Clinical trials: Corona Virus Disease
Chronic Kidney Diseases, COVID-19
COVID-19 Vaccine Boosters in Patients With CKD
This study is a 12-month, four-arm parallel-group randomized control trial of Pfizer-BioNTech versus MODERNA COVID-19 (Corona Virus disease 2019)vaccine boosters in chronic kidney disease and dialysis patients with poor humoral…
- Trial name
- BOOST KIDNEY (NCT05022329)
- Testing
- Pfizer-BioNTech COVID-19 Vaccine, MODERNA SARS-CoV-2 Vaccine
- Where
- 3 sites in Canada
- Volunteers
- 273 people
- Sponsor
- Sunnybrook Health Sciences Centre
Covid19
Hydroxychloroquine as Chemoprevention for COVID-19 for High Risk Healthcare Workers
The study proposes to conduct an open-label Phase II trial to evaluate the feasibility, safety and early efficacy of hydroxychloroquine (HCQ) administration in reduction of transmission of severe acute respiratory syndrome…
- Trial name
- NCT04345653
- Testing
- Hydroxychloroquine Sulfate (HCQ)
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Hackensack Meridian Health
Multiple Osteochondroma, Osteogenesis Imperfecta
Resilience and Coping in a Rare Skeletal Disease Population to Face Coronavirus (COVID-19) Outbreak Distress: a Longitudinal Study
In the COVID-19 outbreak context, people living with rare diseases have been highly troubled with anxiety, loneliness, and depression.
- Conditions
- Multiple Osteochondroma, Osteogenesis Imperfecta, Ollier Disease, Maffucci Syndrome
- Trial name
- RELOAD (NCT04844697)
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- Istituto Ortopedico Rizzoli
Covid19
Conversations You Want About Corona Virus Disease (COVID-19)
Web-enabled virtual topical guide: develop virtual conversations for each concern and intensity level
- Trial name
- COVID-19 (NCT05191420)
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Corona Virus Infection
Salivary SARS-CoV-2 Load of Covid-19 Patients After Oral Antimicrobial Solutions and Dentifrices
The aim of this study is to analyze if the use of oral antimicrobial solutions and dentifricies are able to reduce the SARS-CoV-2 load in the saliva and oral mucosa.
- Trial name
- NCT04537962
- Testing
- Colgate Periogard® mouthwash, Colgate Peroxyl® mouthwash, Colgate Total® Mouthwash
- Where
- Brazil
- Volunteers
- 202 people
- Sponsor
- Hospital Israelita Albert Einstein
COVID-19 Pneumonia, Cough
Kesuting Syrup in the Treatment of Corona Virus Disease 2019 (COVID-19)
This trial is an exploratory study, aiming to explore the preliminary efficacy and safety of Kesuting Syrup in the treatment of novel coronavirus pneumonia. It is planned to include a total of 200 cases.
- Trial name
- NCT05366231
- Testing
- Kesuting syrup, LianHuaQingWen Granules
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Guizhou Bailing Group Pharmaceutical Co Ltd
COVID-19 Testing, Decision Making
Understanding Communications Included With COVID-19 (Corona Virus Disease of 2019) Home Testing Kits
To test competing sets of information for consumers on how to interpret hypothetical SARS-CoV-2 home test kit results and whether they report plans to take CDC-recommended actions to protect themselves and others given their test…
- Trial name
- NCT04758299
- Testing
- decision science-based design
- Where
- United States
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Barry Dewitt
COVID-19; Cardiovascular Diseases
Cardiac complicAtions in Patients With SARS Corona vIrus 2 (COVID-19) regisTrY
CAPACITY (www.capacity-covid.eu) is a registry of patients with COVID-19 across Europe and has been established to answer questions on the role of cardiovascular disease in this pandemic.
- Trial name
- CAPACITY-COVID (NCT04325412)
- Where
- Netherlands
- Volunteers
- 1,000 people
- Sponsor
- UMC Utrecht
Corona Virus Infection
Norwegian Coronavirus Disease 2019 Study
In the current proposal, the investigators aim to investigate the virological and clinical effects of chloroquine treatment in patients with established COVID-19 in need of hospital admission.
- Trial name
- NO COVID-19 (NCT04316377)
- Testing
- Hydroxychloroquine Sulfate
- Where
- Norway
- Volunteers
- 53 people
- Sponsor
- University Hospital, Akershus
Cystic Fibrosis
Covid-19 Antibody Responses in Cystic Fibrosis
Coronavirus disease 2019 (COVID-19) which is caused by the virus Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) has resulted in an ongoing global pandemic.
- Trial name
- CAR-CF (NCT05012306)
- Where
- 8 sites in Germany
- Volunteers
- 500 people
- Sponsor
- Universitätsklinikum Köln
Corona Virus Infection, Acute Respiratory Distress Syndrome
Losartan for Patients With COVID-19 Requiring Hospitalization
This is a multi-center, double-blinded study of COVID-19 infected patients requiring inpatient hospital admission randomized 1:1 to daily Losartan or placebo for 7 days or hospital discharge.
- Conditions
- Corona Virus Infection, Acute Respiratory Distress Syndrome, SARS-CoV Infection
- Trial name
- NCT04312009
- Testing
- Losartan
- Where
- 13 sites in United States
- Volunteers
- 205 people
- Sponsor
- University of Minnesota
Conscious Sedation, Pathologic Processes
Prospective Electroencephalography Evaluation of Sedation in COVID-19
Sedation of severe COVID-19 disease are often complicated. We try to find a correlate for this observation by encephalographic studies.
- Conditions
- Conscious Sedation, Pathologic Processes, Electroencephalogram, Acute Respiratory Distress Syndrome
- Trial name
- NCT04815109
- Testing
- Encephalography measurement
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- Goethe University
Corona Virus Infection, Pregnancy Related
Understanding COVID-19 Infection in Pregnant Women and Their Babies
This national study will recruit expectant mothers with and without positive nasopharyngeal swabs for SARS-CoV-2, and aims to determine the seroepidemiology of SARS-CoV-2 amongst expectant mothers and their infants in the U.K.
- Conditions
- Corona Virus Infection, Pregnancy Related, Neonatal Infection, Breastfeeding
- Trial name
- periCOVID (NCT04703270)
- Where
- United Kingdom
- Volunteers
- 881 people, healthy volunteers welcome
- Sponsor
- St George's, University of London
COVID-19
An Observational Clinical Study to Evaluate COVID-19 Symptoms in "Long Hauler" Patients Who Participated in K031-120 or K032-120
This observational clinical study aims to evaluate the presence of symptoms of COVID-19 infection in patients who participated in K031-120 or K032-120 ("long hauler").
- Trial name
- NCT04814914
- Testing
- KB109 + Self Supportive Care, Self Supportive Care (SSC) Alone
- Where
- 2 sites in United States
- Volunteers
- 333 people
- Sponsor
- Kaleido Biosciences
Covid19, SARS-CoV Infection
SARS-CoV-2 Human Challenge Characterisation Study
This is a dose optimisation study in healthy adults aged 18-30 who will be experimentally inoculated with SARS-CoV-2. The aim is to cause PCR-confirmed upper respiratory infection in the majority of challenged individuals with…
- Conditions
- Covid19, SARS-CoV Infection, Corona Virus Infection, Coronavirus
- Trial name
- NCT04865237
- Testing
- SARS-CoV-2 Virus 1x10^1 TCID50, Remdesivir, SARS-CoV-2 Virus 1x10^2 TCID50
- Where
- 2 sites in United Kingdom
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Corona Virus Infection, Covid19
Clinical Study for Subjects With COVID-19 Using Allogeneic Adipose Tissue-Derived Mesenchymal Stem Cells
This is an interventional new drug clinical trial for a Phase 2 randomized, double-blind, and placebo control study using intravenous injection of allogeneic adipose stem cells (Celltex AdMSCs) for subjects with severe COVID-19.
- Trial name
- AdMSCs (NCT05017298)
- Testing
- Allogeneic adipose-derived stem cells
- Volunteers
- 30 people
- Sponsor
- Celltex Therapeutics Corporation
COVID, COVID-19
Efficacy of Chloroquine or Hydroxychloroquine in Treating Pneumonia Caused by SARS-Cov-2 - COVID-19
Facing the challenge of finding an efficient treatment for COVID-19, the viral pneumonia caused by the Coronavirus SARS-Cov-2, this study intended to test if Chloroquine or Hydroxychloroquine, two drugs with strong in-vitro…
- Conditions
- COVID, COVID-19, SARS-CoV 2, Coronavirus
- Trial name
- NCT04420247
- Testing
- Chloroquine, Hydroxychloroquine, standard care
- Where
- Brazil
- Volunteers
- 142 people
- Sponsor
- Centro de Estudos e Pesquisa em Emergencias Medicas e Terapia Intensiva
Coronavirus Infections, Pneumonia, Viral
Colchicine Counteracting Inflammation in COVID-19 Pneumonia
Cytokines and chemokines are thought to play an important role in immunity and immunopathology during virus infections [3]. Patients with severe COVID-19 have higher serum levels of pro-inflammatory cytokines (TNF-α, IL-1 and…
- Trial name
- ColCOVID-19 (NCT04322565)
- Testing
- Colchicine
- Where
- Italy
- Volunteers
- 193 people
- Sponsor
- Azienda Ospedaliero-Universitaria di Parma
Respiratory Failure, SARS-CoV 2
Stress Related Disorders in Family Members of COVID-19 Patients Admitted to the ICU
Coronavirus disease 2019 (COVID-19) is a novel infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
- Conditions
- Respiratory Failure, SARS-CoV 2, Corona Virus Infection, Post Intensive Care Unit Syndrome
- Trial name
- NCT04476914
- Where
- 9 sites in United States
- Volunteers
- 330 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Kidney Transplant Infection, SARS-CoV Infection
Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2) Immune Kidney Transplant Study (COVID-19)
None of the vaccines approved, or in clinical trials, have so far been tested on transplanted patients. If they produce an immune response to the Spike protein of SARS-CoV-2 it is unknown how long the protective immunity will…
- Trial name
- SCV-KTx-imm (NCT04747522)
- Testing
- SARS-CoV-2 vaccine
- Where
- Norway
- Volunteers
- 200 people
- Sponsor
- Oslo University Hospital