Clinical trials: Corneal Disease
Keratoconus
Refractive Treatment of Early Keratoconus
Keratoconus is a bilateral, progressive corneal degenerative disorder that often leads to significant visual deterioration over time.
- Trial name
- NCT02613780
- Testing
- Crosslinking, Photorefractive keratectomy, iDesign® Advanced WaveScan Studio
- Volunteers
- 24 people
- Sponsor
- Ottawa Hospital Research Institute
Dry Eye Disease
Ocular Surface Immune Response in Dry Eye Disease
In vivo confocal microscopy (IVCM) is a sensitive imaging tool for detecting dry eye-associated subclinical inflammation. Studies have previously shown that IVCM provides an in vivo metric to measure inflammatory changes in the…
- Trial name
- NCT02042820
- Testing
- In vivo confocal microscopy (IVCM)
- Where
- United States
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Tufts Medical Center
Myopia, Orthokeratology
Assessment of Corneal Biomechanics With the Corvis ST in Different Age of Myopia With Orthokeratology
The present research focused on the effect of the age for the corneal biomechanics of low and moderate myopia patients after wearing orthokeratology (OK lens). According to age, the included cases were divided into 3 groups.
- Trial name
- NCT05635526
- Where
- China
- Volunteers
- 134 people
- Sponsor
- Tianjin Eye Hospital
Diabetes Mellitus
Corneal Endothelial Cell Loss in Diabetes Type II During Cataract Surgery
The aim of the present study is to evaluate changes in the morphology and function of the corneal endothelium before and after cataract surgery in patients with diabetes type II.
- Trial name
- NCT00446277
- Testing
- cataract surgery
- Where
- Denmark
- Volunteers
- 30 people
- Sponsor
- Frederiksberg University Hospital
Persistent Corneal Epithelial Defect, Corneal Epithelial Disorders
Efficacy of Topical Mesenchymal Stromal Cell Secretome for Ocular Surface Disease
In this phase II randomized double-masked clinical trials, subjects with non-resolving corneal epithelial disease/defect (i.e., refractory to standard treatments for at least two weeks) will receive 8 weeks treatment of topical…
- Trial name
- NCT06919081
- Testing
- Allogeneic Bone-Marrow Derived Mesenchymal Stromal Cells Secretome, Vehicle Control
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Illinois Chicago
Persistent Corneal Epithelial Defect
An Efficacy and Safety Study of Cenegermin Ophthalmic Solution Compared With Vehicle in the Treatment of PCED
This is a phase 3, randomized, multicenter, double-masked, parallel group, vehicle-controlled prospective clinical trial to evaluate the safety and efficacy of cenegermin in inducing complete epithelial healing in participants…
- Trial name
- NCT07519902
- Testing
- Cenegermin, Vehicle
- Where
- 77 sites in United States, Argentina and 12 more
- Volunteers
- 150 people
- Sponsor
- Dompé Farmaceutici S.p.A
Keratoconus
Cross Linking Corneal Biomechanical Evaluation of CATS Tonometer Prism
The purpose of this study is to determine if the device, CATS tonometer prism, measures intraocular pressure significantly differently than the current standard of care tonometer prism (Goldmann) before and after a corneal…
- Trial name
- NCT04180111
- Testing
- CATS Tonometer
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Intuor Technologies, Inc.
Keratoconus, Corneal Ectasia
Corneal Collagen Crosslinking and Intacs for Keratoconus and Ectasia
This study will determine the efficacy of corneal collagen crosslinking (CXL) combined with Intacs for the treatment of keratoconus and corneal ectasia.
- Trial name
- CXL (NCT01112072)
- Testing
- Riboflavin
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- Cornea and Laser Eye Institute
Eye Diseases
Deep Learning for Classification of Scheimpflug Corneal Tomography Images
Keratoconus is a common disorder. An early diagnosis influences the disease prognosis in the affected patients and prevents postoperative complications in patients with keratoconus considering refractive surgery.
- Trial name
- NCT04497207
- Testing
- Scheimpflug Camera Corneal Tomography
- Where
- Egypt
- Volunteers
- 1,669 people, healthy volunteers welcome
- Sponsor
- Assiut University
Cataracts
Clear Corneal Incisions and Arcuate Incisions Utilizing FemtoSecond Laser Technology for Cataract Surgery
The purpose of this study is to prove the efficacy and safety of the Femtosecond laser to create a clear corneal incision during cataract surgery.
- Trial name
- NCT01383057
- Testing
- Femtosecond Laser
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Innovative Medical
Aphakia, Corneal Astigmatism
Clareon Toric Study (T2-T9)
The purpose of this post-market study is to describe the long-term safety and performance of Clareon Toric Intraocular Lenses (IOLs).
- Trial name
- NCT06285695
- Testing
- Clareon Toric IOL, Cataract surgery
- Where
- 6 sites in Canada
- Volunteers
- 129 people
- Sponsor
- Alcon Research
Corneal Ectasia, Corneal Disease
Computer-aided Diagnosis of Ocular Diseases Based on Corneal Biomechanics
The purpose of this study is the investigation of biomechanical properties of the cornea using computer-aided data analysis. Currently, it is known that keratoconus and glaucoma are ocular disease that are associated with…
- Conditions
- Corneal Ectasia, Corneal Disease, Corneal Astigmatism, Keratoconus
- Trial name
- EyeTwin (NCT04475900)
- Testing
- Corneal biomechanics (Corvis ST, Oculus, Wetzlar, Germany), Corneal topography and tomography (Pentacam, Oculus, Wetzlar, Germany), Optic nerve head measurement
- Where
- Germany
- Volunteers
- 372 people, healthy volunteers welcome
- Sponsor
- Technische Universität Dresden
Corneal Transplant Failure, Corneal Endothelial Cell Loss
The Viability Control of Human Endothelial Cells Before Keratoplasty (V-CHECK) Study
The purpose of this international cohort study is to validate a new method for preoperative assessment of endothelial viability in donor corneal tissues for transplantation, and to correlate endothelial health as assessed by the…
- Trial name
- V-CHECK (NCT05847387)
- Testing
- V-Check
- Where
- 12 sites in Belgium, Germany and 4 more
- Volunteers
- 135 people
- Sponsor
- Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
Inflammation, Uveitis
Evaluation of Corneal Endothelial Cell Density in Subjects Who Have Had a Fluocinolone Acetonide Implant
Investigate the impact of the Fluocinolone Acetonide (FA) intravitreal implants
- Trial name
- NCT01060787
- Testing
- Fluocinolone Acetonide 0.59 mg, Fluocinolone Acetonide 2.1 mg
- Where
- United States
- Volunteers
- 98 people
- Sponsor
- Bausch & Lomb Incorporated
Corneal Endothelial Cell Loss, Fuchs' Endothelial Dystrophy
Technique And Results In Endothelial Keratoplasty
To assess and compare the complications and results of different lamellar endothelial keratoplasty techniques and its variations.
- Trial name
- TREK (NCT02470793)
- Testing
- Descemet Stripping Automated Endothelial Keratoplasty, Descemet Membrane Endothelial Keratoplasty
- Where
- Spain
- Volunteers
- 62 people
- Sponsor
- EDUARD PEDEMONTE-SARRIAS
Pseudophakic Bullous Keratopathy, Glaucoma
The Effect of ROCK Inhibitors on Corneas of Patients With Glaucoma and Pseudophakic Bullous Keratopathy (PBK)
The goal of this clinical trial is to learn if topical netarsudil/latanoprost works to treat pseudophakic bullous keratopathy in patients with glaucoma.
- Trial name
- NCT06960629
- Testing
- Netarsudil 0.02%/latanoprost 0.005% fixed dose combination ophthalmic solution
- Where
- Croatia
- Volunteers
- 50 people
- Sponsor
- University Hospital Dubrava
Cataract Surgery, Cataract and Fuchs Endothelial Corneal Dystrophy
Trial Comparing Cataract Surgery With Triple-DMEK in Patients With Cataract and Fuchs Endothelial Corneal Dystrophy
The purpose of the study is to investigate whether there is a difference in BCVA in patients who receive one of the following two surgeries: intervention group (arm 1) cataract surgery alone and control group (arm 2) cataract…
- Trial name
- ETCF (NCT06425666)
- Testing
- Intervention group /arm 1 (Cataract surgery alone), Control group /arm 2: Corneal transplantation as Descemet Membrane Endothelial Keratoplasty (DMEK) in combination with cataract surgery (triple-DMEK)
- Where
- 4 sites in Denmark, Germany and 2 more
- Volunteers
- 120 people
- Sponsor
- University of Cologne
Limbal Stem-cell Deficiency
Multiple Noninvasive Examination Modality to Evaluate the Severity of Ocular Surface Disorders
Here the investigators proposed this study to collect cases of different etiologies of ocular surface diseases. With at least one of these four non-invasive examination modalities, the investigators aim to analyze and compare the…
- Trial name
- NCT03594370
- Where
- Taiwan
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Myopia, Astigmatism
LASIK Surgery With a New Laser for the Treatment of Myopia Without Astigmatism
The AQUARIUZ ablation laser is a solid-state laser and has been CE approved for corneal surgery since March 2020 for the treatment of short- and longsightedness with and without astigmatism.
- Trial name
- AQUARIUZ2020 (NCT04794023)
- Testing
- Corneal Ablation
- Where
- Switzerland
- Volunteers
- 27 people
- Sponsor
- Ziemer Ophthalmic Systems AG
Open Angle Glaucoma
The Effects of DSLT and SLT on the Corneal Endothelium: A GLAUrious Trial Sub-Study
The objective of this study is to compare the long-term (6 months) effects of Direct Selective Laser Trabeculoplasty (DSLT) treatment and SLT (Selective Laser Trabeculoplasty) treatment on corneal endothelial cell counts and…
- Trial name
- NCT04758598
- Testing
- Direct Selective Laser Trabeculoplasty (DSLT), Selective Laser Trabeculoplasty (SLT)
- Where
- Georgia
- Volunteers
- 20 people
- Sponsor
- BelkinVision