Clinical trials: Corneal Cross-Linking
Keratoconus
Efficacy of Customized Corneal Cross-linking vs. Standard Corneal Cross-linking
The standard or Dresden protocol was established in 2003 and treats the entire cornea. However, recent ultra-structural research showed that keratoconus is localized.
- Trial name
- C-CROSS (NCT04532788)
- Testing
- Customized crosslinking, Standard crosslinking
- Where
- 3 sites in Netherlands
- Volunteers
- 124 people
- Sponsor
- Maastricht University Medical Center
Keratoconus
Evaluate the Safety and Feasibility of Same-Day Bilateral Epithelium-On Corneal Cross-Linking for Keratoconus
Clinical trial to evaluate the safety and feasibility of corneal cross-linking in both eyes on the same day in subjects with keratoconus.
- Trial name
- NCT07629557
- Testing
- Riboflavin Ophthalmic Solutions, UV-A Irradiation System
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Glaukos Corporation
Provide Evidence-based Recommendations for Clinicians to Optimize Pain Control After CXL
Pain Relief After Corneal Collagen Cross-Linking
Keratoconus is a progressive corneal ectasia that can lead to significant visual impairment and decreased quality of life. The introduction of corneal cross-linking (CXL) with riboflavin and ultraviolet-A (UVA) light has…
- Trial name
- NCT06212830
- Testing
- Gabapentin, Targin, NSAID
- Where
- Israel
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Assaf-Harofeh Medical Center
Keratoconus, Unstable, Collagen Crosslinking
Intracanalicular Dexamethasone Insert for Post-Corneal Cross-Linking Inflammation and Pain- The LINK Study
There is no standard of care medication regimen for the management of pain and inflammation post-corneal crosslinking (CXL), although most cornea specialists agree on use of an antibiotic and steroid eye drop in the immediate…
- Conditions
- Keratoconus, Unstable, Collagen Crosslinking, Postoperative Pain
- Trial name
- NCT04168112
- Testing
- Dextenza, Prednisolone Acetate
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Sight Medical Doctors PLLC
Keratoconus
Refractive Corneal Cross-linking for Progressive Keratoconus
Young patients with keratoconus face two problems: disease progression and corneal shape irregularity. Both underlie the 20% rate of corneal transplantation in keratoconics required to maintain useful vision.
- Trial name
- NCT03531047
- Testing
- Customised CXL
- Where
- United Kingdom
- Volunteers
- 53 people
- Sponsor
- Moorfields Eye Hospital NHS Foundation Trust
Keratoconus, Keratoconus, Unstable
Corneal Biomechanical Analysis Using Brillouin Microscopy
The objective of this study is to measure the Brillouin biomechanical properties in keratoconic corneas and characterize biomechanical alterations that occur after corneal procedures that inherently strengthen or weaken the…
- Conditions
- Keratoconus, Keratoconus, Unstable, Keratoconus, Stable
- Trial name
- NCT04598932
- Testing
- Brillouin microscopy
- Where
- United States
- Volunteers
- 220 people
- Sponsor
- The Cleveland Clinic
Corneal Ectasia, Corneal Disease
Dresden Corneal Disease and Treatment Study
The purpose of this study is long-term follow up of patients with corneal diseases to analyze the quality of surgical interventions and diagnosis.
- Conditions
- Corneal Ectasia, Corneal Disease, Corneal Astigmatism, Keratoconus
- Trial name
- NCT04251143
- Testing
- corneal cross-linking, corneal topography and tomography
- Where
- Germany
- Volunteers
- 700 people
- Sponsor
- Technische Universität Dresden
Keratoconus
PRoTECT: Corneal Wavefront Guided PRK + Epi-off CXL vs. PTK+Epi-off CXL in Keratoconus
Keratoconus causes irregular astigmatism and reduced vision. Epi-off corneal crosslinking (CXL) stabilizes the cornea but often leaves higher-order aberrations uncorrected.
- Trial name
- PRoTECT (NCT07372911)
- Testing
- Schwind AMARIS excimer laser, Corneal collagen crosslinking epi-off accelerated
- Where
- Mexico
- Volunteers
- 50 people
- Sponsor
- Instituto de Oftalmología Fundación Conde de Valenciana
Progressive Keratoconus
Epi-keratoplasty Versus Collagen Cross-Linking in Progressive Keratoconus
Epi-keratoplasty Versus Collagen Cross-Linking in Progressive Keratoconus
- Trial name
- NCT02721628
- Testing
- Epi-keratoplasty, Collagen Cross-Linking, Femtosecond laser
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Sun Yat-sen University
Progressive Keratoconus
Transepithelial Corneal Cross-linking Using Iontophoresis
The purpose of the present Randomized Clinical Trial (RCT) is to compare the efficacy and safety of transepithelial corneal cross-linking using iontophoresis (T-ionto CL) to treat progressive keratoconus in comparison with…
- Trial name
- T-iontoCL (NCT02117999)
- Testing
- Cross-linking with iontophoresis, Standard corneal cross-linking
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Fondazione G.B. Bietti, IRCCS
Keratolysis
Vision Restoration With a Collagen Crosslinked Boston Keratoprosthesis Unit
This is a phase I/II prospective, randomized, multi-center, double-masked, vehicle-controlled clinical trial evaluating the safety and efficacy of corneal collagen cross-linking the keratoprosthesis carrier tissue in subjects who…
- Trial name
- NCT02863809
- Testing
- Riboflavin, Dextran, UVA Light Source
- Where
- 13 sites in United States
- Volunteers
- 76 people
- Sponsor
- Joseph B. Ciolino, MD
Unstable Corneas
Corneal Cross-Linking Comparing Variables
The purpose of this study is to evaluate the Safety and Efficacy of Corneal Cross Linking in a Continuous Beam versus Pulsed Treatments across epithelium on and epithelium off surfaces.
- Trial name
- NCT02095730
- Testing
- Epithelium-On Riboflavin, Epithelium-Off Riboflavin, UV Light - Continuous Beam
- Where
- 16 sites in United States
- Volunteers
- 500 people
- Sponsor
- Crowd Health Research, LTD
Myopia
Evaluation of the Safety and Efficacy of Corneal Cross Linking for the Treatment of Myopia.
43 Subjects (43 eyes) qualified for participation will undergo the required screening procedures to determine study eligibility. The surgical protocol involves applying riboflavin 0,22% to 0,25 % up to 20 minutes .
- Trial name
- CXLMyopie (NCT02872766)
- Testing
- CXL Myopia
- Where
- France
- Volunteers
- 24 people
- Sponsor
- University Hospital, Toulouse
Keratoconus
Evaluating Collagen Cross-Linking (CCL) Treatment in Norway
The purpose of this study is to assess safety, efficacy and stability of riboflavin-UV induced cross-linking of corneal collagen in reducing the progression of keratecatasia and in improving visual acuity.
- Trial name
- NCT00435799
- Testing
- corneal cross-linking (CCL), Riboflavin/dextran eyedrops, UV-X system
- Where
- 2 sites in Norway
- Volunteers
- 40 people
- Sponsor
- Ullevaal University Hospital
Infectious Keratitis, Bacterial Keratitis
Collagen Cross-linking in Infectious Keratitis Trial
The purpose of this study is to evaluate the efficacy of collagen cross-linking for treatment of infectious keratitis.
- Conditions
- Infectious Keratitis, Bacterial Keratitis, Fungal Keratitis
- Trial name
- NCT01831206
- Testing
- Collagen cross-linking
- Where
- Thailand
- Volunteers
- 30 people
- Sponsor
- Chulalongkorn University
Keratoconus
Collagen Cross-linking in Keratoconus
Optical Coherence Tomography (OCT) devices are non-contact instruments that can measure the depth of scars, other causes of cloudiness of the cornea, and degree of corneal thinning in patients with keratoconus.
- Trial name
- NCT03760432
- Testing
- Laser Custom Corneal Collagen Cross-Linking
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Oregon Health and Science University
Keratoconus
Transepithelial Corneal Collagen Cross-linking (CXL) in Treatment of Keratoconus
Transepithelial CXL (performed without epithelial removal) seem to have similar clinical effect on keratoconic eyes compared to the standard CXL (which includes epithelial removal).
- Trial name
- NCT01181219
- Testing
- CXL without epithelial removal, CXL with epithelial removal
- Where
- Norway
- Volunteers
- 20 people
- Sponsor
- University Hospital of North Norway
Keratoconus
Customized Crosslinking: Safety and Efficacy in an Epithelium-off Accelerated-pulsated Protocol for Thin Keratoconus
The goal of this clinical trial is to document corneal ectasia stability in patients with keratoconus diagnosis treated with personalized cross linking energy.
- Trial name
- NCT06159881
- Testing
- Corneal Cross Linking
- Where
- Mexico
- Volunteers
- 20 people
- Sponsor
- Instituto de Oftalmología Fundación Conde de Valenciana
Keratoconus
Treatment of Keratoconus Using Collagen Cross-Linking
The purpose of this study is to determine the effectiveness of collagen cross-linking in the cornea in halting the progression and possibly partially reversing the effects of keratoconus.
- Trial name
- NCT00841386
- Testing
- Riboflavin-5-phosphate
- Where
- 2 sites in United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University at Buffalo
Keratoconus
Epi Off Versus Epi on Corneal Collagen Cross-linking in Keratoconus Patients
To evaluate two different techniques of cross linking: standard epithelium off (CXL epi off) versus trans-epithelial (CXL epi on) cross linking in patient with progressive keratoconus.
- Trial name
- NCT03598634
- Testing
- administration of riboflavin for epi-off cross-linking, administration of riboflavin for epi-on cross-linking
- Volunteers
- 32 people
- Sponsor
- University of Molise