Clinical trials: Coronary; Ischemic
Atherosclerosis, Coronary Artery Disease
The OMEGA Clinical Trial
The purpose of this study is to evaluate the safety and effectiveness of the OMEGA Coronary Stent System for the treatment of subjects with a de novo atherosclerotic coronary artery lesion.
- Trial name
- NCT01419171
- Testing
- OMEGA™ Monorail Coronary Stent System
- Where
- 37 sites in United States, Belgium and 5 more
- Volunteers
- 328 people
- Sponsor
- Boston Scientific Corporation
Clinical Study
Chronoprognosis of Myocardial Infarction in Patients With Type 2 Diabetes Mellitus
Purpose: To develop a mathematical model for the occurrence of MI in patients with T2D by studying the relationship between the internal personalized biorhythms of the patients and the external transit rhythms of space objects…
- Trial name
- NCT05645419
- Testing
- personalized chronoprevention
- Where
- Kazakhstan
- Volunteers
- 60 people
- Sponsor
- University Medical Center, Kazakhstan
Percutaneous Coronary Artery Intervention, Coronary Artery Bypass Graft
Effect of Chinese Traditional Medicine for Post Revascularization Treatment of Coronary Artery Disease
The purpose of this study is to built the standard of Chinese Traditional Medicine test for Post percutaneous coronary artery intervention and coronary artery bypass graft，also for acute coronary syndrome，according to the…
- Conditions
- Percutaneous Coronary Artery Intervention, Coronary Artery Bypass Graft, Acute Coronary Syndrome
- Trial name
- NCT00965471
- Testing
- cipher prescription 1, cipher prescription 2
- Volunteers
- 940 people
- Sponsor
- Guangzhou University of Chinese Medicine
Myocardial Infarction
Search for Methods to Predict the Development of Heart Failure After Myocardial Infarction
Introduction Despite significant progresses in the diagnosis of myocardial infarction and the development of reperfusion treatment methods, heart failure still often complicates its course.
- Trial name
- PHFMI (NCT05495516)
- Testing
- without Intervention
- Where
- Russia
- Volunteers
- 186 people
- Sponsor
- Novosibirsk State Medical University
Coronary Artery Disease
Blood Flow Reserve: Effects After Training With Heavy Inspiratory Exercises
The goal of this single-site, parallel-group, double-blind, sham-controlled randomized control trial is to examine the effect of high-intensity inspiratory muscle strength training (IMST) on coronary blood flow assessed using…
- Trial name
- BREATHE (NCT05632614)
- Testing
- High-intensity IMST, Low-intensity IMST
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Acute Coronary Syndrome
Coronary Flow Reserve in Patients With Bio-active Stent or Everolimus-eluting Stent Implanted in Acute Coronary Syndrome
The aim of the trial is to assess coronary artery reactivity using adenosine-induced coronary flow reserve (CFR) by transthoracic echocardiography in patients with Bio-active stent (BAS) and Everolimus-eluting stent (EES) distal…
- Trial name
- BASE-CFR (NCT01080872)
- Testing
- CFR
- Where
- 2 sites in Finland
- Volunteers
- 40 people
- Sponsor
- The Hospital District of Satakunta
Myocardial Infarction (MI), Cardiogenic Shock
Optimal Timing of Microaxial Flow Pump(Impella CP) in AMI-related Cardiogenic Shock
PRIME-SHOCK is a prospective, single-center, open-label, randomized, superiority trial. Eligible participants with AMICS and a clinical decision to use Impella CP will be randomized in a 1:1 ratio before culprit-lesion PCI.
- Conditions
- Myocardial Infarction (MI), Cardiogenic Shock, ST-Segment Elevation Myocardial Infarction(STEMI), Non-ST-Segment Elevation Myocardial Infarction (NSTEMI)
- Trial name
- PRIME-SHOCK (NCT07817472)
- Testing
- Routine pre-PCI Impella CP, Selective post-PCI Impella CP
- Where
- South Korea
- Volunteers
- 126 people
- Sponsor
- Chonnam National University Hospital
Valvular Heart Disease, Coronary Artery Disease
Cardiovascular Acoustics for Early Disease Detection
There are many types of heart disease. Two of the most common causes are narrowings within the blood vessels that supply the heart (known as coronary artery disease), or valves within the heart becoming narrowed (stenosed) or…
- Trial name
- ACOUTECT (NCT07496775)
- Where
- United Kingdom
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Atrial Fibrillation, Acute Coronary Syndromes
DUAL Antithrombotic Therapy in Patients With AF and ACS
The study aims to show inferiority of rivaroxaban plus ticagrelor when compared to rivaroxaban plus clopidogrel in terms of safety.
- Trial name
- NCT04023630
- Testing
- Rivaroxaban 15 MG Oral Tablet, Clopidogrel 75 Mg Oral Tablet, Ticagrelor 90 MG Oral Tablet
- Volunteers
- 4,000 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Coronary Artery Disease
Myovista iECG for Detecting Ischemic Heart Disease: Comparison With Computed Tomography Coronary Angiography
Study evaluates the new technique MyoVista™ iECG sensitivity and ability to predict myocardial diseases, comparing iECG results with Computed Tomography Coronary Angiography findings
- Trial name
- NCT01562730
- Where
- Switzerland
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Cardiocentro Ticino
Diabetes Mellitus, Acute Coronary Syndrome
Cardioprotective Effect of SGLT2-I in Diabetic Patients With AMI (SGLT2-I AMI PROTECT Study)
Despite their potential benefits on the heart with pleiotropic mechanisms, the cardioprotective effects of new glucose-lowering SGLT-2 inhibitors in patients with myocardial infarction - both in the acute and chronic phase - have…
- Trial name
- SGLT2-I AMI (NCT05261867)
- Where
- 7 sites in Belgium, Bulgaria and 1 more
- Volunteers
- 800 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Myocardial Infarction, Ventricular Tachycardia
MAgnetic Resonance Imaging-guided implanTation of Cardioverter DEFibrillators
Implantable cardioverter-defibrillators (ICD) are currently recommended for the primary prevention of sudden cardiac death (SCD) in patients with a remote (>6 weeks) myocardial infarction (MI) and a low (≤35%) left ventricular…
- Conditions
- Myocardial Infarction, Ventricular Tachycardia, Ventricular Fibrillation, Sudden Cardiac Death
- Trial name
- SMART-DEF (NCT06269692)
- Testing
- MRI screening, Implantable Loop Recorder, Implantable Cardioverter Defibrillator
- Where
- France
- Volunteers
- 1,812 people
- Sponsor
- Central Hospital, Nancy, France
Coronary Artery Disease, Drug Resistance
Effect of Clopidogrel Loading and Risk of PCI
This study is a prospective, single-center evaluation of the impact of the variability in platelet response after loading with clopidogrel on the peri-interventional risk of patients undergoing PCI.
- Trial name
- EXCELSIOR (NCT00457236)
- Where
- Germany
- Volunteers
- 800 people
- Sponsor
- University Heart Center Freiburg - Bad Krozingen
Coronary Artery Disease
A Postmarket Clinical Trial for EXCROSSAL Stent in CAD Patients With 3-month DAPT or 12-month DAPT
1. Prospective, randomized, multicenter clinical study 2. This is a post-marketing clinical study to evaluate whether it will affect the safety event when it is used in different treatment ways.
- Trial name
- NCT03716011
- Testing
- EXCROSSAL
- Where
- China
- Volunteers
- 2,700 people
- Sponsor
- JW Medical Systems Ltd
Coronary Artery Disease
The PLATINUM Clinical Trial to Assess the PROMUS Element Stent System for Treatment of Long De Novo Coronary Artery Lesions (PLATINUM LL)
The purpose of this study is to evaluate the safety and effectiveness of the PROMUS Element™ Everolimus-Eluting Coronary Stent System for the treatment of patients with up to 2 de novo atherosclerotic coronary artery lesions.
- Trial name
- PLATINUM LL (NCT01500434)
- Testing
- PROMUS Element Coronary Stent System, Aspirin, Thienopyridine
- Where
- 30 sites in United States, Australia and 5 more
- Volunteers
- 102 people
- Sponsor
- Boston Scientific Corporation
Coronary Artery Disease
Study of the PAS-Port® Proximal Anastomosis System in Coronary Bypass Surgery
The study has been designed to comparatively evaluate the safety and effectiveness of the PAS-Port Proximal Anastomosis System and conventional suturing techniques for creation of the connection between graft veins and the aorta…
- Trial name
- EPIC (NCT00355563)
- Testing
- PAS-Port Automated Proximal Anastomosis System
- Where
- United States
- Volunteers
- 220 people
- Sponsor
- Cardica, Inc
ST Elevation (STEMI) Myocardial Infarction
High-Dose Rosuvastatin Preloading for Enhanced Outcomes in STEMI Patients Undergoing Primary PCI
To compare the efficacy of high dose rosuvastatin preloading vs placebo before primary PCI in terms of MACE at 30 days
- Trial name
- HEROS-PCI (NCT06924684)
- Testing
- Statin monotherapy (rosuvastatin or atorvastatin)
- Where
- 2 sites in Pakistan
- Volunteers
- 66 people
- Sponsor
- Sheikh Zayed Federal Postgraduate Medical Institute
Coronary Artery Disease
Evaluation of Effectiveness and Safety of Ultimaster™ Tansei™ Stent and/or Ultimaster Nagomi™ Stent in Routine Clinical Practice
This study is to evaluate the effectiveness and safety of Ultimaster Tansei stent and/or Ultimaster Nagomi stent in the "real-world" daily practice.
- Trial name
- IRIS Tansei (NCT04443530)
- Testing
- Ultimaster™ Tansei™ stent and/or Ultimaster Nagomi™ stent
- Where
- 11 sites in South Korea
- Volunteers
- 2,000 people
- Sponsor
- Duk-Woo Park, MD
Coronary Artery Disease, Angina Pectoris
Impact of Coronary Sinus Flow Reducer on Coronary Microcirculation and Myocardial Ischemia
The increasing number of coronary revascularization procedures, coupled with improvements in drug therapy, has significantly extended the lifespan of patients with coronary artery disease (CAD).
- Trial name
- NCT06266065
- Testing
- Coronary Sinus Reducer
- Where
- Croatia
- Volunteers
- 25 people
- Sponsor
- Clinical Hospital Centre Zagreb
Heterozygous Familial Hypercholesterolemia (HeFH)
EDIT-401 in Adults Who Require Additional Lowering of Low-Density Lipoprotein Cholesterol (LDL-C)
A phase 1/2, two-part trial consisting of an open label dose-escalation part and a randomized, double blind, placebo-controlled part to investigate safety, tolerability, pharmacokinetics, and efficacy with EDIT-401 gene editing…
- Trial name
- NCT07894887
- Testing
- Drug: EDIT-401
- Where
- 2 sites in Australia
- Volunteers
- 56 people
- Sponsor
- Editas Medicine, Inc.
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