Clinical trials: Corneal Neovascularization
Corneal Neovascularization
Ranibizumab for the Inhibition of Neovascularization in the Cornea Following Corneal Transplant Surgery
The primary purpose of this trial is to evaluate the safety and tolerability of ranibizumab given via subconjunctival injection in patients undergoing corneal transplantation.
- Trial name
- NCT00769145
- Testing
- Ranibizumab
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Miami
Corneal Neovascularisation
Fine-needle Diathermy Combined With Subconjunctival Bevacizumab for Corneal Neovascularization
The goal of this clinical trial is to evaluate the efficacy and safety of combined fine-needle diathermy and subconjunctival Bevacizumab injection in patients with corneal neovascularization.
- Trial name
- FND-CNV (NCT07642960)
- Testing
- Fine-needle diathermy, Bevacizumab
- Where
- Vietnam
- Volunteers
- 51 people
- Sponsor
- HoChiMinh City Eye Hospital
Corneal Neovascularization
Corneal Crosslinking for Treatment of Corneal Neovascularization
The study objective is to assess safety and efficacy of photo-activation of riboflavin for treatment of corneal neovascularization with or without concomitant inflammation and/or infection.
- Trial name
- NCT04787471
- Testing
- 30 minute photoactivation of riboflavin 0.1%, 10 minute photoactivation of riboflavin 0.1%
- Where
- United States
- Volunteers
- 138 people
- Sponsor
- Price Vision Group
Corneal Neovascularization
Clinical Evaluation of Safety and Tolerability of KDR2-2 Eye Drops in Healthy Volunteers With Pharmacokinetic Assessment
A Phase 1 randomized, double blinded, placebo-controlled, single dose escalation (SDE) and repeat dose escalation (RDE) study to evaluate safety and tolerability, and PK of KDR2-2 in healthy volunteers.
- Trial name
- NCT04620109
- Testing
- KDR2-2
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Guangzhou HuiBoRui Biological Pharmaceutical Technology Co. Ltd
Corneal Neovascularization
Topical IL-1-Ra for Treatment of Corneal Neovascularization
The purpose of this study is to determine the effectiveness and safety of Interleukin-1-Receptor Antagonist eye drops for the treatment of corneal blood vessels.
- Trial name
- NCT00915590
- Testing
- IL-1Ra
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Reza Dana, MD
Corneal Neovascularization
Topical Avastin for Treatment of Corneal Neovascularization
The purpose of this study is to determine the effectiveness and safety of Topical Bevacizumab (Avastin) for treatment of corneal neovascularization.
- Trial name
- NCT00559936
- Testing
- Topical Avastin 1%
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Massachusetts Eye and Ear Infirmary
Corneal Neovascularization
Bevacizumab for the Treatment of Corneal Neovascularization
The purpose of the current study is to assess the efficacy and safety of the inhibitory effect of bevacizumab (Avastin) with different routes including topical and subconjunctival application on corneal neovascularization in the…
- Trial name
- NCT00992849
- Testing
- Bevacizumab
- Where
- Taiwan
- Volunteers
- 10 people
- Sponsor
- Chang Gung Memorial Hospital
Corneal Neovascularization, Corneal Graft Failure
Safety and Efficacy of Bevacizumab in High-Risk Corneal Transplant Survival
The leading risk factor for corneal transplant rejection is abnormal blood vessel growth of the host bed. Vascular endothelial growth factor (VEGF) is thought to be a mediator of this corneal neovascularization (NV), therefore we…
- Trial name
- NCT01072357
- Testing
- Avastin® (bevacizumab), 0.9% NaCl & Refresh Liquigel
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Reza Dana, MD
Corneal Neovascularization
Corneal Thinning During Topical Bevacizumab Therapy
The purpose of this study is to determine whether topical bevacizumab is safe or not when used in corneal neovascularization for long term period.
- Trial name
- NCT00515684
- Testing
- bevacizumab (Avastin)
- Where
- South Korea
- Sponsor
- Yonsei University
Corneal Neovascularization, Corneal Graft Failure
A Multi-Center Study of the Safety and Efficacy of Bevacizumab in High-Risk Corneal Transplant Survival
The goal of this study is to investigate whether using bevacizumab (Avastin®) is both safe and effective at decreasing the likelihood of a high-risk corneal graft rejection.
- Trial name
- NCT01996826
- Testing
- Avastin® (bevacizumab), 0.9% NaCl & Refresh Liquigel
- Where
- 3 sites in United States
- Volunteers
- 75 people
- Sponsor
- Reza Dana, MD
Corneal Neovascularization
Subconjunctival Aflibercept (EYLEA®) for the Treatment of Corneal Neovascularization
The goal of this current study is to prospectively evaluate the influence of a single subconjunctival aflibercept injection on the regression of corneal neovascularization.
- Trial name
- NCT02797704
- Testing
- Aflibercept
- Where
- Israel
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Rabin Medical Center