Clinical trials: Coronary; Ischemic
Coronary Heart Disease
Ticagrelor Versus Clopidogrel for CMD in Patients With AMI: A Retrospective Study Based on the Angio-IMR
Coronary microvascular dysfunction (CMD) is increasingly recognized as an important indicator for long-term prognosis in patients with acute myocardial infarction (AMI).
- Trial name
- NCT05978726
- Testing
- Dual antiplatelet therapy with aspirin and either ticagrelor or clopidogrel
- Where
- China
- Volunteers
- 325 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Ischemic Heart Disease
QWISE - Study of Quinapril in Women With Chest Pain, Coronary Flow Reserve Limitations and Evidence of Myocardial Ischemia
INDICATION Microvascular angina. OBJECTIVES To investigate the effect of ACE (angiotensin converting enzyme) inhibition (quinapril) in improving coronary microvascular function.
- Trial name
- NCT00150826
- Testing
- Quinapril
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- University of Florida
Myocardial Infarction, Coronary Artery Disease
Protocol in Reeducation Occupational Therapist in Coronary Patients
The quality of life, linked to physical, social and mental performance in people with coronary heart disease represents the primary goals in terms of rehabilitation.
- Trial name
- NCT04774276
- Testing
- cardiac rehabilitation protocol without occupational therapist, cardiac rehabilitation protocol with occupational therapist
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Percutaneous Coronary Intervention, Coronary Artery Bypass Graft Surgery, With or Without Valve Surgery
Cardiac Rehabilitation Peer Mentorship
The current study is a randomized controlled trial, being conducted at two hospitals in Toronto, Ontario, Canada, involving the randomization of cardiac inpatients into an intervention group, in which they will receive mentorship…
- Conditions
- Percutaneous Coronary Intervention, Coronary Artery Bypass Graft Surgery, With or Without Valve Surgery, Acute Coronary Syndrome, Chronic Stable Heart Failure
- Trial name
- NCT02204449
- Testing
- Cardiac Rehabilitation Peer Mentorship
- Where
- 2 sites in Canada
- Volunteers
- 94 people
- Sponsor
- University Health Network, Toronto
Mesenteric Ischemia
Microcirculation During Extracorporeal Circulation
Digestive tract is supposed to be the motor of multiple organ failure. In ICU patients, mesenteric ischemia appears even when macrocirculatory parameters are controlled especially in our experience in patients coming in ICU after…
- Trial name
- CITRON4 (NCT01389947)
- Where
- France
- Volunteers
- 66 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Acute Cardiovascular Disease, Acute Coronary Syndrome
Naples Federico II Intensive Cardiac Care Unit Registry (Naples FED2-ICCU Registry)
This protocol proposes to prospectively evaluate current epidemiology, pharmacologic and invasive management and clinical outcomes of patients with acute cardiovascular diseases admitted at our ICCU.
- Conditions
- Acute Cardiovascular Disease, Acute Coronary Syndrome, Acute Heart Failure, Cardiogenic Shock
- Trial name
- NCT06162247
- Where
- Italy
- Volunteers
- 5,000 people
- Sponsor
- Federico II University
Pulmonary Edema, Myocardial Infarction
Non-Invasive Ventilation in Pulmonary Edema
This randomized controlled trial is primarily aimed at assessing the rate of acute myocardial infarction with the two noninvasive ventilatory techniques, non-invasive intermittent positive pressure ventilation and non-invasive…
- Trial name
- NCT00453947
- Testing
- CPAP and Non Invasive Ventilation
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Ospedale S. Giovanni Bosco
Coronary Artery Disease
Prospective, Randomized, Multicenter Study to Assess the Safety and Effectiveness of the Orsiro Sirolimus-eluting Stent
BIOFLOW-IV is a prospective, international, multicenter, randomised controlled trial. The purpose of this trial is to compare the Biotronik Orsiro drug eluting stent system with the Xience Prime / Xience Xpedition (Xience)drug…
- Trial name
- BIOFLOW-IV (NCT01939249)
- Testing
- Abbott Laboratories Xience, Biotronik Orsiro
- Where
- 45 sites in Australia, Belgium and 10 more
- Volunteers
- 585 people
- Sponsor
- Biotronik AG
Myocardial Ischemia
Effect of Dapagliflozin on Microvascular Function in Women With Symptoms of Coronary Artery Disease
The goal of this clinical trial is to test the effects of a drug (in the drug class called sodium-glucose cotransporter 2 inhibitors) in women who have symptoms of ischemic heart disease.
- Trial name
- SMILE (NCT05762952)
- Testing
- Dapagliflozin 10mg Tab
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Virginia
Acute Coronary Syndrome
ObseRvation After Acute Coronary Syndrome for deveLopment of trEatment Options
The aim of the study is developing an individualized risk model for the unfavorable outcomes of coronary artery disease and complications from ongoing therapy, according to clinical, instrumental, biochemical and genetic…
- Trial name
- ORACLE (NCT04068909)
- Volunteers
- 1,655 people
- Sponsor
- Central State Medical Academy
Vasoplegia, Hypotension
Hemodynamic Effects of Methylene Blue vs Hydroxocobalamin in Patients at Risk of Vasoplegia During Cardiac Surgery
This is a pilot study to determine the hemodynamic effects when hydroxocobalamin vs methylene blue is administered during cardiopulmonary bypass in patients at risk of vasoplegia by measuring mean arterial pressure (MAP)…
- Conditions
- Vasoplegia, Hypotension, Coronary Artery Disease, Cardiac Valve Disease
- Trial name
- NCT03446599
- Testing
- Hydroxocobalamin, Methylene Blue, Normal saline
- Where
- United States
- Sponsor
- Dartmouth-Hitchcock Medical Center
Increased Drug Resistance
The Effects of Omega-3 Fatty Acids on Aspirin Resistance
The purpose of this study is to determine if omega-3 fatty acids enhance the antiplatelet effects of aspirin.
- Trial name
- NCT00771914
- Testing
- Aspirin, Lovaza, Both Aspirin and Lovaza
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Coronary Stenosis
FrActional Flow Reserve Guided Drug Coated Balloon Only Strategy in De Novo coronarY Lesions (FADDY)
Drug-eluting stent (DES) has been the primary choice for in suit coronary lesions treatment. In comparison to bare-metal stent (BMS), it evidently decreases the rate of restenosis.
- Trial name
- FADDY (NCT03452904)
- Testing
- Drug-coated balloon, Drug-eluting stent
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Coronary Artery Disease
Clinical Validation of PROPECG-TMT
This clinical validation evaluates the performances of physicians with and without learning with PROPECG-TMT assistance for screening coronary artery revascularization on TMT-ECG.
- Trial name
- NCT06624852
- Testing
- Screening for coronary artery revascularization based on TMT-ECG
- Where
- South Korea
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Cardiogenic Shock, Acute Myocardial Infarction (AMI)
CRP Apheresis in Infarct-Related Cardiogenic Shock
Cardiogenic shock complicating acute myocardial infarction remains associated with high short-term mortality despite guideline-directed therapy.
- Trial name
- CRP-SHOCK (NCT07687017)
- Testing
- Selective C-reactive protein apheresis (PentraSorb®-CRP), Standard of care
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- Leipzig Heart Science gGmbH
Spontaneous Coronary Artery Dissection
Angiographic and Psychosocial Evaluation of Peripartum vs. Non: SCAD
This multi-site international clinical research project is a collaboration between investigators from multiple institutions in the USA, Canada, and Europe.
- Trial name
- SCAD (NCT03390998)
- Where
- United States
- Volunteers
- 241 people
- Sponsor
- Katharine Sears Edwards
Atherosclerosis, Cardiovascular Diseases
Epidemiology of Vascular Inflammation & Atherosclerosis
To investigate the relationship of vascular cell phenotypes to atherosclerosis.
- Conditions
- Atherosclerosis, Cardiovascular Diseases, Heart Diseases, Coronary Arteriosclerosis
- Trial name
- NCT00087893
- Volunteers
- 931 people
- Sponsor
- University of Vermont
Stroke, Ischemic, Sleep Disorder
The Role of Circadian Factors in Regulation of Neuroplasticity in Ischemic Stroke (Observational)
The study is aimed at the investigation of the association of biomarkers of circadian rhythms with sleep characteristics and stroke outcome in acute stroke patients.
- Trial name
- NCT05242393
- Testing
- No intervention is planned
- Where
- Russia
- Volunteers
- 250 people
- Sponsor
- Federal State Budgetary Institution, V. A. Almazov Federal North-West Medical Research Centre, of the Ministry of Health
Coronary Artery Disease, Left Main Coronary Artery Stenosis
Concordance Between FFR and iFR for the Assessment of Intermediate Lesions in the Left Main Coronary Artery. A Prospective Validation of a Default Value for iFR
The assessment of Left Main Coronary Artery (LMCA) lesions by means of coronary angiography renders serious limitations. Studies with a limited number of patients have shown that a value of FFR (Fractional Flow Reserve) above…
- Conditions
- Coronary Artery Disease, Left Main Coronary Artery Stenosis, Left Main Coronary Artery Disease, Restenosis, Coronary
- Trial name
- iLITRO (NCT03767621)
- Testing
- Indication of revascularization
- Where
- 38 sites in Spain
- Volunteers
- 300 people
- Sponsor
- Fundación EPIC
Coronary Occlusion
Cohort B of the Pivotal Study to Evaluate the Safety and Effectiveness of the NovaCross™ Micro-catheter
A Prospective, Multi-Center, Non-randomized, Single arm, Open label, Supplemental Study to Evaluate the Safety and Effectiveness of the NovaCross™ Micro-catheter in Facilitating Crossing Chronic Total Occlusion (CTO) Coronary…
- Trial name
- NCT03719014
- Testing
- NovaCross
- Where
- 3 sites in United States
- Volunteers
- 60 people
- Sponsor
- Nitiloop Ltd.
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