Clinical trials: Corneal Neovascularisation
Corneal Neovascularization, Corneal Graft Failure
Safety and Efficacy of Bevacizumab in High-Risk Corneal Transplant Survival
The leading risk factor for corneal transplant rejection is abnormal blood vessel growth of the host bed. Vascular endothelial growth factor (VEGF) is thought to be a mediator of this corneal neovascularization (NV), therefore we…
- Trial name
- NCT01072357
- Testing
- Avastin® (bevacizumab), 0.9% NaCl & Refresh Liquigel
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Reza Dana, MD
Corneal Neovascularization
Corneal Thinning During Topical Bevacizumab Therapy
The purpose of this study is to determine whether topical bevacizumab is safe or not when used in corneal neovascularization for long term period.
- Trial name
- NCT00515684
- Testing
- bevacizumab (Avastin)
- Where
- South Korea
- Sponsor
- Yonsei University
Limbal Stem Cell Deficiency
Limbal Stem Cell Deficiency (LSCD) Treatment With Cultivated Stem Cell (CALEC) Graft
The main aim of the study is to determine the safety and feasibility of a cultivated autologous limbal epithelial cell (CALEC) transplantation in the treatment of limbal stem cell deficiency.
- Trial name
- CALEC (NCT02592330)
- Testing
- Biopsy to collect limbal epithelial stem cells that will be cultivated into a graft, Cultivation of Limbal epithelial cells into a graft, CALEC Transplant
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Massachusetts Eye and Ear Infirmary
Corneal Neovascularization
Topical Avastin for Treatment of Corneal Neovascularization
The purpose of this study is to determine the effectiveness and safety of Topical Bevacizumab (Avastin) for treatment of corneal neovascularization.
- Trial name
- NCT00559936
- Testing
- Topical Avastin 1%
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Massachusetts Eye and Ear Infirmary
Herpes Simplex Keratitis, Corneal Neovascularization
Clinical Study of Intrastromal Anti-VEGF Injection for Corneal Neovascularization.
Corneal stromal injection is an emerging local drug delivery method, characterized by strong targeting, high drug concentration, and prolonged duration of action.
- Trial name
- NCT07329686
- Testing
- Intrastromal anti-VEGF injection and topical antiviral eye drops, Conventional antiviral topical ocular drops.
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Lipid Keratopathy, Penetrating Keratoplasty
Safety and Effectiveness of Subconjunctival Injection of Bevacizumab in the Treatment of Corneal Neovasculization
1. Purpose:Our animal study demonstrated the effectiveness of subconjunctival injection of bevacizumab in the inhibition of corneal neovasculization formation.
- Conditions
- Lipid Keratopathy, Penetrating Keratoplasty, Herpetic Keratopathy, Rosacea
- Trial name
- NCT00681603
- Testing
- subconjunctival injection of bevacizumab ( 1.25 to 2.50 mg)
- Where
- Taiwan
- Volunteers
- 13 people
- Sponsor
- National Taiwan University Hospital
Corneal Neovascularization
Bevacizumab for the Treatment of Corneal Neovascularization
The purpose of the current study is to assess the efficacy and safety of the inhibitory effect of bevacizumab (Avastin) with different routes including topical and subconjunctival application on corneal neovascularization in the…
- Trial name
- NCT00992849
- Testing
- Bevacizumab
- Where
- Taiwan
- Volunteers
- 10 people
- Sponsor
- Chang Gung Memorial Hospital
Corneal Neovascularisation
Strategies for Management of Corneal Neovascularisation
The cornea is the transparent window of the eye, which allows light to enter into the eye and also contributes to the focusing of the light rays.
- Trial name
- NCT02594423
- Testing
- Fine Needle Diathermy, Bevacizumab
- Volunteers
- 40 people
- Sponsor
- University of Nottingham
Corneal Neovascularization
Subconjunctival Aflibercept (EYLEA®) for the Treatment of Corneal Neovascularization
The goal of this current study is to prospectively evaluate the influence of a single subconjunctival aflibercept injection on the regression of corneal neovascularization.
- Trial name
- NCT02797704
- Testing
- Aflibercept
- Where
- Israel
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Rabin Medical Center
Corneal Neovascularization, Neutrophils
Correlation Between a Novel Subset of Neutrophil and Corneal Neovascularization.
The purpose of this study is to determine whether a novel subset of neutrophils is correlated with corneal neovascularization in the patients suffered from ocular chemical injury.
- Trial name
- NCT05659940
- Where
- China
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Corneal Neovascularization
The Safety and Efficacy of KDR2-2 Suspension Eye Drops in the Treatment of Corneal Neovascularization
KDR2-2, as a tyrosine kinase inhibitor, has a strong inhibitory effect on VEGFR2 and a moderate inhibitory effect on PDGFR-β. It can be used for the treatment of corneal neovascularization.
- Trial name
- NCT05011916
- Testing
- KDR2-2 suspension eye drops
- Where
- 2 sites in China
- Volunteers
- 60 people
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University