Clinical trials: Coronary; Ischemic
Acute Coronary Syndrome, ST Elevated Myocardial Infarction
the PrEsentation, Rationale and Impact of reperFUSION for Acute Coronary Syndromes in Cape Town and the Garden Route Health District - the PERFUSION Registry
The global burden and threat of non-communicable diseases (NCDs) have become a major health challenge that undermines social and economic development throughout the world.
- Conditions
- Acute Coronary Syndrome, ST Elevated Myocardial Infarction, Non ST Elevation Myocardial Infarction, Unstable Angina
- Trial name
- PERFUSION (NCT04887571)
- Testing
- No Intervention - Observational Registry
- Where
- 4 sites in South Africa
- Volunteers
- 870 people
- Sponsor
- University of Cape Town
Coronary Artery Disease, Ischemic Mitral Regurgitation
Treatment of Moderate Ischemic Mitral Regurgitation in Patients With Coronary Artery Disease
This study aims to evaluate the effect of angiotensin receptor/neprilysin inhibitors (ARNI) on improving ischemic mitral regurgitation (IMR) in patients with coronary artery disease undergoing isolated coronary artery bypass…
- Conditions
- Coronary Artery Disease, Ischemic Mitral Regurgitation, Angiotensin Receptor/Neprilysin Inhibitor
- Trial name
- NCT06917664
- Testing
- sacubitril/valsartan
- Where
- China
- Volunteers
- 220 people
- Sponsor
- China National Center for Cardiovascular Diseases
Cardiovascular Diseases, Heart Diseases
Genetic Epidemiology of Coronary Heart Disease
To relate observations at the DNA level to the distribution of coronary heart disease in the population at large.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Coronary Disease
- Trial name
- NCT00005209
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Angina Pectoris, Coronary Heart Disease
A Study to Assess the Safety, Tolerability, and Effects of MK-0974 (Telcagepant) on Exercise Tolerance in Patients With Stable Angina (MK-0974-014)
This study will assess the safety of telcagepant in coronary artery disease (CAD) participants with stable angina during exercise treadmill testing and evaluate whether calcitonin gene-related peptide (CGRP) receptor antagonism…
- Conditions
- Angina Pectoris, Coronary Heart Disease, Calcitonin Gene-related Peptide Receptor
- Trial name
- NCT01294709
- Testing
- telcagepant
- Volunteers
- 64 people
- Sponsor
- Merck Sharp & Dohme LLC
Coronary Artery Disease, Congestive Heart Failure
A Collaborative Care Program to Improve Depression Treatment in Cardiac Patients
Depression in cardiac patients is common, persistent, and deadly. However, the vast majority of cardiac patients with depression go unrecognized and untreated, despite the existence of treatments that clearly improve depressive…
- Conditions
- Coronary Artery Disease, Congestive Heart Failure, Arrhythmia, Depression
- Trial name
- NCT00847132
- Testing
- Collaborative Care Treatment, Usual Care Treatment
- Where
- United States
- Volunteers
- 175 people
- Sponsor
- Massachusetts General Hospital
Coronary Artery Disease
Instrumental Sealing of Arterial Puncture Site Closure Device Versus Manual Compression Trial
Are novel vascular closure devices noninferior to manual compression regarding access site complications after coronary angiography?
- Trial name
- ISAR-CLOSURE (NCT01389375)
- Testing
- FemoSeal®, ExoSeal®, Manual compression
- Where
- 2 sites in Germany
- Volunteers
- 4,524 people
- Sponsor
- Deutsches Herzzentrum Muenchen
Unstable Angina
Influence of METHoxyflurane on ANtiplatelet Effect of Ticagrelor in Patients With Unstable Angina Pectoris
The purpose of this study is to evaluate differences in the pharmacokinetics and pharmacodynamics of ticagrelor and its active metabolite in patients who received ticagrelor followed with methoxyflurane versus ticagrelor followed…
- Trial name
- METHANE (NCT04442919)
- Testing
- Ticagrelor followed with Methoxyflurane, Ticagrelor followed with Morphine, Ticagrelor alone
- Where
- Poland
- Volunteers
- 72 people
- Sponsor
- Collegium Medicum w Bydgoszczy
Cardiovascular Diseases, Coronary Disease
Coronary Artery Risk Development in Young Adults
To measure changes in coronary heart disease risk factors in cohorts of Black and White males and females 18 to 30 years of age at baseline.
- Conditions
- Cardiovascular Diseases, Coronary Disease, Hypertension, Heart Diseases
- Trial name
- CARDIA (NCT00005130)
- Volunteers
- 5,115 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Cardiac Disease, Aortic Valve Disease
PREhabilitation in Patients Awaiting Acute Inpatient Cardiac SurgEry
This is a single centre, single arm pilot feasibility study to determine the feasibility and practicality of prehabilitation in acute inpatients waiting for cardiac surgery.
- Conditions
- Cardiac Disease, Aortic Valve Disease, Coronary Artery Disease, Endocarditis
- Trial name
- (PREP-ACE) (NCT06275100)
- Testing
- Prehabilitation
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- University of Hull
Coronary Artery Disease, Myocardial Ischemia
Comparison of Biomatrix and Orsiro Drug Eluting Stent
The primary objective of the BIODEGRADE study is to evaluate clinical efficacy of the Orsiro drug-eluting stent compared with Biomatrix drug-eluting stent, both of which have biodegradable polymer for the treatment of all-comers'…
- Trial name
- BIODEGRADE (NCT02299011)
- Testing
- Orsiro drug eluting stent, Biomatrix drug eluting stent
- Where
- South Korea
- Volunteers
- 2,341 people
- Sponsor
- Seoul National University Bundang Hospital
Coronary Artery Disease
Does Routine Pressure Wire Assessment Influence Management Strategy at Coronary Angiography for Diagnosis of Chest Pain?
The use of coronary angiography to investigate patients at risk of coronary artery narrowings has become universal. In most cases, this investigation leads to a successful treatment plan with revascularisation recommended where…
- Trial name
- RIPCORD (NCT01070771)
- Testing
- Radi pressure wire (pressure wire assessment)
- Where
- 10 sites in Ireland, United Kingdom
- Volunteers
- 203 people
- Sponsor
- University Hospital Southampton NHS Foundation Trust
Physicians' Practice Patterns, Coronary Heart Disease
From Research to Practice - Lipid Management for Low HDL-Cholesterol
The overall purpose of this project is to improve the clinical outcomes of veterans with ischemic heart disease (IHD) through implementation of evidence-based lipid management, with a particular focus on veterans whose primary…
- Trial name
- NCT00057044
- Testing
- education and reminder
- Where
- United States
- Volunteers
- 11,700 people
- Sponsor
- US Department of Veterans Affairs
Ischaemic Heart Diseases
Rotigaptide in Endothelial Dysfunction?
Arterial occlusion can lead to tissue ischemia and, if prolonged, end organ infarction. Clinical and experimental data would suggest that restoration of blood flow might trigger additional injury beyond that induced by the…
- Trial name
- NCT07192744
- Testing
- Forearm vascular study
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Coronary Heart Disease
A Cohort Study of PCI Strategies for Severely Calcified Lesions of Complex Coronary Arteries in the Elderly
The aim of this observational study is to compare the prognostic outcomes of various PCI strategies in elderly patients with complex coronary calcified lesions.
- Trial name
- PSSCCE (NCT06168422)
- Testing
- DES, DCB
- Where
- China
- Volunteers
- 2,100 people
- Sponsor
- Henan Institute of Cardiovascular Epidemiology
Myocardial Infarction
Differences in Epicardial Plaque and Microvascular Function in Women With an Acute Myocardial Infarction
The broad objective is to advance our understanding of both in vivo anatomical and functional changes that are present in the coronary arteries in women who have an acute coronary syndrome.
- Trial name
- NCT00587002
- Testing
- IVUS
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Mayo Clinic
Coronary Disease, Coronary Artery Disease
MGuard Stent and Microcirculation
NSTE-ACS represents the most frequent indication for coronary angiography and percutaneous coronary intervention (PCI) worldwide.
- Conditions
- Coronary Disease, Coronary Artery Disease, Coronary Atherosclerosis, Cardiovascular Diseases
- Trial name
- GUARDIANCORY (NCT03087175)
- Testing
- MGuard stent, Drug eluting stent and bare metal stent
- Where
- 2 sites in France
- Volunteers
- 52 people
- Sponsor
- University Hospital, Grenoble
Coronary Artery Disease
Medtronic Resolute Onyx 2.0 mm Clinical Study
The purpose of this trial is to assess the safety and efficacy of the Resolute Onyx Zotarolimus-Eluting Coronary Stent System for the treatment of de novo lesions in native coronary arteries that allows the use of a 2.0 mm…
- Trial name
- NCT02412501
- Testing
- Resolute Onyx Stent - 2.0 mm
- Where
- 17 sites in United States
- Volunteers
- 101 people
- Sponsor
- Medtronic Vascular
Coronary Artery Disease
Compare Ticagrelor vs Clopidogrel on the Reduction of Arterial Stiffness and Wave Reflectionsin Patients With CAD.
The purpose of this study is to investigate the potential acute and chronic effect of ticagrelor versus clopidogrel on arterial stiffness and other vascular risk markers of interest, the study will consist of two periods: a…
- Trial name
- NOVELTY (NCT02071212)
- Testing
- Ticagrelor
- Where
- Greece
- Volunteers
- 120 people
- Sponsor
- Hellenic Cardiovascular Research Society
STEMI, Myocardial Infarction
Early Diagnosis of Acute Myocardial Infarction: Impact of an Educational and Organizational Intervention
The hypothesis is that an educational program aimed at emergency nurses and the implementation of measures at the organizational level reduce the time between arrival at the emergency room and the opening of the artery or balloon…
- Conditions
- STEMI, Myocardial Infarction, Nurses, Education
- Trial name
- NCT04333381
- Testing
- Educational and organizational intervention, Common Practice
- Where
- Spain
- Volunteers
- 450 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Stable Angina
Boston Scientific COMET Wire Validation Study
Summary of Study Aims To assess, in a randomised fashion: 1. performance of Boston Scientific Pressure Wire versus St Jude Pressure Wire 2. performance of Boston Scientific Pressure Wire versus Boston Scientific Pressure Wire 3.
- Trial name
- COMET (NCT02578381)
- Testing
- Boston Scientific Pressure Wire, Validation of Boston Scientific pressure wire
- Where
- 2 sites in United Kingdom
- Volunteers
- 106 people
- Sponsor
- University Hospital Southampton NHS Foundation Trust
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