sponsor
- Reza Dana, MD
Corneal Endothelial Cell Loss
Comparative Study of Specular Microscopes for Measurements of Cell Density, Coefficient of Variation and Hexagonality
The primary objective of this clinical study is to collect clinical data to support an FDA 510(k) submission for the Nidek CEM-530 Center point method and Corner point method.
- Trial name
- NCT02276638
- Testing
- Specular Microscope Nidek CEM-530, Specular Microscope Konan CELLCHEK XL
- Where
- United States
- Volunteers
- 79 people
- Sponsor
- Nidek Co. LTD.
Keratoconus
Changes in the Tear Film With Scleral Contact Lens Wear for Keratoconic Eyes
The purpose of this study is to investigate changes in the level of inflammatory mediators in the tear film of scleral contact lens wearers in a keratoconic population.
- Trial name
- NCT02806921
- Testing
- ZenLens
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University of Waterloo
Dry Eye Syndrome
Safety and Efficacy Study of RX-10045 on the Signs and Symptoms of Dry Eye
The purpose of this study is to compare the safety and efficacy of RX-10045 to placebo for the treatment of the signs and symptoms of dry eye.
- Trial name
- NCT00799552
- Testing
- RX-10045
- Where
- United States
- Volunteers
- 232 people
- Sponsor
- Resolvyx Pharmaceuticals, Inc
Cataract, Presbyopia
Evaluation of Visual Outcomes in Patients With Complex Corneas Implanted With the IC-8 IOL
The purpose of this study is to evaluate visual outcomes in patients with complex corneas who have been previously implanted with the IC-8 IOL after cataract removal.
- Conditions
- Cataract, Presbyopia, Irregular; Contour of Cornea
- Trial name
- NCT05377515
- Where
- Singapore
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- AcuFocus, Inc.
Keratoconus
Lamellar Transplant With Lyophilized Corneas
The goals of this study are to develop a lyophilization method for anterior lamellar transplants in Brasil and to make a comparative analysis among patients transplanted with lyophilized and optisol corneas
- Trial name
- NCT00409955
- Testing
- Lamellar transplant with lyophilized corneas
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- Federal University of São Paulo
Cataract, Cornea
Agreement and Accuracy of Different Devices for Biometry Measurements in Patients With Cataract
The rationale of this study is to compare repeatability, reproducibility and agreement of three different AS-OCT devices and Pentacam.
- Conditions
- Cataract, Cornea, Surgery
- Trial name
- Comparison (NCT04323358)
- Testing
- Biometry, Keratometry
- Where
- Austria
- Volunteers
- 50 people
- Sponsor
- Medical University of Vienna
Corneal Neovascularization
Subconjunctival Aflibercept (EYLEA®) for the Treatment of Corneal Neovascularization
The goal of this current study is to prospectively evaluate the influence of a single subconjunctival aflibercept injection on the regression of corneal neovascularization.
- Trial name
- NCT02797704
- Testing
- Aflibercept
- Where
- Israel
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Rabin Medical Center
Tomography
UNITY DX Cornea Study
The purpose of this study is to validate the clinical measurement performance of an investigational biometer. Subjects will undergo multiple measurements of the eye, and the agreement, repeatability, and reproducibility of…
- Trial name
- NCT07768735
- Testing
- UNITY DX, ANTERION
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Alcon Research
Corneal Dystrophies, Hereditary, Corneal Disease
Studies in Families With Corneal Dystrophy or Other Inherited Corneal Diseases
This study will explore the clinical and hereditary (genetic) features of corneal dystrophy and other inherited corneal disease.
- Trial name
- NCT00357435
- Where
- 6 sites in United States, China and 1 more
- Volunteers
- 86 people
- Sponsor
- National Eye Institute (NEI)
Dry Eye Syndromes
Quantum Molecular Resonance Effects on Patients With Dry Eye Disease
The Rexon Eye device (Resono Ophthalmic Inc, Trieste, Italy) is a new device based on QMR technology. Quantum Molecular Resonance (QMR) is a technique in which low-intensity, high-frequency electric currents are administered to a…
- Trial name
- NCT05469932
- Testing
- Rexon device
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Assaf-Harofeh Medical Center
Keratoconus
Treatment of Keratoconus With Advanced CXL-II
The purpose of this study is to determine whether individualized, topography-based corneal crosslinking for keratoconus can improve the optical outcomes of the treatment.
- Trial name
- NCT02514200
- Testing
- Topography-based CXL (KXL2), Conventional pulsed CXL (pCXL), Riboflavin
- Volunteers
- 50 people
- Sponsor
- Umeå University
Fuch's Endothelial Dystrophy, Pseudophakic Bullous Keratopathy
Comparison of Corneal Grafts Cultured in Serum-free Versus Corneal Grafts Cultured in Serum Supplemented Culture Media
The goal of this clinical trial is to compare the quality of corneal grafts cultured in a serum-free culture medium with a defined composition versus corneal grafts cultured in a standard serum supplemented culture medium…
- Trial name
- SFM (NCT00623584)
- Testing
- Corneal transplantation
- Where
- 2 sites in Germany
- Volunteers
- 60 people
- Sponsor
- Klinikum Chemnitz gGmbH
Keratoconus
Safety and Effectiveness of the PXL-Platinum 330 System for Cornea Crosslinking in Eyes With Cornea Thinning
This study study is to determine the effectiveness of cornea cross linking in patients with Keratoconus or other cornea thinning conditions.
- Trial name
- CXL (NCT05516004)
- Testing
- PXL Platinum 330 system
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Cohen Laser and Vision Center
Healthy Individuals, Diabetes
Heidelberg In Vivo Confocal Microscopy to Evaluate the Ocular Surface Disorders of Healthy and Diseased Individuals
In vivo confocal microscopy (IVCM) has been used in clinical settings for more than 25 years, and is noninvasive, rapid and easily repeatable technique to investigate ocular surface disorders.
- Conditions
- Healthy Individuals, Diabetes, Hypertension, Fabry Disease
- Trial name
- NCT04025801
- Where
- Taiwan
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital