Clinical trials: Corneal Epithelial Wound Healing
Corneal Epithelial Disorders
Safety and Efficacy of SJP-0035 Ophthalmic Solution in Patients With Moderate to Severe Corneal Epithelial Disorders
The purpose of this study is to determine whether SJP-0035 ophthalmic solution is effective in promoting corneal epithelial wound healing in conditions associated with corneal epithelial disorders.
- Trial name
- NCT02929823
- Testing
- High Dose SJP-0035 Ophthalmic Solution, Low Dose SJP-0035 Ophthalmic Solution, Vehicle of SJP-0035 Ophthalmic solution
- Where
- 19 sites in United States
- Volunteers
- 130 people
- Sponsor
- Senju Pharmaceutical Co., Ltd.
Corneal Epithelial Disorders
Safety and Efficacy Study of SJP-0035 Ophthalmic Solution in Patients With Moderate to Severe Corneal Epithelial Disorders
The purpose of the study is to determine if SJP-0035 ophthalmic solution is effective in promoting corneal epithelial wound healing in conditions associated with corneal epithelial disorders.
- Trial name
- NCT02104388
- Testing
- SJP-0035 Ophthalmic Solution, Vehicle of SJP-0035 Ophthalmic Solution
- Where
- 17 sites in United States
- Volunteers
- 69 people
- Sponsor
- Senju Pharmaceutical Co., Ltd.
Corneal Epithelial Wound Healing
Evaluation of Dexpanthenol and Hyaluronic Acid Eye Drops on Corneal Epithelialization After Trans Epithelial PRK
The aim of this prospective, contralateral, randomized, double-blind, placebo-controlled study is the evaluation of the performance of a fixed combination of dexpanthenol and hyaluronic acid preservative-free eye artificial tears…
- Trial name
- NCT06822608
- Testing
- dexpanthenol and hyaluronic acid preservative-free eye artificial tears eye drops
- Where
- Greece
- Volunteers
- 68 people
- Sponsor
- National and Kapodistrian University of Athens
Corneal Epithelial Wound
Topical Insulin Versus Autologous Serum After Corneal Surgeries
The aim of the study is to test whether use of topical insulin or autologous serum eye-drops can promote corneal epithelial healing following photorefractive keratectomy (PRK).
- Trial name
- NCT05331859
- Testing
- Insulin, autologous serum (AS), conventional
- Where
- 2 sites in Egypt
- Volunteers
- 250 people
- Sponsor
- Benha University
Corneal Epithelial Wound Healing
Effect of Topical Fluoroquinolones on Epithelial Wound Healing After PRK
The prescribed antibiotic for prophylaxis of infection following PRK should be effective at eradicating a potential infection. In addition, the antibiotic should have a rapid onset of action, effectively penetrate the target…
- Trial name
- NCT00569881
- Testing
- gatifloxacin and moxifloxacin
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Donnenfeld, Eric, M.D.
Eye Injuries
Comparison of the Effects on Promoting Corneal Epithelial Wound Healing Between Human Auto-Serum and Cord Blood Serum
Human serum eye drops have been successfully used in the treatment of severe ocular surface disorders and the enhancement of corneal wound healing.
- Trial name
- NCT00598299
- Testing
- venous puncture, obtain serum from perripheral blood or cord blood
- Where
- Taiwan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Corneal Epithelial Wound Healing
Cross-linked CMC and Silk Proteins in Corneal Re-epithelization
Data analyses and revision of the corneal re-epithelization in patients who underwent either PRK (Photorefractive Keratectomy), CXL (Corneal Cross-Linking), PTK (phototherapeutic keratectomy), or experienced a corneal abrasion.
- Trial name
- CLCS (NCT06840990)
- Testing
- CXC-SP, CTRL
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- D&V FARMA srl
Corneal Epithelial Wound Healing
Corneal Epithelial Wound Healing Difference Between Human Autoserum and Cord Blood Serum
Human serum eye drops have been successfully used in the treatment of severe ocular surface disorders and the enhancement of corneal wound healing.
- Trial name
- NCT00681642
- Where
- Taiwan
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Corneal Dystrophy, Epithelial Basement Membrane, Epithelial Recurrent Erosion Dystrophy
Cacicol20® in Corneal Wound Healing and Nerve Regeneration After Phototherapeutic Keratectomy
The objective of this clinical study is to test the efficacy of CACICOL20® (RGTA OTR 4120) in improving wound healing and nerve regeneration in the anterior cornea, in a patient population undergoing therapeutic laser treatment…
- Conditions
- Corneal Dystrophy, Epithelial Basement Membrane, Epithelial Recurrent Erosion Dystrophy, Corneal Erosions
- Trial name
- CACICOL-PTK (NCT02373397)
- Testing
- Cacicol20
- Where
- 2 sites in Sweden
- Volunteers
- 40 people
- Sponsor
- Neil Lagali
Diabetes
A Phase 2 Study of the Safety and Efficacy of Thymosin Beta 4 for Treating Corneal Wounds
As a consequence of damage to multiple organ systems throughout the course of their disease, diabetic patients suffer a number of chronic complications giving rise to increased morbidity, mortality, and health care costs specific…
- Trial name
- NCT00598871
- Testing
- Thymosin Beta 4 (Tβ4)
- Where
- 5 sites in United States
- Volunteers
- 12 people
- Sponsor
- ReGenTree, LLC
Limbal Stem Cell Deficiency
Limbal Stem Cell Deficiency (LSCD) Treatment With Cultivated Stem Cell (CALEC) Graft
The main aim of the study is to determine the safety and feasibility of a cultivated autologous limbal epithelial cell (CALEC) transplantation in the treatment of limbal stem cell deficiency.
- Trial name
- CALEC (NCT02592330)
- Testing
- Biopsy to collect limbal epithelial stem cells that will be cultivated into a graft, Cultivation of Limbal epithelial cells into a graft, CALEC Transplant
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Massachusetts Eye and Ear Infirmary
Comparison of Epitheliotrophic Ability Between Human Serum and Commercialized Human Platelet- Cell and Animal Model
The Effect of Platelet Lysate on Corneal Epithelial Wound healing---the Collection of Human Serum From Volunteers
"Poor corneal epithelialization problem" can be found in a lot of ocular surface disorders, including limbal insufficiency, dry eye, chemical burn and neurotrophic disorders.
- Trial name
- NCT02720146
- Where
- Taiwan
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Corneal Epithelial Wound Healing
Efficacy of Topical Insuline in Corneal Epithelial Healing Post PRK
A prospective randomized double-blind controlled trial will be conducted. The informed consent of each patient will be obtained prior to the procedure.
- Trial name
- NCT06956846
- Testing
- insulin eye drops, Artificial tears eye-drops
- Where
- Lebanon
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Hotel Dieu de France Hospital
Corneal Epithelial Wound Healing
Lacripep for Corneal Wound Healing Study
The objective of this study is to evaluate the safety and effectiveness of Lacripep as a therapy for superficial corneal injury repair after Photorefractive keratectomy (PRK).
- Trial name
- NCT06854393
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- Henry M. Jackson Foundation for the Advancement of Military Medicine
Corneal Epithelial Wound Healing, Post Operative Pain
Insulin Eye Drops and Epithelial Healing After Corneal Cross-linking
The goal of this clinical trial was to learn if topical insulin eye drops affected corneal epithelial wound healing after corneal collagen cross-linking.
- Trial name
- NCT07812129
- Testing
- Insulin eye drops, standard post-operative topical drops
- Where
- Egypt
- Volunteers
- 24 people
- Sponsor
- Cairo University
Corneal Diseases
Effect of Systemic Oxygen on Corneal Epithelial Wound Healing in Diabetic Patients Undergoing Pars Plana Vitrectomy
1. To compare the corneal epithelial defect healing time between diabetic patients receiving and not receiving supplementary oxygen after vitrectomy. 2.
- Trial name
- NCT02344732
- Testing
- Dexamethasone 0.1%, Neomycin Sulfate and Polymyxin B Sulfate topical eye drops four times daily, Homatropine 2% eye drops thrice daily, Oxygen gas
- Volunteers
- 32 people
- Sponsor
- Universiti Sains Malaysia