Clinical trials: Corneal Perforation
Platelet-rich Fibrin, Macular Holes
Platelet-rich Fibrin(PRF) Membrane in Ophthalmic Diseases
The goal of this clinical trial is to observe the role of PRF in treating ophthalmic diseases.The efficacy and safety of PRF were validated for four ophthalmic conditions: macular hole, pterygium, corneal ulcer, and patients…
- Conditions
- Platelet-rich Fibrin, Macular Holes, Pterygium, Glaucoma
- Trial name
- NCT06200727
- Testing
- PRF membrane tamponade surgery in macular hole, ILM peeling in macular hole, PRF membrane grafting in pterygium
- Where
- China
- Volunteers
- 170 people
- Sponsor
- Lei Du
Retinal Perforations, Myopia, Degenerative
Corneal Flap Transplantation for Macular Hole Repair of High Myopia
The goal of this clinical trial is to learn about an innovative surgical technique for macular hole repair. This technique is for patients with high myopia using pars plana vitrectomy (PPV) combined with corneal flap…
- Trial name
- NCT05875909
- Testing
- corneal flap transplantation
- Where
- China
- Volunteers
- 30 people
- Sponsor
- First People's Hospital of Hangzhou
Retinal Diseases, Fuchs Endothelial Dystrophy
DISCOVER Study: Microscope-integrated Intraoperative OCT Study
Optical coherence tomography (OCT )provides high resolution information regarding the anatomic structure of the tissues of the eye in a cross-sectional and 3 dimensional view.
- Conditions
- Retinal Diseases, Fuchs Endothelial Dystrophy, Macular Hole, Epiretinal Membrane
- Trial name
- DISCOVER (NCT02423213)
- Where
- United States
- Volunteers
- 2,911 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Keratitis, Pterygium
Robotic Surgery of the Ocular Surface
The introduction of surgical robots in the OR revolutionized a number of specialties (i. e. urology, gynecology, digestive surgery).
- Conditions
- Keratitis, Pterygium, Corneal Opacity Corneal Thinning, Corneal Perforation
- Trial name
- NCT02116062
- Testing
- 1. Amniotic membrane transplantation on the cornea with the Da Vinci Si HD© robot (Inlay or overlay technique), Pterygium removal and autograft of the conjunctiva with the Da Vinci Si HD© robot (Kenyon technique), Penetrating keratoplasty using Baron trephine and nylon stitches with the Da Vinci Si HD© robot
- Where
- France
- Volunteers
- 12 people
- Sponsor
- University Hospital, Strasbourg, France
Pterygium, Corneal Ulcer
The Application of Fibrin Glue in Ocular Surface Diseases
This clinical trial tries to use tissue fibrin glues (Tisseel) to treat various ocular surface diseases or surgeries, which includes pterygium surgery, corneal melting/perforation, Gunderson's flap, conjunctival laceration, and…
- Trial name
- NCT00155402
- Testing
- tissue fibrin glue application (Tisseel)
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- National Taiwan University Hospital
Corneal Perforation, Corneal Stromal Lenticule,Sandwich Technique
A Novel Sandwich Technique of Minimally Invasive Keratoplasty for Corneal Perforation
The goal of this type of study to describe a new sandwich technique of minimally invasive keratoplasty (STMIK) by using SMILE-extracted lenticules for treatment corneal perforation and effectiveness.
- Trial name
- STMIK (NCT06233409)
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Tianjin Eye Hospital
Corneal Ulcer, Corneal Perforation
Topical Insulin - Utility and Results in Neurotrophic Keratopathy in Stages 2 and 3
Purpose: To evaluate the clinical outcome of patients with refractory Neurotrophic Keratopathy (NK) in stages 2 and 3 treated with topical insulin.
- Conditions
- Corneal Ulcer, Corneal Perforation, Corneal Epithelium Defect, Neurotrophic Keratitis
- Trial name
- NCT04820010
- Testing
- Topical Insulin
- Where
- Portugal
- Volunteers
- 20 people
- Sponsor
- Centro Hospitalar de Vila Nova de Gaia/Espinho, E.P.E.
Corneal Perforation
Combined Amniotic Membrane and Platelet Rich Plasma Clot for Management of Central Corneal Perforation
Use of amniotic membrane(AMT) and platelet rich plasma (PRP) clot for closure of central corneal perforation
- Trial name
- NCT03500796
- Testing
- Platelet rich plasma clot implantation, Wound closure with amniotic membrane
- Where
- Egypt
- Volunteers
- 10 people
- Sponsor
- Minia University
Corneal Perforation
Role of AS-OCT in Assessment of Corneal Perforation
Assessment of healing of thin and perforated cornea after surgical treatment by anterior segment optical coherence tomography
- Trial name
- OCT (NCT06422897)
- Testing
- anterior segment optical coherence tomography
- Where
- Egypt
- Volunteers
- 13 people
- Sponsor
- Minia University
Retinal Detachment, Epiretinal Membrane
PIONEER: Intraoperative and Perioperative OCT Study
OCT provides high-resolution information regarding the anatomic structure of the tissues of the eye in a 2-dimensional and 3-dimensional view. Much of this information is not able to be recognized by a clinician.
- Conditions
- Retinal Detachment, Epiretinal Membrane, Macular Hole, Fuchs Endothelial Dystrophy
- Trial name
- PIONEER (NCT02423161)
- Where
- United States
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Corneal Perforation, Exposure Keratitis
The Role of OmniLenz® in the Treatment of Small Corneal Perforations Secondary to Exposure Keratitis in ICU Patients
Case series of 5 ICU patients in Farwaniya Hospital who developed exposure keratitis and a subsequent small corneal perforation between April 2022 and April 2024.
- Conditions
- Corneal Perforation, Exposure Keratitis, Infectious Keratitis
- Trial name
- NCT06539663
- Testing
- OmniLenz®
- Where
- Kuwait
- Volunteers
- 5 people
- Sponsor
- Farwaniya Hospital