Clinical trials: Coronary; Ischemic
Postoperative Complications, Cardiovascular Complication
Perioperative Inflammatory Response Assessment in High-risk Patients Undergoing Noncardiac Surgery
Postoperative cardiovascular complications are common after noncardiac surgery. The association between perioperative inflammation and the occurrence of cardiovascular complications after surgery is still unknown.
- Conditions
- Postoperative Complications, Cardiovascular Complication, Myocardial Ischemia, Inflammation
- Trial name
- INSIGHT (NCT04753307)
- Testing
- Laboratory measurements
- Where
- Austria
- Volunteers
- 1,400 people
- Sponsor
- Medical University of Vienna
Testicular Cancer, Survivorship
Late Subclinical Cardiovascular Disease in Testicular Cancer Survivors
Late subclinical cardiovascular disease in testicular cancer survivors exposed to cisplatin-based chemotherapy and bone marrow transplant
- Conditions
- Testicular Cancer, Survivorship, ASCVD, Coronary Artery Disease
- Trial name
- NCT05611307
- Testing
- Lipid profile, Coronary artery assessment, Hormone levels for hypogonadism
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Indiana University
Coronary Artery Disease
Angiomax® or Unfractionated Heparin for Patients Undergoing Percutaneous Coronary Intervention
The objective of the study is to assess the safety and efficacy of Angiomax® (bivalirudin) versus unfractionated heparin (UFH) in patients presenting with stable angina or silent ischemia (positive stress test without chest pain)…
- Trial name
- STATUS PCI (NCT01464671)
- Testing
- Bivalirudin, Heparin
- Where
- United States
- Volunteers
- 260 people
- Sponsor
- Stony Brook University
Myocardial Infarction
Additive Effect of Ezetimibe Upon Simvastatin During Myocardial Infarction
During acute coronary syndromes (ACS), the generation of inflammatory mediators negatively influences arterial wall remodeling and the endothelium-dependent vasomotor function in the coronary and systemic arterial systems.
- Trial name
- NCT00905905
- Testing
- Simvastatin, Ezetimibe-Simvastatin
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- Brasilia Heart Study Group
Ischemic Heart Disease
Safety Study of Gene Therapy for Ischemic Heart Disease in Korea
The purpose of this study is to evaluate the safety of VM202 (Engensis) direct injection into the cardiac muscles of the coronary artery territory where complete revascularization could not be done even through Coronary Artery…
- Trial name
- Engensis (NCT01422772)
- Testing
- VM202-0.5 mg, VM202-1.0 mg, VM202-2.0 mg
- Where
- South Korea
- Volunteers
- 9 people
- Sponsor
- Helixmith Co., Ltd.
Ischemic Congestive Cardiomyopathy, Dilated Cardiomyopathy
Optimizing Left Ventricular Lead To Improve Cardiac Output
The purpose of this study is to determine if optimal lead placement, guided by the largest improvement in aortic flow measured by Doppler will: 1. Improve the way the heart's left ventricle functions 2.
- Conditions
- Ischemic Congestive Cardiomyopathy, Dilated Cardiomyopathy, Congestive Heart Failure
- Trial name
- CARE/VOLCANO (NCT01399801)
- Testing
- Doppler flow measurement, standard implantation of the LV lead
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Ann Marie Chikowski
Acute Coronary Syndrome, Heart Failure
International CR Registry
The ICRR is a health services registry to establish the quality of CR delivery, and the effectiveness in terms of patient outcomes, in low-resource settings.
- Conditions
- Acute Coronary Syndrome, Heart Failure, Coronary Artery Disease
- Trial name
- ICRR (NCT04676100)
- Testing
- Cardiac rehabilitation
- Where
- Qatar
- Volunteers
- 7,000 people
- Sponsor
- University Health Network, Toronto
Refractory Angina Pectoris, Spinal Cord Stimulation
Efficacy of Spinal Cord Stimulation in Patients With Refractory Angina Pectoris
There are a growing number of patients with refractory angina pectoris (RAP). RAP is defined as a 'chronic condition (> three months) characterized by diffuse coronary artery disease in the presence of proven ischemia, which is…
- Trial name
- SCRAP (NCT04915157)
- Testing
- Spinal Cord Stimulator
- Where
- Netherlands
- Volunteers
- 72 people
- Sponsor
- Catharina Ziekenhuis Eindhoven
Sudden Cardiac Death
Prospective Study to Identify Patients at Risk of Dangerous Ventricular Arrhythmias
The purpose of this study is to determine how well the device predicts susceptability to potentially lethal ventricular arrhythmias.
- Trial name
- HIP (NCT00562757)
- Where
- 8 sites in United States, Germany and 2 more
- Volunteers
- 320 people
- Sponsor
- Harbinger Medical, Inc.
Myocardial Infarction
Heart Attack Research Program- Imaging Study
The HARP study is a multi-center, diagnostic observational study employing standardized imaging protocols in patients with MINOCA (MI with Non Obstructive Coronary Arteries) to determine the underlying diagnosis in each…
- Trial name
- HARP (NCT02905357)
- Testing
- OCT, CMR
- Where
- 20 sites in United States, Canada and 1 more
- Volunteers
- 450 people
- Sponsor
- NYU Langone Health
Low Cardiac Output Syndrome, Cardiogenic Shock
Milrinone Versus Dobutamine in Critically Ill Patients
The investigators are interested in determining if there is a meaningful difference between two of the most commonly used medications used to improve the pumping function of the heart among critically ill patients admitted to the…
- Conditions
- Low Cardiac Output Syndrome, Cardiogenic Shock, Acute Coronary Syndrome, Pulmonary Edema
- Trial name
- NCT03207165
- Testing
- Milrinone, Dobutamine
- Where
- Canada
- Volunteers
- 192 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Atrial Fibrillation, Transient Ischemic Attack
Optimal Detection of Atrial Fibrillation in TIA
Transient ischemic attack (TIA) is a common neurologic emergency. Although the detection of atrial fibrillation (AF) has identical consequences for preventive therapy in patients with ischemic stroke and TIA, the management…
- Trial name
- ODEA-TIA (NCT04075500)
- Testing
- Subcutaneously implanted event recorder (REVEAL LINQ), 28-day non-invasive continuous ECG monitoring (patch)
- Where
- 27 sites in Germany, Spain
- Volunteers
- 516 people
- Sponsor
- Alfried Krupp Krankenhaus
Myocardial Infarction
Myocardial Ischemia and Transfusion
MINT: A pilot, multi-centre, open-label randomized controlled trial of two commonly used transfusion strategies in patients with myocardial infarction.
- Trial name
- MINT (NCT02619136)
- Testing
- Transfusion
- Where
- 4 sites in Canada
- Volunteers
- 3,501 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Coronary Stenosis
Saline-induced Distal to Aortic Coronary Pressure Ratio vs. Resting and Hyperemic Indices of Coronary Artery Stenosis Severity
The presence of inducible myocardial ischemia is considered as the prerequisite for the clinical benefit of coronary revascularization.
- Trial name
- SALINE (NCT04284345)
- Testing
- Saline Pd/Pa
- Where
- Switzerland
- Volunteers
- 90 people
- Sponsor
- University Hospital, Geneva
Coronary Artery Disease, Plaque
PCCT-Defined High-Risk Plaque and Future Coronary Events: The PREDICT Study
This prospective cohort study aims to determine whether high-risk coronary plaques identified by novel Photon-Counting Detector CT (PCCT) independently predict future major adverse cardiovascular events (MACE).
- Conditions
- Coronary Artery Disease, Plaque, Photon-Counting Computed Tomography
- Trial name
- PREDICT (NCT07822737)
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Beijing Chao Yang Hospital
Coronary Artery Disease, Coronary Restenosis
SCRIPPS V: Intracoronary Brachytherapy for Recurrent Restenosis After Multiple Drug-Eluting Stents
This study is a prospective study of patients treated at Scripps Clinic with intracoronary brachytherapy for recurrent restenosis within drug eluting stents.
- Trial name
- NCT00714545
- Testing
- Intracoronary brachytherapy
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Scripps Health
Acute Coronary Syndrome, Ischemic Heart Disease
Risc Optimisation- Acute cor5onary Syndrome
This study evaluates the percentage of patients that reach the objective levels of LDL cholesterol, glycosylated hemoglobin and blood pressure recommended by clinical guidelines after an acute coronary syndrome, following…
- Trial name
- RiskOp-ACS (NCT03619395)
- Where
- Spain
- Volunteers
- 150 people
- Sponsor
- Parc de Salut Mar
Coronary Artery Bypass Graft Triple Vessel, Apoptotic DNA Damage
Remote Ischemic Preconditioning of Human Myocardium
The investigators aim to definitively show if human myocardium can be remotely preconditioned. In the writings there are no experiments that would prove that the remote preconditioning protocol effects on the higher protection of…
- Trial name
- NCT01994707
- Testing
- Remote ischemic preconditioning
- Where
- Poland
- Volunteers
- 134 people
- Sponsor
- Medical University of Silesia
Cardiovascular Diseases, Coronary Arteriosclerosis
Lifestyle Heart Trial
To assess long-term effects of a strict lifestyle change program on lipids, blood pressure, myocardial perfusion, and coronary atherosclerosis.
- Conditions
- Cardiovascular Diseases, Coronary Arteriosclerosis, Coronary Disease, Heart Diseases
- Trial name
- NCT00000471
- Testing
- diet, vegetarianism, diet, fat-restricted, exercise
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Acute Coronary Syndrome (ACS), STEMI - ST Elevation Myocardial Infarction (MI)
Implementing Precision Medicine Approaches to Guide Anti-platelet Selection
The study aims to determine the feasibility and clinical utility of incorporating precision medicine approaches, incorporating both cytochrome P450 2C19 (CYP2C19) genotyping and platelet reactivity phenotyping, with standard of…
- Conditions
- Acute Coronary Syndrome (ACS), STEMI - ST Elevation Myocardial Infarction (MI), NSTEMI - Non-ST Segment Elevation MI, Unstable Angina (UA)
- Trial name
- NCT04090281
- Testing
- CYP2C19 genotyping
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of Southern California
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