Clinical trials: Corneal Diseases
Diabetes Mellitus, Corneal Endothelial Cell Loss
Effect of Intracameral Dexamethasone After Phacoemulsification in Diabetics on Corneal Endothelial Cell Density
The prevalence of diabetes mellitus (DM) is rapidly growing worldwide. One major concern with diabetes mellitus is how it may affect vision in different ways; including the increased risk of developing cataract.
- Conditions
- Diabetes Mellitus, Corneal Endothelial Cell Loss, Dexamethasone Adverse Reaction, Corneal Endothelial Decompensation
- Trial name
- DIABEDEX (NCT03361709)
- Testing
- Dexamethasone, Saline Solutions, Intraocular
- Sponsor
- Cairo University
Corneal Ulcer, Neurotrophic Corneal Ulcer
Topical Insulin in Neurotrophic Keratopathy After Diabetic Vitrectomy
Various treatment options have been proposed in managing NK such as preservative-free lubrication (PF-L), withdrawal of epitheliotoxic medication, prophylactic antibiotics, applying of bandage contact lenses, using…
- Conditions
- Corneal Ulcer, Neurotrophic Corneal Ulcer, Diabetes Mellitus
- Trial name
- NCT05940376
- Testing
- rapid acting insulin
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Benha University
Herpes Simplex Dendritic Keratitis
Evaluating Adjunctive Cryopreserved Amniotic Membrane Treatment in Herpes Simplex Dendritic Keratitis
To prospectively evaluate the effectiveness of Prokera Slim in adults with primary or recurrent herpetic epithelial keratitis in terms of visual function, corneal opacity, time to resolution, cost of care, number of patient…
- Trial name
- NCT04598282
- Testing
- Prokera Slim, Standard of Care
- Where
- United States
- Sponsor
- Oregon Health and Science University
Glaucoma
Study of Corneal Biomechanics in Glaucoma Patients Using Brillouin Microscopy
This pilot study evaluates the biomechanical properties of the cornea in glaucoma patients using Brillouin microscopy, a non-contact imaging technique.
- Trial name
- NCT06993597
- Testing
- Prostaglandin Analogue -Containing IOP-Lowering Therapy, Beta Blocker, Brillouin Microscopy
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Fuchs Dystrophy, Pseudophakic Bullous Keratopathy
OCT in Fuchs' Dystrophy
This is an observational study using optical coherence tomography (OCT) technology to quantify corneal edema in Fuchs' endothelial dystrophy and predict refractive shift from resolving corneal edema after surgical treatments.
- Trial name
- NCT04258787
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Oregon Health and Science University
Excess Skin of Both Eyelids, Contrast Sensitivity
The Effect of Upper Blepharoplasty on Vision Quality in the Early Postoperative Period
Contrast sensitivity (CS) and tear film (TF) changes are noted in late postoperative period after upper blepharoplasty (UB), while the same was rarely investigated in the early postoperative period.
- Conditions
- Excess Skin of Both Eyelids, Contrast Sensitivity, Tear Film Insufficiency of Both Eyes, Corneal Topography
- Trial name
- NCT05549713
- Testing
- Upper blepharoplasty
- Where
- Croatia
- Volunteers
- 40 people
- Sponsor
- Osijek University Hospital
Myopia, Keratoconus
Assessment of Corneal Biomechanical Properties Using Corvis ST and ECD Following LASIK, PRK, CXL, Veriflex IOL and Implantable Collamer Lens
To evaluate corneal biomechanical changes using the Corvis ST and ECD in patients who have under-gone LASIK, PRK, corneal cross-linking (CXL), Veriflex IOL and ICL.
- Conditions
- Myopia, Keratoconus, Refractive Surgery
- Trial name
- NCT06818461
- Testing
- Corvis St Before and after lasik, PRK, CXL, Veriflex IOL and ICL
- Where
- Egypt
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Beni-Suef University
Cataract, Fuchs Endothelial Corneal Dystrophy
Partial Range Of Field IOLs in DMEK-Enabled Procedures
Study Overview This study aims to evaluate the visual outcomes, quality of vision, and patient satisfaction after receiving an extended range PRoF intraocular lens (IOL) during triple Descemet Membrane Endothelial Keratoplasty…
- Trial name
- PROFIDE (NCT07441616)
- Testing
- combined cataract and lamellar endothelial keratoplasty
- Where
- Belgium
- Volunteers
- 10 people
- Sponsor
- Universitair Ziekenhuis Brussel
Primary Pterygium, Astigmatism
Preoperative and Postoperative Refractive and Topographic Evaluation in Patients With Primary Pterygium: Comparison of Two Surgical Techniques
This study evaluated changes in refractive status and corneal topography before and after surgical treatment of primary pterygium.
- Trial name
- RETOP (NCT07742995)
- Testing
- Conjunctival Autograft, Amniotic Membrane Transplantation
- Volunteers
- 78 people
- Sponsor
- Instituto de Oftalmología Fundación Conde de Valenciana
Corneal Astigmatism, Intraocular Pressure
How Astigmatism Influences Corneal Biomechanics and Intraocular Pressure
The aim of the study was to identify whether preoperative corneal astigmatism can influence corneal biomechanics and the assessment of intraocular pressure (IOP) following micro-incision phacoemulsification.
- Conditions
- Corneal Astigmatism, Intraocular Pressure, Cataract Senile
- Trial name
- NCT03162471
- Testing
- non-contact measurement of intraocular pressure
- Volunteers
- 39 people
- Sponsor
- Medical University of Lodz
Keratoconus
Collagen Cross-linking in Keratoconus
Optical Coherence Tomography (OCT) devices are non-contact instruments that can measure the depth of scars, other causes of cloudiness of the cornea, and degree of corneal thinning in patients with keratoconus.
- Trial name
- NCT03760432
- Testing
- Laser Custom Corneal Collagen Cross-Linking
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Oregon Health and Science University
Dry Eye Syndromes
Quantum Molecular Resonance Effects on Patients With Dry Eye Disease
The Rexon Eye device (Resono Ophthalmic Inc, Trieste, Italy) is a new device based on QMR technology. Quantum Molecular Resonance (QMR) is a technique in which low-intensity, high-frequency electric currents are administered to a…
- Trial name
- NCT05469932
- Testing
- Rexon device
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Assaf-Harofeh Medical Center
Cataract
Corneal Edema After Phacoemulsification
To compare the impact of two phacoemulsification techniques (subluxation versus divide-and-conquer) on postoperative corneal edema at postoperative hour 1 and day 4.
- Trial name
- COPHA (NCT03689270)
- Testing
- Subluxation, Divide and conquer
- Volunteers
- 96 people
- Sponsor
- Centre Hospitalier Régional Metz-Thionville
Keratoconjunctivitis Sicca
Phase 3 Study of OTX-101 in the Treatment of Keratoconjunctivitis Sicca
This is a randomized, double-masked, vehicle-controlled study of the safety and efficacy of OTX-101 (0.09% cyclosporine nanomicellar solution) in the treatment of keratoconjunctivitis sicca to be conducted at approximately 50…
- Trial name
- Emerald (NCT02688556)
- Testing
- cyclosporine, vehicle of OTX-101
- Where
- 3 sites in United States
- Volunteers
- 745 people
- Sponsor
- Sun Pharmaceutical Industries Limited
Corneal Astigmatism
Treatment of Vision Disturbances Due to Corneal Irregularities by Trans-epithelial Optical Phototherapeutic Keratectomy (TE-oPTK)
This study sets out to evaluate the EpiMaster application software for use in predicting the refractive change induced by a trans-epithelial phototherapeutic keratectomy (TE-PTK) procedure in eyes with irregularly irregular…
- Trial name
- NCT03841253
- Testing
- Trans-epithelial PTK, Trans-epithelial PTK (retrospective data collection), EpiMaster Application Software
- Where
- United Kingdom
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- London Vision Clinic
Progressive Keratoconus
Evaluation of Corneal Hysteresis and Corneal Resistance Factor After Corneal Cross-linking for Keratoconus
This study attempts to compare Corneal Hysteresis (CH) and Corneal Resistance Factor (CRF) in a series of keratoconic eyes before and after Corneal collagen cross-linking (CXL).
- Trial name
- NCT01411384
- Testing
- Corneal collagen cross-linking, Ocular Response Analyzer (ORA)
- Volunteers
- 80 people
- Sponsor
- Democritus University of Thrace
Cornea
Intranasal Neurostimulation in Ameliorating Symptoms of Neuropathic Corneal Pain
This study is a prospective, interventional, open-label, single arm, non-randomized trial treating 30 patients with peripheral or mixed neuropathic corneal pain at their baseline exam and following 45 days and 90 days of daily…
- Trial name
- INSTANT (NCT03674892)
- Testing
- TrueTear™ intranasal neurostimulator (ITN)
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Tufts Medical Center
Keratoconjunctivitis Sicca
Effect of Controlled Adverse Environment (CAE) on Tear Film Stability
The purpose of this study is to evaluate the effect of the controlled adverse environment (CAE) on Mean Break-Up Area in subjects diagnosed with Dry Eye Syndrome.
- Trial name
- NCT01547936
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- ORA, Inc.
Keratoconus
Placebo-controlled Study to Evaluate the Safety and Efficacy of GLK-221 Ophthalmic Solution in Subjects With Keratoconus
Multi-center, parallel-group, placebo-controlled trial designed to assess the safety and efficacy of twice-daily topically administered GLK-221 Ophthalmic Solution in subjects with keratoconus.
- Trial name
- NCT07400952
- Testing
- GLK-221 Ophthalmic Solution
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Glaukos Corporation
Dry Eye, Dry Eye Syndromes
Tear Production by Nasal Neurostimulation Compared to Active Control
This crossover design study evaluates the effectiveness of the Oculeve Intranasal Neurostimulator comparing the effect of intranasal (active) versus extranasal (control) stimulation on tear production as measured by the Jones…
- Conditions
- Dry Eye, Dry Eye Syndromes, Keratoconjunctivitis Sicca
- Trial name
- NCT02970799
- Testing
- Intranasal Neurostimulator
- Volunteers
- 27 people
- Sponsor
- Oculeve, Inc.