Clinical trials: Corneal Neovascularization
Herpes Simplex Keratitis, Corneal Neovascularization
Clinical Study of Intrastromal Anti-VEGF Injection for Corneal Neovascularization.
Corneal stromal injection is an emerging local drug delivery method, characterized by strong targeting, high drug concentration, and prolonged duration of action.
- Trial name
- NCT07329686
- Testing
- Intrastromal anti-VEGF injection and topical antiviral eye drops, Conventional antiviral topical ocular drops.
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Corneal Neovascularization
Treatment of Corneal Neovascularization With Topical Pazopanib
The purpose of this study is to determine the safety and efficacy of a drug [Pazopanib (Votrient)] as a treatment for corneal neovascularization.
- Trial name
- NCT01257750
- Testing
- Pazopanib (5mg/ml)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Reza Dana, MD
Corneal Neovascularization
The Safety and Efficacy of KDR2-2 Suspension Eye Drops in the Treatment of Corneal Neovascularization
KDR2-2, as a tyrosine kinase inhibitor, has a strong inhibitory effect on VEGFR2 and a moderate inhibitory effect on PDGFR-β. It can be used for the treatment of corneal neovascularization.
- Trial name
- NCT05011916
- Testing
- KDR2-2 suspension eye drops
- Where
- 2 sites in China
- Volunteers
- 60 people
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Corneal Neovascularization, Neutrophils
Correlation Between a Novel Subset of Neutrophil and Corneal Neovascularization.
The purpose of this study is to determine whether a novel subset of neutrophils is correlated with corneal neovascularization in the patients suffered from ocular chemical injury.
- Trial name
- NCT05659940
- Where
- China
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Corneal Newvessels
Efficacy and Safety Study of Avastin to Treat Neovascularisation of the Cornea
Corneal newvessels may arise from a fan of pathologies, inducing long-standing corneal opacification requiring keratoplasty. These last years, VEGF inhibitors have been designed to reduce newascularization induced by gastric…
- Trial name
- BECONNEC (NCT01501760)
- Testing
- bevacizumab, NaCl
- Where
- 5 sites in France
- Volunteers
- 38 people
- Sponsor
- University Hospital, Limoges
Corneal Neovascularization
Effectiveness and Safety of Topical Bevacizumab (Avastin) for Treatment of Corneal Neovascularization
Purpose: To determine the efficacy and safety of one commonly used VEGF inhibitor, bevacizumab (Avastin, Genentech), as a topical agent for the treatment of corneal neovascularization.
- Trial name
- NCT00512876
- Testing
- Bevacizumab (Avastin)
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Walter Reed Army Medical Center
Corneal Neovascularization
An Exploratory Clinical Trial Evaluating the Tolerability and Efficacy of KH906 in Patients With Corneal Neovascularization
The first stage of this study will evaluates the tolerability of different concentrations of Conbercept eye drop to patients with corneal neovascularization.
- Trial name
- NCT04215393
- Testing
- Conbercept eye drop
- Where
- 2 sites in China
- Volunteers
- 39 people
- Sponsor
- Chengdu Kanghong Biotech Co., Ltd.
Corneal Transplant
Neovascularization Patterns in Corneal Graft Rejection
Corneal transplantation is the most commonly performed human tissue transplant worldwide. Over 40,000 corneal transplants occur in the US each year. .
- Trial name
- NCT01695655
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- University of Michigan
Corneal Neovascularization, Corneal Graft Failure
Subconjunctival IVIg (Gamunex-C) Injection for Corneal Neovascularization and Inflammatory Conditions
The purpose of the study is to test the investigational drug Gamunex-C on the growth of blood vessels over the cornea. This study is being conducted by Dr. Balamurali Ambati at the Moran Eye Center at the University of Utah.
- Conditions
- Corneal Neovascularization, Corneal Graft Failure, Anterior Segment Inflammation
- Trial name
- NCT02042027
- Testing
- Gamunex-C
- Where
- United States
- Sponsor
- University of Utah
Lipid Keratopathy, Penetrating Keratoplasty
Safety and Effectiveness of Subconjunctival Injection of Bevacizumab in the Treatment of Corneal Neovasculization
1. Purpose:Our animal study demonstrated the effectiveness of subconjunctival injection of bevacizumab in the inhibition of corneal neovasculization formation.
- Conditions
- Lipid Keratopathy, Penetrating Keratoplasty, Herpetic Keratopathy, Rosacea
- Trial name
- NCT00681603
- Testing
- subconjunctival injection of bevacizumab ( 1.25 to 2.50 mg)
- Where
- Taiwan
- Volunteers
- 13 people
- Sponsor
- National Taiwan University Hospital
Corneal Neovascularization
Effectiveness and Safety of Topical Ranibizumab for Treatment of Corneal Neovascularization (NV)
The purpose of this study is to determine the effectiveness and safety of ranibizumab (Lucentis) in treatment of corneal neovascularization.
- Trial name
- NCT00681889
- Testing
- Ranibizumab
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Reza Dana, MD
Corneal Neovascularisation, Keratoconus
Investigation of Different Scanning Protocols for 3 Dimensional High-resolution Imaging of the Human Cornea With Optical Coherence Tomography (OCT) - A Pilot Study
The aim of the present study is to develop a protocol for optimal corneal 3-dimensional imaging based on measurements in healthy volunteers. For this purpose, a customized ultra-high resolution Spectral Domain OCT will be used.
- Trial name
- NCT01843101
- Testing
- Optical Coherence Tomography
- Where
- Austria
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Corneal Neovascularization
Randomized Study of Photodynamic Therapy Using Dihematoporphyrin in Patients With Corneal Neovascularization
OBJECTIVES: I. Demonstrate the safety and efficacy of dihematoporphyrin derivative (DHP) in laser photodynamic therapy (PDT) in patients with corneal neovascularization. II.
- Trial name
- NCT00004430
- Testing
- Dihematoporphyrin derivative, prednisolone, Laser surgery
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Medical College of Hampton Roads
Corneal Neovascularization
Using Aflibercept Injection to Treat Blood Vessel Growth Over the Cornea
The cornea is the clear front part of the eye. Corneal neovascularization, the excessive growth of blood vessels into the cornea, is a sight-threatening condition.
- Trial name
- NCT01868360
- Testing
- Subconjunctival aflibercept
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Balamurali Ambati
Rare Diseases, Aniridia
Validation of Human Drugs Target of Repurposed Drugs and Novel Therapies
The cross-sectional observational clinical study related to rare eye diseases is a multi-center study in which the hypothesis is that neurokinin 1 receptor and/or substance P expression is increased in REDs associated with…
- Conditions
- Rare Diseases, Aniridia, Neurotrophic Keratopathy, Limbal Stem Cell Deficiency
- Trial name
- NCT06412718
- Volunteers
- 274 people, healthy volunteers welcome
- Sponsor
- IRCCS Ospedale San Raffaele
Corneal Neovascularization
The Effect of Bevacizumab on Corneal Neovascularization
Eight patients with corneal neovascularization were treated with subconjunctival injection of 1.25 mg bevacizumab and had a follow-up of at least 2 months.
- Trial name
- BQ-1-08-ARVO (NCT00797303)
- Testing
- Bevacizumab
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Instituto de Olhos de Goiania
Corneal Neovascularization
Photodynamic Therapy With Verteporfin for Corneal Neovascularization
Purpose: To investigate the efficacy of photodynamic therapy with verteporfin for the treatment of patients with corneal neovascularization. Design: Prospective, non-comparative case series.
- Trial name
- NCT00471406
- Testing
- Photodynamic Therapy with Verteporfin
- Sponsor
- Chonnam National University Hospital
Corneal Neovascularisation
Strategies for Management of Corneal Neovascularisation
The cornea is the transparent window of the eye, which allows light to enter into the eye and also contributes to the focusing of the light rays.
- Trial name
- NCT02594423
- Testing
- Fine Needle Diathermy, Bevacizumab
- Volunteers
- 40 people
- Sponsor
- University of Nottingham
Limbal Stem Cell Deficiency
Limbal Stem Cell Deficiency (LSCD) Treatment With Cultivated Stem Cell (CALEC) Graft
The main aim of the study is to determine the safety and feasibility of a cultivated autologous limbal epithelial cell (CALEC) transplantation in the treatment of limbal stem cell deficiency.
- Trial name
- CALEC (NCT02592330)
- Testing
- Biopsy to collect limbal epithelial stem cells that will be cultivated into a graft, Cultivation of Limbal epithelial cells into a graft, CALEC Transplant
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Massachusetts Eye and Ear Infirmary
Corneal Neovascularization
Prospective Study to Determine the Effect of Subconjunctival Bevacizumab (AVASTIN) in Corneal Neovascularization
To determine the effect of subconjunctival Bevacizumab in corneal neovascularization
- Trial name
- NCT00555594
- Testing
- Bevacizumab (Avastin)
- Where
- Mexico
- Volunteers
- 18 people
- Sponsor
- Asociación para Evitar la Ceguera en México